what is the treatment for paget disease of bone

What is the prognosis of Paget disease?

Medicine can help reduce the breakdown of bone tissue, control symptoms such as bone pain, and prevent other problems such as arthritis, fractures, or nerve damage. Bisphosphonates are usually the first medicines prescribed for Paget's disease. They often make the disease inactive, sometimes for years or decades.

How to diagnose Paget's disease?

Medication: Many medications can treat Paget’s disease of the bone. The most common type is bisphosphonates. The most effective bisphosphonate is zoledronate (Reclast®). Often, one dose of this drug can result in long-lasting remission of the …

What is Paget disease and what are the symptoms?

There's currently no cure for Paget's disease of bone, but treatment can help relieve the symptoms. If you do not have any symptoms, your doctor may suggest keeping an eye on your condition and delaying treatment until any problems occur. Bisphosphonates. Bisphosphonates are medicines that help regulate bone growth.

What are the top 10 bone diseases?

May 15, 2002 · Calcitonin-salmon is available in injectable and nasal-spray forms, but only the injectable form is approved for treatment of Paget's disease by the U.S. Food and Drug Administration 22, 23 ...

What is the first-line treatment for Paget disease?

Can Paget's disease of bone be cured?

Which drugs is used to treat Paget's disease?

How long can you live with Paget disease?

Is Paget's disease of bone fatal?

Is Paget's disease serious?

What bones are often affected by Paget's disease?

What does Paget's disease of the bone look like?

What are the long term effects of Paget's disease?

What happens if Paget's disease is left untreated?

Is Paget's disease cancerous?

Is there pain with Paget's disease?

What is the best medicine for Paget's disease?

Medicine can help reduce the breakdown of bone tissue, control symptoms such as bone pain, and prevent other problems such as arthritis, fractures, or nerve damage. Bisphosphonates are usually the first medicines prescribed for Paget's disease. They often make the disease inactive, sometimes for years or decades.

Do you need to see a doctor for Paget's disease?

Many people don't need treatment for Paget's disease. But even if you don't need treatment, you will still need to see your doctor on a regular basis from now on. This will let your doctor watch for other problems you might get from the disease, such as arthritis, fractures, or nerve problems.

How to prevent broken bones?

Physical therapy to build your muscles and improve your balance. This can help reduce falls and prevent broken bones. Splints or braces to support your bones and joints and to help keep weak bones from breaking. A cane or walker to help you avoid falling and breaking a bone.

What is the best treatment for a broken hip?

Splints or braces to support your bones and joints and to help keep weak bones from breaking. A cane or walker to help you avoid falling and breaking a bone. A hearing aid if the disease has caused hearing loss. Some people may need surgery to replace a damaged hip or knee joint. Diagnosis.

What is the best treatment for Paget's disease of bone?

Painkillers. Over-the-counter painkillers such as paracetamol and ibuprofen can help relieve pain caused by Paget's disease of bone. Make sure you read the packet or leaflet before taking painkillers, to check whether they're suitable for you and to find out how much to take.

Is there a cure for Paget's disease of bone?

There's currently no cure for Paget's disease of bone, but treatment can help relieve the symptoms. If you do not have any symptoms, your doctor may suggest keeping an eye on your condition and delaying treatment until any problems occur.

How to fix a fractured bone?

Operations that may be done include procedures to: 1 realign the bones after a fracture so that they heal correctly 2 remove and replace a damaged joint with an artificial one, such as a hip replacement or knee replacement 3 cut and straighten deformed bones 4 move bone away from a squashed (compressed) nerve

What are some ways to help people with Paget's disease?

Supportive therapies. Some people with Paget's disease benefit from supportive therapies such as physiotherapy or occupational therapy. These therapies involve exercises and techniques that can help reduce pain, improve movement and make everyday tasks easier.

Does Zoledronate cause bone loss?

The main side effects of zoledronate and pamidronate are flu-like symptoms that last a day or 2. If you're unable to have bisphosphonates, you may need daily injections of another medicine that prevents bone loss called calcitonin.

What is the best treatment for Paget's disease?

Treatment of Paget's disease does not cure the disease but can provide prolonged periods of remission. Bisphosphonates, which decrease bone resorption by inhibiting osteoclast resorption, are the treatment of choice. Disease activity stays low for months or years after cessation of these medications. Alendronate (Fosamax) and pamidronate (Aredia) are used most frequently and will cause about a 70 percent decrease in biochemical markers in one half of patients. 2 Newer-generation bisphosphonates that are still in development are thousands of times more potent than first-generation agents. Calcitonin (Calcimar) also inhibits osteoclastic bone resorption. Calcitonin-salmon is available in injectable and nasal-spray forms, but only the injectable form is approved for treatment of Paget's disease by the U.S. Food and Drug Administration 22, 23 ( Table 4 12). Compared with the bisphosphonates, calcitonin is not as powerful and does not suppress the disease activity for as long after cessation. Patients with Paget's disease should receive adequate doses of calcium (1,000 to 1,500 mg per day) and vitamin D (400 IU per day). Exercise is recommended to maintain skeletal health in patients with Paget's disease; however, exercise programs should be individualized to prevent stress on affected bones.

Does Paget's disease cure?

Treatment of Paget's disease does not cure the disease but can provide prolonged periods of remission. Bisphosphonates, which decrease bone resorption by inhibiting osteoclast resorption, are the treatment of choice. Disease activity stays low for months or years after cessation of these medications.

Is Paget's disease of bone asymptomatic?

The origin of the disease is unknown, and it is frequently asymptomatic; however, the patient may present with symptoms depending ...

What is Paget's disease?

Paget's disease of bone (also known as osteitis deformans) is a nonmalignant disease involving accelerated bone resorption followed by deposition of dense, chaotic, and ineffectively mineralized bone matrix. The origin of the disease is unknown, and it is frequently asymptomatic; however, the patient may present with symptoms depending on the bones involved. The most common symptom is pain in the affected bone; neurologic, hearing, vision, cardiac, and oncologic complications are possible. Diagnosis is primarily made by radiographs. Bisphosphonates are the most common treatment.

What is the most common bone disorder?

A side from osteoporosis, Paget's disease is the most common bone disorder. 1 Paget's disease is equally prevalent in men and women, with increased incidence in persons older than 50 years. It affects approximately 3 percent of persons in the United States, and as many as 10 percent of persons older than 80 years. 2, 3.

How many bones does Paget's disease affect?

Paget's disease most commonly involves the axial skeleton, but it can affect any area ( Table 1). 4 In the majority of patients, Paget's disease affects at least two bones, but in one third of patients only one bone is affected. 1.

Is Paget's disease a viral disease?

Although the etiology of Paget's disease is unknown, studies have provided some support for both viral and hereditary causes. Viral antigens have been detected in affected osteoclasts by numerous methods and research teams. 5 In the United States, the measles virus antigen is most commonly detected in patients with Paget's disease. 6 – 8

How to treat Paget's disease?

Paget’s disease is often treated with a group of drugs called bisphosphonates. These act mainly on the cells that break down old bone to regulate the process of bone renewal. They often help to ease any bone pain caused by Paget’s disease, although it may take a few weeks for symptoms to improve.

What is the process of bone renewal in Paget's disease?

In Paget’s disease, the process of renewal is disrupted: More bone cells than usual are produced and they become larger and more active. The rate of bone renewal is greatly increased and is uncontrolled. The structure of the new bone is abnormal and weaker than usual. The weakened bones can bend or cause damage to nearby joints.

Can Paget's disease be diagnosed by chance?

Often there are no symptoms at all. Paget’s disease is often diagnosed by chance when an x-ray or blood test is taken for some other reason. For those who do have symptoms, pain is the most common problem and is usually felt in the bone itself or in the joints near the affected bones.

Why does Paget's disease hurt?

Pain linked to Paget’s disease may be caused by: increased blood flow in the affected areas, which can also result in those areas feeling unusually warm to the touch. nerve fibres surrounding the bone being stretched as a result of bones growing larger or bending. damage in the joints near the affected bones.

Can Paget's disease cause bone to break?

Fractures: Bone affected by Paget’s disease is weaker than usual, so is more likely to break than healthy bone. It may also take longer than normal for a bone to heal after a fracture. Nerve compression: When the bones expand they can sometimes squeeze nearby nerves.

What causes Paget's disease?

It’s not yet known exactly what causes Paget’s disease but the genes passed on through families may play a part. Lifestyle factors, such as poor diet, or bone injury early in life, may trigger the development of Paget’s disease in people who already have a genetic risk.

Can a doctor diagnose Paget's disease?

If the bone is enlarged or bent, your doctor may be able to diagnose Paget’s from your symptoms and a physical examination. They may also take into account any family history of Paget’s disease. Often, however, x-rays and blood tests are needed to confirm it.

Can Paget's disease be treated?

There is no cure for Paget’s disease but treatment can ease symptoms and reduce the chances of having complications. Usually, people with no symptoms don' t need treatment. If treatment is needed, it can include: over-the-counter pain relievers such as paracetamol and ibuprofen. bisphosphonates, which are prescription-only medicines ...

Does Paget's disease cause pain in the bones?

Many people with Paget’s disease have no symptoms. Some people have pain in the bones. Often, the pain is worse after lying down or resting. People with Paget’s disease may also have: enlarged or deformed bones. bowed legs.

Is Paget's disease a metabolic disease?

Paget's disease mainly affects people aged over 55. In Australia, it is the most common metabolic bone disorder after osteoporosis. Although its cause is unknown, people are more likely to develop Paget’s disease if someone else in their family has it. Paget’s disease is a bone disorder.

What is Paget's disease?

Paget’s disease is a bone disorder. Bone is a living tissue, constantly being broken down and renewed. This process is called bone remodelling. Paget’s disease occurs when something goes wrong with this process — the bone breaks down more quickly than normal, and the new bone that is formed is larger and weaker than normal bone.

What is the process of bone remodelling?

Bone is a living tissue, constantly being broken down and renewed. This process is called bone remodelling. Paget’s disease occurs when something goes wrong with this process — the bone breaks down more quickly than normal, and the new bone that is formed is larger and weaker than normal bone.

What is it called when a bone breaks down?

This process is called bone remodelling. Paget’s disease occurs when something goes wrong with this process — the bone breaks down more quickly than normal, and the new bone that is formed is larger and weaker than normal bone. It can affect bones in one or more places in your body.

What tests are needed to diagnose bone deformity?

You may be asked to have blood or urine tests, an x-ray or a bone scan. In some cases, imaging tests such as a CT scan or MRI scan may be needed to confirm the diagnosis.