What does salvage therapy mean?
Salvage Therapy Synonym (s) Rescue Therapy Therapy given when the standard treatment for a disease or condition is no longer effective and when treatment options are limited. People with HIV who have experienced toxicity and/or developed resistance to many HIV drugs receive salvage therapy. Related Term (s) Drug Resistance Treatment Failure
What alternatives are there to limb salvage therapy?
The term 'Salvage therapy' is broadly defined as any therapy that is administered after a first-line therapy has failed. It doesn't matter if the salvage therapy is with chemo, biological agents, radiation, transplantation—the term 'salvage therapy' covers them all, so long as they are therapies administered in the wake of a failed induction therapy.
What is the law of salvage?
Jun 11, 2021 · Salvage therapy is a term for any treatment you receive after standard treatments have failed. It can take on many forms depending on what condition you’re treating and your overall health. Your...
What is a salvage treatment?
Mar 29, 2022 · In general medical terms, salvage treatment is any kind of therapy which is offered after a patient fails to respond to initial therapy, or when a disease recurs. It may involve different medications, higher doses, and a generally more aggressive course of treatment, or it may be very similar to the initial treatment.
What does salvage treatment mean?
(SAL-vij THAYR-uh-pee) Treatment that is given after the cancer has not responded to other treatments.
What is salvage chemotherapy?
Salvage therapy is a term for any treatment you receive after standard treatments have failed. It can take on many forms depending on what condition you're treating and your overall health. Your salvage therapy could include medications, chemotherapy, radiation, surgery, and more.Jun 11, 2021
What is salvage therapy for lymphoma?
Salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell transplant (ASCT) for patients with chemotherapy-sensitive disease is a standard treatment sequence for relapsed or refractory (rel/ref) HL. Patients who achieve complete response prior to ASCT have better survival outcomes.Aug 29, 2017
What is salvage radiation therapy?
Generally, "salvage" radiotherapy (SRT) is defined as radiation treatment given for suspected recurrent malignant disease after a period of observation after prostatectomy.Jul 15, 2010
Can lymphoma be completely cured?
Overall, treatment for Hodgkin lymphoma is highly effective and most people with the condition are eventually cured.
Can non Hodgkin's lymphoma be completely cured?
Yes, NHL is a very treatable disease and curable in many cases, particularly with aggressive NHL. Before treatment begins, it is necessary to know how far the cancer has advanced. This is called the stage of the disease.Sep 15, 2019
What happens if chemo doesn't work for lymphoma?
If the lymphoma doesn't respond to the initial treatment or if it comes back later, it may be treated with different chemo drugs, immunotherapy, targeted drugs, or some combination of these. If the lymphoma responds to this treatment, a stem cell transplant may be an option.
How often does DLBCL relapse?
Background: DLBCL has a 40% relapse rate in the rituximab era. Patients who relapse within a year do poorly even with salvage treatment.Jun 1, 2018
What is salvage therapy in DLBCL?
Salvage high-dose chemotherapy followed by autologous stem cell transplantation is the standard of care for chemosensitive relapses in DLBCL. Various salvage regimens are available, but the quest for an optimal regimen continues. The addition of rituximab to the salvage regimen has improved the outcome of RR DLBCL.
When do you need salvage radiotherapy?
The European Association of Urology 2007 guidelines recommend salvage radiotherapy when there is evidence of local recurrence, with a dose of 64–66 Gy at a serum PSA level of 1.5 μg/L or less74 (grade B recommendation).
Is salvage radiotherapy successful?
In contrast with the results of primary radiotherapy for localized prostate cancer,8,9 the reported success rates of salvage radiotherapy range between 10% and 50%, suggesting that the majority of unselected patients with an increasing PSA level have occult metastases and do not benefit from salvage radiotherapy.Mar 17, 2004
What does a PSA level of 0.1 mean?
Ideally, your post-prostatectomy PSA will be undetectable, or less than 0.05 or 0.1 nanograms of PSA per milliliter of blood (ng/mL). If that's the case, your doctor may call it a remission.Oct 19, 2017
What is salvage therapy?
Salvage therapy, also known as rescue therapy, is a form of therapy given after an ailment does not respond to standard therapy. The most common diseases that require salvage therapy are HIV and various cancers. The term is not clearly defined; it is used both to mean a second attempt and a final attempt.
How do ARVs help HIV?
If the patient's viral load (the amount of HIV in the blood) rebounds after being suppressed by ARVs, the virus has likely developed resistance to the ARVs. As more and more mutations conferring drug resistance develop in the HIV's genome, it becomes difficult to select an ARV that will meaningfully suppress HIV replication and keep the patient's viral load low. Salvage therapy, in this context, is the attempt to contain the replicating HIV once the usual line of treatments have been exhausted. When at least one regimen containing protease inhibitors has failed in a patient, the subsequent attempts to treat the HIV infection may be referred to as salvage therapy.
What is salvage radiotherapy?
Definition of Salvage Radiotherapy (SRT), and the Distinction Between SRT and Adjuvant RT (ART) Generally, "salvage" radiotherapy (SRT) is defined as radiation treatment given for suspected recurrent malignant disease after a period of observation after prostatectomy.
What are the three randomized trials of SRT?
The use of hormone therapy in combination with SRT is an area of controversy that will hopefully be clarified by three randomized trials: 1) The RTOG 96-01 trial, 2) The RTOG 05-34 SSPORT trial, and 3) The RADICALS trial . The RTOG 96-01 trial is a prospective randomized trial comparing postoperative RT with and without 2 years of bicalutamide 150 mg/day which has completed and should be presented in 2010. [52] The RTOG 0534 is an ongoing phase III trial of short-term androgen deprivation with pelvic lymph node or prostate bed–only radiotherapy (SPPORT) in prostate cancer patients with a rising PSA after RP. This 3-arm randomized trial is assessing prostate bed RT vs prostate bed RT with short-term androgen ablation vs pelvic and prostate RT along with short-term androgen ablation. [52] As noted previously, the RADICALS trial is a prospective trial with two randomizations. The first randomization will investigate immediate ART versus delayed SRT at the time of biochemical recurrence. Patients receiving RT will then be further randomized to RT alone, RT + 6 months of hormones, or RT + 2 years of hormones. [26] Although hormone therapy has been shown to improve overall survival in combination with EBRT for men with prostate cancer of intermediate- or high-risk disease, the value of hormone therapy has not yet been proven for men undergoing either ART or SRT. [53-55]
How many people died from prostate cancer in 2009?
Prostate cancer is the second most common cause of cancer death in American men, with 192,289 new cases and 27,360 deaths expected in 2009. [1] . While radical prostatectomy provides excellent control for clinically localized disease, approximately one-third of patients undergoing surgery will have positive surgical margins ...
How long does it take for a man to recover from prostate cancer?
[60-63] It can take erectile functioning 18 months to 2 years to recover after prostatectomy, and radiation may further damage vascular structures in the penis. [64,65] It is unknown whether receiving RT before healing completely from surgery exacerbates the problem. In addition to avoiding overtreatment of patients, SRT has the benefit over ART of allowing patients more healing time. Of course, this advantage must be weighed against decreasing chances of efficacy if RT is postponed for too long. [66]
Does prostate cancer recur after radical prostatectomy?
Conclusion. The treatment of prostate cancer that has recurred months or years after radical prostatectomy is an evolving field, and multiple consensus guidelines and prognostic features exist to help the clinician make a decision regarding treatment fields and likelihood of efficacy.
Is grade 3 GI toxic?
More serious toxicity was rare, with grade 3 GU toxicities in only 1% of all patients and grade 3 GI toxicities in 0.2 % of all patients. Given the small number of events, there were no predictors that correlated with late GI toxicity, and there was no difference in GI toxicity between ART and SRT.
Is radiation therapy curative after RP?
Radiation treatment is the only potentially curative treatment available for most patients with biochemical failure after RP. However, some would argue that quality of life (QOL) is as important as survival. Despite the evidence in support of using RT in this setting, the decision to use it must take into account the side effects associated with treatment. There have been multiple reports of acute and late toxicities after post-operative radiation therapy in prostate cancer. Overall, RT appears to be well-tolerated in patients undergoing ART and SRT, and lessons drawn from patients undergoing ART are therefore broadly applicable to SRT.
What Is Salvage Therapy?
- Salvage therapy is not a specific treatment. It means that a person has been treated in line with standard protocols—from first-line therapy to second-line therapy to third-line therapy, and so on—but those treatments have proven ineffective or intolerable. It essentially means that standa…
Conditions
- Salvage therapy is structured and follows guidelines based on available scientific research. It may extend into clinical trials or involve experimental drugs, but, even then, treatment decisions are based on the best available evidence. Salvage therapies are commonly used in people with advanced HIV infection or advanced cancer, but there are other situations in which salvage ther…
Side Effects
- Salvage therapy is presumed to cause more side effects of traditional therapies because more treatments are involved. But this is not always the case. Moreover, the consequences of nottreating diseases like HIV and cancer can be more serious than the side effects of treatment. Ultimately, how well the patient handles the adverse effects of the treatment (the tolerability) wil…
How to Cope
- Salvage therapy is generally an indication that your immune system is in a weakened state. When you are immunosuppressed or immunocompromised, your body is less able to fight infection. In people with HIV, this low immune state is the result of the virus, which depletes immune cells.18 In people with cancer, both the tumor and cancer treatment contribute.19 To prevent infection w…
After Salvage Therapy
- After salvage therapy has been prescribed, the single most important thing you can do is to see your doctor regularly. Because salvage therapy poses a risk of toxicity, regular blood tests may be needed to proactively identify liver or kidney problems before they turn severe. At the same time, the doctor will want to evaluate your response to treatment. With HIV, this would involve a viral l…
A Word from Verywell
- As scary as salvage therapy may sound—suggesting your good health is being "salvaged"—don't assume that you are at the end of the line as far as treatment options are concerned. Salvage therapy aims to continue treatment to stabilize your condition and ideally improve it. If faced with salvage therapy, ask your doctor as many questions as needed to understand what is involved a…