Treatment FAQ

what is one of the most serious adverse reactions during iontophoresis treatment?

by Carolyne Langworth Published 2 years ago Updated 2 years ago

Iontophoresis is a safe and painless procedure. Some people may experience side effects as a result of iontophoresis, but the effects usually aren’t serious. The most common side effect is dryness of the skin. Blistering, peeling, and irritation might also occur on the skin.

Iontophoresis induces a sensation of tingling or itching, depending on the density of the applied current. Besides these uncomfortable but harmless effects, skin irritation is the most common local adverse effect of cutaneous iontophoresis. It occurs at both the anode and the cathode.

Full Answer

What are the side effects of iontophoresis?

Iontophoresis is a safe procedure, and side effects are minimal. While receiving the stimulation, you may feel a slight pin prick tingling sensation. Redness may also occur underneath the electrodes used for it. Some patients notice some dryness or rough skin in the area where the iontophoresis was administered.

What is Iontophoresis for inflammation?

Iontophoresis for Inflammation. There are a number of drugs that can be driven into the subcutaneous tissues including steroids, NSAIDS, local anesthetics, salicylates, and individual substances such as zinc oxide, iodine, acetic acid, and calcium chloride, to name a few.

Is Iontophoresis of rather lipophilic drugs possible?

In the same way, iontophoresis of rather lipophilic drugs is possible (e.g. treprostinil log octanol/water partition coefficient is 4) 11). The pH of the solution is of primary importance, because it will determine the ionization of the compound 12).

What drugs can be used with iontophoresis?

Corticosteroids are the primary drugs used with iontophoresis in physical therapy and rehabilitation medicine in general. Formulated as a water soluble salt, the corticosteroid molecule has a negative charge and so the negative-electrode drug reservoir must be used.

What are contraindications for iontophoresis?

Contraindications to iontophoresis include those related to direct electrical stimulation and from the therapeutic agent involved. Patients with a history of hypersensitivity or adverse reactions associated with the delivered drug in question should avoid iontophoresis of the offending agent.

What is iontophoresis pain?

What does iontophoresis feel like? Iontophoresis involves electrical currents going through an area of your body. This can cause a tingling sensation while the machine is on. You shouldn't feel pain or a serious electrical shock, though.

Can iontophoresis cause burns?

Burn injuries can result from the pilocarpine iontophoresis sweat test used in the diagnosis of cystic fibrosis. The actual incidence of burn injuries as a result of this test may be under-reported.

What do you do after iontophoresis treatment?

Many times, withholding ice or heat treatments after iontophoresis is recommended since these treatments alter circulation to the injured area. This altered circulation might "wash away" the medication that was just introduced to your body.

What are the side effects of iontophoresis?

Side effects are minimal and most patients have no problems with iontophoresis. There is a temporary tingling sensation during and after treatment. A harmless, but uncomfortable electrical shock may occur if the patient suddenly stops treatment (for example by removing a hand). The skin can become too dry and cracked.

What are the physiological effects of iontophoresis?

Iontophoresis is a safe and painless procedure. Some people may experience side effects as a result of iontophoresis, but the effects usually aren't serious. The most common side effect is dryness of the skin. Blistering, peeling, and irritation might also occur on the skin.

Does iontophoresis affect the heart?

Blood Pressure and heart rate did not change significantly from the baseline during the histamine iontophoresis and direct currents treatments (P > 0.05). The findings suggest that the subjects' BP and HR were not affected by histamine iontophoresis during the twenty minutes treatment.

Is iontophoresis safe during pregnancy?

Don't use iontophoresis if you are pregnant, have a pacemaker, have a substantial metal implant in the current path (such as a joint replacement), or have a cardiac condition or epilepsy.

What is iontophoresis in skin care?

Iontophoresis is a treatment to deeply penetrate molecules of substances into the skin that ordinarily cannot permeate or be absorbed into the skin, such as vitamin C, vitamin A, and Tranexamic acid, by ionizing the molecules with electric currents.

What is iontophoresis electrotherapy?

Iontophoresis is a type of electrotherapy, during which a drug is introduced deep into the tissues as a means of systemic and local drug application [1].

How do you use iontophoresis in physical therapy?

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Can iontophoresis make sweating worse?

When side effects do occur during studies they are usually mild and don't involve an increase in sweat production. The side effects that have been recorded include redness of the skin, small shocks, scratches, cuts, discomfort (feeling of pins and needles), vesiculation, and dry or cracked skin.

What class is iontophoresis?

When used for systemic drug delivery, iontophoresis machines are classified by the U.S. Food and Drug Administration (FDA) as a class 3 device alongside total artificial disc replacements and implanted neurostimulators. 4 .

Why is iontophoresis important?

It is used to introduce medication into your body to achieve specific therapeutic goals. Iontophoresis may be one treatment that can help you return to normal activity quickly and safely after injury.

What is iontophoresis therapy?

One such treatment is iontophoresis. Iontophoresis is a therapeutic modality often used by physical therapists to treat a variety of conditions. It is a type of electrical stimulation that is used to administer medication into your body through your skin. Illustration by Lisa Fasol, Verywell.

What is ionically charged medication?

The medication used in iontophoresis is ionically charged. So if your physical therapist decides to introduce medication into your injured tissues via iontophoresis and that medication is negatively charged, he or she will use a negative current to drive that medication into your body. 1 .

What do you need to know before iontophoresis?

Before applying iontophoresis, your PT must first decide on which type of medication to use. The medication used in iontophoresis depends on the goals of the treatment. Different medications have different effects on the body, and your PT will decide on the best medication for your specific condition.

How long does it take to get iontophoresis?

A typical iontophoresis treatment takes 10 to 20 minutes, depending on the amount of medication that your PT is administering to you.

How does an electrode work with a medication?

The electrode with the medication is applied to the area of your body that is being treated. The electrode without the medication is applied to your body nearby. The electrical stimulation unit is then turned on , and the electricity pushes the medication into your injured body part while you relax.

What are the side effects of iontophoresis?

Adverse effects may include: Redness of treated skin. Small blisters (vesicles) or pompholyx. Dry and cracked skin or dermatitis. Although these side effects from iontophoresis are expected to resolve within a few days, emollients/moisturisers should be applied several times daily to reduce symptoms.

What are the effects of cutaneous iontophoresis?

Besides these uncomfortable but harmless effects, skin irritation is the most common local adverse effect of cutaneous iontophoresis. It occurs at both the anode and the cathode.

How long does it take for palmar hyperhidrosis to improve?

Limited robust data is available; however some studies suggested that up to 80-85% of patients with palmar hyperhidrosis notice subjective improvement in their symptoms within 2–4 weeks.

How does iontophoresis reduce sweating?

The mechanism of action of iontophoresis in reducing sweating is not completely understood. Sweat forms in response to an electrical gradient produced by sympathetic nerve activity on the cells of the sweat gland. There are several theories as to how a change in electrical gradient reduces sweat production.

What is iontophoresis used for?

Iontophoresis has been used to reduce sweating and enhances the delivery of drugs and macromolecules into and through the skin.

What is iontophoresis in medical terms?

Iontophoresis is a procedure in which an electrical current is passed through skin soaked in tap water or normal saline (0.9%), allowing ionized (charged) particles to cross the normal skin barrier.

Is iontophoretic delivery faster than topical delivery?

Iontophoresis may be used as a route of administration for systemic drugs or as local therapy. Indeed, cutaneous iontophoretic delivery is faster than the usual topical routes and allows the administration of high concentrations in the target tissue while limiting systemic toxicity.

What is iontophoresis used for?

Common Uses for Iontophoresis. In rehabilitation medicine, including physical therapy, iontophoresis is used to reduce inflammation that might be seen in musculoskeletal conditions such as lateral epicondylitis, medial epicondylitis, plantar fasciitis, tendo-nitis/bursitis, rheumatoid arthritis, and enthesopathic conditions of various origins.

How long does iontophoresis treatment take?

The treatment is administered clinically for 15-20 minutes per session. In a physical therapy setting, iontophoresis is typically one of several treatment interventions applied, so the addition of another 15-20 minutes to a pre-existing 60 minute program is a time burden for some patients.

What drugs can be used for inflammation?

Iontophoresis for Inflammation. There are a number of drugs that can be driven into the subcutaneous tissues including steroids, NSAIDS, local anesthetics, salicylates, and individual substances such as zinc oxide, iodine, acetic acid, and calcium chloride, to name a few.

What is an electrode patch?

Electrode patches have a unique composition that allows ionic movement into human skin tissue. One patch, for example, is made up of embedded zinc and silver chloride electrodes and is activated when the treatment solution bathing one electrode comes into contact with the saline solution bathing the opposite electrode.

What is the main barrier to drug transport?

This article will focus on iontophoresis, a form of transdermal drug delivery (TDD) that utilizes electrical current to drive or push ionized drugs through the skin’s outermost layer (stratum corneum) which is typically the main barrier to drug transport.

Is corticosteroid a negative electrode?

Formulated as a water soluble salt, the corticosteroid molecule has a negative charge and so the negative-electrode drug reservoir must be used. In applying an iontophoresis treatment the area to be treated must be cleaned or prepped with alcohol then the active electrode placed as close to the target area as possible.

Does dexamethasone help with calcific deposits?

In physical therapy, the use of dexamethasone for inflammation and acetic acid for calcific deposits has been used for many years in numerous clinical settings.

Is it safe to use iontophoresis?

Iontophoresis is widely regarded a safe form of treatment, and side effects are normally limited to moderate “pins and needles” sensations and mild coloring of the skin. In very few instances, painful stinging, itching, and mild shocks can also be experienced by the patient.

Does iontophoresis help with sweating?

For individuals with hyperhidrosis of the hands and feet, Iontophoresis treatments have shown to substantially decrease high levels of unusual sweating.One study found that Iontophoresis helped 91% of patients with excessive hand and feet sweating, which is sweating of the palms and feet. After completing the initial recommended treatment schedule, up to 85% of people will find relief from their symptoms for the hands and feet

How Iontophoresis Work

  • Without explicit medical approval and supervision, iontophoresis should never be used on patients: 1. with a pacemaker 2. with an ICD ( implantable cardioverter-defibrillator) 3. who are pregnant 4. who have an IUD containing metal 5. with metal implants near the region where the …
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Common Uses

Procedure

What to Expect

Side Effects

  • There are many different uses for iontophoresis. These include, but are not limited to:2 1. Decrease inflammation 2. Decrease pain 3. Decrease muscle spasm 4. Decrease swelling and edema 5. Reduce calcium deposits in the body 6. Manage scar tissue Your PT will work with you to decide on the treatment goals and the rationale for using iontophoresis.
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Contraindications

  • Before applying iontophoresis, your PT must first decide on which type of medication to use. The medication used in iontophoresis depends on the goals of the treatment. Different medications have different effects on the body, and your PT will decide on the best medication for your specific condition. Many states require that your PT obtain a prescription from your healthcare p…
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Evidence

  • When your physical therapist applies iontophoresis to your body, he or she uses an electrical stimulation device. When the electrical current is turned on, you will likely feel a slight tingling sensation. Sometimes the stimulation feels like a tiny bee sting. If you are uncomfortable during the iontophoresis treatment, notify your physical therapist and adjustments can be made. A typi…
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