What is G-CSF used for?
G-CSF is a type of growth factor. You might have G-CSF after chemotherapy to help your white blood cells recover after treatment. Or you might have it before and after a stem cell transplant. long acting (pegylated) filgrastim (pegfilgrastim, Neulasta, Pelmeg, Ziextenco) and …
What is the role of G-CSF in the treatment of SCN?
Mar 18, 2021 · Granulocyte colony stimulating factor (G-CSF) is a type of drug that doctors prescribe to manage neutropenia, which is the term for a lower-than-normal white blood cell count. People with...
What is the prognosis of GCSF treatment?
Feb 22, 2022 · What Is G-Csf Used For? The treatment involves freezing haerogen that occurs when certain types of chemotherapy are used and freezing that occurs in chronic neutractic patients who are not treated for cancer. Additionally, it is a tool used when autologous stem cells are needed to expand.
What is granulocyte colony stimulating factor G-CSF?
Treatment Granulocyte-Colony Stimulating Factor (G-CSF) G-CSF is a cytokine normally produced by the human body itself. Cytokines are proteins and peptides that allow cells to communicate with one another. They act like hormones and neurotransmitters and are involved in a variety of immunological, inflammatory, and infectious diseases.
What is G-CSF injection for?
Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy. Filgrastim is a support medication.
How quickly does G-CSF work?
This usually takes 5 to 7 days, although it can be longer. If you are having G-CSF before a stem cell transplant, you usually have your first dose 4 to 6 days before your stem cells are going to be collected.
What are the side effects of G-CSF injections?
What side effects may I notice from receiving this medicine?allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue.back pain.dizziness or feeling faint.fever.pain, redness, or irritation at site where injected.pinpoint red spots on the skin.shortness of breath or breathing problems.More items...
Why is G-CSF given?
It is given: during treatment with chemotherapy, to stimulate the bone marrow to make white blood cells. These cells are called neutrophils. They help to fight infection.
Is G-CSF injection painful?
The most relevant adverse event of G-CSF administration is bone pain. Approximately 20% of cancer patients experienced bone pain with the administration of prophylactic daily G-CSFs (lenograstim and filgrastim).
What is G-CSF injection in IVF?
Granulocyte-colony stimulating factor (G-CSF) seems to play an important role in the process of embryo implantation and continuation of pregnancy. It has been used during in vitro fertilisation (IVF) treatment for subfertile women with chronically thin endometrium and those with previous multiple IVF failures.Jan 24, 2020
How much does G-CSF cost?
About Filgrastim The lowest GoodRx price for the most common version of Neupogen is around $317.44, 20% off the average retail price of $400.00.
How long does G-CSF stay in your system?
You can also take ibuprofen up until 24 hours before your donation (which means on days 1-3 of G-CCSF, but not on the 4th day). You must not take aspirin; this is due to the fact it can stay in the system and affect platelet function for 7 days).
Can G-CSF cause leukemia?
Abstract. A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.
Why is G-CSF given 24 hours after chemo?
Post-chemotherapy prophylactic granulocyte colony-stimulating factor (G-CSF) is customarily started 24 hours after chemotherapy in most of the current pediatric and adult solid tumors protocols to ameliorate the myelotoxicity of cytotoxic agents and reduce neutropenia-related complications.
Is G-CSF the same as filgrastim?
Granulocyte colony-stimulating factor (G-CSF) is a protein naturally produced by the body to increase the production of white blood cells. Filgrastim is a man-made version of G-CSF that stimulates white blood cell production, and in particular, neutrophil production.
Why does G-CSF cause bone pain?
Background: The bone pain frequently emerges as one of the side effects of G-CSF administration. Rising pressure within bone marrow by increased granulocytes, edema within bone marrow by histamine release, and increased level of bradykinin are thought to be the mechanisms underlying it.Jun 1, 2005
What is G-CSF treatment?
People undergoing leukapheresis. Trusted Source. — a procedure that collects stem cells from the blood — may also require G-CSF treatment. G-CSF moves hematopoietic stem cells, which will go on to form blood cells, from the bone marrow into the bloodstream.
What is G-CSF drug?
G-CSF drugs are a type of protein called glycoproteins. They target hematopoietic cells stored in the bone marrow. G-CSF promotes the growth and development of these cells into different types of blood cells, including white blood cells.
What are the risks of G-CSF?
The manufacturers also warn of several health risks of using G-CSF drugs. These include: 1 ruptured spleen, which causes significant blood loss and can be fatal 2 acute respiratory distress syndrome, a lung condition that causes fluid to leak into the lungs 3 serious allergic reactions, which can include anaphylactic shock 4 sickle cell crisis, a condition that occurs in people with sickle cell disease, causing moderate-to-severe pain and swelling of the hands and feet 5 glomerulonephritis, or inflammation of the glomeruli of the kidneys, which reduces the function of these organs and causes fluid buildup and hypertension 6 myelodysplastic syndrome and acute myeloid leukemia, which are forms of blood cancer
What do doctors check for when taking G-CSF?
Doctors will monitor people receiving G-CSF for fever and check their level of white blood cells. These are two factors that researchers have tested when studying the efficacy of G-CSF.
What is G-CSF injection?
G-CSF drugs are a type of protein called glycoproteins.
Can you use Granix for G-CSF?
Uses of G-CSF. Doctors can prescribe G-CSF drugs for different uses, although these vary depending on the specific drug. Doctors prescribe Granix for people 1 month and older to lower the duration of severe neutropenia in people with certain types of cancer who are taking drugs that lower white blood cell levels.
Is Filgrastim a biologic?
Filgrastim is a biologic drug that comes in the form of a sterile solution for injection. The cost may depend on the purchasing pharmacy and whether the person has health insurance. As the drug is available in biosimilar forms, people can ask their pharmacist which biosimilar is cheapest.
What is G-CSF used for?
G-CSF stimulates the production and enhances the activity of mature neutrophils to improve their bacteria-killing function.
What is the G-CSF?
Granulocyte-Colony Stimulating Factor (G-CSF) G-CSF is a cytokine normally produced by the human body itself. Cytokines are proteins and peptides that allow cells to communicate with one another. They act like hormones and neurotransmitters and are involved in a variety of immunological, inflammatory, and infectious diseases.
How do steroids affect neutrophils?
Steroids work by encouraging neutrophils to leave the bone marrow and enter the blood stream. However, they do not induce the production of new neutrophils in the bone marrow.
How much does a G-CSF injection cost?
G-CSF treatments can be expensive, up to $4000 a month. However, it might be possible to get financial help with G-CSF supplies.
Where is G-CSF administered?
G-CSF is usually administered by an injection just under the skin in areas such as the abdomen below the naval, upper outer arms, and upper outer thighs. It is possible to self-administer G-CSF depending on the age of the patient.
Is bone marrow transplant a first choice treatment for SCN?
It may be considered for failure to respond to treatment, or for patients who develop leukemia or MDS in the course of their disease. BMT is a very intensive procedure, carrying serious risks and therefore it is not recommended as first choice treatment.
Does G-CSF cause muscle pain?
Some SCN patients receiving G-CSF report bone or muscle pain and splenomegaly (enlargement of spleen).
Why do we need G-CSF?
It is a colorless liquid that is either injected under the skin or given into a vein. G-CSF helps the body make infection-fighting white blood cells, called neutrophils. Some St. Jude patients need this medicine to help build up neutrophils that have been destroyed by chemotherapy.
What are the side effects of G-CSF?
Possible side effects of G-CSF 1 Mild bone pain 2 Pain/bruising at the injection site
How long can you keep G-CSF at room temperature?
Special instructions for G-CSF. Until you are ready to use it, keep the G-CSF refrigerated but not frozen. G-CSF may be kept at room temperature for up to 24 hours if needed. Before giving a dose of G-CSF, take it out of the refrigerator about an hour before and let it warm to room temperature.
Can you use G-CSF after the expiration date?
Do not use G-CSF if the liquid looks cloudy, changes color, or has flakes or specks in it. Do not use G-CSF if the date on the vial has expired. If you receive G-CSF in syringes from the pharmacy, do not use them after the expiration date listed on the syringe.
What is G-CSF used for?
A recombinant form of G-CSF (Neupogen) is used in certain cancer patients to accelerate recovery from neutropenia after chemotherapy [79]. G-CSF is also widely used to increase the number of HSCs in the blood of the donor before collection by leukapheresis for use in HSC transplantation [80].
What is G-CSF? What are its functions?
G-CSF (Neupogen or Filgrastim), granulocyte-colony stimulating factor, is a glycoprotein that has multiple functions in both physiological and pathophysiological conditions. G-CSF stimulates the BM to produce granulocytes and stem cells and release them into the bloodstream. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils via signal transduction pathways. A recombinant form of G-CSF (Neupogen) is used in certain cancer patients to accelerate recovery from neutropenia after chemotherapy [79]. G-CSF is also widely used to increase the number of HSCs in the blood of the donor before collection by leukapheresis for use in HSC transplantation [80].
What is the effect of G-CSF on neutropenia?
Granulocyte colony-stimulating factor (G-CSF) administered subcutaneously daily is effective treatment of cyclic neutropenia. G-CSF is thought to affect intracellular signaling as well as stimulate production. Adverse effects associated with G-CSF include osteopenia and osteoporosis; anecdotal evidence suggests beneficial effect of bisphosphonate therapy. Although there is a substantial risk of myelodysplasia and acute myelogenous leukemia in children with severe congenital neutropenia compared with cyclic neutropenia, many experts in the field believe that with increasing survival of patients receiving G-CSF, such cases will occur in cyclic neutropenia.90 The causal role of G-CSF therapy in development of myelodysplasia and acute myelogenous leukemia versus the genetic defect is uncertain.
What is the role of G-CSF in the production of neutrophils?
Studies of G-CSF −/− mice confirmed that G-CSF is required for the steady-state production of neutrophils and implicate G-CSF in the “emergency production” of neutrophils that occurs in response to acute injury or infection.
What is the function of G-CSF-R?
G-CSF-R binds G-CSF as a homodimer. Unlike the other single-chain cytokine receptors, G-CSF-R activates multiple JAK kinases including JAK1, JAK2, and TYK2. Once activated, the JAK kinases induce phosphorylation of receptor tyrosines, which become docking sites for multiple SH2-containing signaling proteins as well as STAT1, STAT3, and STAT5. Pathways activated by G-CSF-R include those leading to activation of Ras, MAPKs, and Akt. Negative regulation occurs through the phosphatase SH-PTP1 and through SOCs. Experiments with G-CSF-R lacking one or more of the four cytoplasmic tyrosines suggest that pathways that regulate proliferation, differentiation, or survival differ, and characterization of these differences have important implications for understanding disorders of granulopoiesis.
How long does G-CSF last?
G-CSF promotes a rapid increase in neutrophilic leukocytes, which lasts about 24 hours. Despite the multitude of patients who have received G-CSF, few side effects have been reported. Even very long-term G-CSF administration seems fairly innocuous; the most common toxicity is bone pain.
Is G-CSF effective for neutropenia?
G-CSF has revolutionized the treatment of neutropenia and its sequelae (infection). It has been used by millions of patients worldwide and is remarkably effective and virtually devoid of side effects (see Table 57-211). Some patients with solid tumors present with significantly increased leukocyte counts due to G-CSF secretion. Finally, point mutations in the gene for the G-CSF receptor have been described anecdotally in patients with AML that evolved from severe congenital neutropenia.
What is a G-CSF?
G-CSF. A biosimilar is a biologic medical product that is almost an identical copy of an original medication that is manufactured by a different pharmaceutical company. Other Names: G-CSF, granulocyte-colony stimulating factor. Chemocare.com uses generic names in all descriptions of drugs.
How is filgrastim given?
How Filgrastim Is Given: Filgrastim may be given subcutaneous (the layer between the skin and muscle) injection or infused into a vein ( intravenous, IV). Filgrastim is generally given on a daily basis. The number of days you receive filgrastim will be prescribed by your doctor.
What is the trade name for filgrastim?
Neupogen, Granix and Zarxio are trade names for filgrastim. Granulocyte - colony stimulating factor (G-CSF) is another name for filgrastim. In some cases, health care professionals may use the trade name Neupogen, Granix or Zarxio when referring to the generic drug name filgrastim. Drug type: Filgrastim is a biologic response modifier.
What is Filgrastim used for?
What Filgrastim Is Used For: Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy. Filgrastim is a support medication.
How long to wait to take filgrastim before injection?
Remove from refrigerator 30 minutes before injection. Do not shake the medication. Protect from light. The amount of filgrastim that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.
How long after chemo can you take filgrastim?
The manufacturer recommends that the first dose of filgrastim be given no sooner than 24 hours after chemotherapy. Your doctor will discontinue therapy with filgrastim when your white blood cell count has reached acceptable levels.
Is Filgrastim a support medication?
Filgrastim side effects may be quite manageable. There are many options to minimize or prevent the side effects of filgrastim. Filgrastim is a support medication .
What Is G-CSF?
- Granulocyte colony stimulating factor, also called G-CSF or Filgrastim, is a man-made form of a natural human hormone. It is a colorless liquid that is either injected under the skin or given into a vein. G-CSF helps the body make infection-fighting white blood cells, called neutrophils. Some St. Judepatients need this medicine to help build up neu...
How to Give G-CSF
- Inject just below the skin
1. If your G-CSF is injected under the skin (subcutaneous injection), a nurse will teach you how to give the injection (refer to “Do you know… How to give subcutaneous injections” or “Do you know… Subcutaneous tissue infusion set”). 2. Your subcutaneous injection dose is __________ microgra… - By IV
If your G-CSF is given into a vein, a nurse will give the G-CSF dose.
Possible Side Effects of G-CSF
- Mild bone pain
- Pain/bruising at the injection site
Special Instructions For G-CSF
- Until you are ready to use it, keep the G-CSF refrigerated but not frozen.G-CSF may be kept at room temperature for up to 24 hours if needed.
- Before giving a dose of G-CSF, take it out of the refrigerator about an hour before and let it warm to room temperature.
- G-CSF should always be a clear, colorless liquid. Do not use G-CSF if the liquid looks cloudy, …
- Until you are ready to use it, keep the G-CSF refrigerated but not frozen.G-CSF may be kept at room temperature for up to 24 hours if needed.
- Before giving a dose of G-CSF, take it out of the refrigerator about an hour before and let it warm to room temperature.
- G-CSF should always be a clear, colorless liquid. Do not use G-CSF if the liquid looks cloudy, changes color, or has flakes or specks in it.
- Do not use G-CSF if the date on the vial has expired. If you receive G-CSF in syringes from the pharmacy, do not use them after the expiration date listed on the syringe. For safety, throw away the...
