Treatment FAQ

what happens to syphillis test after treatment

by Kailyn Kuphal MD Published 2 years ago Updated 2 years ago
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After adequate treatment of syphilis, nontreponemal tests eventually become nonreactive. However, even with sufficient treatment, patients sometimes have a persistent low-level positive nontreponemal test (referred to as a serofast reaction). Titers are not interchangeable between different test types.Jul 15, 2003

Common tests & procedures

Yes, syphilis is a very easily treatable and curable bacterial infection. But it’s important to get treated as soon as possible so that the infection is not able to spread to other parts of your body. It is possible to contract syphilis again after it’s been treated if you continue to engage in unprotected or risky sexual activities.

Why should syphilis be treated soon as possible?

You can have sex two weeks after finishing the treatment. Please note that to avoid giving syphilis to someone else, it is essential to avoid even skin-to-skin contact and protected sex during the treatment period and to stop having sex until two weeks after the end of treatment.

How long are you contagious after treatment for syphilis?

Shortly after infection occurs, the body produces syphilis antibodies that can be detected by a blood test. Even after full treatment, antibodies to syphilis remain in the blood and may be detectable for many years after the infection has gone. An infected baby can be severely ill, but some babies will show no signs of syphilis.

How long does syphilis stay in your system after treatment?

The response of the Treponema Pallidum Haemagglutination Assay (TPHA) to treatment was studied in 61 cases of early infectious syphilis. In none of the 55 cases of early syphilis in which the pre-treatment TPHA was positive did the TPHA test become consistently negative after treatment.

Does TPHA become negative after syphilis treatment?

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Can you still test positive for syphilis after treatment?

A person can still test positive for treponemal antibodies after completing syphilis treatment. This means that treponemal antibody tests cannot distinguish between a current and a past syphilis infection.

How long does syphilis test stay positive after treatment?

Because the antibodies detected in treponemal tests usually remain detectable for life, even after successful treatment, the non-treponemal titer (RPR or VDRL) must be used to monitor for a re-infection with syphilis. An increase in titer of two dilutions represents re-infection with Treponema pallidum.

How long after treatment is syphilis test negative?

Your results may be false-negative if the test is done too soon after you are infected with syphilis. It takes 14 to 21 days after infection with the spirochetes for your body's immune response to be found by the test. Drinking alcohol within 24 hours of the test also can give a false-negative result.

Why do I keep testing positive for syphilis?

The antibodies produced as a result of a syphilis infection can stay in your body even after your syphilis has been treated. This means you might always have positive results on this test.

How do you know if syphilis is cured?

After you're treated for syphilis, your doctor will ask you to:Have periodic blood tests and exams to make sure you're responding to the usual dosage of penicillin. ... Avoid sexual contact with new partners until the treatment is completed and blood tests indicate the infection has been cured.More items...•

How long does it take to cure syphilis after penicillin shot?

If you had syphilis for more than one year, you need three shots—one shot a week for three weeks. If you're allergic to penicillin, be sure to tell your doctor. If you have an advanced case of syphilis, you may need stronger treatment. You may get shots of penicillin every day for 10 days.

Can you test negative for syphilis and still have it?

A negative test result is considered normal. However, the body does not always produce antibodies specifically in response to the syphilis bacteria, so the test is not always accurate. False-negatives may occur in people with early- and late-stage syphilis. More testing may be needed before ruling out syphilis.

Can syphilis be dormant and test negative?

So, while it is possible to be positive for an STD and test negative, this is usually in the initial “Window Period” and not due to the STD being dormant in your body. Dormant STDs can still be affecting your health even if you are not experiencing symptoms.

What happens if you catch syphilis in a late stage?

If the syphilis was caught in a late stage, it may have affected your body in other ways. You may need other medical tests. People also need follow-up syphilis blood tests to make sure the syphilis treatment worked. Taking good care of yourself also plays an important role in your treatment.

What to do if you have syphilis?

If you might have syphilis, your doctor will order a blood test. If this blood test is positive, the lab typically performs a second test on your blood to confirm that you have syphilis. If you have syphilis, you need treatment.

How long does it take to get penicillin for syphilis?

Here’s how you may get the antibiotic: Early stage: One shot of penicillin. Late stage: Three shots of penicillin, with one shot given each week for three weeks. Syphilis affects your nervous system: Penicillin given through an IV (intravenous) infusion, with treatment given once a week for two weeks. To treat syphilis with penicillin, you need ...

How long after syphilis treatment can you have sex?

To treat syphilis with penicillin, you need a shot or IV infusion. Taking penicillin pills cannot cure you. You should not have sex for at least 1 week after treatment and until all symptoms have gone away.

How long does it take for a bacterial reaction to go away?

It’s possible that the person’s immune system is reacting to the dying bacteria. The reaction clears quickly on its own, usually disappearing completely within 24 hours.

Can you use latex condoms for syphilis?

When you start having sex again, use latex condoms and/or dental dams to prevent getting syphilis again or other sexually transmitted diseases. While the right antibiotic can cure syphilis, it cannot undo damage already done. If syphilis caused hearing loss, you’ll continue to have hearing loss after being treated.

Can you take doxycycline for syphilis?

If your doctor decides to treat you with one of these antibiotics, you will need several follow-up appointments. These antibiotics can be less effective at treating syphilis.

Testing

Unlike testing for other conditions, syphilis testing is complicated and needs to be explained in more detail.

Who should be screened for syphilis

People should be screened for syphilis is they are symptomatic or high risk by asymptomatic.

Interpretation of syphilis tests

Test interpretation is more complex with syphilis than with other infectious diseases. A positive test can mean multiple things, from newly diagnosed to previously treated syphilis.

Causes of false-positive syphilis tests

The chance of a false-positive syphilis test is about 1% to 2%. “False positive” means the test is positive but the patient, in reality, does not have syphilis.

Positive syphilis test interpretation

In this section, our expert doctor will answer real-life patient questions on syphilis testing. Most questions are grouped so it’s easier to cover more topics. Dr. Fuzayloff has been a practicing physician at a busy STD center in Midtown Manhattan, NYC, for over two decades.

Can syphilis be cured?

Syphilis can be cured with the right antibiotics. However, treatment will not undo any damage that the infection has already caused. If playback doesn't begin shortly, try restarting your device. Videos you watch may be added to the TV's watch history and influence TV recommendations.

Does penicillin kill syphilis?

Treatment will kill the syphilis bacterium and prevent further damage, but it will not repair damage already done. Selection of the appropriate penicillin preparation is important to properly treat and cure syphilis.

Is there a cure for syphilis?

What is the treatment for syphilis? There are no home remedies or over-the-counter drugs that will cure syphilis, but syphilis is easy to cure in its early stages.

Can you take penicillin for syphilis?

Combinations of some penicillin preparations (e.g., Bicillin C-R, a combination of benzathine penicillin and procaine penicillin) are not appropriate treatments for syphilis, as these combinations provide inadequate doses of penicillin.

How long does it take for syphilis to show up?

Symptoms usually appear about two to three weeks after infection and include: Small, painless sore (chancre) on the genitals, anus, or mouth.

What is the test for syphilis?

Syphilis tests are used to screen for and diagnose syphilis. Screening tests for syphilis include: Rapid plasma reagin (RPR), a syphilis blood test that looks for antibodies to the syphilis bacteria. Antibodies are proteins made by the immune system to fight foreign substances, such as bacteria. Venereal disease research laboratory (VDRL) ...

What does it mean if your syphilis test is negative?

If your screening results were negative or normal, it means no syphilis infection was found. Since antibodies can take a couple of weeks to develop in response to a bacterial infection, you may need another screening test if you think you were exposed to the infection.

What does a follow up test for syphilis look for?

Most of these follow up tests will also look for syphilis antibodies. Sometimes, a healthcare provider will use a test that looks for actual syphilis bacteria, instead of the antibodies. Tests that look for the actual bacteria are used less often because they can only be done in specialized labs by specially trained health care professionals.

What is a VDRL test?

Venereal disease research laboratory (VDRL) test, which also checks for syphilis antibodies. A VDRL test can be done on blood or spinal fluid. If a screening test comes back positive, you will need more testing to rule out or confirm a syphilis diagnosis. Most of these follow up tests will also look for syphilis antibodies.

Can you get syphilis with penicillin?

If these tests confirm you have syphilis, you will probably be treated with penicillin, a type of antibiotic. Most early-stage syphilis infections are completely cured after antibiotic treatment. Later-stage syphilis is also treated with antibiotics.

Can a blood test show lumbar puncture?

There is very little risk to having a blood test. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly. If you had a lumbar puncture, you may have pain or tenderness in your back where the needle was inserted. You may also get a headache after the procedure.

How long does it take for syphilis to get better?

This happens as the antibiotic starts to kill the bacteria that caused your syphilis. These symptoms usually get better in 1 or 2 days. Drink plenty of liquids and rest during this time.

How to treat syphilis?

Antibiotics help treat the bacteria that caused your syphilis. Take your medicine as directed. Contact your healthcare provider if you think your medicine is not helping or if you have side effects. Tell him of her if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take.

How does syphilis spread?

Syphilis is spread through direct contact with the sores of an infected person. This usually happens through sexual activity, especially unprotected sex. It can also spread through sharing needles or contact with the blood of an infected person .

Do syphilis symptoms go away?

You are pregnant and think you have syphilis. You have a new rash, sore throat, or swollen joint. Your symptoms do not go away after treatment, or they come back. You have questions or concerns about your condition or care.

Does acetaminophen help with fever?

Acetaminophen decreases pain and fever. It is available without a doctor's order. Ask how much to take and how often to take it. Follow directions. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist.

How many cases of syphilis in New York City in 2018?

In New York City there were about 2,654 cases of syphilis in 2018. This is about 12.7% higher than in 2017. The increase is most noticeable among homosexual males (the number has almost doubled in recent years). 3

How many cases of syphilis are there in the world?

There are more than 10.6 cases of it worldwide every year. 1. Though syphilis is potentially life-threatening, it is easily treated if diagnosed early. That’s why it’s essential to visit the STD clinic as soon as you realize you might have been exposed to this infection.

Is it necessary to start syphilis treatment immediately?

It’s not necessary to start treatment immediately. However, syphilis is a progressive disease, so the earlier you begin treatment , the easier and quicker the treatment will be. The more time the passes, the more time it will take to cure the infection.

Is post exposure treatment urgent?

Post-exposure treatment is not urgent. It is ideal to be treated sooner rather than later but it is not an urgent matter (not an emergency). Post-exposure treatment is not extremely time-sensitive and can be given later.

Can you take syphilis medication before or after a test positive?

If you decide not to take the medication: Some people prefer not to take medication unless they know they have a disease. This is the ideal way of dealing with any condition.

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Nontreponemal Tests and Traditional Algorithm

Treponemal Tests and Reverse Sequence Algorithm

Cerebrospinal Fluid Evaluation

Medically reviewed by
Dr. Karthikeya T M
Your provider may recommend one or more of these diagnostic tests and procedures as part of an evaluation.
It can be diagnosed by blood test and spinal fluid tests.
Common tests & procedures

Physical examination: Physical examination of the rashes or sores.

Blood test: Blood test to detect bacteria.

Fluid examination: Examination of the fluid from the sore.

Spinal tap (lumbar puncture): Extracting the spinal fluid to examine for infection in case of nervous system problems.

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