Therefore, the strength and type of statin you take will depend on the severity of your hyperlipidemia and how your body responds to the medication. Generally, the worse your cholesterol levels are, the more potent a statin you will need to dramatically lower your levels. Statin therapy is divided into three categories of intensity: 8
Full Answer
What is hyperlipidemia and how is it treated?
The term covers several disorders that result in extra fats, also known as lipids, in your blood. You can control some of its causes; but not all of them. Hyperlipidemia is treatable, but it's often a life-long condition.
How do you get a diagnosis of hyperlipidemia?
Getting a diagnosis. Hyperlipidemia has no symptoms, so the only way to detect it is to have your doctor perform a blood test called a lipid panel or a lipid profile. This test determines your cholesterol levels. Your doctor will take a sample of your blood and send it to a lab for testing, then get back to you with a full report.
How common is hyperlipidemia?
Hyperlipidemia is very common. Ninety-three million American adults (age 20 and older) have a total cholesterol count above the recommended limit of 200 mg/dL. How serious is hyperlipidemia?
What is hyperlipidemia Quizlet?
Hyperlipidemia isan increasein one or more of the plasma lipids, including triglycerides, cholesterol, cholesterol esters andphospholipids and or plasma lipoproteinsincluding very low-density lipoprotein and low-density lipoprotein,and reducedhigh-density lipoprotein levels 3,4.
What is the criteria for hyperlipidemia?
According to this criterion, definite FH is defined as: total cholesterol higher than 6.7 mmol/L or LDL-C greater than 4.0 mmol/L in a child whose aged under 16 years or total cholesterol greater than 7.5 mmol/L or LDL-C higher than 4.9 mmol/L in an adult (levels either pre-treatment or highest on treatment).
Who is indicated for high-intensity statin?
High-intensity statins are recommended for 2 categories of patients: those with ASCVD (secondary prevention) and high-risk patients without clinical ASCVD. Most patients with ASCVD are candidates for high-intensity statins, with a goal for low-density lipoprotein cholesterol reduction of 50% or greater.
When do you prescribe high-intensity statins?
The ACC/AHA guideline recommends starting moderate- to high-intensity statins if the risk is 7.5% or greater, whereas the NICE and USPSTF guidelines recommend statins if the risk is 10% or greater.
What is the major approach to the treatment of hyperlipidemia?
Statins are the first line medication for hyperlipidemia. If you cannot tolerate statins or if they do not reduce your LDL cholesterol enough, mRNA and monoclonal antibody drugs have been developed recently.
What is the difference between low intensity and high intensity statins?
Statins can be placed into three different categories based on how much they can lower LDL: Low intensity statins: these can lower LDL by no more than 30%. Moderate intensity statins: these can lower LDL between 30% and 49%. High intensity statins: these can lower LDL by 50% or more.
What is the criteria for statin therapy?
The following are guideline recommendations for statin treatment: Patients ages 20-75 years and LDL-C ≥190 mg/dl, use high-intensity statin without risk assessment. T2DM and age 40-75 years, use moderate-intensity statin and risk estimate to consider high-intensity statins.
Who gets moderate-intensity statin?
Persons 40 to 75 years of age who have diabetes should start or continue moderate-intensity statin therapy. In those with 7.5% or greater estimated 10-year ASCVD risk, high-intensity statin therapy is reasonable, unless contraindicated.
What are low-intensity statins?
Statin Use for the Prevention of Cardiovascular Disease in Adults: A Systematic Review for the U.S. Preventive Services Task Force [Internet]....Table 1Statin Dosing and ACC/AHA Classification of Intensity.StatinAtorvastatinDosageLow-intensity (LDL-C reduction <30%)NAModerate-intensity (LDL-C reduction 30% to <50%)10 to 20 mgHigh-intensity (LDL-C reduction >50%)40 to 80 mg6 more columns
What does high intensity statin mean?
Definitions: *High Intensity Statin Therapy–defined as dose expected to reduce LDL- C by greater than or equal to 50% and includes the following: (1,2) Atorvastatin 40-80mg everyday. Rosuvastatin 20-40mg everyday.
What is the first line treatment for hyperlipidemia?
HMG-CoA reductase inhibitors, or statins, are the recommended first-line therapy for most patients. These are the most prescribed drugs in the world and are considered the most effective lipid-lowering agents available, both in lowering LDL-C levels and in the prevention of CV events.
What is the first line of defense when treating hyperlipidemia?
Lifestyle changes such as exercising and eating a healthy diet are the first line of defense against high cholesterol.
What is the primary target of treatment in lipid management?
Low-density lipoprotein cholesterol (LDL-C) has been recommended as the primary treatment target on lipid management in coronary heart disease (CHD) patients for past several decades.
How to tell if you have hyperlipidemia?
Hyperlipidemia has no symptoms, so the only way to detect it is to have your doctor perform a blood test called a lipid panel or a lipid profile. This test determines your cholesterol levels. Your doctor will take a sample of your blood and send it to a lab for testing, then get back to you with a full report. Your report will show your levels of:
How to prevent high cholesterol?
You can make changes to your lifestyle to prevent high cholesterol or reduce your risk of developing hyperlipidemia: Exercise several days per week. Eat a diet low in saturated and trans fats. Include lots of fruits, vegetables, beans, nuts, whole grains, and fish regularly into your diet.
What is the name of the condition that causes high cholesterol and high triglycerides?
It’s called familial combined hyperlipidemia. Familial combined hyperlipidemia causes high cholesterol and high triglycerides. People with this condition often develop high cholesterol or high triglyceride levels in their teens and receive a diagnosis in their 20s or 30s. This condition increases the risk of early coronary artery disease and heart attack.
What is the term for a high level of fat in the blood?
Hyperlipidemia is a medical term for abnormally high levels of fats (lipids) in the blood. The two major types of lipids found in the blood are triglycerides and cholesterol. Triglycerides are made when your body stores the extra calories it doesn’t need for energy.
What is considered high cholesterol?
Generally, a total cholesterol level above 200 milligrams per deciliter is considered high. However, safe levels of cholesterol can vary from person to person depending on health history and current health concerns, and are best determined by your doctor. Your doctor will use your lipid panel to make a hyperlipidemia diagnosis.
How to lower cholesterol?
Eat a heart-healthy diet. Making changes to your diet can lower your “bad” cholesterol levels and increase your “good” cholesterol levels. Here are a few changes you can make: Choose healthy fats. Avoid saturated fats that are found primarily in red meat, bacon, sausage, and full-fat dairy products.
Can hyperlipidemia cause heart disease?
People with untreated hyperlipidemia have a greater chance of getting coronary heart disease than the general population. Heart disease is a condition in which plaque builds up inside the coronary (heart) arteries. Hardening of the arteries, called atherosclerosis, happens when plaque builds up on the walls of arteries. Over time, plaque buildup narrows the arteries and can block them completely, preventing normal blood flow. This can lead to heart attack, stroke, or other problems.
What is the test for lipids?
How It's Diagnosed. Your doctor should check your lipid levels regularly. It is a blood test called a lipoprotein panel. The results show the levels of: LDL cholesterol: The "bad" cholesterol that builds up inside your arteries. HDL cholesterol: The "good" cholesterol that lowers your risk for heart disease.
What is the term for high cholesterol?
Symptoms and Risks . How It's Diagnosed . Treatment . Medications . You call it high cholesterol. Your doctor calls it hyperlipidemia . Either way, it's a common problem. The term covers several disorders that result in extra fats, also known as lipids, in your blood. You can control some of its causes; but not all of them.
Does Fibrates help with LDL?
It lowers your LDL cholesteroland triglyceridesand raises your HDL cholesterol. Fibrates are another kind of drug that work on your liver. They lower triglycerides and may boost HDL, but they aren't as good for bringing down your LDL. Resins, another type of medication, trick your body into using up cholesterol.
Does hyperlipidemia raise cholesterol?
That can lead to putting on extra pounds, which can raise your cholesterol. As you get older, your cholesterol levelsoften creep up, too. Hyperlipidemia can run in families. People who inherit the condition can get very high cholesterol.
Why is hyperlipidemia acquired?
it is acquired because it is caused by another disorder like diabetes, nephritic syndrome, chronic alcoholism, hypothyroidism and with use of drugs like corticosteroids, beta blockers and oral contraceptives. Secondary hyperlipidemia together with significanthypertriglyceridemiacan cause pancreatitis 20.
What is the term for an increase in lipids?
Hyperlipidemia is a medical condition characterized by an increase in one or more of the plasma lipids, including triglycerides, cholesterol, cholesterol esters, phospholipids and or plasma lipoproteins including very low-density lipoprotein and low-density lipoprotein along with reduced high-density lipoprotein levels. This elevation of plasma lipids is among the leading risk factors associated with cardiovascular diseases. In the meantime, statins and fibrates remain the major anti-hyperlipidemic agents for the treatment of elevated plasma cholesterol and triglycerides respectively, with the price of severe side effects on the muscles and the liver. The present review focuses mainly on the types of hyperlipidemi as, lipid metabolism, treatments and new drug targets for the treatment of elevated lipid profile. Many agents such as lanosterol synthase inhibitors, squalene epoxidase inhibitors, diacyl glycerol acyl transferase inhibitors, ATP citrate lyase inhibitors have shown a promising potential in the treatment of hyperlipidemia in clinical trials.
What is the term for an increase in one or more of the plasma lipids, including triglycer
Hyperlipidemia isan increasein one or more of the plasma lipids, including triglycerides, cholesterol, cholesterol esters andphospholipids and or plasma lipoproteinsincluding very low-density lipoprotein and low-density lipoprotein,and reducedhigh-density lipoprotein levels 3,4.
Why are plasma lipoproteins important?
Plasma lipoproteins are important for lipid solubilization in order to transporttriglycerides, an importantenergy source,which synthesized and absorbedto places of utilization and storage;and to transport cholesterol between different placesof absorption, synthesis, catabolism, and elimination 10.
How does VLDL convert to IDL?
After the release of VLDL into the blood stream it will be converted into IDL by the action of lipoprotein lipase and hepatic lipase, where phospholipids and apolipoproteins transferred back to HDL. Furthermore, after the hydrolysis by hepatic lipase, IDL will be converted to LDLand loss more apolipoproteins 17.
Is hyperlipidemia a risk factor for cardiovascular disease?
Introduction. Hyperlipidemia is considered one of the major risk factors causingcardiovascular diseases (CVDs).CVDs accounts for one third of total deaths around the world, it is believed that CVDs will turn out to be the main cause of death and disability worldwide by the year 2020 1,2.
Is hyperlipidemia a genetic defect?
it is also called familial due to a genetic defect, it may be monogenic: a single gene defect or polygenic: multiple gene defects.Primary hyperlipidemia can usually be resolved intoone of the abnormal lipoprotein patternssummarized in table 1 19.
What is the goal of hyperlipidemia?
The overall goal of treating hyperlipidemia is: 1.Maintain an LDL level of less than 160 mg/dL. 2.To reduce atherogenesis. 3.Lowering apo B, one of the apoliproteins. 4.All of the above. Click card to see definition 👆. Tap card to see definition 👆. 2.
What is Sharlene's LDL?
A fibric acid derivative. 1. Sharlene is a 65-year-old patient who has been on a lipid-lowering diet and using plant sterol margarine daily for the past 3 months. Her LDL is 135 mg/dL. An appropriate treatment for her would be: 1. A statin. 2.