What are the three treatment options for tuberculosis?
Overview. This is fourth edition of Treatment of tuberculosis: guidelines, adhering fully to the new WHO process for evidence-based guidelines.Several important recommendations are being promoted in this new edition. First, the recommendation to discontinue the regimen based on just 2 months of rifampicin (2HRZE/6HE) and change to the regimen based on a full 6 months of …
What is the best treatment for tuberculosis?
Worldwide, the treatment of tuberculosis is based on evidence-based guidelines developed by the World Health Organization (WHO) for national tuberculosis programs. However, the importance of health related quality of life, the adequate management of side effects associated with antituberculosis drug …
What should I do after the treatment of tuberculosis?
Previous editions had different title : "Treatment of tuberculosis : guidelines for national programmes" WHO/HTM/TB/2009.420 x, 147 p. Bosnian translation version is in Bosnian cyrillic and Bosnian latin respectively. ISBN 9789241547833
What medications are used to treat tuberculosis?
This is fourth edition of Treatment of tuberculosis: guidelines, adhering fully to the new WHO process for evidence-based guidelines.Several important recommendations are being promoted in this new edition. First, the recommendation to discontinue the regimen based on just 2 months of rifampicin (2HRZE/6HE) and change to the regimen based on a full 6 months of rifampicin …
What is the WHO recommended treatment protocol for TB?
The preferred regimen for treating adults with TB remains a regimen consisting of an intensive phase of 2 months of isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB) followed by a continuation phase of 4 months of INH and RIF.Aug 11, 2016
WHO consolidated guidelines on tuberculosis?
The WHO consolidated guidelines on tuberculosis: tuberculosis preventive treatment provides a comprehensive set of recommendations for programmatic management of tuberculosis preventive treatment (PMTPT) geared towards the implementers of the WHO End TB Strategy and also for countries intent upon TB elimination (9).
What are the 4 first line drugs for the treatment of TB?
TB can be treated effectively by using first line drugs (FLD) isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), ethambutol (EMB) and streptomycin (SM). However, this first line therapy often fails to cure TB for several reasons.
What is first line treatment for TB?
Of the approved drugs, isoniazid (INH), rifampin (RIF), ethambutol (EMB), and pyrazinamide (PZA) are considered first-line anti-TB drugs and form the core of standard treatment regimens (Figure 6.4) (Table 6.2). Rifabutin (RBT) and rifapentine (RPT) may also be considered first- line drugs under certain circumstances.
WHO isoniazid preventive therapy guidelines?
The recommended duration of isoniazid preventive treatment varies from 6 to 12 months of continuous therapy (9). Twelve months of therapy is recommended for persons with HIV infection and persons with stable abnormal chest radiographs consistent with past tuberculosis.
WHO TB drug classification?
2. Classifications(1) WHO 2011 TB drugs classificationGroup 1 First-line oral anti-TB drugs• Isoniazid • Rifampicin • Ethambutol • PyrazinamideGroup 2 Injectable anti-TB drugs (injectable or parenteral agents)• Streptomycin • Kanamycin • Amikacin • Capreomycin4 more rows
What is 2nd line drug?
Second line drugs are the TB drugs that are used for the treatment of drug resistant TB. The second line drugs include levofloxacin, moxifloxacin, bedaquiline, delamanid and linezolid. There is also pretomanid which is a new second line drug recommended in 2019 for the treatment of drug resistant TB.
What are the 3 types of tuberculosis?
Tuberculosis is a bacterial infection that usually infects the lungs. It may also affect the kidneys, spine, and brain. Being infected with the TB bacterium is not the same as having active tuberculosis disease. There are 3 stages of TB—exposure, latent, and active disease.
Why is streptomycin given TB?
Streptomycin is the most effective antibacterial agent known for tuberculosis. In vitro it has a marked bacteriostatic action on the tubercle bacillus, and in vivo it tends to exert a deterrent effect on the disease in both animals and man.
What are second-line drugs for TB?
Kanamycin, Capreomycin and Amikacin are injectable second-line. Bedaquiline and Delamanid are new drugs. Ethambutol, Pyrazinamide, Thioamides, Cycloserine, Para-aminosalicylic acid, Streptomycin, and Clofazimine are possibly effective.
WHO latent TB Guidelines 2020?
Key RecommendationsThe first of three preferred regimens is once-weekly isoniazid plus rifapentine, for 3 months. ... The second preferred regimen, daily rifampin for 4 months, is also strongly recommended, especially for HIV-negative persons, and has perhaps the lowest toxicity.More items...•Feb 28, 2020
What is the triple treatment for TB?
The major historical landmarks of tuberculosis (TB) therapy include: the discovery of effective medications (streptomycin and para-aminosalicylic acid) in 1944; the revelation of “triple therapy” (streptomycin, para-aminosalicylic acid and isoniazid) in 1952, which assured cure; recognition in the 1970s that isoniazid ...
What is the treatment of tuberculosis?
Treatment of tuberculosis is focused on both curing the individual patient and minimizing the transmission of Mycobacterium tuberculosis to other persons; successful treatment of tuberculosis has benefits both for the individual patient and the community in which the patient resides.
What is the ATS guideline?
The American Thoracic Society (ATS), Centers for Disease Control and Prevention (CDC), and Infectious Diseases Society of America (IDSA) jointly sponsored the development of this guideline on the treatment of drug-susceptible tuberculosis, which is also endorsed by the European Respiratory Society (ERS) and the US National Tuberculosis Controllers Association (NTCA). This guideline provides recommendations on the clinical and public health management of tuberculosis in children and adults in settings in which mycobacterial cultures, molecular and phenotypic drug susceptibility tests, and radiographic studies, among other diagnostic tools, are available on a routine basis. Nine PICO (population, intervention, comparators, outcomes) questions and associated recommendations, developed based on the evidence that was appraised using GRADE (Grading of Recommendations Assessment, Development, and Evaluation) methodology [1, 2], are summarized below. A carefully selected panel of experts, screened for conflicts of interest, including specialists in pulmonary medicine, infectious diseases, pharmacokinetics, pediatrics, primary care, public health, and systematic review methodology were assembled and used GRADE methods to assess the certainty in the evidence (also known as the quality of evidence) and strength of the recommendations (see Supplementary Appendix A: Methods and Table 1). This executive summary is a condensed version of the panel's recommendations. Additional detailed discussion of the management of pulmonary and extrapulmonary tuberculosis is available in the full-text version of this guideline.
