Medication
What are the treatments for osteogenesis imperfecta (OI)? OI treatments are designed to prevent or control symptoms and vary from person to person. Early intervention is important to ensure optimal quality of life and outcomes. Treatment for OI and its related symptoms may include:
Procedures
Bisphosphonates are still the most widely used pharmacological treatment for adult OI, but the current evidence supporting this is sparse and investigations on indications for choice and duration of treatment are needed. Treatment of osteogenesis imperfecta in adults Eur J Endocrinol. 2014 Aug;171(2):R79-90.doi: 10.1530/EJE-14-0017.
Therapy
Osteogenesis imperfecta (OI) is an inherited (genetic) bone disorder that is present at birth. It is also known as brittle bone disease. A child born with OI may have soft bones that break (fracture) easily, bones that are not formed normally, and other problems.
Self-care
Treatment for OI and its related symptoms may include: Casting, splinting, and bracing fractured bones can help them heal properly. However, bones may weaken if they are held in one place for long periods.
Nutrition
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What are the treatments for osteogenesis imperfecta (OI)?
Are bisphosphonates the best treatment for osteogenesis imperfecta?
What is osteogenesis imperfecta?
How is osteoarthritis (Oi) treated?
What treatments are used for osteogenesis imperfecta?
What are the treatments for osteogenesis imperfecta (OI)?Fracture care.Physical therapy.Bracing.Surgical procedures.Medication.Treatments for Related Conditions.
What surgical intervention might be recommended for a child with osteogenesis imperfecta?
Intramedullary rodding surgery for children with Osteogenesis Imperfecta (OI) Children and young people with Osteogenesis Imperfecta (OI) are more likely to develop fractures and bony changes such as bowing (bending) and shortening. Rodding surgery may be suggested or recommended by your child's medical team.
How do bisphosphonates treat osteogenesis imperfecta?
Osteogenesis imperfecta is caused by a genetic defect resulting in an abnormal type I collagen bone matrix which typically results in multiple fractures with little or no trauma. Bisphosphonates are used in an attempt to increase bone mineral density and reduce these fractures in people with osteogenesis imperfecta.
What is a bone infusion for osteogenesis imperfecta?
Pamidronate strengthens the bone by increasing bone density and corrects the imbalance between bone reabsorption and bone formation which occurs in osteogenesis imperfecta (OI). Pamidronate infusions are most effective when they are given every six weeks in small children and three-monthly in older children.
How to diagnose osteogenesis imperfecta?
Specific treatment for osteogenesis imperfecta will be determined by your physician based on: 1 Your age, overall health, and medical history 2 Extent of the disease 3 Your tolerance for specific medications, procedures, or therapies 4 Expectations for the course of the disease 5 Your opinion or preference
What is the management of OI?
Management of the disease includes focusing on preventing or minimizing deformities, and maximizing the individual's functional ability at home and in the community. Management of OI is either non-surgical or surgical.
What is OI in medical terms?
Osteogenesis imperfecta (OI) is a progressive condition that needs life-long management to prevent deformity and complications. The interdisciplinary healthcare team helps the family to improve the functional outcomes and to provide support.
Is the Osteogenesis Imperfecta Society an important resource?
The Osteogenesis Imperfecta Society can also be an important resource.
Can osteogenesis imperfecta be treated?
To date, there is no known treatment, medicine, or surgery that will cure osteogenesis imperfecta (OI). The goal of treatment is to prevent deformities and fractures and allow the child to function as independently as possible. Treatments for preventing or correcting symptoms may include: Care of fractures. Surgery.
What is osteogenesis imperfecta in children?
Osteogenesis imperfecta (OI) is an inherited (genetic) bone disorder that is present at birth. It is also known as brittle bone disease. A child born with OI may have soft bones that break (fracture) easily, bones that are not formed normally, and other problems. Signs and symptoms may range from mild to severe.
How is osteogenesis imperfecta diagnosed in a child?
Your baby's healthcare provider will ask questions about your baby's medical history, your family and pregnancy history, and your baby's current symptoms. He or she will examine your baby, looking for signs and symptoms of OI. The milder forms of OI may be difficult to diagnose in a baby.
What are the possible complications of osteogenesis imperfecta in a child?
Complications may affect most body systems in a baby or child with OI. The risk of developing complications depends on the type and severity of your baby's OI. Complications may include the following:
What are the different types of OI?
These include findings on X-rays and other imaging tests. The OI types are as follows: Type I. Mildest and most common type. About 50% of all affected children have this type. There are few fractures and deformities. Type II. Most severe type.
How to care for a fractured bone?
To prevent further problems, it is recommended that a child begin moving or using the affected area as soon as possible .
How is OI passed on?
OI is passed on through the genes. The different types are passed on in different ways. The gene may be inherited from one or both parents. Or the gene can be passed on from an unexplained change (spontaneous mutation) of a gene. Most babies with OI have a defect of one of two genes.
What is the effect of bisphosphonates on osteoblasts?
As a result, unopposed osteoblastic new bone formation on the periosteal surface results in an increase in cortical thickness.
What is the role of orthotics in OI?
Orthotics play a limited role in management of OI and are used to stabilize lax joints (eg, ankle and subtalar joints with ankle-foot orthoses [AFOs]) and to prevent progressive deformities and fractures.
What is soft tissue surgery?
Soft-tissue surgery is used in specific circumstances ( eg, lower-limb contractures, particularly those of the Achilles tendon). Skilled administration of anesthetics and awareness of the limitations of surgery are essential prerequisites. [ 28] .
When is a home visit necessary for a fracture?
Home visits and regular clinic assessments are necessary, particularly in the first few years of life. Postoperatively, close follow-up is vital to ensure fracture healing and restoration of function.
Is surgery a pillar of treatment for OI?
Surgery remains a pillar of treatment for patients with OI, [ 8] but it should be performed only if it is likely to improve function and only if the treatment goals are clear. Surgical interventions include intramedullary rod placement, surgery to manage basilar impression, and correction of scoliosis. Soft-tissue surgery is used in specific circumstances (eg, lower-limb contractures, particularly those of the Achilles tendon).
Is osteogenesis imperfecta a cure?
Because osteogenesis imperfecta (OI) is a genetic condition, it has no cure. For many years, surgical correction of deformities, physiotherapy, and the use of orthotic support and devices to assist mobility (eg, wheelchairs) were the primary means of treatment. [ 27] . Subsequently, as a consequence of improved understanding ...
What are the alternatives to the treatment?
However, complications may arise if you do not take proper post-surgical care. A healthy diet and light to moderate physical exercise are recommended. Oral bisphosphonates have a long-term effect on increasing bone mass. Vitamin D and calcium supplements help strengthen bones but it is advisable to not continue them for a prolonged period of time and instead consume a diet rich in vitamin D and calcium.
What to do after bone fracture?
Some of the post-treatment guidelines include maintaining a healthy diet rich in vitamin D and calcium, regular exercise and avoiding caffeine and smoking. You must avoid bone fracture and take precautionary measures depending on the severity of your condition.
How is the treatment done?
Osteogenesis imperfecta is a very rare group of genetic disorder that affects the bones. This disease makes the bones brittle and breaks easily without any cause.
Who is not eligible for the treatment?
A person is eligible for starting treatment for Osteogenesis Imperfecta if they show symptoms such as: bone deformity, several fractures due to no reason, teeth problems, loose joints, breathing problems, loss of muscle tone, easy bruising, fatigue, blue color in the whiten portion of the eye, temperature sensitivity and loss of hearing. The disease will be confirmed through DNA or collagen testing.
What are the post-treatment guidelines?
The side effects of the medicines used for the treatment of Osteogenesis Imperfecta are mild and absent in many patients. People taking alendronate or risedronate might have gastric discomfort, a burning sensation in the esophagus and other gastric disturbances. Other problems reported include muscle pain, severe headaches, and eye irritation. Recent evidence has associated bisphonates with birth defects if consumed at the time of conception or during pregnancy.
Why is it important to take care of a fractured bone?
Taking care of fractured bones is crucial for avoiding deformed bones. Acute immobility after a fracture may cause the bones to become more brittle and reduce muscles. It is recommended to address pain and manage it, wear a proper splint and slowly move muscles.
Can osteogenesis imperfecta be confirmed?
Osteogenesis imperfecta can be confirmed through DNA or collagen testing. Since, it is a genetic disorder; there is no cure for it. Healthy lifestyle choices like exercising and avoiding smoking can help prevent fractures. Painkillers, braces and proper care for fractured bones are useful.
What Is Osteogenesis Imperfecta?
Osteogenesis imperfect is a hereditary bone disorder, characterized by brittle bones with many other symptomatic anomalies such as difficulty in hearing, fragile teeth, weakness in muscles, short stature etc.
What Causes Osteogenesis Imperfect?
Osteogenesis imperfect is a hereditary genetic disorder in most of the cases.
Symptoms Of Osteogenesis Imperfect
One thing is common in all people suffering from osteogenesis imperfect. They have delicate and brittle bones. The bones break easily, sometimes even without any apparent cause. Symptoms of osteogenesis imperfect may vary from one person to another depending on the severity of disease.
Diagnosis Of Osteogenesis Imperfecta
The symptoms of disease begin in childhood during the growth period. Detailed clinical examination and family as well as personal history help the doctor if he is suspecting the osteogenesis imperfect. Frequent fracture in a child is the most common reason to suspect osteogenesis imperfect.
Treatment Guidelines For Osteogenesis Imperfect
Frequent fracture during childhood and adulthood in a person suffering from osteogenesis imperfecta has miserable life.
