50 to 70 mg/m2 by slow IV infusion once every 3 to 4 weeks; for heavily pretreated patients, an initial dose of 50 mg/m2 by slow IV infusion once every 4 weeks is recommended Comments: -The dosing presented is manufacturer suggested.
How dangerous is the chemo drug cisplatin?
Warnings. Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys. Call your doctor if you have a fever, mouth sores, cough, sore throat, unusual bleeding or bruising, hearing problems, numbness or tingling in your hands or feet, little or no urinating, swelling or rapid weight gain, or shortness of breath.
Does cisplatin cause high blood pressure?
What other drugs will affect cisplatin? Cisplatin can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve ).
Can cisplatin cause heart disease?
Will you have Heart disease with Cisplatin? Heart disease is found among people who take Cisplatin, especially for people who are male, 60+ old , have been taking the drug for < 1 month, also take medication Etoposide, and have Gastric cancer.
Does cisplatin cause ototoxicity?
Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life.
What is the normal amount of chemo treatments?
During a course of treatment, you usually have around 4 to 8 cycles of treatment. A cycle is the time between one round of treatment until the start of the next. After each round of treatment you have a break, to allow your body to recover.
What are the doses of cisplatin?
Advanced Bladder Cancer -Cisplatin (cisplatin injection) should be administered as a single agent at a dose of 50 to 70 mg/m2 IV per cycle once every 3 to 4 weeks depending on the extent of prior exposure to radiation therapy and/or prior chemotherapy.
How long is cisplatin given?
Your course of chemotherapy Each cycle of cisplatin usually takes 21 days (3 weeks). You usually have the cisplatin on the first day of each cycle. But this will depend on the type of cancer you have. Your doctor or nurse will discuss your treatment plan with you.
How many cycles of cisplatin can you have?
You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months.
Is cisplatin a strong chemo?
Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical [20]. In ovarian germ cell cancer, the use of cisplatin brings about high response rates [21].
Can cisplatin be given every week?
Chemoradiation with cisplatin 100 mg/m2 given once every 3 weeks is the standard of care in locally advanced head and neck squamous cell cancer (LAHNSCC). Increasingly, low-dose once-a-week cisplatin is substituted because of perceived lower toxicity and convenience.
How long does it take to recover from cisplatin?
Nadir: 18-23 days. Recovery: 39 days.
How do you feel after cisplatin?
Side EffectsBlack, tarry stools.blood in urine or stools.burning, numbness, tingling, or painful sensations.change in frequency of urination or amount of urine.cough or hoarseness.difficulty in breathing.feeling of fullness in the ears.fever or chills.More items...•
What are the long term effects of cisplatin?
Cisplatin (CDDP) is a frequently employed chemotherapeutic drug both in curative and palliative settings. When cancer patients are cured due to CDDP therapy, they unfortunately often experience severe long‐term side effects including irreversible hearing loss (ototoxicity) and permanent neuronal and renal damage.
Will I lose my hair with cisplatin?
v Hair loss is minimal with cisplatin, but some patients do experience more hair loss than others. Hair growth should return upon completion of treatment. v Nausea and vomiting are not unusual but are less common today than in the past because of much improved anti-nausea medications.
How much does cisplatin chemo cost?
The cost for cisplatin intravenous solution (1 mg/mL) is around $16 for a supply of 50 milliliters, depending on the pharmacy you visit....Intravenous Solution.QuantityPer unitPrice50 milliliters$0.32$15.80100 milliliters$0.22$22.10200 milliliters$0.17$34.70
How good is cisplatin?
In particular, cisplatin's success as a chemotherapy drug against testicular cancer is phenomenal. When used in combination with other chemotherapy drugs, its cure rate is more than 90 percent.
How long does it take to get cisplatin?
Each cycle of cisplatin usually takes 21 days (3 weeks). You usually have the cisplatin on the first day of each cycle. But this will depend on the type of cancer you have. Your doctor or nurse will discuss your treatment plan with you.
How does a nurse give cisplatin?
Your nurse will give the cisplatin as a drip (infusion) that is attached to your cannula or line. They will usually put the drip through a pump. This will give you the treatment over a set time.
What is the treatment for cervical cancer?
Cisplatin. Cis platin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer.
Can you get cisplatin in a day unit?
You will be given cisplatin in a chemotherapy day unit or during a stay in hospital. A chemotherapy nurse will give it to you. Cisplatin can be given in combination with other cancer drugs or with radiotherapy . During treatment you usually see a cancer doctor, a chemotherapy nurse or a specialist nurse, and a specialist pharmacist.
Does Cisplatin cause hearing loss?
Cisplatin may cause hearing changes, including hearing loss. You may have ringing in the ears. This is called tinnitus. You may also become unable to hear some high-pitched sounds. Hearing changes usually get better after this treatment ends. But some can be permanent. Tell your doctor if you notice any changes in your hearing. You may have a hearing test before you start treatment.
Does cisplatin affect kidneys?
You will be given extra fluids through the drip before and after the cisplatin. You may also have a drug called mannitol. The fluids and mannitol can help prevent kidney damage. Your nurse will explain how long it will take to have the extra fluids.
Is Cisplatin used for cancer?
Testicular cancer that has metastasized. It is used with other drugs in patients who have already had surgery or radiation therapy. Cisplatin is also being studied in the treatment of other types of cancer.
Can Cisplatin be used for bladder cancer?
Use in Cancer. Cisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced disease that cannot be treated with other therapies, such as surgery or radiation therapy. Ovarian cancer that has metastasized (spread to other parts of the body).
How is cisplatin administered?
How Cisplatin Is Given: Cisplatin is administered through a vein (intravenously or IV) as an infusion. There is no pill form of cisplatin. Cisplatin is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If cisplatin escapes from the vein it can cause tissue damage.
How long does nausea last after cisplatin?
The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy.
What is the trade name for SIS pla tin?
Cisplatin. (SIS pla tin) Trade Names: Platinol®, Platinol®-AQ. Other Name: CDDP. Cisplatin is the generic name for the trade name drug Platinol® and Platinol®-AQ. In some cases, health care professionals may use the trade name Platinol® and Platinol®-AQ, or other names such as CDDP, when referring to the generic drug name cisplatin. Drug Type:
Can cisplatin cause tissue damage?
If cisplatin escapes from the vein it can cause tissue damage. The nurse or doctor who gives cisplatin must be carefully trained. If you experience pain or notice redness or swelling at the IV site while you are receiving cisplatin, alert your health care professional immediately.
Does cisplatin help with kidney function?
Before and/or after the cisplatin infusion, extra IV fluids are given and care is taken to ensure adequate hydration before both during and after cisplatin, to protect your kidney function. Cisplatin also has been used as an infusion into the abdominal cavity (contains the abdominal organs).
Does cisplatin cause hair loss?
Hair loss may cause hair loss; however, this side effect is uncommon. Not all cisplatin side effects are listed above, some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.
Does cisplatin have side effects?
Cisplatin side effects are often predictable in terms of their onset, duration, and severity. Cisplatin side effects will improve after therapy is complete. Cisplatin side effects may be quite manageable. There are many options to help minimize or prevent the side effects of cisplatin.
How often is cisplatin given?
A healthcare provider will give you this injection. Cisplatin is sometimes given for 5 days in a row, or once every 3 to 4 weeks. How often and how many times you receive cisplatin will depend on the type of cancer you have.
What is cisplatin used for?
What is cisplatin? Cisplatin is used together with other cancer drugs to treat bladder cancer, testicular cancer, or ovarian cancer. Cisplatin may also be used for purposes not listed in this medication guide.
What are the side effects of Cisplatin?
numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Cisplatin side effects (more detail)
How long does it take for cisplatin to cause nerve damage?
Nervous system problems may occur up to several weeks after you receive cisplatin, and these effects may not be reversible. Talk to your doctor if you have concerns about this risk. Nervous system problems may be more likely in older adults. Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Can cisplatin cause leukemia?
A child treated with cisplatin may need a hearing test before receiving the first dose. Using cisplatin may increase your risk of developing leukemia. Ask your doctor about your individual risk.
Can you have a severe reaction to cisplatin?
You may have a severe allergic reaction within minutes of receiving a cisplatin injection. Your caregivers will quickly treat you if you if this occurs. Call your doctor at once if you have: severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears;
Can you take cisplatin if you are allergic to it?
Before taking this medicine. You should not be treated with cisplatin if you are allergic to it. Tell your doctor if you have ever had: if you have had a severe allergic reaction to similar cancer drugs such as carboplatin or oxaliplatin.
What is cisplatin used for?
Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein.
When was Cisplatin first used?
Cisplatin was approved for use in testicular and ovarian cancers by the U.S. Food and Drug Administration on 19 December 1978. and in the UK (and in several other European countries) in 1979. Cisplatin was the first to be developed.
What is the compound cis?
The compound cis - [Pt (NH 3) 2 Cl 2] was first described by Michele Peyrone in 1845, and known for a long time as Peyrone's salt . The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University discovered that electrolysis of platinum electrodes generated a soluble platinum complex which inhibited binary fission in Escherichia coli ( E. coli) bacteria. Although bacterial cell growth continued, cell division was arrested, the bacteria growing as filaments up to 300 times their normal length. The octahedral Pt (IV) complex cis - [PtCl 4 (NH 3) 2 ], but not the trans isomer, was found to be effective at forcing filamentous growth of E. coli cells. The square planar Pt (II) complex, cis - [PtCl 2 (NH 3) 2] turned out to be even more effective at forcing filamentous growth. This finding led to the observation that cis - [PtCl 2 (NH 3) 2] was indeed highly effective at regressing the mass of sarcomas in rats. Confirmation of this discovery, and extension of testing to other tumour cell lines launched the medicinal applications of cisplatin. Cisplatin was approved for use in testicular and ovarian cancers by the U.S. Food and Drug Administration on 19 December 1978. and in the UK (and in several other European countries) in 1979. Cisplatin was the first to be developed. In 1983 pediatric oncologist Roger Packer began incorporating cisplatin into adjuvant chemotherapy for the treatment of childhood medulloblastoma. The new protocol that he developed led to a marked increase in disease-free survival rates for patients with medulloblastoma, up to around 85%. The Packer Protocol has since become a standard treatment for medulloblastoma. Likewise, Cisplatin has been found to be particularly effective against testicular cancer, where its use improved the cure rate from 10% to 85%.
What is the prefix for cisplatin?
The prefix cis indicates the cis isomer in which two similar ligands are in adjacent positions. The systematic chemical name of this molecule is cis –diamminedichloroplatinum, where ammine with two m's indicates an ammonia (NH 3) ligand, as opposed to an organic amine with one m.
What is the formula for transplatin?
Transplatin, the trans stereoisomer of cisplatin, has formula trans - [PtCl 2 (NH 3) 2] and does not exhibit a comparably useful pharmacological effect. Two mechanisms have been suggested to explain the reduced anticancer effect of transplatin.
What are the mechanisms of cisplatin resistance?
Many mechanisms of cisplatin resistance have been proposed including changes in cellular uptake and efflux of the drug, increased detoxification of the drug, inhibition of apoptosis and increased DNA repair.
How does Cisplatin work?
It works in part by binding to DNA and inhibiting its replication. Cisplatin was discovered in 1845 and licensed for medical use in 1978 and 1979. It is on the World Health Organization's List of Essential Medicines.
How often should I take Cisplatin?
Cisplatin Injection should be administered as a single agent at a dose of 50 to 70 mg/m2 IV per cycle once every 3 to 4 weeks depending on the extent of prior exposure to radiation therapy and/or prior chemotherapy. For heavily pretreated patients an initial dose of 50 mg/m2 per cycle repeated every 4 weeks is recommended.
How much Cisplatin should I take for testicular cancer?
The usual Cisplatin Injection dose for the treatment of testicular cancer in combination with other approved chemotherapeutic agents is 20 mg/m2 IV daily for 5 days per cycle.
How long to hydrate before ciplatin injection?
Pretreatment hydration with 1 to 2 liters of fluid infused for 8 to 12 hours prior to a Cisplatin Injection dose is recommended. The drug is then diluted in 2 liters of 5% Dextrose in 1/2 or 1/3 normal saline containing 37.5 g of mannitol, and infused over a 6- to 8-hour period. If diluted solution is not to be used within 6 hours, protect solution from light. Do not dilute Cisplatin Injection in just 5% Dextrose Injection. Adequate hydration and urinary output must be maintained during the following 24 hours.
How long does it take for neuropathy to develop after cisplatin?
Although symptoms and signs of cisplatin neuropathy usually develop during treatment, symptoms of neuropathy may begin 3 to 8 #N#weeks after the last dose of cisplatin. Cisplatin therapy should be discontinued when the symptoms are first observed. The neuropathy, however, may progress further even after stopping treatment. Preliminary evidence suggests peripheral neuropathy may be irreversible in some #N#patients. Elderly patients may be more susceptible to peripheral neuropathy (see
What is ciplatin injection?
Cisplatin Injection is indicated as a single agent for patients with transitional cell bladder cancer which is no longer amenable to local treatments, such as surgery and/or radiotherapy.
How long does nausea last after cisplatin?
Nausea and vomiting may begin within 1 to 4 hours after treatment and last up to 24 hours. Various degrees of vomiting, nausea and/or anorexia may persist for up to 1 week after treatment. #N#
How long does cisplatin stay in the body?
Plasma concentrations of the parent compound, cisplatin, decay monoexponentially with a half-life of about 20 to 30 minutes following bolus administrations of 50 or 100 mg/m2 doses. Monoexponential decay and plasma half-lives of about 0.5 hour are also seen following 2-hour or 7-hour infusions of 100 mg/m2. After the latter, the total-body clearances and volumes of distribution at steady-state for cisplatin are about 15 to 16 L/h/m2 and 11 to 12 L/m2 . Due to its unique chemical structure, the chlorine atoms of cisplatin are more subject to chemical displacement reactions by nucleophiles, such as water or sulfhydryl groups, than to enzyme-catalyzed metabolism. At physiological pH in the presence of 0.1M NaCl, the predominant molecular species are cisplatin and monohydroxymonochloro cis-diammine platinum (II) in nearly equal concentrations. The latter, combined with the possible direct displacement of the chlorine atoms by sulfhydryl groups of amino acids or proteins, accounts for the instability of cisplatin in biological matrices. The ratios of cisplatin to total free (ultrafilterable) platinum in the plasma vary considerably between patients and range from 0.5 to 1.1 after a dose of 100 mg/m2 . Cisplatin does not undergo the instantaneous and reversible binding to plasma proteins that is characteristic of normal drug-protein binding. However, the platinum from cisplatin, but not cisplatin itself, becomes bound to several plasma proteins, including albumin, transferrin, and gamma globulin. Three hours after a bolus injection and two hours after the end of a three-hour infusion, 90% of the plasma platinum is protein bound. The complexes between albumin and the platinum from cisplatin do not dissociate to a significant extent and are slowly eliminated with a minimum half-life of five days or more.