Why did the Odones look on their own for therapy?
· Why did the medical community resist the Odones' treatment ideas? because they thought that they had knew everything there was about the disease and they did want people thinking otherwise about...
What did the Odones do that no ethical scientist would do?
What opposition do the Odone’s face from the medical community and care givers? -the caregivers’ focus is more on coping than actually healing 4. What is an orphan drug? - a drug used to treat a rare disease affecting fewer than 200,000 Americans. -a drug used to treat a rare disease affecting fewer than 200,000 Americans 5.
Why did the Odones think the experiment was not successful?
The medical community resist the Odones ’ treatment ideas because Lorenzo 's parent have not thoroughly tested on a large scale yet . The medical community did n’t want the Odones t to give people false hope or aggravate the children ’s conditions until they know for sure it works .
What disease does Lorenzo Odone have in the Outsiders?
· Australian doctor-turned-film-director George Miller was as doubtful as many in the medical community when he first read about the Odones' medical odyssey. "Life doesn't happen that way -- even ...
How did the odones help to revolutionize the treatment for ALD?
It apparently worked by breaking down the long-chain fatty acids that are considered a major cause of damage to nerve cells in people with ALD.
How did Augusto and Michaela demonstrate lifelong learning?
Most of us will and should regard ourselves as “lifelong learners” even if we don't spend another day in school. How did Augusto and Michaela Odone demonstrate this? -They set out to educated themselves to tackle a complex medical mystery, take on the slow-moving medical establishment in the process.
What did the odones learn at the symposium that was helpful in their quest to find a therapy for their son?
The Odones realize that more rapid improvement of his son's severe condition will require treatments to repair the myelin sheath (a lipid insulator) around the nerves, and Augusto is shown taking on the new challenge of organizing biomedical efforts to heal myelin damage in patients.
What is the purpose of ALD symposiums?
The aim of the symposium was to identify new therapeutic approaches for adrenomyeloneuropathy, the adult form of adrenoleukodystrophy, for which there are currently few therapeutic options available and to particularly focus on the therapeutic tests which ELA is funding keno bc.
What did Augusto's dream about the paper clips help him realize?
Normal paper clips were representative of Good Fats and Triangle paper clips represented the Bad Fats. Augusto had dream of Lorenzo putting both paper clips together on same chain! Thus, Augusto woke up and had an epiphany... both Fats, paper clip types, use the same Enzyme!!!!!
What was found out from the Polish biochemist in Lorenzo's oil?
9. What was found out from the Polish biochemist? That when rats ate oleic acid, their level of VLCFSAs went down.
Is Lorenzo's oil on Netflix?
Rent Lorenzo's Oil (1992) on DVD and Blu-ray - DVD Netflix.
Is Lorenzo's oil true story?
Based on a true story, the film is about a boy named Lorenzo Odone. He is diagnosed with a rare disease called adrenoleukodystrophy (ALD) after he begins to experience seizures, hearing loss, a lack of balance, and other neurological symptoms.
Is Lorenzo from Lorenzo's oil still alive?
Lorenzo died in 2008, a day after his 30th birthday. Researchers found that Lorenzo's oil can stave off symptoms only in boys who, although they inherited the ALD gene, still appear to be normal.
Why does ALD only affect males?
A mutated gene on the X chromosome (the strand of DNA that decides if you're born male or female) is the cause of ALD. Males have one X chromosome, so only need to inherit one damaged gene from a parent to be affected. Females have two X chromosomes so are less likely to have ALD.
How Lorenzo's oil prevents the destruction of myelin in sufferers of ALD?
In ALD pre-symptomatic boys, however, Lorenzo's Oil can (but not always) slow down the onset of the disease by stopping the body from producing the very long chain fatty acids, whose buildup leads to demyelination.
Why does lorenzos oil work?
The oil works by blocking the enzymes required to synthesise the very long chain fatty acids, but how this prevents the devastating symptoms is uncertain. These are caused by the progressive loss of myelin, the fatty sheath that insulates nerve fibres, enabling them to conduct impulses properly.
What are the benefits of Lorenzo's oil?
“Lorenzo’s Oil” is an enthralling medical detective story. It can serve as a motivator in the study of the scientific method, chemistry, biology, neurology, and genetics. The film is an excellent introduction to the medical research establishment and the ethics of clinical trials.
What causes myelin to be lost?
By an unknown mechanism, perhaps an autoimmune response, this causes inflammation and the loss of myelin. (The name of the disease comes from “adreno” relating to the adrenal gland; “leuko” referring to the white color of the healthy myelin sheath; and “dystrophy” which means abnormal development.)
What is the cause of ALD?
ALD causes the loss of the white fatty insulating covering (myelin sheath) on nerve fibers within the brain. See diagram of a neuron showing myelin sheath. The disease also causes the progressive degeneration of the adrenal gland. Its basis is genetic. The ALD genetic defect is very rare, with a minimum incidence of one in every 16,800 births. ALD affects all races equally.
Does Lorenzo's oil work for ALD?
At the time the movie was released, scientific studies had demonstrated that Lorenzo’s Oil did not work for other ALD patients who, like Lorenzo, had already developed symptoms of the disease. Lorenzo’s reaction to the Oil was an anomaly. (We are not aware of any explanation for why the Oil worked with Lorenzo.)
Is Lorenzo the Odones a true story?
The film may upset sensitive children. It may be a good idea to tell children as they watch this movie that it is a mostly true story, that Lorenzo, in the end, survives, although he is still seriously disabled, and that the Odones’ efforts to save their son have allowed other children affected by the disease to live happy and productive lives.