Cisplatin + pemetrexed (cis/pem) is given to shrink lung tumors and decrease symptoms of lung cancer. Cisplatin + pemetrexed can be given either after surgery to eliminate microscopic cells, or cisplatin + pemetrexed can be given before surgery to shrink the size of the tumor and minimize the size of the lung surgery.
How is cisplatin used to treat cancer?
Cisplatin (cis-diammine-dichloro-platinum II) was initially discovered to prevent the growth of Escherichia coli and was further recognized for its anti-neoplastic and cytotoxic effects on cancer cells. Administered intravenously to humans, cisplatin is used as first-line chemotherapy treatment for patients diagnosed with various types of malignancies, such as leukemia, …
Which is better cisplatin or carboplatin chemotherapy?
Cisplatin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "alkylating agent." (For more detail, see "How Cisplatin Works" section below). What Cisplatin Is Used For: Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer.
Is carboplatin still used in cancer treatment?
Cisplatin was also approved by the FDA for the treatment of advanced ovarian and bladder cancer in 1978. Cisplatin helps save lives from testicular cancer. In particular, cisplatin's success as a chemotherapy drug against testicular cancer is phenomenal. When used in combination with other chemotherapy drugs, its cure rate is more than 90 percent. The U.S. death rate from …
What is medicinal importance of cisplatin?
Why is cisplatin given?
Why is cisplatin used to treat cancer and not Transplatin?
Is cisplatin an anti cancer agent?
How effective is cisplatin?
Why does cisplatin bind to guanine?
Why is cisplatin more effective than transplatin?
Why is transplatin less effective than cisplatin?
What is the difference between cisplatin and transplatin?
Why is cisplatin so toxic?
Does cisplatin cause cancer?
How is cisplatin administered?
How Cisplatin Is Given: Cisplatin is administered through a vein (intravenously or IV) as an infusion. There is no pill form of cisplatin. Cisplatin is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If cisplatin escapes from the vein it can cause tissue damage.
Is cisplatin an irritant?
Cisplatin is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given . If cisplatin escapes from the vein it can cause tissue damage. The nurse or doctor who gives cisplatin must be carefully trained.
Is cisplatin a generic drug?
In some cases, health care professionals may use the trade name Platinol® and Platinol®-AQ, or other names such as CDDP, when referring to the generic drug name cisplatin. Cisplatin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "alkylating agent.". (For more detail, see "How Cisplatin ...
Does cisplatin have side effects?
Cisplatin side effects are often predictable in terms of their onset, duration, and severity. Cisplatin side effects will improve after therapy is complete. Cisplatin side effects may be quite manageable. There are many options to help minimize or prevent the side effects of cisplatin.
Does Cisplatin cause nausea?
There are many options to help minimize or prevent the side effects of cisplatin. There is no relationship between the presence or severity of Cisplatin side effects and effectiveness of cisplatin. The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting.
How long does nausea last after cisplatin?
The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy.
How to reduce nausea?
Self-Care Tips: To reduce nausea, take anti-nausea medications as prescribed by your doctor, eat small amounts of food frequently. Try dry cereal, toast, or crackers, especially in the morning, to help curb nausea. Maintaining a good fluid intake is very important to help to avoid kidney damage.
Is cisplatin good for cancer?
Cisplatin plays a key role in fighting multiple cancer types. Less dramatically but far more broadly, cisplatin "became the backbone of combination therapy " for a wide range of solid tumors, according to Dr. Chabner.
Does cisplatin kill tumors?
Testing it in a sarcoma mouse model, he and his colleagues found that it did indeed attack tumors. While cisplatin was highly toxic—for example, causing kidney damage when used at a high dose—the mice were able to tolerate the drug in low doses. More importantly, the tumors responded to cisplatin and shrank.
Who discovered cisplatin?
Barnett Rosenberg, Ph.D. discovered cisplatin, which led to successful treatment for testicular and other cancers. An "accidental" discovery leads to cisplatin. Because platinum was thought to have no biological activity, Dr. Rosenberg and his colleagues put platinum electrodes into a solution containing the common laboratory bacteria E.
Is cisplatin toxic to mice?
While cisplatin was highly toxic—for example, causing kidney damage when used at a high dose—the mice were able to tolerate the drug in low doses. More importantly, the tumors responded to cisplatin and shrank. Six months later, the mice remained healthy and showed no return of the tumors.
Is cisplatin a cancer drug?
Cisplatin, a platinum-based drug, is used in combination chemotherapy for a wide range of solid tumors. At first, the cancer research community was skeptical about cisplatin . Heavy metals were considered poisons, and "the idea of putting a heavy metal into a person was an abomination," Dr. Rosenberg recalled.
When was cisplatin approved?
Cisplatin was also approved by the FDA for the treatment of advanced ovarian and bladder cancer in 1978. Cisplatin helps save lives from testicular cancer. In particular, cisplatin's success as a chemotherapy drug against testicular cancer is phenomenal.
Does cisplatin help with testicular cancer?
Cisplatin helps save lives from testicular cancer. In particular, cisplatin's success as a chemotherapy drug against testicular cancer is phenomenal. When used in combination with other chemotherapy drugs, its cure rate is more than 90 percent. The U.S. death rate from testicular cancer has dropped by two-thirds since 1975.
Is Cisplatin used for cancer?
Testicular cancer that has metastasized. It is used with other drugs in patients who have already had surgery or radiation therapy. Cisplatin is also being studied in the treatment of other types of cancer.
Can Cisplatin be used alone?
Cisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced disease that cannot be treated with other therapies, such as surgery or radiation therapy. Ovarian cancer that has metastasized (spread to other parts of the body).
What are the different types of cisplatin?
Cisplatin is approved to be used alone or with other drugs to treat: 1 Bladder cancer. It is used alone in patients with advanced disease that cannot be treated with other therapies, such as surgery or radiation therapy. 2 Ovarian cancer that has metastasized (spread to other parts of the body). It is used with other drugs in patients who have already had surgery or radiation therapy. It is used alone in patients whose disease has not gotten better with standard chemotherapy and who have not received previous cisplatin. 3 Testicular cancer that has metastasized. It is used with other drugs in patients who have already had surgery or radiation therapy.
Why are drugs studied?
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Is a syringe a substitute for medical advice?
It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.
Can bladder cancer be treated with radiation?
Bladder cancer. It is used alone in patients with advanced disease that cannot be treated with other therapies, such as surgery or radiation therapy. Ovarian cancer that has metastasized (spread to other parts of the body). It is used with other drugs in patients who have already had surgery or radiation therapy.
Is Cisplatin a chemotherapy drug?
Cisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer.
How long does it take to get cisplatin?
You usually have cisplatin as cycles of treatment. Each cycle takes 3 to 4 weeks. You might have cisplatin: You might have cisplatin on its own or in combination with other cancer treatments such as different chemotherapy drugs or radiotherapy.
Can cancer drugs interact with other drugs?
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
What do they check before and during a chemo treatment?
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
What are the symptoms of an infection?
Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. You might have other symptoms depending on where the infection is.
How do you know if you have an infection?
Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. You might have other symptoms depending on where the infection is. Infections can sometimes be life threatening. You should contact your advice line urgently if you think you have an infection.
How to get rid of tiredness?
Various things can help you to reduce tiredness and cope with it, for example exercise. Some research has shown that taking gentle exercise can give you more energy. It is important to balance exercise with resting.
What is cisplatin used for?
What is cisplatin? Cisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other cancers. It is best to read this information with our general information about chemotherapy and the type of cancer you have.
How does cisplatin work?
a fine tube into a vein in your arm and through into a vein in your chest ( PICC line ). Your nurse will give the cisplatin as a drip (infusion) that is attached to your cannula or line. They will usually put the drip through a pump. This will give you the treatment over a set time. Cisplatin can affect the kidneys.
What is the treatment for cervical cancer?
Cisplatin. Cis platin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer.
Can cancer drugs make you pregnant?
Some cancer drugs can affect whether you can get pregnant or make someone pregnant. If you are worried about this, it is important to talk with your doctor before you start treatment.
What to do if you have cancer?
Medical and dental treatment. If you need medical treatment for any reason other than cancer, always tell the doctors and nurses you are having cancer treatment . Give them the contact details for your cancer doctor so they can ask for advice. If you think you need dental treatment, talk to your cancer doctor or nurse.
What to expect before chemo?
You will see a doctor or nurse before you have chemotherapy. They will talk to you about your blood results and ask you how you have been feeling. If your blood results are okay, the pharmacist will prepare your chemotherapy. Your nurse will tell you when your treatment is likely to be ready.
Does cisplatin affect kidneys?
You will be given extra fluids through the drip before and after the cisplatin. You may also have a drug called mannitol. The fluids and mannitol can help prevent kidney damage. Your nurse will explain how long it will take to have the extra fluids.
What is cisplatin used for?
What is cisplatin? Cisplatin is used together with other cancer drugs to treat bladder cancer, testicular cancer, or ovarian cancer. Cisplatin may also be used for purposes not listed in this medication guide.
How often is cisplatin given?
A healthcare provider will give you this injection. Cisplatin is sometimes given for 5 days in a row, or once every 3 to 4 weeks. How often and how many times you receive cisplatin will depend on the type of cancer you have.
Can you take cisplatin if you are allergic to it?
Before taking this medicine. You should not be treated with cisplatin if you are allergic to it. Tell your doctor if you have ever had: if you have had a severe allergic reaction to similar cancer drugs such as carboplatin or oxaliplatin.
Can you breastfeed while taking cisplatin?
However, it is important to use birth control to prevent pregnancy because cisplatin can harm an unborn baby. You should not breastfeed while using cisplatin.
Does Cisplatin harm kidneys?
Cisplatin can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve ).
Can cancer be delayed?
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is not a complete list of side effects and others may occur.
What are the side effects of a syringe?
Common side effects may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is ciplatin used for?
Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others.
Is cisplatin used for lung cancer?
Use of cisplatin for treatment of other cancers. Cisplatin is not limited for treatment of testicular, ovarian and lung cancers, it is broadly used for treatment of childhood brain tumors [117], gastric cancer [118], leukemia [119], anal cancer [120], etc.
Is cisplatin a metal?
Cisplatin is one of the best and first metal-based chemotherapeutic drugs (see Fig. 1 for 3D structure of cisplatin ) [10], [287]. It is reported that ∼2 billion U.S. dollars of platinum-based anticancer drugs are sold worldwide [6], [7] and nearly about 50% of all patients are treated with cisplatin [8].
What are the side effects of cisplatin?
The major side effects of cisplatin are nephrotoxicity, ototoxicity, hepatotoxicity, gastrointestinal toxicity, etc. Table 1. Cisplatin dosages for different types of cancer.
What is the difference between radiation therapy and chemotherapy?
On the other hand, chemotherapy is an effective and widespread way of cancer treatment in which one or more chemotherapeutic or alkylating agents are used [3], [4], [5].
Is cisplatin used in chemotherapy?
New chemotherapy drugs have arrived on the scene over the past few decades, but cisplatin still finds wide use. Even when it is not the only or main drug given the the cancer patient, it can be a valuable part of a combination chemotherapy regimen. Look at the regimens given to patients and you will often see cisplatin as one of the drugs.
Why is cisplatin called the penicillin of cancer?
Cisplatin is called the “penicillin of cancer” because it is used so widely and it was the first big chemotherapy drug. Cisplatin also plays an interesting role in the history of chemistry. First synthesized in the 1800s, long before anyone thought of using it against cancer, cisplatin was a target compound chemists used to prove their moxie in inorganic synthesis. The shape and symbols of the molecule as represented in that discipline's iconography is aesthetically pleasing which is another reason people like to talk about cisplatin.
What is the name of the drug that is used to treat colorectal cancer?
Other drugs in this class include carboplatin, a drug with fewer and less severe side effects introduced in the 1980s, and oxaliplatin, a drug which is part of the FOLFOX treatment for colorectal cancer. The other names for cisplatin are DDP, cisplatinum, ...
What is the drug used for ovarian cancer?
Information on the chemotherapy medication Cisplatin. Cisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer.
Is cisplatin still used?
By the late 1970s it was widely used and is still used today despite the many newer chemotherapy drugs developed over the past decades. Cancer Research UK has a great article about how cisplatin came to be recognized as a cancer drug. Cisplatin is off-patent.
What happens when DNA is crosslinked?
When DNA is cross-linked in this manner, the cell undergoes apoptosis, or systemic cell death. Damage to the DNA activates the cell's repair mechanisms. Once the repair mechanisms are activated and the cells are found to not be salvageable, the death of those cells is triggered instead.
Do anticancer drugs kill cancer cells?
On the one hand, anticancer antibiotics can kill cells in the whole proliferation cycle, even G0 phase cells, thereby achieving the anti-proliferation ability of cancer cells by affecting the cell cycle, such an example with cyclinenon-specific drugs (CCNSC) 20.
What is the best treatment for cancer?
Surgical treatment. Surgical treatment is one of the most effective and common methods for the treatment of cancers. With the exception of malignant cancers of the blood system (such as leukemia, malignant lymphoma), most solid cancers can be treated in the early stages of the disease with surgery.
Can antibiotics cause cancer?
Various antibiotics have been used in the treatment of cancers, via their anti-proliferative, pro-apoptotic and anti-epithelial-mesenchymal-transition (EMT) capabilities. However, increasingly studies have indicated that antibiotics may also induce cancer generation by disrupting intestinal microbiota, which further promotes chronic inflammation, ...
Do antibiotics kill bacteria?
However, the administration of antibiotics can also indiscriminately kill advantageous bacterial groups, such as Lactobacillusand Bifidobacterium, in addition to the pathogenic bacteria 6.
When were antibiotics invented?
The first breakthrough in antibiotics dates back to 1929 by Alexander Fleming. As the years pass, the antibiotics commonly used at present mainly include β~lactams, aminoglycans, tetracycline, chloramphenicol, macrocyclic lipids, lincomines, polypeptides, rifamycin and quinolones 4.
What are the mechanisms of antibiotics?
The four major mechanisms: inhibition of bacterial cell wall synthesis, enhancement of bacterial cell membrane permeability, interference with bacterial protein synthesis and inhibition of bacterial nucleic acid replication and transcription.
What is the role of actinomycin in DNA?
Actinomycin is a class of antibiotics containing cyclic peptides, which can be embedded in the groove of the DNA double helix to form a complex with DNA , thereby inhibiting the function of RNA polymerase and ultimately inhibiting RNA synthesis 18.