Microbial secondary metabolites with potential use in cancer treatment. (Plasmid involvement in biosynthesis and compounds Abstract Antibiotics and small molecular enzyme inhibitors produced by micro-organisms are microbial secondary metabolites which have no obvious function in the growth of microorganisms.
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Which secondary metabolites are the most effective against cancer?
On the basis of this structure of microbial world, the author has found the microbial products which have various activities useful in treatment of cancer or in suppression of carcinogenesis. In this paper, the author reviewed his following studies: the plasmid involvement in biosyntheses of bioactive microbial secondary metabolites; the mechanism of therapeutic effect of bleomycin, …
What is second primary cancers?
Apr 29, 2014 · Recent research has shown that G-quadruplex formation in the telomere decreases telomerase activity, making stabilizing these formations a potential target for cancer treatment. G-quadruplex binding compounds are known, but many lack specificity for G-quadruplex formations and also bind duplex DNA structures, which can lead to increased toxicity during …
Which chemotherapy agents have an increased risk for second cancer?
Jan 05, 2020 · Isolates from Nemania serpens and Nemania aenea var. aureolatum were the most active compounds against human colorectal cancer (HT-29, HCT116) and human prostate cancer (PC-3, DU145) cell lines. These isolates induced apoptosis characterized by activated caspase 3, 8, PARP cleavage and chromatin fragmentation [ 114 ].
Can you have two types of cancer at once?
Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promoting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis).
Which compound is used for cancer treatment?
Which elements are used in cancer treatment?
Which of the following secondary metabolites is used as anticancer agent?
Which coordination compounds is used in cancer chemotherapy?
Which isotope is used for treatment of cancer?
Cobalt-60 is most commonly used in the treatment of cancer.
Which elements isotope is used in treatment of cancer?
Which of the following are examples of secondary metabolites?
Is cellulose a secondary metabolite?
Which of following are secondary metabolites?
| Some Secondary Metabolites | |
|---|---|
| Pigments | Carotenoids, anthocyanins, etc. |
| Alkaloids | Morphine, Codeine, etc. |
| Terpenoids | Monoterpenes, Diterpenes, etc. |
| Essential oils | Lemon grass oil, etc. |
Which metal is used in treatment of cancer Cobalt?
What are the different approaches to cancer treatment?
Different conventional approaches to treat cancer include chemotherapy or radiotherapy . However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addition, there are increasing concerns about drug resistance.
Is phenolic a cytotoxic agent?
Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promo ting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis).
Leukemia and myelodysplastic syndrome
Past radiation exposure is one risk factor for most kinds of leukemia, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), and acute lymphoblastic leukemia (ALL). Myelodysplastic syndrome (MDS), a bone marrow cancer that can turn into acute leukemia, has also been linked to past radiation exposure.
Solid tumors
There is also a risk for other cancers, which are mostly solid tumors, after having radiation therapy. Most of these cancers develop 10 years or more after radiation therapy. The effect of radiation on the risk of developing a solid tumor cancer depends on factors such as:
Chemotherapy
Some types of chemotherapy (chemo) drugs have been linked with different kinds of second cancers. The cancers most often linked to chemo are myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). Sometimes, MDS occurs first, then turns into AML. Acute lymphocytic leukemia (ALL) has also been linked to chemo.
Targeted therapy drugs
Some drugs used to treat cancer are called targeted therapy drugs because they were designed to find and attack certain genes or proteins that are in specific types of cancer. Targeted therapies are newer, so not a lot is known about the risk for second cancer yet.
What is the role of research in the prevention and treatment of second cancers?
Research into the etiology, prevention, and treatment of second cancers has the potential to improve public health, guide clinical management of survivors, and provide further insight into the mechanisms of carcinogenesis.
How many cancer survivors are there in 2012?
As the population of cancer survivors continues to grow (over 13 million in 2012), there is a great need to understand the long-term health of this population. Nearly one in five cancers diagnosed today occurs in an individual with a previous diagnosis of cancer, and these “second cancers” are a leading cause of morbidity ...
What are the factors that contribute to the development of radiation-related neoplasms?
Multiple, complex genetic pathways such as DNA damage repair, oxidative stress, and cell cycle control likely contribute to the development of radiation- and chemotherapy-related neoplasms, supporting a polygenic model for sensitivity to treatment-related neoplasms.