What are the treatment options for Paget's disease?
Paget's disease is a chronic condition that affects your bones. First line treatments for Paget's disease include medications, surgery, joint replacement, diet and exercise. While there is no cure for Paget’s disease, treatment can help ease the discomfort associated with the disorder.
What's new in bisphosphonates for Paget's disease?
Bisphosphonates are first-line therapy for Paget's disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment. The optimal treatment regimen should obtain normalisation or quasi-normalisation of markers of bone remodelling. This result has the potential for a long-term control of the disease.
Does Paget's disease show up on Xray?
The first indication of Paget's disease of bone is often abnormalities found on X-rays done for other reasons. X-ray images of your bones can show areas of bone breakdown, enlargement of the bone and deformities that are characteristic of the disease, such as bowing of your long bones. Bone scan.
What is a bone scan for Paget disease?
A bone scan is a test that helps doctors identify which bones are affected by Paget’s disease. The test may help your doctor understand the extent of the disease. During a bone scan, a safe amount of radioactive substance is injected into a vein in your arm.
What is the preferred treatment for Paget's disease?
Currently, six bisphosphonates are approved by the U.S. Food and Drug Administration (FDA) for the treatment of Paget's disease. These include zoledronic acid (Reclast) and pamidronate disodium (Aredia) which are given intravenously. Zoledronic acid (Reclast) is the preferred treatment.
Which of the following drugs is the drug of choice for Paget's disease?
Alendronate (Fosamax) It is recommended for treatment of Paget disease.
Are there any new treatment for Paget's disease?
There is widespread agreement that a single intravenous injection (5 mg) of zoledronate (also known as zoledronic acid) is the first-line therapy for Paget's disease 18, 19.
What do bisphosphonates do for Pagets disease?
Nitrogen-containing bisphosphonates are among the first line medications being used to treat Paget's disease of bone. They suppress disease activity by reducing osteoclast-mediated bone resorption and bone turnover, which is reflected by the reduction or normalization of the raised serum ALP level.
Which is the first-line treatment for Paget's disease oral alendronate oral calcium intravenous pamidronate intravenous zoledronic acid?
Bisphosphonates should be used as first-line agents over salmon calcitonin. Zoledronic acid infusions at 6 months shows significant normalization of alkaline phosphatase over oral risedronate.
How is Paget's disease diagnosed and treated?
The most common symptom is pain in the affected bone; neurologic, hearing, vision, cardiac, and oncologic complications are possible. Diagnosis is primarily made by radiographs. Bisphosphonates are the most common treatment.
Why is calcitonin given in Paget's disease?
Salmon calcitonin is a highly effective therapeutic agent in the treatment of Paget's disease. During chronic treatment with salmon calcitonin, alkaline phosphatase activity and urinary hydroxyproline excretion decrease on an average of 50% in patients with Paget's disease.
How often is pamidronate given?
It may be given once every 3 to 4 weeks, once a day for 3 days in a row, or as a single dose that may be repeated after 1 week or longer. The treatment schedule depends on your condition.
What medications are bisphosphonates?
Osteoporosis Medications (Bisphosphonates)Risedronate (Actonel)Alendronate (Fosamax)Ibandronate (Boniva)Zoledronic Acid (Reclast)Pamidronate (Aredia)Etidronate (Didronel)
What is the most common presenting symptom of Paget disease?
When symptoms occur, the most common complaint is bone pain. Because this disease causes your body to generate new bone faster than normal, the rapid remodeling produces bone that's less organized and weaker than normal bone, which can lead to bone pain, deformities and fractures.
Why alkaline phosphatase is high in Paget's disease?
In bone, alkaline phosphatase is made by the bone forming osteoblasts. Alkaline phosphatase produced by bone is increased in Paget disease, which can cause increased blood levels. Bone scan — A bone scan may be done to identify the bones that may have Paget disease.
Which of the following diagnostic tests confirms Paget's disease?
Bone scan. This is the best test for diagnosing Paget's disease. You may have a bone scan of your whole body to find out which bones are affected. Blood and urine tests.
What is the best treatment for Paget's disease?
Osteoporosis drugs (bisphosphonates) are the most common treatment for Paget's disease of bone. Bisphosphonates are typically given by injection into a vein, but they can also be taken by mouth. When taken orally, bisphosphonates are generally well tolerated but can irritate the stomach.
What test can you do for Paget's disease?
Lab tests. People who have Paget's disease of bone usually have elevated levels of alkaline phosphatase in their blood, which can be revealed by a blood test.
What tests can be done to confirm Paget's disease?
During the physical exam, your doctor will examine areas of your body that are causing you pain. He or she may also order X-rays and blood tests that can help confirm the diagnosis of Paget's disease of bone.
Do you need treatment for a symtom?
If you don't have symptoms, you might not need treatment. However, if the disease is active — indicated by an elevated alkaline phosphatase level — and is affecting high-risk sites in your body, such as your skull or spine, your doctor might recommend treatment to prevent complications, even if you don't have symptoms.
Can you get Paget's disease of bone?
Most people with Paget's disease of bone don't have any symptoms and are diagnosed when an X-ray or blood test taken for another reason reveals signs of Paget's disease of bone. In some cases, you may be referred to a doctor who specializes in metabolic and hormonal disorders (endocrinologist) or in joint and muscle disorders (rheumatologist).
Diagnosis
- During the physical exam, your doctor will examine areas of your body that are causing you pain. He or she may also order X-rays and blood tests that can help confirm the diagnosis of Paget's disease of bone.
Treatment
- If you don't have symptoms, you might not need treatment. However, if the disease is active — indicated by an elevated alkaline phosphatase level — and is affecting high-risk sites in your body, such as your skull or spine, your doctor might recommend treatment to prevent complications, even if you don't have symptoms.
Lifestyle and Home Remedies
- To reduce your risk of complications associated with Paget's disease of bone, try these tips: 1. Prevent falls.Paget's disease of bone puts you at high risk of bone fractures. Ask your doctor for advice on preventing falls. He or she may recommend that you use a cane or a walker. 2. Fall-proof your home.Remove slippery floor coverings, use nonskid ...
Preparing For Your Appointment
- Most people with Paget's disease of bone don't have any symptoms and are diagnosed when an X-ray or blood test taken for another reason reveals signs of Paget's disease of bone. In some cases, you may be referred to a doctor who specializes in metabolic and hormonal disorders (endocrinologist) or in joint and muscle disorders (rheumatologist). Here's some information to …