The potassium-sparing diuretics used for treating HF are the aldosterone receptor antagonists spironolactone and eplerenone.
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Which is a potassium-sparing diuretic used in the treatment of heart failure (HF)?
May 26, 2020 · What are the main uses of potassium-sparing diuretics? The main uses of potassium-sparing diuretics are: To prevent low levels of potassium (hypokalaemia) occurring …
How do potassium-sparing diuretics work?
when heart tissue is converted to fibrotic tissue due to heart failure. Contraindication. Hyperkalemia; this drug does not potassium waste, so patients are at risk for toxicity of …
What is the most common diuretic used to treat hyperkalemia?
Oct 01, 2015 · The potassium-sparing diuretics used for treating HF are the aldosterone receptor antagonists spironolactone and eplerenone. They act at the cortical collecting duct, in …
Can renal physiology explain the role of diuretic therapy in heart failure?
Potassium-Sparing Diuretics. STUDY. PLAY. what are the drugs of potassium sparing diuretics? spironolactone (Aldactone) triamterene (Dyrenium) amiloride (Midamor) action of potassium …
Can diuretics be used for heart failure?
The use of diuretics is common in patients with heart failure (HF), to relieve the congestive symptoms of HF. Although they are widely used, there are limited data on their ability to modulate HF-related morbidity and mortality. Diuretic efficacy may be limited by adverse neurohormonal activation and by ‘congestion-like’ symptoms.
What is HF in medical terms?
Heart failure (HF) is a syndrome defined by the failure of the heart to deliver oxygen at a rate commensurate with the requirements of the metabolising tissues, despite normal filling pressures (or only at the exp ense of increased filling pressure s), [1] secondary to an abnormality of the cardiac structure or function.
What are the different types of loop diuretics?
Loop diuretics include furosemide, bumetanide, torsemide and ethacrynic acid. While the bioavailability of oral furosemide ranges from 40 to 80 %, the bioavailability of torasemide and bumetanide exceeds 80 %; so these two molecules may be more effective in treating patients suffering from HF.[7]
Why do we need diuretics?
Diuretics are used to achieve and maintain euvolaemia (the patient’s ‘dry weight’) with the lowest possible dose. This means that the dose must be adjusted, particularly after restoration of the dry body weight, to avoid the risk of dehydration, which leads to hypotension and renal dysfunction.[10] .
What is the best diuretic for HF?
In general, due to their greater effectiveness, loop diure tics, such as furosemide, are the mainstay of diuretic therapy in HF. Indeed loop diuretics produce more intense and shorter diuresis than thiazides, which results in more gentle and prolonged diuresis.
What is loop diuretic?
Loop diuretics remain a cornerstone in the pharmacological treatment of ADHF and are administered in about 90 % of patients hospitalised for HF.[1] . These drugs are routinely used as initial therapy in ADHF due to their ability to greatly improve the symptoms.
Is thiazide a diuretic?
Conversely, because of their lower natriuretic effect, thiazide diuretics are used infrequently and are limited to cases where there is diuretic resistance. The same is true for potassium-sparing diuretics, which are only used in cases of refractory oedema or concomitant hypokalaemia.
What is the effect of angiotensin converting enzyme inhibitors?
One of the principal effects of angiotensin-converting enzyme (ACE) inhibitors is hyperkalemia, which is due to decreased aldosterone release arising from blockage of angiotensin I I. There is no indication that careful monitoring of sodium for increased levels is indicated.
Does furosemide cause diuresis?
Furosemide is a loop diuretic, which can produce profound diuresis very quickly even when the glomerular filtration rate (GFR) is low. An ACE inhibitor will not reduce fluid volume overload. Digoxin has a positive inotropic effect on the heart, which may improve renal perfusion, but this is not its primary effect.
What is spironolactone used for?
Spironolactone is a potassium-sparing diuretic with weak diuresis effects; it is used in conjunction with other diuretics to improve electrolyte balance. A patient newly diagnosed with heart failure is admitted to the hospital. The nurse notes a pulse of 90 beats per minute.
Is hyperkalemia a concern?
The drug therapy should be monitored to ascertain its effectiveness, but hyperkalemia is the main concern. Hyperkalemia, not hypokalemia, is a concern because of the decreased aldosterone release that occurs with blockage of angiotensin II. Click again to see term 👆. Tap again to see term 👆.