Treatment FAQ

which antiepileptic drug is used as the first-line treatment for absence seizures

by Francisca Grimes Published 2 years ago Updated 2 years ago

Ethosuximide (Zarontin).
This is the drug most doctors start with for absence seizures. In most cases, seizures respond well to this drug.
Feb 24, 2021

Medication

Drugs prescribed for absence seizure include: 1 Ethosuximide (Zarontin). This is the drug most doctors start with for absence seizures. 2 Valproic acid (Depakene). Girls who continue to need medication into adulthood should discuss... 3 Lamotrigine (Lamictal). Some studies show this drug to be less effective than ethosuximide...

Therapy

Not a cure: Although AEDs are called “antiepileptic,” they do not cure epilepsy, but just suppress seizures while the medications are in the body. carbamazepine (Tegretol, Carbatrol): A favorite partial seizure medicine in the developed world. Carbamazepine affects sodium channels, and inhibits rapid firing of brain cells.

Self-care

Dietary therapy. Following a diet that's high in fat and low in carbohydrates, known as a ketogenic diet, can improve seizure control. This is used only if traditional medications fail to control the seizures.

Nutrition

Frequently used antiepileptic drugs include phenytoin or fosphenytoin, valproate, levetiracetam, phenobarbital, and lacosamide.

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What are the drugs prescribed for absence seizures?

How do antiepileptic drugs work to treat epilepsy?

What is the best treatment for seizures in epilepsy?

What are the most commonly used antiepileptic drugs?

What is the first-line treatment for absence seizures?

First-line medications (seizure medicines that are most helpful) include ethosuximide, valproic acid and lamotrigine. In most cases, these provide effective seizure control. In a recent study, ethosuximide (Zarontin) was shown to be the first drug of choice to treat absence seizures.

What is the drug of choice for absence seizures?

Ethosuximide and valproate (VPA) are drugs of choice for generalized absence seizures. For patients who have other seizure types, such as generalized tonic–clonic or myoclonic seizures, VPA is the only choice supported by clinical trials.

What is the best treatment for absence seizures?

Absence seizures are treated with antiseizure medications. Ethosuximide (Zarontin®) is the preferred medication to treat absence seizures. Other medications that your healthcare provider might try include valproate (Depakene®), lamotrigine (Lamictal®) and topiramate (Topamax®).

Which medications are considered the first-line treatment for status epilepticus?

Early status epilepticus: first-line treatmentDiazepam. Diazepam is the first benzodiazepine used for the treatment of epilepsy and SE. ... Lorazepam. Lorazepam can be administered intravenously. ... Midazolam. Midazolam is a water-soluble benzodiazepine.

Does lamotrigine treat absence seizures?

Ethosuximide, valproate and lamotrigine are currently used to treat absence seizures. This review aims to determine the best choice of antiepileptic drug for children and adolescents with AS.

Is Keppra used for absence seizures?

Background: Levetiracetam is prescribed for a broad spectrum of seizure types but does not have a specific indication for absence epilepsy.

Does carbamazepine help absence seizures?

Carbamazepine (CBZ) aggravates many generalized seizures types, particularly absence seizures, but the mechanisms underlying this are poorly understood. GABA signaling within the reticular nucleus (Rt) and the ventrobasal complex (VB) of the thalamus is critical to the neurophysiology of absence seizures.

Why is phenytoin not used in absence seizures?

Medications that should not be used Similarly, oxcarbazepine, phenytoin, phenobarbital, gabapentin, and pregabalin should not be used in the treatment of absence seizures because these medications may worsen absence seizures.

Why is ethosuximide used for absence seizures?

Ethosuximide lowers the threshold calcium currents (T currents) in thalamic neurons. These currents, in turn, affect the oscillatory activity of thalamocortical neurons, which are generators of the 3-Hz spike-and-wave rhythms of patients with absence epilepsy.

What is the recommended treatment for absence petit mal seizures in children?

Certain seizure medicines can help prevent absence seizures. Usually these are recommended for most children. The medicines most commonly used for absence seizures include ethosuximide (Zarontin), lamotrigine (Lamictal), valproic acid (Depakene), or divalproex sodium (Depakote).

What is the best initial drug to administer to a seizure patient who has been seizing for 2 minutes in the prehospital setting?

IM injection of midazolam should be the first line EMS treatment of the actively seizing febrile pediatric patient. The suggested initial dose of IM midazolam is 0.2 mg/kg, with a max of 10 mg in children greater than 40 kg.

What is the medicine carbamazepine used for?

Carbamazepine: medicine to treat epilepsy and nerve pain - NHS.

Diagnosis

Treatment

Clinical Trials

Lifestyle and Home Remedies

Medically reviewed by
Dr. Karthikeya T M
Your provider will work with you to develop a care plan that may include one or more of these treatment options.
Medicines help in controlling the absence seizures. Use of anticonvulsant medications can minimize absence seizures.
Medication

Anticonvulsants: To prevent or stop seizure attacks.

Valproic acid . Lamotrigine . Ethosuximide

Therapy

Psychotherapy:As patients or their relatives may start worrying about their future, counseling is essential and helps management.

Self-care

Always talk to your provider before starting anything.

  • Avoid driving
  • Avoid swimming

Nutrition

Foods to eat:

  • Diet high in fat and low in carbohydrates

Foods to avoid:

  • Synthetic food colors
  • Processed sugar
  • Monosodium glutamate
  • Artificial sweeteners

Specialist to consult

Neurologist
Specializes in treating diseases of the nervous system, which includes the brain, the spinal cord, and the nerves.
Neurosurgeon
Specializes in surgery on the nervous system, especially the brain and spinal cord.
Primary care physician
Specializes in the acute and chronic illnesses and provides preventive care and health.
Pediatrician
Specializes in the health of children, including physical, behavioral, and mental health issues

Coping and Support

Preparing For Your Appointment

  • Your doctor likely will start at the lowest dose of anti-seizure medication possible and increase the dosage as needed to control the seizures. Children may be able to taper off anti-seizure medications, under a doctor's supervision, after they've been seizure-free for two years. Drugs prescribed for absence seizure include: 1. Ethosuximide (Zaront...
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