Precautions
· Methylin is a stimulant medicine used to treat attention deficit disorder (ADD), attention deficit hyperactivity disorder ( ADHD ), and narcolepsy. Methylin may also be used for purposes not listed in this medication guide. Warnings
What is Methylin used to treat?
· Methylin ™ and Methylin ™ ER should be used as a part of a total treatment program for ADHD that may include counseling or other therapies. Methylin ™ and Methylin ™ ER is also used in the treatment of a sleep disorder called narcolepsy.
How should I take Methylin?
Methylin Chewable Tablets are also used in the treatment of a sleep disorder called narcolepsy. Methylin Chewable Tablets are a federally controlled substance (CII) because they
What is methylphenidate used to treat?
Methylin Oral Solution is also used in the treatment of a sleep disorder called narcolepsy. Methylin Oral Solution is a federally controlled substance (CII) because it can be
What kind of drug is Methylin 10 mg?
· Continuing Education Activity. Methylphenidate is FDA-approved for treating attention deficit hyperactivity disorder (ADHD) in children and adults and as a second-line treatment for narcolepsy in adults. Children diagnosed with ADHD should be at least six years of age or older before being started on this medication.
What is the drug methylin used for?
Methylphenidate (Methylin) is also used to treat narcolepsy (a sleep disorder that causes excessive daytime sleepiness and sudden attacks of sleep). Methylphenidate is in a class of medications called central nervous system (CNS) stimulants. It works by changing the amounts of certain natural substances in the brain.
How much methylin should I take?
Methylin Chewable Tablets are usually taken 2 to 3 times a day. Take Methylin Chewable Tablets 30 to 45 minutes before a meal. Chew Methylin Chewable Tablets well and swallow with at least 8 ounces (a fullglass) of water or other liquid.
What can methylphenidate treat?
Methylphenidate is used to treat attention deficit hyperactivity disorder (ADHD). It belongs to the group of medicines called central nervous system (CNS) stimulants. Methylphenidate is also used to treat narcolepsy. Narcolepsy is an uncontrollable desire for sleep or a sudden attack of deep sleep.
What does methylphenidate do to the brain?
Methylphenidate works in the treatment of attention deficit hyperactivity disorder by increasing levels of dopamine in children's brains, according to a study reported in the Journal of Neuroscience (2001;21:121).
How long does it take methylin to work?
This means it might take a few weeks before you see any benefits. When your doctor has found the right dose, methylphenidate should start to work within 30 to 60 minutes of your child taking it. The medicine makes your child less hyperactive or impulsive, and helps their concentration.
Can methylphenidate make you gain weight?
Sometimes the medicines most often used to treat ADHD can cause weight loss. Stimulant drugs like methylphenidate (Ritalin) and amphetamine/dextroamphetamine (Adderall) make you less hungry and make your body burn calories faster than usual. Some of them are even used to help people lose weight or treat binge eating.
Can methylphenidate make you sleepy?
Conclusion: In a group of children with ADHD taking methylphenidate, there was a significant increase in sleepiness a few hours after taking the medication, which may then have a significant impact on their learning.
When should you take methylphenidate?
Adults—20 to 30 milligrams (mg) given in divided doses 2 or 3 times a day, taken 30 to 45 minutes before meals (breakfast and lunch). Your doctor may adjust your dose as needed. However, the dose is usually not more than 60 mg per day.
What is the most common side effect of methylphenidate?
The most common side-effects experienced with methylphenidate include sleeplessness, nervousness, reduced appetite, headache, abdominal pain, tachycardia, changes in blood pressure and heart rate.
How does methylphenidate make you feel?
As stimulant drugs, methylphenidate and the methylphenidate-based drugs can make you feel very 'up', awake, excited, alert and energised, but they can also make you feel agitated and aggressive. They may also stop you from feeling hungry.
How do you know methylphenidate is working?
How do I tell if stimulant drugs are working?increased heart rate or blood pressure.decreased appetite.trouble falling or staying asleep.irritability, as the medicine wears off.nausea or vomiting.headaches.mood swings.
Does methylphenidate help you focus?
People tend to think that Ritalin and Adderall help them to focus. And they do, in some sense. But what this study shows is that they do so, in part, by increasing your cognitive motivation. Your perceived benefits of performing a demanding task are elevated, while the perceived costs are reduced.
What is methylin used for?
Methylin is indicated as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. The diagnosis of this syndrome should not be made with finality when these symptoms are only of comparatively recent origin. Nonlocalizing (soft) neurological signs, learning disability, and abnormal EEG may or may not be present, and a diagnosis of central nervous system dysfunction may or may not be warranted.
What is the mechanism of action of methylin?
Methylin - Clinical Pharmacology. Methylin is a mild central nervous system stimulant. The mode of action in man is not completely understood, but Methyl in presumably activates the brain stem arousal system and cortex to produce its stimulant effect.
How many mg of methylin is in a USP?
Each Methylin ™ (methylphenidate HCl tablet USP) 20 mg is available as a round, white scored tablet debossed with 20 on one side of the tablet and a on the other side.
What is the formula for methylphenidate?
Methylphenidate hydrochloride is methyl α-phenyl-2-piperidineacetate hydrochloride, and its structural formula is.
How long does methylphenidate last?
In a study conducted in young rats, methylphenidate was administered orally at doses of up to 100 mg/kg/day for 9 weeks, starting early in the postnatal period (Postnatal Day 7) and continuing through sexual maturity (Postnatal Week 10).
Is methylphenidate excreted in milk?
It is not known whether methylphenidate is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised if Methylin is administered to a nursing woman.
Is methylphenidate teratogenic?
Teratogenic Effects. Pregnancy Category C – In studies conducted in rats and rabbits, methylphenidate was administered orally at doses of up to 75 and 200 mg/kg/day, respectively, during the period of organogenesis. Teratogenic effects (increased incidence of fetal spina bifida) were observed in rabbits at the highest dose, which is approximately 40 times the maximum recommended human dose (MRHD) on a mg/m 2 basis. The no effect level for embryo-fetal development in rabbits was 60 mg/kg/day (11 times the MRHD on a mg/m2 basis). There was no evidence of specific teratogenic activity in rats, although increased incidences of fetal skeletal variations were seen at the highest dose level (7 times the MRHD on a mg/m 2 basis), which was also maternally toxic. The no effect level for embryo-fetal development in rats was 25 mg/kg/day (2 times the MRHD on a mg/m 2 basis). When methylphenidate was administered to rats throughout pregnancy and lactation at doses of up to 45 mg/kg/day, offspring body weight gain was decreased at the highest dose (4 times the MRHD on a mg/m 2 basis), but no other effects on postnatal development were observed. The no effect level for pre- and postnatal development in rats was 15 mg/kg/day (equal to the MRHD on a mg/m 2 basis).
What is methylin used for?
Methylin can also be used to treat narcolepsy.
What are the warning signs of methylin?
Call your doctor immediately if you or your child experiences warning signs such as chest pain, shortness of breath, or fainting while taking Methylin. Also disclose to your physician all mental health issues including any family history of suicide, bipolar illness, or depression.
What is methylphenidate hydrochloride?
Methylin (Generic Name: methylphenidate hydrochloride) is a central nervous system stimulant primarily used to treat attention deficit hyperactivity disorder (ADHD) in children ages 6-12, adolescents, and adults up to age 65. Methylin may improve focus, and decrease impulsivity and hyperactive behavior — hallmark symptoms in some patients with ...
Can methylin disrupt sleep?
Dosage for Methylin. As with all medications, follow your Methylin prescription instructions exactly. Taking Methylin after 6pm can disrupt sleep for some patients. The optimal dosage varies patient by patient. It is not determined by age, weight, or height, but rather by how a person metabolizes the medication, and the condition treated.
Is methylin a controlled substance?
It contains the same active ingredient as medications like Ritalin and Daytrana. According to the FDA, Methylin is a federally controlled substance (CII) because it can be abused or lead to dependence. It has not been studied in children under the age of 6.
Can Methylin be stopped?
During treatment , your doctor may periodically ask you to stop taking your Methylin so that he or she can monitor ADHD symptoms; check vital statistics including blood, heart, and blood pressure; or evaluate height and weight. If any problems are found, your doctor may recommend discontinuing treatment.
Can you drink alcohol while taking methylin?
Dosage does not typically exceed 60 mg per day. Do not drink alcohol while taking this medication, as it can cause the medicine to be released too quickly. Taking Methylin after eating a high-fat meal can delay the release of the medication, and therapeutic effects.
What is the mechanism of action of methylphenidate?
Mechanism of Action. Methylphenidate blocks the reuptake of two neurotransmitters, norepinephrine (NE) and dopamine, by presynaptic neurons.
How long after discontinuation of MAOIs can you take methylphenidate?
Patients must not use methylphenidate if they are currently on monoamine oxidase inhibitors (MAOIs). There should be a minimum of at least 14 days after discontinuation of MAOIs before methylphenidate can be considered a safe treatment option to begin due to the risk of hypertensive crisis.
How old do you have to be to take methylphenidate?
Children diagnosed with ADHD should be at least six years of age or older before being started on this medication. Off-label uses of methylphenidate include treatment for fatigue in patients with cancer, refractory depression in the geriatric population, apathy in Alzheimer's disease, and enhancing cognitive performance (e.g., memory).
What are the side effects of methylphenidate?
Insomnia and nervousness are the most commonly reported adverse effects in patients on methylphenidate. Other frequent side effects mainly involve the CNS (dizziness, headache, tics, restlessness/akathisia), gastrointestin al (nausea/vomiting, dry mouth, decreased appetite, weight loss, abdominal pain), and cardiovascular systems (tachycardia, and palpitations). Dermatologically, patients can complain of excessive sweating and ulceration of their digits. Some patients may even develop blurry vision or decreased libido. Patients are more prone to become easily agitated, irritable, or depressed and go through mood swings/lability). While many of the common side effects can be relieved by adjusting the dosage or avoidance of an afternoon or evening dose, some require treatment emergently to prevent complications. While it rarely occurs, priapism is a medical emergency that requires immediate attention. [14]
Can methylphenidate cause cardiac death?
Stroke and myocardial infarction also have been observed in adults. Due to the risk of such fatal side effects, it is advisable to avoid methylphenidate in patients with a structural cardiac abnormality, cardiomyopathy, or arrhythmias. [15]
Does methylphenidate increase dopamine levels?
Compared to other medications (i.e., amphetamines) that are phenethylamine derivatives, methylphenidate appears to increase the firing rate of neurons.[10] It is also a weak agonist at the 5HT1A receptor, which is an additional mechanism that contributes to the increased levels of dopamine. [11] .
Is methylphenidate a transdermal patch?
For medical purposes, methylphenidate is mainly given orally or, less commonly, as a transdermal patch. Multiple oral formulations are available that categorize according to how quickly the drug is released: immediate (IR), extended (XR or ER), and sustained.
Why is methylin given cautiously?
Methylin should be given cautiously to emotionally unstable patients, such as those with a history of drug dependence or alcoholism, because such patients may increase dosage on their own initiative.
What is methylphenidate used for?
Methylin Oral Solution ( methylphenidate HCI) is a prescription medicine used to treat the symptoms of Attention Deficit Hyperactivity Disorder ( ADHD) and Narcolepsy. Methylin Oral Solution may be used alone or with other medications.
What is the class of medication that contains methylin?
Methylin Oral Solution belongs to a class of drugs called Stimulants; ADHD Agents.
Why is careful supervision required during drug withdrawal?
Careful supervision is required during drug withdrawal, since severe depression as well as the effects of chronic overactivity can be unmasked. Long-term follow-up may be required because of the patient's basic personality disturbances.
Does methylin decrease guanethidine?
Methylin may decrease the hypotensive effect of guanethidine. Use cautiously with pressor agents.
Does MedicineNet provide medical advice?
MedicineNet does not provide medical advice, diagnosis or treatment. See additional information.
Is methylin safe for pregnancy?
Adequate animal reproduction studies to establish safe use of Methylin during pregnancy have not been conducted.
What is methylphenidate used for?
Methylphenidate, brand name Ritalin, is a prescription drug commonly used to treat Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy. It has a high potential for abuse and is becoming more widely available, especially among teens and young adults. Some people use methylphenidate outside of prescription guidelines to boost focus, ...
What is the best treatment for methylphenidate addiction?
Behavioral therapies are commonly used to help people with a methylphenidate addiction to examine thoughts and behaviors and identify negative influences in their lives. These therapies may be combined with counseling and support groups to encourage emotional growth and positive relationships.
What happens if you take methylphenidate?
As with other stimulants, such as amphetamine ( Adderall ), methamphetamine, and cocaine, a person may experience a burst of energy, heightened alertness and exhilaration after taking methylphenidate. Also like cocaine, a methylphenidate high may be followed by a crash, with symptoms like extreme fatigue, exhaustion, insomnia and depression.
Why is methylphenidate used in studies?
Methylphenidate abuse is most commonly linked to students who use Ritalin in order to focus better on certain tasks. It makes it easier for someone to cram for a big test or project, allowing them to concentrate more deeply and for longer than usual. For this reason, methylphenidate is sometimes called a “study drug.”.
Why do people abuse methylphenidate?
Some people abuse methylphenidate for its potential to produce euphoria. They may take high doses of the drug to achieve this.
Is methylphenidate a pill?
Methylphenidate comes in pill form and is usually taken orally. That being said, a study on prescription stimulant abuse among college students reports that 38 percent of people surveyed who used stimulants outside of prescription guidelines took them by snorting (insufflation).
Does Ritalin help with ADHD?
As a central nervous system stimulant, Ritalin increases the availability of brain chemicals that produce stimulation. This helps a person with ADHD becomes less inclined to self-stimulate and allows them to focus on the task at hand. Regardless of whether the person taking methylphenidate has ADHD, the drug prevents dopamine from being reabsorbed ...
Why is methylin given cautiously?
Methylin should be given cautiously to emotionally unstable patients, such as those with a history of drug dependence or alcoholism, because such patients may increase dosage on their own initiative.
What is methylphenidate used for?
Methylin Chewable Tablets (methylphenidate HCI) is a prescription medicine used to treat the symptoms of Attention Deficit Hyperactivity Disorder (ADHD) and Narcolepsy. Serious side effects of Methylin include hives, difficulty breathing, swelling of your face, lips, tongue, or throat; chest pain, lightheadedness, hallucinations, new behavior problems, aggression, hostility, paranoia, and others.
What class is methylin?
Methylin Chewable Tablets belongs to a class of drugs called Stimulants; ADHD Agents.
What is the name of the medication that is used to treat ADHD?
Brand name: Methylin. Methylin Chewable Tablets ( methylphenidate HCI) is a prescription medicine used to treat the symptoms of Attention Deficit Hyperactivity Disorder ( ADHD) and Narcolepsy. Methylin Chewable Tablets may be used alone or with other medications. Methylin Chewable Tablets belongs to a class of drugs called Stimulants; ADHD Agents.
Why is methylin discontinued?
Methylin should be periodically discontinued to assess the child's condition. Improvement may be sustained when the drug is either temporarily or permanently discontinued.
What are the side effects of Methylin?
The most common side effects of Methylin Chewable Tablets include: excessive sweating, mood changes, nervousness, irritableness, sleep problems ( insomnia ), fast heart rate, pounding heartbeats,
Can methylin cause hypertension?
Concomitant use of MAOIs and CNS stimulants, including Met hylin can cause hypertensive crisis. Potential outcomes include death, stroke, myocardial infarction, aortic dissection, ophthalmological complications, eclampsia, pulmonary edema, and renal failure. Concomitant use of Methylin with MAOIs or within 14 days after discontinuing MAOI treatment is contraindicated.
When was methylphenidate first used?
Methylphenidate was first synthesized in 1944 and was approved for medical use in the United States in 1955. It was originally sold by Swiss company CIBA, now Novartis Corporation. It is estimated that in 2013, 2.4 billion doses of methylphenidate were taken worldwide. In 2019, it was the 51st most commonly prescribed medication in the United States, with more than 14 million prescriptions. It is available as a generic medication.
Who made methylphenidate?
Methylphenidate was synthesized by Ciba (now Novartis) chemist Leandro Panizzon. He named the drug after his wife Margarita, nicknamed Rita, who used Ritalin to compensate for low blood pressure.
How many isomers of methylphenidate are there?
Four isomers of methylphenidate are possible, since the molecule has two chiral centers. One pair of threo isomers and one pair of erythro are distinguished, from which primarily d-threo-methylphenidate exhibits the pharmacologically desired effects. The erythro diastereomers are pressor amines, a property not shared with the threo diastereomers. When the drug was first introduced it was sold as a 4:1 mixture of erythro:threo diastereomers, but it was later reformulated to contain only the threo diastereomers. "TMP" refers to a threo product that does not contain any erythro diastereomers, i.e. (±)-threo-methylphenidate. Since the threo isomers are energetically favored, it is easy to epimerize out any of the undesired erythro isomers. The drug that contains only dextrorotatory methylphenidate is sometimes called d-TMP, although this name is only rarely used and it is much more commonly referred to as dexmethylphenidate, d-MPH, or d-threo-methylphenidate. A review on the synthesis of enantiomerically pure (2 R ,2' R )- (+)- threo -methylphenidate hydrochloride has been published.
How does methylphenidate affect the central nervous system?
Psychostimulants like methylphenidate and amphetamine may be effective in treating ADHD because they increase neurotransmitter activity in these systems. When reuptake of those neurotransmitters is halted, its concentration and effects in the synapse increase and last longer, respectively. Therefore, methylphenidate is called a norepinephrine–dopamine reuptake inhibitor. By increasing the effects of norepinephrine and dopamine, methylphenidate increases the activity of the central nervous system and produces effects such as increased alertness, reduced fatigue, and improved attention.
How long does methylphenidate take to release?
Ritalin), 3–8 hours for sustained release (i.e. Ritalin SR), and 8–12 hours for extended release (i.e. Concerta). The half-life of methylphenidate is 2–3 hours, depending on the individual.
What is the best medication for narcolepsy?
Narcolepsy, a chronic sleep disorder characterized by overwhelming daytime drowsiness and uncontrollable sleep, is treated primarily with stimulants. Methylphenidate is considered effective in increasing wakefulness, vigilance, and performance. Methylphenidate improves measures of somnolence on standardized tests, such as the Multiple Sleep Latency Test (MSLT), but performance does not improve to levels comparable to healthy people.
What are the side effects of methylphenidate?
Nervous system adverse effects may include akathisia (agitation/restlessness), irritability, dyskinesia (tics), oromandibular dystonia, lethargy (drowsiness/fatigue), and dizziness. Cardiac adverse effects may include palpitations, changes in blood pressure and heart rate (typically mild), and tachycardia (rapid heart rate). Smokers with ADHD who take methylphenidate may increase their nicotine dependence, and smoke more often than before they began using methylphenidate, with increased nicotine cravings and an average increase of 1.3 cigarettes per day. Ophthalmologic adverse effects may include blurred vision and dry eyes, with less frequent reports of diplopia and mydriasis.
Overview
- Methylin (Generic Name: methylphenidate hydrochloride) is a central nervous system stimulant primarily used to treat attention deficit hyperactivity disorder (ADHD) in children ages 6-12, adolescents, and adults up to age 65. Methylin may improve focus, and decrease impulsivity and hyperactive behavior hallmark symptoms in some patients with the c...
Treatment
- The American Academy of Pediatrics recommends treatment with behavioral therapy before medication for children under the age of 6. For children ages 6 to 11, the AAP says The primary care clinician should prescribe US Food and Drug Administrationapproved medications for ADHD and/or evidence-based parent- and/or teacher-administered behavior therapy as treatment for A…
Preparation
- Before starting or refilling a Methylin prescription, read the medication guide included with your pills, as it may be updated with new information.
Risks
- This guide should not replace a conversation with your doctor, who has a holistic view of your or your childs medical history, other diagnoses, and other prescriptions. If you have questions, ask your doctor or pharmacist before you begin taking the medication. As with all medications, follow your Methylin prescription instructions exactly. Taking Methylin after 6pm can disrupt sleep for …
Side effects
- The most common side effects of Methylin are as follows: nervousness, trouble sleeping, headache, stomach ache, fast heartbeat, nausea, decreased appetite, dizziness, and weight loss. Other serious side effects include slowing of growth in children, seizures, priapism, and eyesight changes or blurred vision.
Diagnosis
- Report to your doctor any heart-related problems or a family history of heart and blood pressure problems. Patients with structural cardiac abnormalities and other serious heart problems have experienced sudden death, stroke, heart attack, and increased blood pressure while taking Methylin. Stimulants can increase blood pressure and heart rate. Physicians should monitor the…
Interactions
- Stimulants like Methylin have a high potential for abuse and addiction, especially among people who do not have ADHD. It is a Schedule II Stimulant, a designation that the Drug Enforcement Agency uses for drugs with a high potential for abuse. Other Schedule II drugs include Dexedrine, Ritalin, and cocaine. People with a history of drug abuse should use caution when trying this me…
Contraindications
- Store Methylin in a secure place out of the reach of children, and at room temperature. Do not share your Methylin prescription with anyone, even another person with ADHD. Sharing prescription medication is illegal, and can cause harm. You should not take Methylin if you have any of the following conditions: allergy or hypersensitivity to Methylin or any of the ingredients i…
Prevention
- If youre thinking of becoming pregnant, discuss the use of Methylin with your doctor. Animal studies indicate a potential risk of fetal harm. Methylin is passed through breastmilk, so it is recommended that mothers do not nurse while taking it.