CyBorD (Cyclophosphamide + Bortezomib + Dexamethasone) is a Chemotherapy Regimen for Multiple Myeloma (MM) How does CyBorD work? Each of the medications in CyBorD is designed to kill or slow the growth of myeloma cells. Cy - Cyclophosphamide (Cytoxan)
Full Answer
What are steroids used for in myeloma treatment?
Steroids are often used as treatment for myeloma. They help destroy myeloma cells and also make chemotherapy and targeted therapies work better. Steroids help destroy myeloma cells and also make chemotherapy and targeted therapies work better. You usually have them along with these treatments which are given over a few months.
What is the cybord treatment regimen for newly diagnosed multiple myeloma?
In summary, CyBorD with treatment given on a 28 day cycle is a highly active regimen in newly diagnosed MM and produces rapid and profound responses. The regimen is tolerable with manageable toxicities although neuropathy was common.
What is the best chemo drug for multiple myeloma?
Chemo drugs used to treat multiple myeloma include: Melphalan Vincristine (Oncovin) Cyclophosphamide (Cytoxan) Etoposide (VP-16) Doxorubicin (Adriamycin) Liposomal doxorubicin (Doxil) Bendamustine (Treanda)
Which proteasome inhibitors are used to treat multiple myeloma?
Bortezomib (PS-341): a novel, first-in-class proteasome inhibitor for the treatment of multiple myeloma and other cancers. Cancer Control. 2003;10:361–369.
Why is dexamethasone used with Revlimid?
According to results recently presented at the 2007 annual meeting of the American Society of Hematology, use of low doses of the steroid dexamethasone in combination with Revlimid® (lenalidomide) provided significantly improved survival in multiple myeloma compared with higher-doses of the steroid in this treatment ...
What is Cyborg chemotherapy?
CyBorD or VCd or cybord is given to alleviate symptoms and slow the progression of multiple myeloma, not for disease cure. After treatment, patients who respond to CyBorD are typically monitored in the clinic using blood tests, continue on to maintenance therapy, or proceed to bone marrow transplant.
Why is dexamethasone used with Velcade?
The addition of the proteasome inhibitor Velcade® (bortezomib) to the treatment combination Revlimid® (lenalidomide) plus dexamethasone improves survival when used as initial therapy in multiple myeloma among patients who do not intend to immediately undergo a stem cell transplant according to clinical trial results ...
Is Velcade dexamethasone?
Velcade clinical studies suggest that Velcade-dexamethasone is an effective initial therapy for patients with myeloma, including patients who are eligible for high-dose chemotherapy and stem cell transplant and those who are not.
Is dexamethasone a steroid?
Dexamethasone is a steroid (corticosteroid) medicine. Steroids closely copy the effects of natural hormones produced in your adrenal glands. The adrenal glands sit above your kidneys. When prescribed in doses higher than your body's usual levels, steroids like dexamethasone reduce inflammation.
Does bortezomib cause hair loss?
Hair loss. Hair loss isn't a direct side effect of Velcade, but it may be a side effect of other drugs used with Velcade. For example, hair loss may occur in people using Velcade with cyclophosphamide, which is a cytotoxic drug.
Why do multiple myeloma patients take dexamethasone?
Dexamethasone and the other steroids are useful in myeloma treatment because they can stop white blood cells from traveling to areas where cancerous myeloma cells are causing damage. This decreases the amount of swelling or inflammation in those areas and relieves associated pain and pressure.
Does dexamethasone give you energy?
Dexamethasone can give people an increase in energy. They may also develop insomnia, or difficulty sleeping. Taking the medication in the morning may help to prevent this.
What is the difference between Velcade and bortezomib?
Bortezomib is also called by its brand name Velcade. It is a treatment for myeloma and mantle cell lymphoma. You can have bortezomib on its own.
What is the purpose of dexamethasone for chemotherapy?
Background: Dexamethasone is a steroid, which is often given into the vein before chemotherapy to help control acute nausea and vomiting. It can also be given as an oral tablet for patients to take for the two days following chemotherapy to help minimise delayed nausea and vomiting.
Is VELCADE chemo or immunotherapy?
VELCADE (bortezomib) is a type of chemotherapy called a targeted therapy. VELCADE belongs to a class of medicines called proteasome inhibitors. It is approved by the FDA for the treatment of multiple myeloma and mantle cell lymphoma. VELCADE has been studied in many important clinical trials.
How do you know when multiple myeloma is in remission?
When you're in remission, you won't have any symptoms of multiple myeloma, but a few abnormal plasma cells still remain in your body. Treatments can't kill every single cancer cell. There just may be too few abnormal cells for tests to spot.
Where is myeloma found?
Multiple Myeloma is a disease of the white blood cells, called plasma cells, found in the blood or bone marrow. Plasma cells are a type of white blood cell known as a B-lymphocyte. Sometimes plasma cells form collections on bone and weaken or destroy it. These are known as "lytic lesions".
How many days does a person have to take a bortezomib injection?
Bortezomib (Velcade) subcutaneous injection on Days 1, 4, 8, and 11. Dexamethasone 40 mg (ten 4 mg tablets) by mouth on Days 1, 2, 3, 4, then 9, 10, 11, 12, then 17, 18, 19 and 20. Bortezomib is usually given in an outpatient infusion center, allowing the person to go home afterwards.
How often is cyclophosphamide given?
On occasion, CyBorD may be given in the hospital if someone is too sick. CyBorD is repeated every 28 days. This is known as one Cycle. Each cycle may be repeated up to 4 times, depending upon the stage of the disease.
What is cybord used for?
Each of the medications in CyBorD is designed to kill or slow the growth of myeloma cells. CyBorD or VCd or cybord is given to alleviate symptoms and slow the progression of multiple myeloma, not for disease cure. After treatment, patients who respond to CyBorD are typically monitored in the clinic using blood tests, ...
How long does Cybord last?
Duration of therapy may last up to 4 months, depending upon response, tolerability, and number of cycles prescribed. There are various alternative dosing schedules for CyBorD. Click here for common starting doses. Tap along the timeline to move to different parts of the audio file.
Can you take pain medication before a biopsy?
You may request sedative medications prior to the procedure if you have anxiety. You should arrange to have someone drive you home if you take anxiety medications or receive pain medications prior to the procedure. You may have discomfort around the biopsy area and experience soreness for a few days afterwards.
Does Medicare preauthorize cyclophosphamide?
Medicare and Medicaid patients (Patients 65 years or older): The clinic providing treatment will likely pre-authorize medications and immune therapies such as CyBorD (Cyclophosphamide + Bortezomib + Dexamethasone) and are the best source to help you understand drug cost.
What is the best treatment for myeloma?
dexamethasone. Steroids may also be used to treat a possible bone complication of myeloma called spinal cord compression.
Can steroids cause swelling?
Side effects of steroids. If you only take small doses of a steroid, you may not have many side effects. If you need larger doses for longer, you may have more. Some of the side effects of steroids include: build-up of fluid, which may cause swelling in your hands and feet. The side effects of steroids are temporary.
Can steroids help myeloma?
Steroids are often used as treatment for myeloma. They help destroy myeloma cells and also make chemotherapy and targeted therapies work better. On this page. About steroids and myeloma. Side effects of steroids. How we can help.
Do steroids go away?
The side effects of steroids are temporary. They gradually go away as treatment finishes or your doctor lowers the dose. Some side effects are more likely if you are taking steroids for a long time. With myeloma it is unusual to take them for a long time.
Can you take steroids if you have myeloma?
This is when myeloma is in the bones of the spine and putting pressure on the spinal cord. You will usually have steroids as tablets. If you have difficulty swallowing them, you can have steroids that are liquid or dissolve.
How they are given
The typical steroids used for myeloma are dexamethasone and prednisolone. These are usually given with chemotherapy or other anti-myeloma drugs. Steroids are most often taken as tablets but can also be given intravenously. They are usually given in high doses, but for short periods only.
Side effects
Common side effects include difficulty sleeping, mood changes, increased appetite, fluid retention, heartburn, infections and weight gain. To reduce the risk of sleeplessness at night and irritation to your stomach, take steroids in the morning with food or milk.
Need to talk?
Call 13 11 20 to talk to a health professional Or email us your questions.
What is the treatment for multiple myeloma?
Chemotherapy. Chemotherapy (chemo) is the use of certain kinds of drugs that destroy or control the growth of cancer cells. These drugs can be taken by mouth or given in a vein or a muscle. They enter the bloodstream and reach almost all areas of the body. At one time, chemo was often part of the main treatment for multiple myeloma.
How many different drugs are used for multiple myeloma?
Although a single drug may be used to treat multiple myeloma, it is preferable to use at least 2 or 3 different kinds of drugs in combination because the cancer responds better. For example:
What is Daratumumab used for?
This is thought to both kill the cancer cells directly and to help the immune system attack them. This drug is used mainly in combination with other types of drugs, although it can also be used by itself in patients who have already had several other treatments for their myeloma.
What happens when a myeloma cell cannot transport proteins from its nucleus?
When the myeloma cell cannot transport proteins from its nucleus, the cell dies. This drug is used with dexamethasone: for people whose myeloma has been treated with and no longer responds to at least 5 other myeloma drugs, including proteasome inhibitors, immunomodulatory drugs, and a monoclonal antibody to CD38 OR.
What is an antibody-drug conjugate?
Antibody-drug conjugates. An antibody-drug conjugate is a monoclonal antibody linked to a chemotherapy drug. In this case, the antibody looks for and then attaches to the BCMA protein on myeloma cells, bringing the chemo directly to them.
What antibody is used to fight SLAMF7?
Antibodies against SLAMF7. Elotuzumab (Empliciti) is a monoclonal antibody that attaches to the SLAMF7 protein, which is found on myeloma cells. This is thought to help the immune system attack the cancer cells. This drug is used mainly in patients who have already had other treatments for their myeloma.
Can you take acyclovir with bortezomib?
To help prevent this, your doctor may have you take an anti-viral medicine (like acyclovir) while you take bortezomib. In patients where the myeloma was put into remission after either a stem cell transplant or initial treatment, bortezomib may also be given for maintenance therapy to prolong the remission.
What is the most common medication used to treat myeloma?
Overview. Corticosteroids are a class of prescription drugs approved by the Food and Drug Administration (FDA) to treat inflammation. Corticosteroids are sometimes used to treat people with myeloma. The most common corticosteroids used to treat myeloma include Dexamethasone, Prednisone, Prednisolone, and Methylprednisolone.
How do corticosteroids help with myeloma?
Corticosteroids can help fight myeloma in several ways. First, corticosteroids are believed to help kill myeloma cells on their own. Second, corticosteroids can boost the effectiveness of other anti-myeloma drugs such as those used in chemotherapy. Finally, corticosteroids can help reduce side effects – such as nausea, vomiting, ...
How many people died from multiple myeloma in 2007?
In 2007, an estimated 19,900 people in the United States will be diagnosed with multiple myeloma and an estimated 10,790 people will die of the disease.
When was lenalidomide approved?
Lenalidomide, a derivative of thalidomide, was approved by the U.S. Food and Drug Administration in 2006 to be used in combination with dexamethasone for the treatment of multiple myeloma in patients who received at least one prior therapy for their disease.
How long does dexamethasone last?
Researchers found that patients in the study who received low-dose dexamethasone and lenalidomide had a one-year survival of 96 percent compared to 86 percent for patients treated with the standard-dose of dexamethasone and lenalidomide. In addition, there were fewer side effects associated with the low-dose dexamethasone and lenalidomide.
Who makes lenalidomide?
Celgene, Inc. , Summit, N.J., which manufactures lenalidomide, provided lenalidomide for the trial under a Cooperative Research and Development Agreement with NCI for the clinical development of lenalidomide. Multiple myeloma is a cancer of plasma cells that are found in blood and bone marrow.
Who sponsored the ECOG trial?
The clinical trial was sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and conducted by a network of researchers led by the Eastern Cooperative Oncology Group (ECOG).
Is Dexamethasone an immunosuppressant?
Dexamethas one is a steroid that acts as an anti-inflammatory and as an immunosuppressant and has numerous uses in medical practice. ”ECOG has a long history in developing new treatments for multiple myeloma,” according to Robert L. Comis, M.D., ECOG group chairperson.
