WARNING: Do not discontinue drug abruptly after long-term therapy (hypersensitivity to catecholamines may have developed, causing exacerbation of angina, MI, and ventricular arrhythmias). Taper drug gradually over 2 wk with monitoring. Ensure that patient swallows the ER tablets whole; do not cut, crush, or chew.
Full Answer
What should be monitored during intravenous administration of metoprolol?
A significant increase in triglycerides was observed after 6 and 12 months, together with a decrease in high-density lipoprotein cholesterol (HDL-C) after 12 months (P less than 0.05) of treatment in patients on metoprolol. In patients treated with both hydrochlorothiazide and metoprolol, total cholesterol increased after 3 (P less than 0.001) and 6 months (P less than …
How many patients on metoprolol and propranolol received additional therapy?
Jan 19, 2022 · Treatment will vary based on the amount of metoprolol amount taken, comorbidities, age, and other co-investments. On arrival, assess ABCs and monitor appropriate blood work, including coingestants, ECG, large-bore IVs, and pregnancy status if female. Consult poison control/toxicology early in the course.
What is the best way to take metoprolol?
Give oral drug with food to facilitate absorption. Provide continual cardiac monitoring for patients receiving IV metoprolol. Teaching points Do not stop taking this drug unless instructed to do so by a health care provider. Swallow the extended-release tablets whole; do …
Is long-term oral use of metoprolol associated with psoriasiform and eczematous skin lesions?
Jun 29, 2015 · During the intravenous administration of Metoprolol, blood pressure, heart rate,and electrocardiogram should be carefully monitored.In patients who tolerate the full intravenous dose (15 mg), Metoprolol tartrate tablets, 50 mg every 6 hours, should be initiated 15 minutes after the last intravenous dose and continued for 48 hours.
Metoprolol - Clinical Pharmacology
Mechanism of Action Metoprolol tartrate is a beta1-selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolut...
Indications and Usage For Metoprolol
Metoprolol tartrate tablets, USP are indicated for the treatment of hypertension. They may be used alone or in combination with other antihypertens...
Metoprolol Dosage and Administration
Individualized the dosage of Metoprolol tartrate tablets. Metoprolol tartrate tablets should be taken with or immediately following meals.The usual...
How Is Metoprolol Supplied
Metoprolol Tartrate Tablets, USP are available as follows: Tablets 25 mg are white round shaped, film coated tablets debossed with ‘C over 73’ on o...
What are the adverse reactions to metoprolol?
The following adverse reactions have been reported during post-approval use of Metoprolol: confusional state, an increase in blood triglycerides and a decrease in High Density Lipoprotein (HDL). Because these reports are from a population of uncertain size and are subject to confounding factors, it is not possible to reliably estimate their frequency.
How long does it take to take metoprolol tartrate?
In patients who tolerate the full intravenous dose (15 mg), initiate Metoprolol tartrate tablets, 50 mg every 6 hours, 15 minutes after the last intravenous dose and continue for 48 hours.
How much metoprolol is excreted in breast milk?
Metoprolol is excreted in breast milk in a very small quantity. An infant consuming one liter of breast milk daily would receive a dose of less than 1 mg of the drug.
Is metoprolol a beta 1 or beta 2?
Metoprolol is a beta 1 -selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolute, however, and at higher plasma concentrations, Metoprolol also inhibits beta 2 adrenoreceptors, chiefly located in the bronchial and vascular musculature.
Does metoprolol increase heart rate?
By blocking catecholamine-induced increases in heart rate, in velocity and extent of myocardial contraction, and in blood pressure, Metoprolol reduces the oxygen requirements of the heart at any given level of effort, thus making it useful in the long-term management of angina pectoris. Myocardial Infarction.
Does metoprolol cross the blood brain barrier?
About 10% of Metoprolol in plasma is bound to serum albumin. Metoprolol is known to cross the placenta and is found in breast milk. Metoprolol is also known to cross the blood brain barrier following oral administration and CSF concentrations close to that observed in plasma have been reported.
Is metoprolol a metabolite?
Metoprolol is primarily metabolized by CYP2D6. Metoprolol is a racemic mixture of R- and S- enantiomers, and when administered orally, it exhibits stereoselective metabolism that is dependent on oxidation phenotype. CYP2D6 is absent (poor metabolizers) in about 8% of Caucasians and about 2% of most other populations.
How does metoprolol work?
Metoprolol works by blocking the effects of epinephrine on beta-1 receptors within the heart tissue, causing the heart to pump more slowly and with less force.
How long does metoprolol affect heart rate?
With oral metoprolol tartrate, significant effects on the heart rate are seen within an hour, and effects last for six to 12 hours depending on the dose. With injectable metoprolol tartrate, significant effects are seen within 20 minutes, and a single injection lasts for approximately 5 to 8 hours, depending on the dose.
Does metoprolol succinate cause dizziness?
Side effects are similar for both metoprolol tartrate and metoprolol succinate because they both contain the same active drug, metoprolol. Dry eyes, blurred vision, dizziness (particularly when rising from a sitting to a standing position), fatigue, nightmares,a slow heart beat, and sweating are common.
Does metoprolol cause angina?
Avoid abrupt discontinuation. Stopping metoprolol ( both tartrate and succinate) suddenly can exacerbate angina and may increase the risk of a heart attack.
Is metoprolol a beta blocker?
Metoprolol is a selective beta-blocker at dosages usually prescribed to lower blood pressure or relieve the symptoms of angina. Two different salts are available, metoprolol tartrate and metoprolol succinate. These are not interchangeable. Metoprolol should not be stopped abruptly.
Can metoprolol be stopped abruptly?
Metoprolol should not be stopped abruptly. 5. Tips. Take metoprolol at the same time each day. Report any shortness of breath or facial swelling immediately to your doctor. Also talk to your doctor if you develop a very slow heartbeat or cold feeling in your hands or feet.
What is the best medication for depression?
antifungals, such as terbinafine. antihistamines, such as diphenhydramine. bupropion, which may be used for the treatment of depression and as a stop-smoking aid. antimalaria agents, such as hydroxychloroquine.
Question
I am on a 22-bed unit. Six beds are stepdown. However, we have been administering Metoprolol piggyback to patients that are not monitored but in a general floor bed. These patients may have taken Metoprolol by mouth but now are NPO and still require the med, so the physicians have changed the med to IV piggyback every six hours.
Nancy Brent replies
Your question did not contain details about the patients who are receiving Metoprolol IV.
How It Works
Upsides
- Metoprolol tartrate 1. Lowers blood pressure and relieves symptoms of angina in people with heart disease or who have had a heart attack. 2. Immediate-release metoprolol tartrate has been shown to reduce the risk of death or another heart attack when given immediately following a heart attack. 3. May also be used to lower the risk of a heart attack in people with heart disease. …
Downsides
- If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: 1. Heart rate slowing, depression, diarrhea, skin rash and shortness of breath. Side effects are similar for both metoprolol tartrate and metoprolol succinate because they both contain the same active drug, …
Bottom Line
- Metoprolol is a selective beta-blocker at dosages usually prescribed to lower blood pressure or relieve the symptoms of angina. Two different salts are available, metoprolol tartrate and metoprolol succinate. These are not interchangeable. Metoprolol should not be stopped abruptly.
Tips
- Take metoprolol at the same time each day.
- Report any shortness of breath or facial swelling immediately to your doctor.
- Also, talk to your doctor if you develop a very slow heartbeat or cold feeling in your hands or feet.
- If you are diabetic, talk to your doctor about the possibility that metoprolol may reduce your s…
- Take metoprolol at the same time each day.
- Report any shortness of breath or facial swelling immediately to your doctor.
- Also, talk to your doctor if you develop a very slow heartbeat or cold feeling in your hands or feet.
- If you are diabetic, talk to your doctor about the possibility that metoprolol may reduce your symptoms of hypoglycemia.
Response and Effectiveness
- With oral metoprolol tartrate, significant effects on the heart rate are seen within an hour, and effects last for six to 12 hours depending on the dose. With injectable metoprolol tartrate, signif...
- With oral metoprolol succinate extended-release (ER) tablets, peak concentrations are reached in about seven hours following a single dose. With regular dosing; however, concentrations o…
- With oral metoprolol tartrate, significant effects on the heart rate are seen within an hour, and effects last for six to 12 hours depending on the dose. With injectable metoprolol tartrate, signif...
- With oral metoprolol succinate extended-release (ER) tablets, peak concentrations are reached in about seven hours following a single dose. With regular dosing; however, concentrations of metoprolo...
Interactions
- Medicines that interact with metoprolol may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with metoprolol. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions sh…
Further Information
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use metoprolol only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Copyright 1996-2022 Drugs.com. Revision date: March 22, 2022. Medical Disclai…