Treatment FAQ

what is the treatment options for acute lymphocytic leukemia

by May Halvorson Published 3 years ago Updated 2 years ago
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The main treatment for acute lymphocytic leukemia (ALL) in adults is typically long-term chemotherapy (chemo). In recent years, doctors have begun to use more intensive chemo regimens, which has led to more responses to treatment.Oct 8, 2021

Nutrition

Chronic lymphocytic leukemia (CLL) can rarely be cured. Still, most people live with the disease for many years. Some people with CLL can live for years without treatment, but over time, most will need to be treated. Most people with CLL are treated on and off for years. Treatment may stop for a while, but it never really ends.

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While there is no cure for CLL, regular checkups and medical treatments can help keep the disease stable for many years. The best way to preserve your quality of life is to receive the proper medical care, stay positive and maintain a healthy lifestyle. Sources & references used in this article:

Will there be a cure for chronic lymphocytic leukemia?

While there’s no specific dietary guidelines for people with chronic lymphocytic leukemia (CLL), certain diet patterns may help boost your energy and support recovery. Eating a nutrient-dense diet can also help support recovery after treatments like chemotherapy.

Are We close to a cure for chronic lymphocytic leukemia?

The symptoms of acute leukemia, which tend to appear earlier and be more severe than the symptoms of chronic leukemia, can include: Chronic leukemia inhibits the development of blood stem cells, ultimately causing them to function less effectively than healthy mature blood cells.

Can diet help with chronic lymphocytic leukemia?

Is acute leukemia more painful than chronic leukemia?

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Is there any treatment for acute leukemia?

How is acute myeloid leukemia treated? The main treatment for most types of AML is chemotherapy, sometimes along with a targeted therapy drug. This might be followed by a stem cell transplant. Other drugs (besides standard chemotherapy drugs) may be used to treat people with acute promyelocytic leukemia (APL).

How curable is acute lymphocytic leukemia?

What are the survival rates for acute lymphoblastic leukemia? About 98% of children with ALL go into remission within weeks after starting treatment. About 90% of those children can be cured. Patients are considered cured after 10 years in remission.

What is the survival rate for acute lymphocytic leukemia?

While acute lymphoblastic leukemia in children is more common than other types of cancer, it has high cure rates. Survival rates are lower in adults, but they are improving. The 5-year relative survival rate for ALL is 68.8%. The statistics further break down to 90% in children and 30-40% in adults.

What is one of the newest forms of treatment for leukemia?

The Food and Drug Administration (FDA) recently approved two new treatments for some adult patients with acute myeloid leukemia (AML): enasidenib (Idhifa®), a drug that targets aberrant forms of the IDH2 protein; and liposomal cytarabine-daunorubicin CPX-351 (Vyxeos™), a two-drug chemotherapy combination encapsulated ...

Which medication is beneficial for a patient with acute lymphocytic leukemia?

The drug used most often is methotrexate, but sometimes cytarabine or a steroid such as prednisone may be used as well. Intrathecal chemo can be given during a lumbar puncture (spinal tap) or through an Ommaya reservoir (as discussed in the surgery section).

Is acute lymphocytic leukemia terminal?

Acute lymphocytic leukemia (ALL) is also called acute lymphoblastic leukemia. “Acute” means that the leukemia can progress quickly, and if not treated, would probably be fatal within a few months.

What is the most treatable leukemia?

While it is similar in many ways to the other subtypes, APL is distinctive and has a specific treatment regime. Treatment outcomes for APL are very good, and it is considered the most curable type of leukemia, with cure rates as high as 90%.

Which type of leukemia has the highest survival rate?

The survival rates are highest for acute lymphoblastic leukemia (ALL). The rates vary depending on person's age, the type of leukemia they have, and if (and how far) the leukemia has spread at the time of diagnosis. A child who has lived at least five years after a diagnosis of acute leukemia is probably cured.

Is acute lymphocytic leukemia painful?

Signs and symptoms of acute lymphocytic leukemia may include: Bleeding from the gums. Bone pain.

Which is worse acute or chronic leukemia?

Chronic leukemia inhibits the development of blood stem cells, ultimately causing them to function less effectively than healthy mature blood cells. As compared to acute leukemia, chronic leukemia tends to be less severe and progresses more slowly.

What's new in acute lymphocytic leukemia?

New chemo drugs are also being developed and tested. For example, clofarabine (Clolar) is approved to treat childhood ALL and shows promise in early studies of adults with this disease. Nelarabine (Arranon) is a newer drug that can be used to treat T-cell ALL. Many other new drugs are also being studied.

Can leukemia be cured without chemo?

Traditionally, leukemia is primarily treated with chemotherapy or radiation therapy. Stem cell transplants may also be used in conjunction with chemotherapy, particularly in children. Immunotherapy and targeted therapies are newer treatments for certain types of leukemia.

What is the treatment for leukemia?

Engineering immune cells to fight leukemia. A specialized treatment called chimeric antigen receptor (CAR)-T cell therapy takes your body's germ-fighting T cells, engineers them to fight cancer and infuses them back into your body. CAR -T cell therapy might be an option for children and young adults.

What is the first phase of treatment for acute lymphocytic leukemia?

In general, treatment for acute lymphocytic leukemia falls into separate phases: Induction therapy. The purpose of the first phase of treatment is to kill most of the leukemia cells in the blood and bone marrow and to restore normal blood cell production. Consolidation therapy. Also called post-remission therapy, ...

What is the needle used to remove bone marrow from the hipbone?

Bone marrow test. During bone marrow aspiration and biopsy, a needle is used to remove a sample of bone marrow from the hipbone or breastbone. The sample is sent to a lab for testing to look for leukemia cells.

How long does it take to cure acute lymphocytic leukemia?

Depending on your situation, the phases of treatment for acute lymphocytic leukemia can span two to three years. Chemotherapy. Chemotherapy, which uses drugs to kill cancer cells, is typically used as an induction therapy for children and adults with acute lymphocytic leukemia.

Where is chemo injected for lymphocytic leukemia?

In this type of treatment, chemotherapy drugs are often injected directly into the fluid that covers the spinal cord.

Where is the bone marrow removed?

In a bone marrow aspiration, a doctor or nurse uses a thin needle to remove a small amount of liquid bone marrow, usually from a spot in the back of your hipbone (pelvis). A bone marrow biopsy is often done at the same time.

What is the best treatment for cancer?

If the cancer cells have spread to the central nervous system, your doctor may recommend radiation therapy . Bone marrow transplant. A bone marrow transplant, also known as a stem cell transplant, may be used as consolidation therapy or for treating relapse if it occurs.

Why is it important to discuss treatment options?

It’s important to discuss all of your treatment options and their goals and possible side effects, with your treatment team to help make the decision that best fits your needs. Some important things to consider include: It’s also very important to ask questions if there is anything you’re not sure about.

What do people with cancer need?

People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care.

What is complementary medicine?

Complementary methods refer to treatments that are used along with your regular medical care. Alternative treatments are used instead of a doctor’s medical treatment.

How long does ALL treatment last?

Treatment of ALL typically lasts for about 2 years. It is often intense, especially in the first few months of treatment, so it's important that you are treated in a center that has experience with this disease. The treatment approach for children with ALL can be slightly different from that used for adults.

What are the services offered by the American Cancer Society?

These might include nursing or social work services, financial aid, nutritional advice, rehab, or spiritual help. The American Cancer Society also has programs and services – including rides to treatment, lodging, and more – to help you get through treatment.

Can you continue cancer treatment?

Whether or not you continue treatment, there are still things you can do to help maintain or improve your quality of life.

Is treatment information given here official policy of the American Cancer Society?

The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor.

What is the best treatment for leukemia?

The specific treatments used may include: Daunorubicin (Cerubidine) Doxorubicin (Adriamycin), cyclophosphamide (Neosar), or vincristine (Vincasar), given by an injection into a vein.

What is standard of care for leukemia?

This section tells you the treatments that are the standard of care for this type of leukemia. “Standard of care” means the best treatments known. When making treatment plan decisions , patients are encouraged to consider clinical trials as an option.

How long does chemotherapy stay in the hospital?

Side effects of chemotherapy and targeted therapy. Induction therapy usually begins in the hospital. Patients will often need to stay in the hospital for 3 to 4 weeks during treatment. However, depending on the situation, many patients can leave the hospital.

What is the procedure called when you have a stem cell?

A stem cell transplant is a medical procedure in which bone marrow that contains leukemia is destroyed and then replaced by highly specialized cells, called hematopoietic stem cells, that develop into healthy bone marrow. Hematopoietic stem cells are blood-forming cells found both in the bloodstream and in the bone marrow. These stem cells make all of the healthy cells in the blood. Today, this procedure is more commonly called a stem cell transplant , rather than bone marrow transplant, because it is the stem cells in the blood that are typically being transplanted, not the actual bone marrow tissue.

What is the term for a technique used to find small amounts of leukemia?

Techniques can be used to find small amounts of leukemia, called minimal residual disease (MRD). These are used to help predict a patient’s prognosis and guide treatment options. Remission consolidation or intensification therapy. This stage of therapy involves the use of a combination of drugs.

What do doctors want to learn about new treatments?

Doctors want to learn whether the new treatment is safe, effective, and possibly better than the standard treatment. Clinical trials can test a new drug, a new combination of standard treatments, or new doses of standard drugs or other treatments. Your doctor can help you consider all your treatment options.

Is leukemia permanent?

While many remissions are permanent, it’s important to talk with your doctor about the possibility of the leukemia returning. Understanding your risk of recurrence and the treatment options may help you feel more prepared if the disease does return. Learn more about coping with the fear of recurrence .

What are the treatments for acute lymphoblastic leukemia?

Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer . When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.

Which type of cell fights infection?

Granulocytes ( white blood cells) that fight infection and disease. A lymphoid stem cell becomes a lymphoblast cell and then one of three types of lymphocytes (white blood cells): B lymphocytes that make antibodies to help fight infection.

What is the name of the cancer that is caused by the bone marrow making too many lymphocytes?

Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). Adult acute lymphoblastic leukemia (ALL; also called acute lymphocytic leukemia) is a cancer of the blood and bone marrow. This type of cancer usually gets worse quickly if it is not treated.

What is the disease that affects the white blood cells?

Adult acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). Leukemia may affect red blood cells, white blood cells, and platelets. Previous chemotherapy and exposure to radiation may increase the risk of developing ALL.

What is combination chemo?

Combination chemotherapy is treatment using more than one anticancer drug. Intrathecal chemotherapy may be used to treat adult ALL that has spread, or may spread, to the brain and spinal cord. When used to lessen the chance leukemia cells will spread to the brain and spinal cord, it is called CNS prophylaxis. Enlarge.

How does chemo work?

Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the cerebrospinal fluid (intrathecal chemotherapy), an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas ( regional chemotherapy ). Combination chemotherapy is treatment using more than one anticancer drug.

Can leukemia cause side effects?

Treatment for adult acute lymphoblastic leukemia may cause side effects. For information about side effects that begin during treatment for cancer, see our Side Effects page. Side effects from cancer treatment that begin after treatment and continue for months or years are called late effects. Late effects of treatment for ALL may include ...

ALL treatment plans

Newly diagnosed adult ALL patients typically undergo chemotherapy, which is given in three phases. Depending on the features of the patient’s cancer, targeted therapy may also be prescribed.

Chemotherapy

Chemotherapy drugs kill cancer cells, control their growth or relieve disease-related symptoms. Chemotherapy may involve a single drug or a combination of two or more drugs, depending on the type of cancer and how fast it is growing.

Targeted therapy

Targeted therapy drugs are designed to stop or slow the growth or spread of cancer. This happens on a cellular level. Cancer cells need specific molecules (often in the form of proteins) to survive, multiply and spread. These molecules are usually made by the genes that cause cancer, as well as the cells themselves.

Stem cell transplantation

A stem cell transplant (also known as a bone marrow transplant) is a procedure that replaces cancerous bone marrow with new, healthy bone marrow stem cells. Stem cell transplants are usually given after an intense round of chemotherapy that kills the patient’s existing bone marrow cells and prepares the body for transplant.

Radiation therapy

Radiation therapy uses powerful beams of energy to kill cancer cells. Since leukemia cells travel in the blood stream, there is no distinct tumor to target with radiation therapy. Instead, radiation may be used when the disease has spread to the central nervous system.

CAR T-cell therapy

T cells are a type of immune system cell. They help the immune system respond to disease and directly kill diseased cells. In Chimeric Antigen Receptor (CAR) T-cell therapy, T cells are modified so they can recognize and attack cancer cells.

Clinical trials

As a top-ranked cancer center, MD Anderson offers multiple clinical trials for ALL. Many of these cannot be found anywhere else. Trials explore new drug combinations and new drugs, including targeted therapies and immunotherapies.

Induction treatments for acute lymphocytic leukemia

Induction treatment for acute lymphocytic leukemia (ALL) is given to clear the blood and bone marrow of leukemia cells. Learn about induction treatment for ALL.

Consolidation treatments for acute lymphocytic leukemia

Consolidation treatment for acute lymphocytic leukemia (ALL) is given to keep leukemia cells from coming back. Learn about consolidation treatment for ALL.

Maintenance treatments for acute lymphocytic leukemia

Maintenance treatment for ALL is given to maintain remission and often lasts for 2–3 years. Learn about maintenance treatment for acute lymphocytic leukemia.

Treatments for relapsed or refractory acute lymphocytic leukemia

Both relapsed and refractory acute lymphocytic leukemia need more treatment to reach a remission. Learn about treatment for relapsed or refractory ALL.

Chemotherapy for acute lymphocytic leukemia

Chemotherapy is the main treatment for acute lymphocytic leukemia (ALL) and is usually given for 2 to 3 years. Learn about chemotherapy for ALL.

Targeted therapy for acute lymphocytic leukemia

Targeted therapy uses drugs to target specific molecules on the surface of cancer cells. Learn when it is used to treat acute lymphocytic leukemia (ALL).

Radiation therapy for acute lymphocytic leukemia

Radiation therapy uses high-energy rays to destroy cancer cells. It is sometimes used to treat ALL. Learn about radiation for acute lymphocytic leukemia.

Induction

The goal of induction chemotherapy is induce remission. Remission is when doctors are no longer able to find signs of your cancer. The induction phase can take up to 4 weeks, during which time you’ll stay in the hospital.

Intensification and consolidation

The intensification and consolidation phase consists of additional chemotherapy to destroy lingering cancer cells that may be in your body, but aren’t detectable. You may also receive a bone marrow transplant at this time. This stage may last several months.

Maintenance

The maintenance phase involves taking a lower dose of chemotherapy drugs for typically about 2 years to prevent relapse. Medications may include:

Bone marrow transplant

Chemotherapy damages healthy cells in your body that divide quickly like the cells in your bone marrow that produce blood cells. A bone marrow transplant helps replace these damaged bone marrow cells.

CAR T cell therapy

A type of immunotherapy called CAR T-cell therapy is a new treatment available for adults up to age 25. It’s sometimes used when ALL doesn’t respond to other treatments.

Supportive care

This helps address the side effects of treatment, especially when cancer is aggressive or not responding to treatments. This can include antibiotics, as well as red blood cell and platelet transfusions.

Low risk

For low-risk children, an allogeneic bone marrow transplant may be performed after remission if there’s a poor response to chemotherapy.

Why is it important to discuss all of your treatment options?

It’s important to discuss all of your treatment options and their goals and possible sideeffects, with your treatment team to help make the decision that best fits your needs.Some important things to consider include:

What do people with cancer need?

People with cancer need support and information, no matter what stage of illness theymay be in.Knowing all of your options and finding the resources you need will help youmake informed decisions about your care.

What age can you use Car T cell therapy?

This is a type of CAR T-cell therapy that targets the CD19 protein on certain leukemiacells. It can be used in children and young adults up to age 25 to treat B-cell ALL thathas come back after treatment or that is no longer responding to treatment.

How long does all treatment last?

Treatment of ALL typically lasts for about 2 years. It is often intense, especially in thefirst few months of treatment, so it's important that you are treated in a center that hasexperience with this disease.

Can leukemia be treated with palliative care?

At some point, it may become clear that further treatment, even in clinical trials, is extremely unlikely to cure the leukemia . At that time, the focus of treatment may shift tocontrolling the leukemia and its symptoms for as long as possible, rather than trying tocure it. This may be called palliative treatment 11 or supportive care. For example, thedoctor may advise less intensive chemo to try to slow the leukemia growth instead oftrying to cure it.

Is induction chemo a cure?

But a remission is not necessarily a cure, as leukemia cells may still be hidingsomewhere in the body.

Can chemo be given through lumbar puncture?

In this treatment,called intrathecal chemo, the medicines can be given through a lumbar puncture(spinal tap) or through an Ommaya reservoir.

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Diagnosis

Treatment

Clinical Trials

Alternative Medicine

Medically reviewed by
Dr. Karthikeya T M
Your provider will work with you to develop a care plan that may include one or more of these treatment options.
The main focus of the treatment is to bring back the blood count to normal. Treatment involves chemotherapy and bone marrow transplantation.
Nutrition

Foods to eat:

  • Have foods rich in vitamin D such as fish but make sure they are well cooked.
  • Steamed vegetables such as mushrooms, broccoli, and carrots
  • Whole grains such as brown rice and quinoa
  • Plenty of proteins such as well-cooked lean meat

Foods to avoid:

Any type of raw/undercooked foods including

  • Meat, seafood, eggs, and vegetables
  • Unpeeled fruits
  • Dairy products

Specialist to consult

Oncologist
Specializes in the diagnosis and treatment of cancer.
Primary care physician
Specializes in the acute and chronic illnesses and provides preventive care and health.
Hematologist
Specializes in the study of the blood and blood disorders.
Pediatrician
Specializes in the health of children, including physical, behavioral, and mental health issues
Pediatric oncologist
Specializes in the diagnosis and treatment of cancer in children.

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