by Kayden Smitham
Published 2 years ago
Updated 2 years ago
Xiaflex is a prescription medication used to treat adults with Dupuytren's contracture once a cord can be felt in the palm. Xiaflex is an injectable solution of enzymes (purified collagenase clostridium histoliticum) that is injected directly into the Dupuytren's cord.
Procedures
Jan 26, 2020 · 7 Treatment Options for Dupuytren's Contracture Observation. The traditional "treatment" recommendation for people with this condition was to wait on Dupuytren's... Stretching and Injections. There used to be a time when healthcare providers recommended stretching, splinting, and... Collagenase ...
Therapy
Jan 27, 2022 · Operative treatments include percutaneous needle fasciotomy (PNF), open fasciotomy (OF), Clostridium collagenase histolyticum (CCH) injections, limited fasciectomy (LF) and dermofasciectomy (DF). The various methods of DD treatment are reviewed. Results: We summarize the highlights of each treatment option as well as the strengths and weaknesses.
Self-care
Feb 26, 2019 · Surgery used to be the only option for patients in the advanced stages of Dupuytren’s, but that has recently changed. Now, a medication can be injected into the hands that breaks up the collagen and allows the fingers to be straightened. “It ruptures those cords, and it enables them to have straight fingers again,” Mendenhall says.
Are injections for Dupuytren's contracture painful?
Conclusions: Collagenase Clostridium histolyticum injection for treating Dupuytren contracture can be a painful process.
What do they inject for Dupuytren's contracture?
XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren's contracture when a “cord” can be felt. It starts breaking down the cord as soon as you receive the injection.
How painful is Xiaflex injection?
Pain. Although Xiaflex is not uncomfortable to receive, some patients have significant pain for up to 48 hours after the injection, with rare patients having discomfort beyond this period. Verapamil is more painful to receive, likely due to the volume of fluid, but is not significantly painful thereafter.Aug 19, 2015
Do cortisone shots help Dupuytren's contracture?
For treating Dupuytren's, cortisone injections are administered during the nodule, or hard bump, stage. The goal is to reduce the inflammatory nature of the nodules and therefore stop the disease in its tracks.Aug 9, 2019
Where is xiaflex injected?
Xiaflex is designed to be injected into the collagen scar tissue in the penis and dissolve it. The medication is FDA-approved for men with stable curvature between 30 and 90 degrees, and is not approved for men with complex deformities, calcified scar, or scar on the underside of the penis.
What is the latest treatment for Dupuytren's contracture?
XIAFLEX Injections: The University of Michigan is also using a new FDA-approved treatment for Dupuytren's disease: clostridial collagenase (XIAFLEX) injections that destroy the excess collagen causing the thickening and shortening of the tissue.
Does XIAFLEX really work for Dupuytren's contracture?
XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren's contracture when a cord can be felt. Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections.
How effective is XIAFLEX for Dupuytren's?
Xiaflex has an average rating of 3.7 out of 10 from a total of 30 ratings for the treatment of Dupuytren's contracture. 27% of reviewers reported a positive experience, while 70% reported a negative experience.
Can I drive after XIAFLEX injection?
You will be able to drive yourself home after the appointment. You may use ice as needed for 15-20 minutes to reduce swelling. You may take Tylenol or Ibuprofen as needed for pain.
What makes Dupuytren's contracture worse?
Smoking and drinking.
Both alcohol and smoking are frequently mentioned as risk factors for Dupuytren's contracture. “The evidence for smoking is stronger than for drinking, and it makes sense because smoking, like diabetes, decreases blood supply to the hand,” Evans says.Jul 9, 2013
How do you fix Dupuytren's contracture without surgery?
XIAFLEX® is the only FDA-approved treatment for Dupuytren's contracture that does not require surgery. A hand specialist will inject this enzyme treatment directly into the cord that's causing limited mobility in the finger. The enzyme releases the cord.
Is there a pill for Dupuytren's contracture?
Collagenase Clostridium histolyticum (Xiaflex) was approved for the treatment of Dupuytren contracture by the US Food and Drug Administration (FDA) in 2010.Nov 16, 2021
Diagnosis
Treatment
Lifestyle and Home Remedies
Preparing For Your Appointment
Medically reviewed by
Dr. Shreenidhi Kulkarni
Your provider will work with you to develop a care plan that may include one or more of these treatment options.
Surgery and the therapies are the available treatment options. Includes Needle aponeurotomy, fasciotomy and collagenase injection.
Procedures
Procedures
Needle aponeurotomy: Procedure involves the use of needles to puncture the cord and weaken it.
Fasciotomy: A surgical removal of the affected cords.
Therapy
Therapy
Enzyme replacement therapy:The enzyme collagenase which is injected softens the collagen tissue in the cord.
Physical therapy:To maintain the mobility of the finger after surgery.
Self-care
Self-care
Always talk to your provider before starting anything.
Avoid a tight grip on tools
Use gloves with heavy padding during heavy grasping tasks
