Medication
Treatment options for multiple myeloma or first line therapy (induction therapy) consists of drug combinations to control the disease and prevent complications. If you have recently been diagnosed, you must first be assessed by your healthcare team and undergo tests to determine the stage and the type of myeloma.
Procedures
Surgery for Multiple Myeloma Radiation Therapy for Multiple Myeloma Systemic treatments Multiple myeloma can also be treated using drugs, which can be given by mouth or directly into the bloodstream. These systemic therapies can reach cancer cells anywhere in the body. Drug Therapy for Multiple Myeloma Stem Cell Transplant for Multiple Myeloma
Therapy
Within the last two decades the therapeutic options for newly diagnosed multiple myeloma have changed dramatically. The implementation of high-dose chemotherapy with melphalan and subsequent autologous blood stem cell transplantation initially led to prolonged survival in younger, fit patients. Furthermore, recent data suggest that patients with high-risk disease …
Nutrition
Jul 22, 2017 · Starting a new combination or myeloma treatment if you have stopped all drugs in the prior line of treatment. The unplanned addition or substitution of one or more drugs in the existing regimen. For example, if you were on a triple combination and the lenalidomide portion stopped working and you started on pomalidomide instead, this would be considered a new …
Is there a complete cure for multiple myeloma?
Jun 16, 2021 · Corticosteroid medications regulate the immune system to control inflammation in the body. They are also active against myeloma cells. Bone marrow transplant. A bone marrow transplant, also known as a stem cell transplant, is a procedure to replace your diseased bone marrow with healthy bone marrow.
How to live longer with multiple myeloma?
Common front-line treatment regimens in multiple myeloma Open in a separate window * Doses of dexamethasone and bortezomib reduced from initial trial reports to once weekly schedules. Abbreviations: CR, complete response; VGPR, very good partial response. Table 4 Selected randomized studies of non-melphalan regimens in newly diagnosed patients
What to do if your multiple myeloma treatment stops working?
Sep 03, 2021 · Then all of a sudden, we tell you, “Marcella, we’re going to give you three brand-new medications called chemotherapy that will have some side effects, but you may or may not have them.”. Marcella Worrell: Yes. Kenneth H. Shain, M.D., Ph.D.: Then we give you aspirin, acyclovir, and a bone-building medication.
How effective is Revlimid for multiple myeloma?
Mar 15, 2021 · What Are the First-Line Treatment Options for Newly Diagnosed Myeloma Patients? Dr. Bessudo: Well, I don't have a treatment that I will use all the time. It really depends a lot on the situation. But of course, as a first line, I like to use a proteasome inhibitor that will be drugs like Velcade (bortezomib) or Kyprolis (carfilzomib).
What is the most common treatment for multiple myeloma?
What is the drug of choice for multiple myeloma?
What is the gold standard treatment for multiple myeloma?
What is the newest treatment for multiple myeloma?
What is usually the first symptom of multiple myeloma?
How many chemo treatments are needed for myeloma?
What is the treatment for multiple myeloma?
Patients with multiple myeloma also receive supportive treatments, such as transfusions to treat low blood cell counts, and antibiotics and sometimes intravenous immunoglobulin (IVIG) for infections. A stem cell transplant may be part of treatment.
Can multiple myeloma be treated with stem cells?
Patients with multiple myeloma also receive supportive treatments, such as transfusions to treat low blood cell counts, and antibiotics and sometimes intravenous immunoglobulin (IVIG) for infections. A stem cell transplant may be part of treatment. Options for stem cell transplant are discussed in Stem Cell Transplant for Multiple Myeloma.
Can lenalidomide be used for myeloma?
This is known as maintenance treatment, and helps delay the return of the myeloma, but it can cause serious side effects. Many drugs and drug combinations can be useful in treating myeloma.
How to treat multiple myeloma?
Multiple myeloma can also be treated using drugs, which can be given by mouth or directly into the bloodstream. These systemic therapies can reach cancer cells anywhere in the body.
Is treatment information given here official policy of the American Cancer Society?
The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor.
What is local therapy?
Some treatments are called local therapies. This means they treat the tumor without affecting the rest of the body. These treatments are more likely to be useful for earlier stage (less advanced) cancers, although they might also be used in some other situations.
Can stem cell transplants be combined?
Depending on the stage of the cancer, whether or not you are a candidate for a stem cell transplant, and other factors, different types of treatment may be combined at the same time or used after one another.
What is the difference between a radiation oncologist and a medical oncologist?
A radiation oncologist: a doctor who treats cancer with radiation therapy. A medical oncologist: a doctor who treats cancer with medicines such as chemotherapy or targeted therapy. A bone marrow transplant specialist: A cancer doctor who specializes in performing bone marrow transplants. You might have many other specialists on your treatment team ...
Why are clinical trials important?
Clinical trials are one way to get state-of-the art cancer treatment. In some cases they may be the only way to get access to newer treatments. They are also the best way for doctors to learn better methods to treat cancer. Still, they're not right for everyone.
What is complementary medicine?
Complementary methods refer to treatments that are used along with your regular medical care. Alternative treatments are used instead of a doctor’s medical treatment. Although some of these methods might be helpful in relieving symptoms or helping you feel better, many have not been proven to work.
What is the best treatment for myeloma?
Corticosteroids. Corticosteroid medications regulate the immune system to control inflammation in the body. They are also active against myeloma cells. Bone marrow transplant. A bone marrow transplant, also known as a stem cell transplant, is a procedure to replace your diseased bone marrow with healthy bone marrow.
Can you get treatment for multiple myeloma?
If you have multiple myeloma but aren't experiencing any symptoms (also known as smoldering multiple myeloma), you might not need treatment right away. Immediate treatment may not be necessary for multiple myeloma that is slow growing and at an early stage.
Can multiple myeloma be diagnosed?
Sometimes multiple myeloma is diagnosed when your doctor detects it accidentally during a blood test for some other condition. It can also be diagnosed if your doctor suspects you could have multiple myeloma based on your signs and symptoms.
How to diagnose multiple myeloma?
Tests and procedures used to diagnose multiple myeloma include: Blood tests . Laboratory analysis of your blood may reveal the M proteins produced by myeloma cells. Another abnormal protein produced by myeloma cells — called beta-2-microglobulin — may be detected in your blood and give your doctor clues about the aggressiveness of your myeloma.
What is the abnormal protein in myeloma?
Another abnormal protein produced by myeloma cells — called beta-2-microglobulin — may be detected in your blood and give your doctor clues about the aggressiveness of your myeloma. Additionally, blood tests to examine your kidney function, blood cell counts, ...
What stage of myeloma is the most aggressive?
Stage I indicates a less aggressive disease, and stage III indicates the most aggressive disease. Your multiple myeloma may also be assigned a risk category, ...
What kind of doctor treats multiple myeloma?
If you're diagnosed with multiple myeloma, you'll likely be referred to a doctor who specializes in treating blood and bone marrow disorders (hematologist) or a doctor who specializes in treating cancer (oncologist).
What Are the First-Line Treatment Options for Multiple Myeloma?
What are the first-line treatment options for a newly diagnosed multiple myeloma patient? What questions should you ask your doctor to determine the best course of care for your needs? Finally, what are some of the side effects patients may face?
What Are the First-Line Treatment Options for Newly Diagnosed Myeloma Patients?
Dr. Bessudo: Well, I don't have a treatment that I will use all the time. It really depends a lot on the situation. But of course, as a first line, I like to use a proteasome inhibitor that will be drugs like Velcade (bortezomib) or Kyprolis (carfilzomib). Velcade is a drug that I'm going to use number one.
What Are the Side Effects of Multiple Myeloma Treatment?
Dr. Berenson: Yeah. I mean, I'm a big believer that people have to maintain their quality of life. So, I've used lower doses. I don't use Velcade at the standard dose. I use 30% less, because in the first trial we ran 20 years ago, it worked just as well. Similarly, the doses of Revlimid I use are about a third of the FDA approved dose.
Multiple Myeloma Experts Explain the Treatment Classes
Listen in as Alfred Garfall, MD, and Edward Stadtmauer, MD, from Penn Medicine talk to host Cindy Chmielewski about the different classes of treatments that are available to individuals with multiple myeloma.
What Is the Difference Between Using a Drug in a First-Line or Second-Line Setting?
Dr. Garfall: Yeah, that is the million-dollar question. And, you can come up conceptually with the reason why one or the other answer might be true.
What Are the Protocols for Using New Treatments Like Monoclonal Antibodies?
Dr. Stadtmauer: Alright. So, we've talked about proteasome inhibitors, which are really key, and immunomodulatory agents. And as you can see, we have got three of each and each one's like a different generation. And what's really nice is that if one stops losing its activity frequently, the next generation will work for a subset of those patients.
