Is metronidazole an effective treatment for Helicobacter pylori infection?
Abstract Aim: Triple therapy consisting of a proton pump inhibitor (PPI) and two antibiotics is used as first choice in treating Helicobacter pylori (H. pylori) infection. Since in the North Italian population, metronidazole resistance is less than 40%, this antibiotic would be preferable as first approach.
What is the treatment for Helicobacter pylori infection?
Treatment-naive H. pylori-infected subjects were randomly (1:1) assigned to receive 14-day amoxicillin- and metronidazole-containing triple therapy consisting of esomeprazole 20 mg twice a day, amoxicillin 1 g, and metronidazole 400 mg both thrice daily with or without 220 mg bismuth twice a day.
Can omeprazole and metronidazole be taken together?
A one week course of omeprazole 40 mg once daily in combination with amoxycillin 500 mg and metronidazole 400 mg three times daily has been shown to be effective even in the presence of pre-treatment metronidazole resistant strains (MRS) of H. pylori, with 75% eradication[50].
How effective is omeprazole for Helicobacter pylori infection?
The OAM combination is effective in curing H. pylori infection. Primary metronidazole resistance may reduce its effectiveness, but an increased daily dosing of metronidazole may partly overcome this problem. Omeprazole, amoxycillin and metronidazole for the cure of Helicobacter pylori infection
What is the gold standard for treating H pylori infection?
Classical treatment . During the 90s, the standard triple therapy was the gold standard in the treatment of H. pyloriinfections. The standard triple therapies are based on a proton pump inhibitor, clarithromycin, and amoxicillin or metronidazole.
What is the best treatment for H. pylorieradication?
2014a, b), using a proton pump inhibitor or ranitidine bismuth citrate, combined with clarithromycin and amoxicillin or metronidazole.
How many people are infected by Helicobacter pylori?
Helicobacter pyloriis a common bacteria infecting about half of world’s population, with higher prevalence in developing countries, where H. pyloricould infect up to 80% of the population (Moayyedi and Hunt 2004), than in developed ones.
What should be taken into account before establishing a treatment plan for the patient to avoid repeated treatments?
Information about local resistant to antibiotics should be taken into account before establishing a treatment plan for the patient to avoid repeated treatments. Several expositions to antibiotic treatments could result in more side effects and a decrease in the percentage of antibiotic resistance.
What is H. pyloriis involved in?
H. pyloriis also involved in the development of other extra-gastric disorders such as mucosa-associated lymphoid tissue lymphoma (MALT), idiopathic thrombocytopenic purpura, vitamin B12deficiency, and iron deficiency (Kuipers 1997).
What are the alternatives to eradication of H. pylori?
Alternative treatments have been proposed for the eradication of H. pylori. Some of them including novel antibiotics or classical ones in different combinations; these treatments are being used in the regular clinical practice as novel and more effective treatments.
Is clarithromycin a triple therapy?
Due to the increase in the prevalence of H. pyloriresistance to antibiotics, triple therapy with clarithromycin is no longer the best treatment for H. pylori, especially in some areas where the local resistance to this antibiotic is higher than 20%. Alternative treatments have been proposed for the eradication of H. pylori.