An interchangeable basket treatment system receives a removable agitation basket preloaded with articles through a first door. Once positioned within the chamber and the chamber is sealed, the basket is, in one embodiment, suspended so that it may be manipulated to produce mechanical interaction between the articles and treatment fluids within the chamber.
What is a basket study in clinical trials?
A more recent development for oncology clinical trials is known as a basket study, and includes patients with a certain genetic mutation in common regardless of the site or origin of cancer in the body.
What are the different types of cancer treatment gift baskets?
Men's cancer treatment gift baskets and women's cancer treatment gift baskets include specially designed skin products, immune system boosters, and nausea reducers to keep the patient comfortable during chemotherapy or radiation.
What are basket options and how do they work?
This is possible because basket options often trade over-the-counter (OTC), and are therefore customizable based on the buyer's and seller's needs. The most important feature of a basket option is its ability to efficiently hedge risk on multiple assets at the same time.
What is a “basket”?
Patients with that factor who agree to be study participants are grouped together in one cohort, or “basket,” to receive an experimental product which is designed to work, or to work best, in that specific category of disease (see Figure 1).
What does Basket job mean?
1a informal : a person who is functionally incapacitated from extreme nervousness, emotional distress, mental or physical overwork, etc. I was so worried about losing my job that I was a complete basket case. At 6 o'clock nearly every morning, Harvey Mackay hits the floor running.
What is an umbrella trial?
An umbrella trial enrolls patients with one cancer type but with different genetic changes within each tumor (Fig. 1). It consists of many small sub-trials to test multiple drugs simultaneously in one large trial [2, 6]. Patients receive different targeting treatments matched to their genetic aberration.
What is a basket clinical trial?
Listen to pronunciation. (BAS-ket TRY-ul) A type of clinical trial that tests how well a new drug or other substance works in patients who have different types of cancer that all have the same mutation or biomarker.
What are umbrella and basket trials?
Basket trials refer to designs in which a targeted therapy is evaluated on multiple diseases that have common molecular alternations. Umbrella trials, on the other hand, evaluate multiple targeted therapies for a single disease that is stratified into subgroups by molecular alternation.
What is basket trial?
Basket trials can be relatively simple in design to include specific treatment arms or 'baskets' for cancers of different origins or locations. The design can also become more complex with the baskets including more than 1 genetic mutation across multiple cancer locations or they may be designed to evaluate multiple drugs across a selected number ...
Why are basket studies important?
Some strengths of basket studies are that they can be efficient in identifying effective treatments for cancers at multiple sites with a common genetic mutation . If a drug is already approved for treating cancer with a specific genetic mutation at 1 location, a basket study can be useful to see if the efficacy translates to cancer ...
What are the weaknesses of basket studies?
5. Some weaknesses of basket studies are that they may have small sample sizes, particularly if the genetic mutation is rare. Basket studies may not include a comparator arm, so it can be difficult to interpret efficacy.
What happens after a drug is approved?
After approval, getting prescribers to perform the appropriate test to identify the genetic mutation for which the drug is approved will be an important consideration. This may be a challenging task, particularly if the genetic mutation is rare and not typically evaluated in current regularly used genetic tests.
Who developed larotrectinib?
Larotrectinib, developed by Loxo Oncology, is positioned to potentially become the first FDA approval as a new drug to be based on the results of a basket study. It’s currently under review by the FDA for the treatment of TRK+ genetic mutation regardless of origin or site of cancer.
Does basket study have comparator arm?
Basket studies may not include a comparator arm, so it can be difficult to interpret efficacy. There may be also be difficulties in distinguishing prognostic aspects, information about a patient’s overall cancer outcome, from predictive aspects, which involves information about the impact of treatment. 5.
What is basket clinical trial?
A basket clinical trial takes a collection of conditions that share a similar trait (such as a specific biomarker or perhaps a particular genetic characteristic) and tests a single treatment on all of them to determine if that agent works better for one compared to the others.
What is a multi-arm, multi-stage trial?
A MAMS trial is a study that allows for the assessment of several potential therapies at the same time in a large group of individuals with a specific medical condition, like Parkinson’s.
What is umbrella study?
If you recall, an umbrella study is one in which different drugs are tested on a single condition, with the drug allocation being determined by the presence of particular biomarkers in each participant.
What is basket option?
A basket option is an option where the underlying is a basket or group of any asset desired. Basket options trade OTC, and are therefore customized based on the buyer's and seller's needs. Basket options reduce trading fees, since it is one transaction instead of having to take individual trades on every position in the basket.
Why is basket option important?
The most important feature of a basket option is its ability to efficiently hedge risk on multiple assets at the same time. Rather than hedging each individual asset, the investor can manage risk for the basket, or portfolio, in one transaction.
Why is basket option pricing problematic?
This makes sense because investors often structure diversified portfolios so that component assets do not correlate. Therefore, a basket may not necessarily react to changes in volatility, time, and price level in the same way as its components do individually.
What is a currency basket option?
A currency basket option provides a more cost-effective method for multinational corporations (MNCs) to manage multi-currency exposures on a consolidated basis. For example, a global corporation such as McDonald's (MCD) might buy a basket option involving Indian rupees, British pounds, euros, and Canadian dollars in exchange for U.S. dollars.
Does a basket react to volatility?
Therefore, a basket may not necessarily react to changes in volatility, time, and price level in the same way as its components do individually. A rainbow option is a similar type of derivative that uses multiple underlying assets.
Is an equity option a basket option?
Technically, an equity index option is a basket option because the underlying asset is a weighted basket of component stocks. However, because the index is a standardized basket where a third party calculates and maintains it, index options trade similar to individual options and are not considered exotic options.
What is basket trial?
This is the premise of a “basket” trial design: that patients from different disease groups or subgroups, such as those with different types of cancer, are identified within those groups based on the presence of a specific factor. Patients with that factor who agree to be study participants are grouped together in one cohort, or “basket,” to receive an experimental product which is designed to work, or to work best, in that specific category of disease (see Figure 1).
Why is it important to use a basket design?
In planning trials that employ a basket design, it’s important to look at the operational implications, where the advent of master protocol designs has brought changes as well. These include the use of screening platforms to allow potential participants to be screened for multiple studies at the same time.
Why is it so hard to restore a basket?
Basketry repair and restoration is extremely difficult, because of the brittle nature of the basket, material matching problem (sometimes it’s no longer available), and color matching difficulties, to say nothing of destroying antique value if repaired badly.
How to remove dust from baskets?
A feather duster or a clean, dry natural bristle paintbrush is the best way to remove dust from a basket. Or use the upholstery attachment of your vacuum cleaner with a nylon stocking placed over the end.
What is wicker basket?
Wicker baskets are a delightful decoration for your home decor and can make quite a dramatic statement about your taste. Enjoy your collection for many years and extend the useful life of your baskets by following these simple how-to care for wicker basket tips and hints.
How to keep baskets from fading?
Keep Baskets out of Sunlight and Away from Heat Sources. Keep all baskets away from heat sources such as fireplaces, wood stoves, gas stoves, heat registers, radiators, and/or sunlight. The intense heat and ultraviolet rays of the sun may cause fading and bleaching in addition to drying the fibers out prematurely, making them brittle.
What to do if your basket is hung on the wall?
If your basket is to be hung on the wall, use wall hangers appropriate to the weight of the basket and its embellishments. Incorrect mounting devices may distort your basket in an undesirable way.
What happens if you soak a basket in water?
Soaking a basket in water or giving it a thorough “ shower” can result in swelling of the fibers, and can contribute to color fading and loss of patina (a valuable asset for antique collectors).
Can you use lotion on baskets?
It’s best to handle your baskets with clean hands; free of lotion, oil or grease of any kind. Body oils can damage the baskets as can high humidity, by causing stains, mold, and mildew.
What is basket retention?
Basket retention is a type of insurance policy that covers multiple types of risks through a single insurance product. Rather than purchasing separate insurance policies to cover individual risks, a policyholder might simplify their insurance arrangements by purchasing a single basket retention policy. In that scenario, the policyholder would pay ...
What is basket retention insurance?
In the insurance industry, the term “basket retention” refers to an insurance policy that covers several types of risk at once. Oftentimes, these insurance policies are less expensive compared to purchasing individual insurance policies for each of the risks insured under the policy.
What Our Healthy Cancer Gift Packages Contain
Our gift baskets include items specially designed to support cancer patients during treatments to assist in their health and physical comfort. Each item has been specifically chosen to be useful for cancer patients going through chemotherapy or radiation, and we design all of our baskets to be bold, colorful and empowering.
Put a Smile on Their Face & Give a Gift Basket They Can Really Use
We don’t just sell gift baskets – at ROCK the TREATMENT™ we offer gift baskets for cancer patients that are “in tune” with everything they need to ROCK the TREATMENT™!
Basket Clinical Trials
Operational Considerations
- In planning trials that employ a basket design, it’s important to look at the operational implications, where the advent of master protocol designs has brought changes as well. These include the use of screening platforms to allow potential participants to be screened for multiple studies at the same time. Further, the centralization of study governance committees and institu…
Summary
- As therapeutic agents evolve and our understanding and ability to utilize precision medicine grows, the study designs that we use to test the safety and efficacy of these novel therapies must evolve as well. While there is still a place for the standard randomized, parallel-group clinical trial, designs such as for basket trials allow the enrichment of study populations for specific markers …
References
- https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-pembrolizumab-first-tissuesite-agnostic-indication
- Mullard, A. 2019. FDA approves landmark tissue-agnostic cancer drug. Nat Rev Drug Discov18(7). https://doi.org/10.1038/nrd.2018.226
- Woodcock J, LaVange LM. 2017. Master protocols to study multiple therapies, multiple disea…
- https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-pembrolizumab-first-tissuesite-agnostic-indication
- Mullard, A. 2019. FDA approves landmark tissue-agnostic cancer drug. Nat Rev Drug Discov18(7). https://doi.org/10.1038/nrd.2018.226
- Woodcock J, LaVange LM. 2017. Master protocols to study multiple therapies, multiple diseases, or both. NEJM377:62–70. doi: 10.1056/NEJMra1510062
- CREATE: Cross-tumoral Phase 2 with Crizotinib. https://clinicaltrials.gov/ct2/show/NCT01524926
