Treatment FAQ

what is it called when the effects of one treatment influence the scores in a second treatment

by Dr. Hilton Stanton DDS Published 2 years ago Updated 1 year ago
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Carry-over effects occur when one treatment condition produces a change in the participants that affects their scores in subsequent treatment conditions.

How does the time period between treatment conditions affect the results?

The time period between treatment conditions reduces the chances of history influencing the results of a within-subjects experiment Between-subjects design If a researcher would like to conduct an experiment but is concerned about strong order effects, one solution is to use a______________

How many scores are obtained in each treatment condition?

A between-subjects experiment comparing four treatment condition produces 20 scores in each treatment condition. How many score were obtained for each participant? 80 A between-subjects experiment comparing four treatment conditions produces 20 scores in each treatment condition. How many individuals participated in the entire experiment?

What is a 'treatment effect?

A ‘treatment effect’ is the average causal effect of a binary (0–1) variable on an outcome variable of scientific or policy interest. The term ‘treatment effect’ originates in a medical literature concerned with the causal effects of binary, yes-or-no ‘treatments’, such as an experimental drug or a new surgical procedure.

How many scores does a between-subjects experiment compare four treatment conditions produce?

80 A between-subjects experiment comparing four treatment conditions produces 20 scores in each treatment condition. How many individuals participated in the entire experiment? Only one score is obtained for each participant

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What is the effect of counterbalancing?

Counterbalancing does not eliminate order or sequence effects, but it distributes them evenly across all experimental conditions so that their influence is “balanced” and does not confound the main effects due to the independent variables.

What is the effect of increasing the time between treatment conditions?

What is the effect of increasing the time between treatment conditions in a within-subjects experiment? It decreases the threat of the order effect fatigue.

What is the explanation for the repeated practice effect?

Changes that participants undergo with repeated testing. Practice effects are the summation of both positive (e.g., familiarity with a task) and negative (e.g., boredom) factors associated with repeated measurement.

What is a maturation threat?

Maturation. This is a threat that is internal to the individual participant. It is the possibility that mental or physical changes occur within the participants themselves that could account for the evaluation results.

What is counterbalanced order?

Counterbalancing is a technique used to deal with order effects when using a repeated measures design. With counterbalancing, the participant sample is divided in half, with one half completing the two conditions in one order and the other half completing the conditions in the reverse order.

Which research design involves measuring the same group of participants in two or more different treatment conditions?

A within-subjects design is also called a dependent groups or repeated measures design because researchers compare related measures from the same participants between different conditions. All longitudinal studies use within-subjects designs to assess changes within the same individuals over time.

What is the carryover effect?

carryover effect the effect on the current performance of a research participant of the experimental conditions that preceded the current conditions; where such an effect is significant, it may be difficult to determine the specific influence of the variable under study.

What is the practice effect?

Practice effects, defined as improvements in cognitive test performance due to repeated evaluation with the same test materials, have traditionally been viewed as sources of error variance rather than diagnostically useful information.

What is a repeated measure design in psychology?

Repeated Measures design is an experimental design where the same participants take part in each condition of the independent variable. This means that each condition of the experiment includes the same group of participants. Repeated Measures design is also known as within groups, or within-subjects design.

What is diffusion of treatment?

a situation in which research participants adopt a different intervention from the one they were assigned because they believe the different intervention is more effective.

What is regression threat?

A regression threat, also known as a “regression artifact” or “regression to the mean” is a statistical phenomenon that occurs whenever you have a nonrandom sample from a population and two measures that are imperfectly correlated. The figure shows the regression to the mean phenomenon.

What is attrition in internal validity?

Attrition– Effect of outcome caused by subject mortality or attrition by dropping out of a study before its completion.

What is the effect size of GPA?

The reported effect size was 0.1 points of grade point average (GPA). GPA is measured on something like a 1-4 scale, so 0.1 is not so much; indeed one commenter wrote, “I hope all this fuss is for more than that. Ouch.”

What did Feynman call the field of education research?

Feynman called the field of education research “cargo cult science .” Has anything changed since then? If yes, what are the notable findings? What positive impacts have those findings had on student achievements? Would US students’ math proficiency for example have been worse if all those reforms in pedagogy of the past century were not adopted?

What is net effect?

The net effect is an expected value and not a description of a process. And thinking of the heterogeneity of treatment effects highlights that. As does the idea that a small net effect might be due to a large process for a subset of the population.

Why do colleges exist?

Colleges of education exist because presumably their research and teaching of pedagogy make a positive difference. If there is no clear evidence that they do in practice, then federal funding agency has to look closely to see if continued investment is warranted.

Is 0.1 GPA a lot?

Actually, though, an effect of 0.1 GPA point is a lot. One way to think about this is that it’s equivalent to a treatment that raises GPA by 1 point for 10% of people and has no effect on the other 90%.

Does 0.1 GPA affect 90%?

Actually, though, an effect of 0.1 GPA point is a lot. One way to think about this is that it’s equivalent to a treatment that raises GPA by 1 point for 10% of people and has no effect on the other 90%. That’s a bit of an oversimplification, but the point is that this sort of intervention might well have little or no effect on most people. In education and other fields, we try lots of things to try to help students, with the understanding that any particular thing we try will not make a difference most of the time. If mindset intervention can make a difference for 10% of students, that’s a big deal. It would be naive to think that it would make a difference for everybody: after all, many students have a growth mindset already and won’t need to be told about it.

Is Martha right about the effect size?

Martha is definitely right. But suppose you do have a known variable, like for example there’s a genetic SNP which changes the rate at which the drug is metabolized and so certain groups who have this SNP are not helped as much by the drug… so we can estimate a distribution of effect sizes p (effectsize | snp_yes) and p (effectsize | snp_no).

When should the effects of an outside factor be seen before the treatment is administered?

If an outside factor is influencing the scores, the effects should be seen before the treatment is administered

How many scores are obtained for each participant?

Only one score is obtained for each participant

How many conditions are assigned to each participant in the experiment?

Each participant is assigned to one condition of the experiment

What does a graph of a two factor study indicate?

A graph of a two-factor study indicates an interaction when the lines on the graph

How many levels of the independent variable does each participant experience?

each participant experiences only one level of the independent variable

What is interrupted time series?

Time series examines the effect of a treatment and interrupted time series examines the effect of an outside event

Why are order effects a confounding variable?

Order effects can become a confounding variable because. Counterbalancing. A way to control for order effects in a within-subjects experiment is to use. Within-subjects designs to distribute order effects evenly across the treatment condition. Counterbalancing is used in. Counterbalance order of treatments.

How many scores are obtained for each participant?

A. only one score is obtained for each participant

Why do the scores differ from one treatment to another?

C. the scores may differ from one treatment to another because the participants gain experience in each treatment.

What is repeated measures experiment?

In a repeated-measures experiment, each individual participates in one treatment condition and then moves on to a second treatment condition. One of the major concerns in this type of study is that participation in the first treatment may influence the participant's score in the second treatment.

Can confounding variables increase variability?

C. they can become confounding variables and they can increase the variability.

What is a 2 x 2 factorial design?

This design can answer two or more research questions with one trial and delivers more “bang for the buck” with limited sample sizes. In a 2 × 2 factorial design with placebo, patients are randomized into four groups: (i) to treatment A plus placebo; (ii) treatment B plus placebo; (iii) both treatments A and B; or (iv) neither of them, placebo only. Outcomes are analyzed using two-way analysis of variance (ANOVA) comparing all patients who receive treatment A (groups 1 and 3) with those not treated with A (groups 2 and 4), and all patients who receive treatment B (groups 2 and 3) with those not treated with B (groups 1 and 4). The sample size requirement reduces by almost 50% as compared to carrying out drug A and drug B comparison with placebo in 2 different trials. However, a prerequisite requirement is that there is no interaction between treatments A and B. If interaction exits, then loss of power is possible in case of separate analyses of the four different combinations. If an interaction is anticipated, then that has to be factored into the sample size in addition to estimated sample size. Hence, it is not suited for rare diseases where interaction between A and B are likely. The limitations of this trial design are complexity of trial, difficulty in meeting inclusion criteria of both drugs during study subject recruitment, inability to combine two incompatible interventions, complex protocols, and statistical analytical complexities. Incomplete factorial designs are used when it is deemed unethical to exercise a non-intervention option and here the placebo only arm is eliminated.

What is randomization in RCT?

In randomized controlled trials, trial participants are randomly assigned to either treatment or control arms. The process of randomly assigning a trial participant to treatment or control arms is called “randomization”. Different tools can be used to randomize (closed envelopes, computer generated sequences, random numbers). There are two components to randomization: the generation of a random sequence and the implementation of that random sequence, ideally in a way that keeps participants unaware of the sequence (allocation concealment). Randomization removes potential for systematic error or bias. The biggest upside of an RCT is the balancing of both the known and unknown confounding factors which leads to wrong conclusions.

How does early escape design work?

Early escape design – The early escape design using a placebo control allows a patient to be withdrawn from the study as soon as a predefined negative efficacy criterion has been attained. This reduces the time on placebo or in treatment failure. This design analyses failure rate, so minimizes exposure to ineffective treatment. The time for withdrawal is then used as the primary outcome variable. The patient could then be switched over to another therapy, including the test treatment if appropriate. The attendant limitations are sacrifice of study power with increased “escape” cases and evaluation of only short-term efficacy. If the drug has a slow and deliberate effect on long-term use then that might be missed in this design

What is randomized consent in a trial?

Allocation by randomized consent (Zelen trials)– Eligible patients are allocated to one of the two trial arms prior to informed consent. This is utilized when informed consent process acts as an impediment to study subject accrual. However, this design raises serious ethical uncertainties and must only be used in severely flagging trials in terms of insufficient sample size of great public health importance and is not recommended in routine clinical trial design

What is cluster randomization?

Cluster randomization– Study patients and treating interventionists do not exist in isolation. Sometimes interventions need to be applied at ward level, village level, hospital level, or group practice level. Hence intervention is administered to clusters by randomization to prevent contamination. Each cluster forms a unit of the trial and either active or comparator intervention is administered for each cluster

What is split body trial?

Randomization by body halves or paired organs (Split Body trials) – This is a scenario most often used in dermatology and ophthalmic practice where one intervention is administered to one half of the body and the comparator intervention is assigned to other half of the body.

What are the advantages and disadvantages of historical control?

The advantage of historical controls is in studying rare conditions where sample size generation is difficult. The downside is that no randomization or blinding is possible in this design. A disadvantage is that the co-interventions evolve in due course of time thereby reducing the comparability of the present intervention versus historic control. Another deficiency of this design is the difference between baseline characteristics of subjects in trial arm versus historical arm.

What is independent measure design?

A researcher runs an independent-measures design for two treatment groups. The variability within each group is high, so the researcher splits each group by the participant variable of gender and attempts to run a factorial design ANOVA. The variability within each group is still high. What can the researcher conclude?

Why are the F-ratios the same?

Because the denominators of FA and FB are equal, the two F-ratios are the same whenever their numerators are equal, i.e. MSA = MSB. SSA = SSB 
 only guarantees equal F-ratios when we also have dfA = dfB. See 14.2: An Example of the Two-Factor ANOVA and Effect Size.

What is the F-ratio?

The F-ratio is the ratio of the variance between sample means and the variance expected with no treatment effect.

What happens when SSwithin is decreased?

Because SSwithin occurs in the denominator of F, a decrease in SSwithin will cause an increase in F, which will increase the likelihood of rejecting the null hypothesis. An increase in sample sizes will also increase the likelihood of rejecting the null hypothesis.

What is the Pearson correlation of a set of n = 25 pairs of X and Y values?

A set of n = 25 pairs of X and Y values has a Pearson correlation of r = 0.24. If each of the X values were multiplied by –3, and each Y value is increased by 2, then what is the correlation for the resulting data?

What is the primary effect of large mean differences within each sample?

In an analysis of variance, the primary effect of large mean differences within each sample is to increase the value for

When is ANOVA used in research?

For each group, scores will be taken before the therapy, right after the therapy, and one year after the therapy. How many different sample means will there be?

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