Dosing regimen
| Drug | Dose | Mode | Days |
| R ituximab | 375 mg/m 2 | IV infusion | Day 1 |
| I fosfamide | 5000 mg/m 2 | IV continuous infusion over 24 hours | Day 2 |
| Mesna for haemorrhagic cystitis prophyla ... | 5000 mg/m 2 | IV continuous infusion over 24 hours | Day 2 |
| C arboplatin | Optimized to get AUC = 5 (max. 800 mg) | IV infusion | Day 2 |
What is a typical regimen of chemotherapy?
Many chemotherapy regimens for B-cell NHL include the monoclonal antibody rituximab (Rituxan), which is usually abbreviated with the letter R and placed at the beginning or end of the regimen abbreviation, such as R-CHOP or CHOP-R (cyclophosphamide [Cytoxan], doxorubicin [Adriamycin], vincristine [Oncovin], and prednisone [Deltasone]).
What are the phases of chemotherapy?
- Induction
- Consolidation (also called intensification)
- Maintenance
What is the average chemotherapy cycle?
There is no average chemotherapy cycle, because the length of chemotherapy cycles is dependent on a huge number of factors, including the type of cancer, the drugs used in treatment, the patient's response to treatment, and the goal of the therapy. Patients preparing for chemotherapy should anticipate three to six months of chemotherapy treatment and may go through four to eight cycles during this time period.
What is chemotherapy and what does it do?
Chemotherapy is the use of chemical drugs to treat cancer in humans and animals. It is rarely used by itself and is typically combined with surgery, immunotherapy and radiotherapy. While chemotherapy is a highly effective treatment for many cancers, it can be improved.
How effective is ICE chemotherapy?
Event-free survival for patients who achieved a CR after ICE and transplantation is 88% versus 45% for those who achieved a PR. These data confirm the efficacy and tolerability of fractionated ICE chemotherapy as both a salvage and mobilisation regimen that can be readily delivered in an outpatient setting.
How long is ICE chemo?
You usually have ICE chemotherapy as cycles of treatment. You might have between 2 and 4 cycles. Each cycle lasts 3 weeks so the whole course of chemotherapy may last from 6 to 12 weeks.
What is ICE treatment for cancer?
An abbreviation for a chemotherapy combination that is used to treat non-Hodgkin and Hodgkin lymphomas that have come back and do not respond to other treatments. It includes the drugs ifosfamide, carboplatin, and etoposide phosphate. Also called ICE.
How long is oxaliplatin treatment?
You have oxaliplatin as a drip into your bloodstream (intravenously). Each treatment takes between 2 and 6 hours. You can have it through a thin, short tube (a cannula) put into a vein in your arm each time you have your treatment.
Why do they put ICE on hands and feet during chemo?
What are cooling therapies? Cooling therapy is a system used to apply cold to your scalp, hands, or feet while you are having chemotherapy (chemo). It may help reduce problems that some chemo medicines can cause with your hair, skin, and nails. Wearing a cooling cap on your head may help reduce hair loss.
Why can't chemo patients have ICE?
You are being treated for cancer with a chemotherapy medication called Oxaliplatin. This medication has an unusual side effect called “cold dysesthesia”. This means that different parts of your body may be very sensitive to cold – cold drinks, cold food, and cool or cold outdoor temperatures.
Does freezing cancer cells work?
Cryotherapy, also called cryosurgery, uses extreme cold to freeze and kill cancer cells. It's also used to ease pain and control bleeding. All cells, including cancer cells, contain water.
How do you use an ICE pack for chemo?
Your nurse and other members of your healthcare team will wrap your hands, feet, or both in ice packs or ice bags, at least 15 minutes before you start chemotherapy (see Figure 2). The ice will stay on throughout your treatment and will be removed 15 minutes after your chemotherapy ends.
How do they freeze cancer cells?
Cryoablation for cancer is a treatment to kill cancer cells with extreme cold. During cryoablation, a thin, wandlike needle (cryoprobe) is inserted through your skin and directly into the cancerous tumor. A gas is pumped into the cryoprobe in order to freeze the tissue. Then the tissue is allowed to thaw.
Is oxaliplatin a strong chemo?
Oxaliplatin is considered the most neurotoxic chemotherapy, and at the origin of peripheral neuropathies. These neuropathies remain a problem in oncology because currently no prevention strategy has proved effective and only duloxetine seems to have a therapeutic benefit in improving symptoms.
How successful is oxaliplatin?
Results: The introduction of oxaliplatin was associated with no significant improvement in the slopes (per half-year) of the three-year disease-free survival rate (0.2%, 95% CI: −1.7∼2.2%) and five-year overall survival rate (0.6%, 95% CI: −1.8∼3%).
How toxic is oxaliplatin?
Overviewof Toxicity With Oxaliplatin Therapy [7,8] The oxaliplatin dose was 130 mg/m2every 3 weeks. Among the most common toxicities seen in these trials weregastrointestinal side effects such as nausea, vomiting, or diarrhea, andhematologic toxicities such as neutropenia and thrombocytopenia.
What is ICE chemotherapy for Hodgkin?
ICE in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-Hodgkin's lymphoma and Hodgkin lymphoma. In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab.
Do the side effects of chemo get worse with each treatment?
The effects of chemo are cumulative. They get worse with each cycle. My doctors warned me: Each infusion will get harder. Each cycle, expect to feel weaker.
How do you know if chemo is killing you?
Here are some signs that chemotherapy may not be working as well as expected: tumors aren't shrinking. new tumors keep forming. cancer is spreading to new areas....Along the way, the timeline may have to be adjusted due to:low blood counts.adverse effects to major organs.severe side effects.
How long is R-epoch?
So, generally, R-EPOCH can last up to ~8 months, depending upon response, tolerability, and number of cycles prescribed.
Why is chemotherapy better than single drugs?
Chemotherapy is often given as a combination of drugs. Combinations usually work better than single drugs because different drugs kill cancer cells in different ways. Each of the drugs in this combination is approved by the Food and Drug Administration (FDA) to treat cancer or conditions related to cancer.
Is a syringe a substitute for medical advice?
It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.
How is ice given?
How ICE is given. You will be given ICE during a stay in hospital. A chemotherapy nurse will give it to you. During treatment you usually see a cancer doctor, a blood specialist (haematologist), a chemotherapy nurse or specialist nurse, and a specialist pharmacist. This is who we mean when we mention doctor, nurse or pharmacist in this information.
What is ice used for?
ICE is used to treat lymphoma. It may sometimes be used to treat other cancers. It is best to read this information with our general information about chemotherapy and the type of cancer you have. ICE is named after the initials of the drugs used: ifosfamide. carboplatin.
How long does it take for etoposide to be infused?
Day 3: Your nurse will give you a 1-hour infusion of etoposide. When the 24-hour infusion of ifosfamide and mesna from day 2 has finished, the nurse will give you a 12-hour infusion of mesna. After this, you have a rest period with no chemotherapy for 18 or 25 days. Then you start the next cycle of your treatment.
What is etoposide chemo?
etoposide (Etopophos ®, Vepesid ® ). Some people may also have a drug called rituximab with ICE chemotherapy. This treatment is called R-ICE chemotherapy. Your doctor will talk to you about this treatment and its possible side effects before you agree ( consent) to have treatment.
How long does it take to get ice?
You usually have a course of several cycles of treatment over a few months. Each cycle of ICE usually takes 21 days, but it may also be given over 28 days . Your doctor and nurse will tell you the length of cycle you are going to have. You have treatment for the first 3 days of the cycle. This is how your treatment is given:
What to do if you need medical treatment for cancer?
If you need medical treatment for any reason other than cancer, always tell the doctors and nurses you are having cancer treatment. Give them the contact details for your cancer doctor so they can ask for advice.
Where do you put chemo in the arm?
The chemotherapy drugs can be given through: a short thin tube the nurse puts into a vein in the arm or hand ( cannula) a fine tube that goes under the skin of the chest and into a vein close by ( central line) a fine tube that is put into a vein in the arm and goes up into a vein in the chest ( PICC line ).
What is ice chemotherapy?
ICE is the name of a chemotherapy combination that includes: ifosfamide. carboplatin. etoposide (also known as Vepesid, Etopophos or Eposin) It is a possible treatment for Hodgkin and non-Hodgkin lymphoma that has come back. Most people who have ICE will also have a stem cell transplant.
How long does ice chemotherapy last?
You usually have ICE chemotherapy as cycles of treatment. You might have between 2 and 4 cycles. Each cycle lasts 3 weeks so the whole course of chemotherapy may last from 6 to 12 weeks. You can have ICE chemotherapy in a number of ways. A common way of having it is described below.
How long does it take for ifosfamide to drip?
You start a 24 hour drip of ifosfamide and mesna. Day 3. You finish the ifosfamide and mesna drip. You have etoposide as a drip into your bloodstream for 1 hour. You start a mesna drip for 12 hours or you may have mesna tablets to take. Day 4 to 21.
How long does it take for etoposide to drip into the bloodstream?
A common way of having it is described below. Day 1. You have etoposide as a drip into your bloodstream for 1 hour. Day 2. You have etoposide as a drip into your bloodstream for 1 hour. You have carboplatin as a drip into your bloodstream for 1 hour. You start a 24 hour drip of ifosfamide and mesna. Day 3.
What do they check before and during a chemo treatment?
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
Is ifosfamide a chemo drug?
You usually have ifosfamide with another drug called mesna. You have mesna either as a drip (infusion) into your bloodstream or as tablets. Mesna is not a chemotherapy drug. It stops the ifosfamide from irritating your bladder and making the lining bleed.
Ifosfamide
Ifosfamide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "alkylating agent."
Etoposide
Testicular, bladder, prostate, lung, stomach, and uterine, cancers. Hodgkin's and non-Hodgkin's lymphoma, mycosis fungoides, Kaposi's sarcoma, Wilm's tumor, rhabdomyosarcoma, Ewing's sarcoma, neuroblastoma, brain tumors.
Mesna
Prevention of ifosfamide-induced hemorrhagic cystitis (syndrome of bleeding and irritation of the bladder).
Why did more patients drop out of the study?
With increased cycles, more patients dropped out of the study due to a change in their treatment and for other reasons. Therefore, at the end of the study, there were fewer patients and the researchers no longer detected a difference in the side effect frequency between the two patient groups.
Does cooling affect chemotherapy?
Cooling of specific body parts constricts blood vessels and decreases blood flow to those areas. Prior studies have shown that targeted cooling can decrease the amount of chemotherapy drug that is delivered to a particular region.
Is oxaliplatin a chemotherapy drug?
Now a study from researchers at the University of Pennsylvania in Philadelphia shows that there may be a no-cost way to mitigate one of the symptoms caused by oxaliplatin, a chemotherapy drug commonly used to treat patients with gastrointestinal cancers, including colon and pancreatic cancer. The study, published in the April 2019 issue ...
Does chemotherapy cause hair loss?
For example, a randomized study found that women with breast cancer who wore a scalp-cooling device while receiving their chemotherapy infusion were less likely to have hair loss compared to patients who did not cool their scalp while receiving chemotherapy.
Do ice chips help with nerve damage?
Those patients who were able to keep the ice chips in their mouth for a longer period had improved oral symptoms following the chemotherapy dose. Patients who kept ice chips in their mouths also reported fewer symptoms of nerve damage in the hands and feet.
