First-line treatment is usually the standard treatment (the "gold standard") given when someone is diagnosed with a particular disease or condition, such as lung cancer. In other words, it is likely the treatment most oncologists would first choose in treating someone.
What is first-line therapy for cancer?
Jul 22, 2019 · More recently, a 4-drug regimen of carboplatin, paclitaxel, bevacizumab (Avastin), and atezolizumab (Tecentriq) was approved based on results from the Impower150 study, which compared chemotherapy to chemotherapy plus immunotherapy, and investigated the importance of VEGF inhibition.
What is the difference between first-line and second-line therapy for breast cancer?
Abstract. Purpose of review: The current article reviews the advances and challenges in the fight with cancer and the hope for cure, with a focus on clinical trials, at the one time with the best outcomes; first-line therapy. Recent findings: To date there have been four great stories that bridge inception to development of new drugs in ovarian ...
What is another name for first-line treatment?
Oct 24, 2019 · Our standard treatment is going to be a combination of surgery and chemotherapy—sometimes surgery first, sometimes chemotherapy first.
What are the side effects of frontline?
Jun 15, 2021 · What has been the historical frontline standard of care for HER2+ metastatic breast cancer? Ian E. Krop, MD, PhD: For about the last 20 years, we’ve been using the combination of chemotherapy and HER2 therapy for patients with newly diagnosed metastatic HER2+ breast cancer. That was based on this realization that the reason these HER2+ breast …
What is the difference between first-line and second-line treatment?
Second-line treatment is treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren't tolerated.Jun 9, 2020
What are 3 types of treatment for cancer?
The most common treatments are surgery, chemotherapy, and radiation. Other options include targeted therapy, immunotherapy, laser, hormonal therapy, and others. Here is an overview of the different treatments for cancer and how they work.Oct 28, 2021
What is a first-line medication?
a drug that is the first choice for treating a particular condition because it is considered a very effective treatment for that condition with the least likelihood of causing side effects. A first-line medication may be a class of drugs (e.g., SSRIs for depression) as well as a single drug.
What is Frontline for ovarian cancer?
PARP Inhibitors as Frontline Treatment in Patients With Ovarian Cancer. The time has come for maintenance treatment with poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors to become the standard of care in the frontline setting for patients with ovarian cancer.Mar 19, 2020
What is the most successful treatment for cancer?
Chemotherapy is one of the most commonly used treatments for advanced cancer. It may also be used for symptom relief. A combination of chemotherapy drugs may be used, or chemotherapy may be combined with other treatments as part of a broader treatment plan.Mar 4, 2021
Which cancer is known as silent killer?
Ovarian cancer has been termed the silent killer because its presenting symptoms are often mistaken for other benign conditions, particularly the ones that affect the gastrointestinal system, or simply changes in a woman's body as she ages.Sep 1, 2017
What is the strongest blood pressure medication?
the ACE inhibitor lisinopril (Prinivil, Zestril) tops the list, followed by amlodipine besylate (Norvasc), a calcium channel blocker, and. generic hydrochlorothiazide (HCTZ).
Does second line chemo work?
Second-line treatment often works very well for certain types of cancer. People with other types of cancer may have only a small chance that second-line treatment will work. Other factors that affect whether second-line therapy may work include: The stage of the cancer.
What does third line treatment mean?
Treatment that is given when both initial treatment (first-line therapy) and subsequent treatment (second-line therapy) don't work, or stop working.
Are PARP inhibitors approved for ovarian cancer?
Three PARP inhibitors are currently approved for ovarian cancer treatment including, niraparib (Zejula), olaparib (Lynparza), and rucaparib (Rubraca).Mar 10, 2022
What is PARP maintenance?
PARP inhibitors for maintenance therapy PARP inhibitors are a type of targeted therapy that can be used as treatment or as maintenance after treatment. PARP inhibitors are only used for maintenance therapy to treat women who had a complete or partial response to their most recent treatment with chemotherapy.
What does PARP inhibitor mean?
PARP inhibitors are a type of targeted (biological) therapy. PARP stands for poly-ADP ribose polymerase. It's a protein that helps cells repair themselves if they become damaged. PARP inhibitors stop the PARP from repairing cancer cells.
Impower150 Trials
More recently, a 4-drug regimen of carboplatin, paclitaxel, bevacizumab (Avastin), and atezolizumab (Tecentriq) was approved based on results from the Impower150 study, which compared chemotherapy to chemotherapy plus immunotherapy, and investigated the importance of VEGF inhibition.
KEYNOTE Trials
The FDA also approved single-agent pembrolizumab for patients with PD-L1 expression TPS ranging from 1% or higher based on results from the KEYNOTE-042 study, which examined pembrolizumab monotherapy versus a chemotherapy doublet. Patients with PD-L1 expression greater than 1% had improved outcomes on pembrolizumab.
The Future of Lung Cancer Treatment
Looking ahead, Sequist said that it is important now more than ever for patients with NSCLC to get genetic testing. Practitioners should remember that chemotherapy/immunotherapy combinations are not standard of care for patients with driver mutations.
What is the role of fibroblasts in breast cancer?
Cancer-associated fibroblasts fuel breast cancer growth. Researchers at MD Anderson have discovered that cancer-associated fibroblasts (CAF) help fuel the growth of breast tumors. Their...
Where does ovarian cancer metastasize?
Ovarian cancer metastasis study identifies important protein... Advanced ovarian cancer most commonly metastasizes to the omentum, a layer of fatty tissue that wraps around and protects internal...
OncLive: What is the standard first-line treatment option for patients with ovarian cancer?
In an interview during the 2018 OncLive® State of the Science Summit™ on Ovarian Cancer, Dalton, a gynecologic oncologist at Arizona Oncology, discussed the developing standard of care for the frontline treatment of patients with ovarian cancer. Dalton: This is a controversial subject.
Are there emerging strategies that could be looked at as a frontline option?
I would say, for suboptimally debulked patients, most would agree that the dose-dense regimen or an appropriate clinical trial are good choices. For patients who are not the most robust, consideration of fractionated treatments, such as dose-dense carboplatin and paclitaxel, are good options.
Are there any concerns or unanswered questions that we have with PARP inhibitors or immunotherapy in the frontline setting?
Additionally, we are seeing the introduction of checkpoint inhibitors in the frontline setting. Those are all very exciting, so it will be interesting to see what comes out of those trials because there are [encouraging] data in the second-line setting. We are learning more about these medications and the class-specific AEs associated with them.
If we get to a point where PARP inhibitors are looked at in the frontline setting, will we run into sequencing challenges?
With checkpoint inhibitors, we are at a time where there is potential with modulating the immune system, but these also have anticipated AEs. Those are often serious, but are usually manageable and can be recognized earlier. As time goes on, we can learn more about these medications so that we can handle things more effectively.
What is the best flea treatment for dogs?
Alternative Treatments. While Frontline has been a successful treatment for flea infections without problems in many dogs, if you are concerned about putting chemicals on your dog, alternative therapies are available. Some essential oils, such as lavender and eucalyptus, have been successful at repelling fleas.
Where is Melinda Weaver?
Melinda Weaver graduated from the University of Kansas with a journalism degree in 2001. Weaver has worked as a writer since graduation, published in several newspapers and websites. She currently owns a dog training business in Phoenix, Pawsitive Partners, and is pursuing a PhD in animal behavior at Arizona State University.
What essential oils are good for fleas?
Some essential oils, such as lavender and eucalyptus, have been successful at repelling fleas. You can also prevent with frequent bathing and cleaning. Clean dog areas frequently, and empty the vacuum cleaner outside to remove eggs that can lie dormant for months.
Is Fipronil harmful to dogs?
Fipronil is a known carcinogen whose potency increases in sunlight -- even though it is not as effective as disrupting mammalian neural receptors, it can be harmful to both dogs and humans, especially if ingested. Frontline also contains S-Methoprene, which is an insect growth regulator.
Does Frontline cause diarrhea?
Advertisement. Topically applied, Frontline sometimes causes irritation around the spot of application. Some dogs have experienced rashes, diarrhea, vomiting and seizures, but these side effects were typically caused by ingestion.
Is fipronil bad for you?
Side Effect for Humans. Fipronil is a suspected human carcinogen and endocrine disruptor. It can also be toxic to the nervous system, particularly if ingested. Signs of a negative reaction include headache, dizziness and seizures. Less serious reactions of nausea, vomiting and weakness may be signs of your body responding to the toxicity.
Is Frontline flea killer safe for dogs?
It can also cause less serious side effects in dogs, such as irritation at the spot of application, diarrhea, ...
Understanding First-Line Treatment
Questions to Ask
- When you and your healthcare provider consider a first-line treatment or first-line treatments, think through these questions. 1. Clarify the type and stage and molecular profile of your tumor. Is there any further testing that should be done? (If you've been diagnosed with advanced cancer, ask about the molecular profile of your tumor, and if this hasn't been done, ask why not). 2. What is y…
Alternative and Complementary Treatments
- It's important when talking about treatment to clarify what is meant by "alternative treatments." Most people now use the phrase alternative treatments to refer to complementary treatments that are offered by some cancer centers. In this setting, therapies such as acupuncture, meditation, massage, and yoga are used in an integrative fashion—that is, they are used along with tradition…