Treatment FAQ

what is first treatment agent to treat depression in elderly

by Mr. Donny Johns III Published 2 years ago Updated 2 years ago

Antidepressants are considered first line treatment. Both SSRIs

Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders. The exact mechanism of action of SSRIs is unknown. They are believed to increase the extracellular level of the neurotransmitter ser…

and SNRIs

Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors are a class of antidepressant drugs that treat major depressive disorder and can also treat anxiety disorders, obsessive–compulsive disorder, attention-deficit hyperactivity disorder, chronic neuropathic pain, fibromyalgia syndrome, and m…

are efficacious and well-tolerated in the elderly. Some SSRIs are strong inhibitors of the cytochrome P450 hepatic pathway whereas others have less potential for drug interaction.

Many doctors start by prescribing a type of drug called a selective serotonin reuptake inhibitor (SSRI), such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil) or sertraline (Zoloft).

Full Answer

What is the first line treatment for depression in the elderly?

Antidepressants are the best-studied treatment option, but psychotherapy, exercise therapy, and electroconvulsive therapy may also be effective. Psychotherapy is recommended for patients with mild to moderate severity depression. Many older patients need the same doses of antidepressant medication that are used for younger adult patients.

What is the best medication for older adults with depression?

These newer medications may be grouped into three classes: the selective serotonin reuptake inhibitors, the serotonin and norepinephrine reuptake inhibitors, and the norepinephrine-dopamine reuptake inhibitor. While the modern classes of antidepressants offer superior tolerability and safety over older medications such as the tricyclic antidepressants, there …

Should antidepressants be used to treat depression in older adults with dementia?

Electroconvulsive therapy may be indicated in these cases. Patients with treatment-resistant depression should also be referred to mental health services. Summary The impact of clinical depression in older adults can be significant. Predisposing risk factors include previous clinical depression and disabling illness.

Is psychotherapy an effective treatment for depression in the elderly?

Jul 07, 2021 · However, if you’ve experienced depression as a younger person, you may be more likely to have depression as an older adult. Read and share this infographic and help spread the word about depression and older adults. Depression is serious, and treatments are available to help. For most people, depression gets better with treatment.

Which drug is the first choice for treating depression in older adults?

SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline.

What is the most effective treatment for depression in older adults?

Research also suggests that for older adults, psychotherapy is just as likely to be an effective first treatment for depression as taking an antidepressant. Some older adults prefer to get counseling or psychotherapy for depression rather than add more medications to those they are already taking for other conditions.

What is the first-line of treatment for patients with depression?

Choosing an antidepressant — For the initial treatment of severe depression, we use serotonin-norepinephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs).Oct 21, 2021

Which of the following antidepressant is a good first-line agent for a geriatric patient?

Selective Serotonin Reuptake Inhibitors (SSRIs) Currently, SSRIs are the first choice for treatment of depression in elderly patients.

What are the two treatment approaches for treating older adults with depression?

Examples of approaches specific to the treatment of depression include cognitive-behavioral therapy (CBT) and interpersonal therapy (IPT). Medications for depression that may balance hormones that affect mood, such as serotonin. There are many different types of commonly used antidepressant medications.6 days ago

How can the elderly prevent depression?

Here are some tips to keep active and feel better – physically, mentally and socially.Exercise. Stay active. ... Stay in touch with others. ... Get enough sleep. ... Eat healthy meals, making it a point to avoid too much sugar and junk food.Volunteer, care for a pet, or find a good movie or book that makes you laugh.Aug 23, 2021

What is standard treatment for depression?

Medications and psychotherapy are effective for most people with depression. Your primary care doctor or psychiatrist can prescribe medications to relieve symptoms. However, many people with depression also benefit from seeing a psychiatrist, psychologist or other mental health professional.

What is the drug of choice for depression?

Antidepressants are a popular treatment choice for depression. Although antidepressants may not cure depression, they can reduce symptoms. The first antidepressant you try may work fine.

Is paroxetine first-line?

Like other SSRIs, paroxetine is also an appropriate first-line therapy for OCD, panic disorder, social anxiety disorder, GAD and PTSD.

When is the use of antidepressant therapy appropriate in an elderly patient?

Depressive illness in later life should be treated with antidepressants that are appropriate for use in geriatric patients. A comprehensive, multidisciplinary approach, including consideration of electroconvulsive treatment in some cases, is important.May 15, 2004

Is Paxil safe for elderly?

Per the 2015 American Geriatrics Society Updated Beers Criteria, paroxetine is a strong anticholinergic and is considered potentially inappropriate for elderly patients with dementia and cognitive impairment.Oct 20, 2016

Which antidepressant should be avoided in the elderly?

Tricyclic antidepressants, especially amitriptyline and dothiepin,16 are known to pose a high risk of death in overdosage. These drugs should therefore be avoided in older people whose medication is not supervised and who are at risk of taking an overdose.

What is the best treatment for depression in older people?

Depression occurring in older patients is often undetected or inadequately treated. Antidepressants are the best-studied treatment option, but psychotherapy, exercise therapy, and electroconvulsive therapy may also be effective. Psychotherapy is recommended for patients with mild to moderate severity depression.

How to treat depression in older adults?

Major depression in older adults is common and can be effectively treated with antidepressants and electroconvulsive therapy. Psychological therapies and exercise may also be effective for mild-moderate depression, for patients who prefer nonpharmacological treatment, or for patients who are too fra ….

How many people have major depression?

Major depression occurs in 2% of adults aged 55 years or older, and its prevalence rises with increasing age. In addition, 10% to 15% of older adults have clinically significant depressive symptoms, even in the absence of major depression.

Why are antidepressants dangerous?

Although antidepressants may effectively treat depression in older adults, they tend to pose greater risk for adverse events because of multiple medical comorbidities and drug-drug interactions in case of polypharmacy.

What is the treatment for late life depression?

Once late-life depression has been detected and assessed, psychotherapy and pharmacotherapy are both options for treating this common mental health problem. A+ A-.

What is interpersonal therapy?

Interpersonal therapy is a structured, time-limited treatment based on the premise that onset and recurrence of depression is related to interpersonal relationships. IPT focuses on grief, interpersonal conflicts, role transitions, and interpersonal deficits.

What is LLD in medical terms?

Late-life depression (LLD) is defined as a depressive disorder occurring in a patient older than 60 years, although the onset and definition of cutoff may vary. [ 1] . The impact of clinical depression in older adults can be significant, and choosing effective psychotherapeutic and pharmacological management options can be challenging.

What is the ICMJE?

About the ICMJE and citation styles. The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in 1978 to establish guidelines for the format of manuscripts submitted to their journals. The group became known as the Vancouver Group.

Does citalopram prolong QT?

Citalopram and escitalopram can be associated with QT interval prolongation. In patients over 65, clinicians must be cautious with citalopram doses above 20 mg and escitalopram doses above 10 mg, and exercise care regarding concurrent QT-prolonging medications.

Is late life depression a mental health problem?

ABSTRACT: Late-life depression is a major mental health problem that challenges clinicians and will remain so as the population of British Columbians older than 65 continues to grow. Late-life depression contributes to adverse functional, social, and medical outcomes, and can interfere with treatment for medical problems such as stroke.

What is the best treatment for depression?

This evaluation will help determine a diagnosis and a treatment plan. Common forms of treatment for depression include: Psychotherapy, counseling, or “talk therapy” that can help a person identify and change troubling emotions, thoughts, and behavior.

What is the purpose of antidepressants?

Antidepressants are medicines that treat depression . There are many different types of antidepressants. They may help improve the way your brain uses certain chemicals that control mood or stress. You may need to try several different antidepressant medicines before finding one that improves your symptoms and has manageable side effects.

What are the risk factors for depression?

There are many things that may be risk factors of depression. For some people, changes in the brain can affect mood and result in depression. Others may experience depression after a major life event, like a medical diagnosis or a loved one’s death.

How long does it take to get depression?

However, some of the most common symptoms are listed below. If you have several of these symptoms for more than 2 weeks , you may have depression.

Is depression a mood disorder?

Depression is more than just feeling sad or blue. It is a common but serious mood disorder that needs treatment. It causes severe symptoms that affect how you feel, think, and handle daily activities, such as sleeping, eating, and working.

What is the meaning of "difficulty"?

Difficulty concentrating, remembering, or making decisions. Difficulty sleeping, waking up too early in the morning, or oversleeping. Eating more or less than usual, usually with unplanned weight gain or loss. Thoughts of death or suicide, or suicide attempts.

How does age affect medicine?

As you get older, body changes can affect the way medicines are absorbed and used. Because of these changes, there can be a larger risk of drug interactions among older adults. Share information about all medications and supplements you’re taking with your doctor or pharmacist.

What is the therapy for depression?

This is a form of therapy for depression that involves analyzing the relationship between thoughts, behaviors, and emotions. A therapist will work with a person to help them correct errors in their thinking as a result of feeling depressed and may suggest certain behavioral changes in attempt to improve their mood.

What is the importance of antidepressants for elderly?

benefits. It is also important to be aware of any interactions and side effects associated with the medication. Finally the elderly patient should estimate a realistic length of treatment and evaluate their quality of life with each treatment.

What is cognitive behavioral therapy?

Cognitive-behavioral therapy is a proven intervention for treating depression in people of all ages. Meta-analyses have compared the efficacy of psychotherapy (CBT) versus antidepressant medication for the treatment of major depression and anxiety disorders.

How long does it take for a medication to work?

Although it does require up to 8 weeks of treatment to work, in many cases medications can take this long for a person to experience an effect. If you are an elderly individual, this is one of the top therapies for depression to try.

Can depression be overcome without medication?

Realize that there are plenty of ways to overcome depression without meds. Obviously if your diet isn’t optimal for your mental health, you don’t feel socially connected (or are isolated from family and friends), you aren’t getting sunlight each day, ...

How long does it take for antidepressants to work?

There is evidence that many traditional antidepressants take a long time to work (sometimes 6 to 8 weeks). Waiting can be detrimental to the health of the elderly patient and decrease likelihood of treatment adherence if the patient speculates that the medication isn’t working.

Is transcranial magnetic stimulation effective?

If you want to try the treatment with the biggest upside and lowest risk of side effects, transcranial magnetic stimulation is clearly your best bet. While low field-magnetic stimulation (LFMS) may be even more effective, it is currently undergoing clinical trials to validate its preliminary efficacy. Studies evaluating TMS in elderly patients have demonstrated that it is effective.

What is the management of depression?

Management of depression involves comprehensive assessment and proper establishment of diagnosis. The assessment must be based on detailed history, physical examination and mental state examinations. History must be obtained from all sources, especially the family.

What is the first line of antidepressants?

In general, because of the side effect and safety profile, selective serotonin reuptake inhibitors (SSRIs) are considered to be the first line antidepressants. Other preferred options include tricyclic antidepressants, mirtazapine, bupropion, and venlafaxine.

What is depression in health?

INTRODUCTION. Depression is a common disorder, which often leads to poor quality of life and impaired role functioning. It is known to be a major contributor to the global burden of diseases and according to World Health Organization (WHO), depression is the fourth leading cause of disability worldwide and it is projected that by 2020, ...

What is the goal of acute phase treatment?

The goal of acute phase treatment is to achieve remission, as presence of residual symptoms increase the risk of chronic depression, poor quality of life and also impairs recovery from physical illness. Treatment generally results in improvement in quality of life and better functional capacity.

What are the determinants of psychotherapy?

The major determinants of type of psychotherapy are patient preference and the availability of clinicians with appropriate training and expertise in specific psychotherapeutic approaches. Other clinical factors which will influence the type of psychotherapy include the severity of the depression.

What is maintenance phase treatment?

The goal of maintenance phase treatment is to prevent recurrence of depressive episodes. On an average, 50-85% of patients with a single episode of major depression have at least one more episodes. Therefore, maintenance phase treatment may be considered to prevent recurrence.

What are the areas of assessment?

Area to be covered in assessment include symptom dimensions, symptom-severity, comorbid psychiatric and medical conditions, particularly comorbid substance abuse, the risk of harm to self or others, level of functioning and the socio-cultural milieu of the patient.

Which antidepressants should be used for the initial treatment of depression?

Andrea: Family physicians regularly encounter patients with depression. With the ever-increasing number of new-generation antidepressants available and their competing claims of tolerability and effectiveness, it's hard to determine which antidepressant to use for initial treatment of major depression.

What does this article say?

Andrea: The authors of this study reviewed 117 randomized controlled trials comparing one antidepressant with another; placebo-controlled trials were excluded.

Should we believe this study?

Andrea: The authors used two outcomes that we care about: effectiveness (how well the medication works) and tolerability (whether the patients actually took the medication). Adverse effects and cost of the medication can affect drop-out rates.

What should the family physician do?

Bob: This study gives me a reasonable starting point for choosing antidepressants for my patients. I would likely start with sertraline over escitalopram, because it is one fourth the cost. 3 Fluvoxamine and duloxetine will remain low on my list of first-line antidepressants.

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