Precautions
What can you expect after discontinuing LUPRON DEPOT?
- After completion of a full course of treatment with LUPRON DEPOT therapy, the hormonal effects you may have experienced should subside. 1
- Your normal menstrual cycle should return. The amount of time for your menstrual cycle to return is different for each woman. ...
- Bone loss might not be completely reversible in some patients. ...
What is Lupron Depot used for?
The mild side effects of Lupron Depot that are less common** can include:
- dehydration
- muscle pain
- dizziness
- general tingling or numbness
- increase in total cholesterol
- injection site reactions (see “Side effect details” below)
What are the side effects of Lupron Depot?
Some of these products are starting to come off patent, but are too complex to manufacture in generic form. One such drug is AbbVie’s Lupron Depot, used to treat prostate cancer and endometriosis. Another is Gilead Science’s AmBisome, a liposomal injection to treat fungal infections. There are no approved generics for either drug in the U.S.
Is there an approved generic drug to Lupron Depot?
People say that Lupron is chemotherapy because a lot of people are concerned about the long term negative side effects of the drug, and because Lupron is used in the treatment of some cancers (prostate cancer being the big one). But in reality, Lupron is not chemotherapy.
Is Lupron Depot a chemotherapy treatment?
What are the side effects of Lupron injections?
Mild burning/pain/bruising at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal discomfort/dryness, vaginal bleeding, swelling of the ankles/feet, increased ...
What are the long term side effects of Lupron?
Women have reported to the FDA hundreds of cases of insomnia, depression, joint pain, and more than 100 cases of blurred vision. About 900 reports cite side effects that children below age 13 have suffered, mostly within months of taking Lupron.
Is Lupron considered chemotherapy?
Official Answer. Lupron Depot (leuprolide acetate) injection is not a chemotherapy treatment, but a prescription hormone medicine used in the palliative treatment of advanced prostate cancer. Palliative treatment is used to relieve pain or other symptoms and improve the quality of your life.
Does Lupron make you gain weight?
Weight gain or weight loss Weight changes may occur with Lupron Depot use. One of the most common side effects of women taking Lupron Depot is weight gain.
Where do they inject the Lupron shot?
Here are step-by-step instructions for taking Lupron® (leuprolide acetate) injections: Lupron® is injected subcutaneously—or into the fatty tissue under your skin. The primary sites for injection are your abdomen—2 inches on either side of the navel—and your upper, outer-thigh where the skin is loose.
How long can you stay on Lupron?
The duration of therapy with LUPRON DEPOT is limited to 3 months. The symptoms associated with fibroids will return after stopping therapy.
Does Lupron compromise your immune system?
Do Eligard or Lupron Depot affect the immune system? No. Neither Eligard nor Lupron affect the immune system. They're a form of hormone therapy and don't affect the bone marrow like chemotherapy.
Does Lupron extend life?
Other hormone-blocking drugs like Lupron have mostly taken its place, and may be even more effective, Dr. Zietman said. The study proved the concept that hormone blocking increases survival, he added, so other drugs that do the same thing should also help patients live longer.
Can you drink alcohol while on Lupron?
Both Lupron and alcohol can cause upset stomach, nausea, and dizziness. Drinking alcohol while using Lupron may worsen these effects. Avoid or limit drinking alcohol while taking Lupron.
What should I expect after my first Lupron shot?
What to expect at the start of treatment. While LUPRON DEPOT ultimately reduces testosterone in your body, during the first few weeks of therapy, your testosterone levels may rise before they fall. You may experience temporary new or worsening symptoms of prostate cancer, including urinary symptoms and bone pain.
Is Lupron the same as Depo Provera?
Depo Provera in clinical trials However, compared to Lupron Depot, Depo Provera has fewer damaging side effects, such as a reduced impact on bone mineral density, which can reduce the risk of osteoporosis when taken long-term.
How much does Lupron injection cost?
The cost for Lupron Depot intramuscular kit (7.5 mg/month) is around $1,962 for a supply of 1 kits, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Are the effects of Lupron permanent?
Lupron Depot side effects are almost always reversible and will go away after treatment is complete.
Is 20 units of Lupron a lot?
LUPRON INJECTION (leuprolide acetate) is indicated in the palliative treatment of advanced prostatic cancer. The recommended dose is 1 mg (0.2 mL or 20 unit mark) administered as a single daily subcutaneous injection.
Is there a class action lawsuit against Lupron?
No lawsuits involving Lupron patients have been successful in court, suggesting many have been settled out of court to spare great financial losses on Abbvie and TAP Pharma.
How do you reverse the side effects of Lupron?
Initially, testosterone levels may rise the first weeks of treatment after Lupron Depot injection, causing a flare of side effects, such as pain or urinary symptoms. Your doctor may prescribe antiandrogen agents like bicalutamide (Casodex) or flutamide (Eulexin) to help reduce this flare.
How long should you take Lupron for prostate cancer?
Patients treated with Lupron Depot (leuprolide acetate) for prostate cancer usually continue treatment upon development of castration-resistant pro...
Is Lupron Depot a chemotherapy treatment?
Lupron Depot (leuprolide acetate) injection is not a chemotherapy treatment, but a prescription hormone medicine used in the palliative treatment o...
How do you inject Lupron Depot for prostate cancer?
Lupron Depot (leuprolide acetate) is a depot suspension formulation only injected by your doctor. Lupron Depot is injected into a muscle of your up...
Does Lupron Depot need to be refrigerated?
Before reconstitution, Lupron Depot for treatment of prostate cancer can be stored in its original container at room temperature (77°F [25°C]), wit...
Will I get my period while on Lupron?
In clinical studies evaluating endometriosis, 95% of women started their periods (normal menstrual cycle) in the third month after treatment ended...
What does Lupron do for IVF?
During an vitro fertilization (IVF) protocol, your doctor may use leuprolide (Lupron) injection as part of an ovarian stimulation regimen. Leuproli...
Are Lupron Depot and Eligard the same drug?
Lupron Depot and Eligard are brand name medicines that both contain the active ingredient leuprolide acetate. Both Lupron Depot and Eligard are pre...
How long does it take Lupron Depot (leuprolide) to lower testosterone levels?
In clinical studies, it took about one month for Lupron Depot (leuprolide) to drop testosterone to very low levels.
Will Lupron Depot (leuprolide) cure prostate cancer?
Lupron Depot (leuprolide) isn't a cure for prostate cancer, but it can help lessen symptoms by lowering your levels of testosterone. Testosterone i...
Can Lupron Depot (leuprolide) make my symptoms worse?
Lupron Depot (leuprolide) can make your symptoms worse when you first start treatment, because it can temporarily raise testosterone levels. These...
What's the difference between Lupron Depot (leuprolide) and Eligard?
Lupron Depot (leuprolide) and Eligard both contain the active ingredient leuprolide to relieve symptoms of advanced prostate cancer. They have the...
Can Lupron Depot (leuprolide) lead to broken bones?
Lupron Depot (leuprolide) can cause your body to lose bone density and weaken your bones. This can make it easier for bones to break. Ask your your...
What is the difference between Lupron Depot and Eligard?
The main difference is how the medication is injected. Lupron Depot (leuprolide) is administered into the muscle, whereas Eligard is administered under the skin.
What is luprolide used for?
Lupron Depot (leuprolide) is used to relieve symptoms of advanced prostate cancer. It's an injection that's either given under the skin or into your muscle. Lupron Depot (leuprolide) must be given by a healthcare provider.
Where is luprolide injected?
It's either injected in your shoulder, buttock, or outer thigh muscle. Eligard is a version of the medication that's injected under the skin (subcutaneously) by a healthcare provider. It's usually injected under the skin in your stomach ...
Does leuprolide raise blood sugar?
Higher blood sugar levels and risk of diabetes. Men using Lupron Depot (leuprolide) have had a rise in their blood sugars and a greater risk of developing diabetes. Your healthcare provider will regularly check your labs to make sure your blood sugar-related labs are normal.
Does leuprolide cause urinary problems?
Let your provider know if these symptoms don't go away after a month.
Does leuprolide help with prostate cancer?
Lupron Depot (leuprolide) isn't a cure for prostate cancer, but it can help lessen symptoms by lowering your levels of testosterone. Testosterone is a natural hormone that causes your prostate gland and cancer cells to grow, so Lupron Depot (leuprolide) will slow down the growth of your prostate gland. Can Lupron Depot (leuprolide) ...
Does leuprolide cause infertility?
Lupron Depot (leuprolide) can make it difficult for you to get or maintain an erection, because this medication lowers testosterone levels. This is a normal side effect. It's possible for Lupron Depot (leuprolide) to cause infertility in males, so discuss this with your healthcare provider before starting this medication.
What is Lupron Depot?
Lupron Depot (leuprolide acetate for depot suspension), a GnRH agonist, is a hormonal agent that significantly reduces estrogen levels. The medication works in two distinct phases.
Can you have a period with luporn?
Most women stop having menstrual periods during Lupron therapy. Lupron is not a contraceptive, however, and it is possible for pregnancy to occur during the first few weeks of therapy. Non-hormonal birth control should be used to prevent pregnancy.
Does Lupron Depot cause headaches?
Side Effects. Side effects that have been associated with the use of Lupron Depot include hot flashes and night sweats and, less frequently, palpitations, syncope, and tachycardia. Other side effects include: generalized pain 2 . headaches.
Is Lupron good for menstrual bleeding?
Lupron is prescribed for women with acute endometriosis or severe menorrhagia (abnormally heavy bleeding during menstruation). 1 It is not a cure for endometriosis but can provide pain relief that lasts for several years. It also may be administered before assisted reproduction, or be used in children who are diagnosed with central precocious puberty (early puberty).
What is luporn depot ped?
Lupron Depot-Ped is a brand-name prescription medication that’s used to treat central precocious puberty in children. With this condition, children begin their sexual development earlier than usual (before age 8 for girls and before age 9 for boys).
What is the FDA's approval for luporn?
The Food and Drug Administration (FDA) approves prescription drugs such as Lupron Depot to treat certain conditions. Lupron Depot may also be used off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.
How does luporn work?
Lupron Depot-Ped works by blocking certain hormones that make children’s bodies undergo puberty. This delays puberty as long as the child uses the medication.
How often should I take luporn?
For advanced prostate cancer, Lupron Depot is given either every month, 3 months, 4 months, or 6 months. For central precocious puberty in children, Lupron Depot-Ped is given either every month or 3 months. Your doctor’s office will work with you to make sure the injection appointments fit your schedule.
When to give luteal luporn?
Lupron Depot is sometimes used off-label as a part of an infertility treatment called the “ luteal Lupron#N#Trusted Source#N#protocol.” With this treatment, Lupron Depot is given 7 days before your normal menstrual cycle. It’s used with other hormones to increase the odds of getting pregnant by mimicking ideal hormonal levels.
Does luprolide acetate cause scar tissue?
These lesions can bleed and break down, resulting in pain and scar tissue. The lesions grow with the help of a hormone called estrogen that’s naturally produced in the body. Lupron Depot contains the drug leuprolide acetate, which belongs to a class of drugs called gonadotropin releasing hormone (GnRH) agonists.
Does luporn cause hair loss?
Lupron Depot may cause hair loss in some people. This is likely due to the hormonal changes the drug causes. It’s not known if the hair that was lost will regrow after you stop taking Lupron Depot.
How many injections of Lupron Depot?
A patient may receive up to 3 monthly injections of LUPRON DEPOT 3.75 mg. Alternatively, a single injection of LUPRON DEPOT 11.25 mg may be used only if your doctor decides 3 months of hormonal suppression is necessary. Please see Important Safety Information you should know about Lupron Depot.
What is Lupon Depot?
LUPRON DEPOT ® (leuprolide acetate for depot suspension) 3.75 mg for 1‑month and 11.25 mg for 3‑month administration are prescription medications used for the management of endometriosis, including pain relief and reduction of endometriotic lesions. LUPRON DEPOT 3.75 mg for 1‑month and 11.25 mg for 3‑month administration may be used with daily norethindrone acetate 5 mg as add‑back therapy for initial management of the painful symptoms of endometriosis and for management of recurrence of symptoms. Add‑back therapy is intended to reduce the thinning of bone and reduce hot flashes associated with LUPRON DEPOT. For safe and effective use of norethindrone acetate with LUPRON DEPOT 11.25 mg, refer to the norethindrone prescribing information.
How much Leuprolide acetate is needed for prostate cancer?
LUPRON DEPOT® (leuprolide acetate for depot suspension) 7.5 mg for 1‑month, 22.5 mg for 3‑month, 30 mg for 4- month, and 45 mg for 6‑month administration are prescribed for the palliative treatment of advanced prostate cancer.
How much leuprol is used for depot suspension?
LUPRON DEPOT‑PED ® (leuprolide acetate for depot suspension) 7.5 mg, 11.25 mg, and 15 mg for 1‑month and 11.25 mg and 30 mg for 3‑month administration are prescribed for the treatment of children with central precocious puberty (CPP).
Can you use Lupron Depot alone?
LUPRON DEPOT should not be used alone for retreatment. The total duration of therapy with LUPRON DEPOT plus add‑back therapy should not exceed 12 months due to concerns about adverse impact on bone thinning. Please see the full Prescribing Information for Lupron Depot and discuss it with your doctor.
Can you get pregnant with Lupon Depot?
• You should not receive LUPRON DEPOT if you are pregnant, think you may be pregnant, or are planning to become pregnant during treatment with LUPRON DEPOT; are breast‑feeding; have undiagnosed uterine bleeding; or have experienced any type of allergic reaction to LUPRON DEPOT or similar drugs • Thinning of your bones can occur and may not be completely reversible after stopping treatment; do not exceed the prescribed duration of treatment • LUPRON DEPOT may cause harm to your unborn child • A condom, a diaphragm with contraceptive jelly, or a copper IUD is required to prevent pregnancy • Serious allergic reactions can occur • Fibroid symptoms, such as abdominal bloating or pelvic pain or pressure, may increase during the first days of therapy • Convulsions have occurred in patients taking LUPRON DEPOT • Development or worsening of depression has occurred
2.1 LUPRON DEPOT 7.5 mg for 1-Month Administration
The recommended dose of LUPRON DEPOT 7.5 mg for 1-month administration is one injection every 4 weeks. Do not use concurrently a fractional dose, or a combination of doses of this or any depot formulation due to different release characteristics.
2.2 LUPRON DEPOT 22.5 mg for 3-Month Administration
The recommended dose of LUPRON DEPOT 22.5 mg for 3-month administration is one injection every 12 weeks. Do not use concurrently a fractional dose, or a combination of doses of this or any depot formulation due to different release characteristics.
2.3 LUPRON DEPOT 30 mg for 4-Month Administration
The recommended dose of LUPRON DEPOT 30 mg for 4-month administration is one injection every 16 weeks. Do not use concurrently a fractional dose, or a combination of doses of this or any depot formulation due to different release characteristics.
2.4 LUPRON DEPOT 45 mg for 6-Month Administration
The recommended dose of LUPRON DEPOT 45 mg for 6-month administration is one injection every 24 weeks. Do not use concurrently a fractional dose, or a combination of doses of this or any depot formulation due to different release characteristics.
2.5 Reconstitution and Administration for Injection of LUPRON DEPOT
Reconstitute and administer the lyophilized microspheres as a single intramuscular injection.
What are the side effects of leuprolide?
Check with your doctor immediately if any of the following side effects occur while taking leuprolide: For adults. Less common. Fast or irregular heartbeat. Rare. Bone, muscle, or joint pain. fainting. fast or irregular breathing. numbness or tingling of the hands or feet.
What are the symptoms of a vaginal injection?
Bleeding, bruising, burning, itching, pain, redness, or swelling at the injection site. decreased interest in sexual intercourse. swelling of the feet or lower legs. swelling or increased tenderness of the breasts. trouble sleeping. weight gain. For females only (adults) More common. Light, irregular vaginal bleeding.
Does leuprolide need immediate medical attention?
Side effects not requiring immediate medical attention. Some side effects of leuprolide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Does leuprolide cause side effects?
Along with its needed effects, leuprolide (the active ingredient contained in Lupron Depot) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
What is lupron depot?
Lupron Depot is a hormone therapy that is used to treat prostate cancer. Prostate cancer growth is increased or stimulated by the male hormone testosterone. Lupron Depo causes a decrease in testosterone levels which can slow the growth of prostate cancer. References. Lupron Depo Medication Information: https://www.drugs.com/pro/lupron-depot.html.
What is luporn depot used for?
Official Answer. Lupron Depot is a hormone therapy that is used to treat prostate cancer. Prostate cancer growth is increased or stimulated by the male hormone testosterone, which is an androgen. Reducing levels of androgens can slow the growth of prostate cancer.
How long does a testosterone flare last with luporn?
What is a testosterone flare or surge with Lupron? The first time Lupron depo injection is given there is a temporary increase in luteinizing hormone (LH) and follicle stimulating hormone (FSH) that leads to an increase in testosterone (the 'testosterone flare') and dihydrotestosterone that lasts approximately 5 to 12 days.
How long does it take for testosterone to drop?
In clinical studies testosterone levels usually remain low over 24 to 32 weeks, with regular administration of Lupron Depo.
Does luporn depot slow down prostate growth?
Reducing levels of androgens can slow the growth of prostate cancer. Lupron depot is a slow release injection that works to treat prostate cancer by reducing levels of testosterone to below the level you would expect with castration.
What are the side effects of Lupron?
Other potential side effects of Lupron can include: skin reaction at the injection site. shrunken testicles. hot flashes. mood swings. breast tenderness or growth of breast tissue. erectile dysfunction or loss of sex drive. osteoporosis. loss of muscle mass.
What is luprolide acetate?
Lupron is a brand name for leuprolide acetate, a luteinizing hormone-releasing hormone (LHRH) agonist. LHRH is a naturally occurring hormone that stimulates the production of testosterone in the testes. Lupron effectively blocks LHRH, so it reduces the amount of testosterone in your body. Lupron is a type of hormone therapy used to treat prostate ...
What is the best treatment for prostate cancer?
Learn more about other prostate cancer drugs. Your doctor may also recommend surgery, radiation, or chemotherapy. In some cases where hormone treatment is no longer effective, a cancer vaccine can help prompt your immune system to attack cancer cells. Ask your doctor if this is an option for you.
How long does luporn last?
This can make symptoms of advanced prostate cancer worse, but it should last for only a few weeks. Depending on where your tumors are located, these symptoms could include: bone pain. problems with urination.
How long does testosterone treatment last?
There’s no way to know for certain how long the treatment will continue to work. It could be anywhere from a few months to a few years.
Does luporn slow down prostate cancer?
Rather, it works to slow down the growth and spread of the cancer. Lupron can be used to treat any stage of prostate cancer, but it’s usually used for recurrent or advanced cancers.
Is Lupron a cure for prostate cancer?
The goal of hormone treatments, such as Lupron, is to deprive cancer cells of this fuel to slow disease progression. That said, Lupron is not a cure for prostate cancer. Rather, it works to slow down the growth and spread of the cancer.
What is the purpose of luporn depot?
Both Lupron Depot and Eligard are prescribed to treat the symptoms of advanced prostate cancer. Lupron Depot is also approved to treat endometriosis, uterine fibroids, or central precocious puberty (CPP) in children (early puberty). Continue reading.
What is a leuprolide?
Leuprolide is a prescription gonadotropin releasing hormone (GnRH) medicine. Leuprolide overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. Leuprolide reduces the amount of testosterone in men or estrogen in women.
How often is Viadur injection?
One 45 mg injection every 6 months, Viadur: one implant inserted for 12 months. Each implant contains 65 mg leuprolide. The implant is inserted subcutaneously in the inner aspect of the upper arm and provides continuous release of leuprolide for 12 months of hormonal therapy.
How long does it take for leuprolide to get worse?
Keep using the medicine as directed, and tell your doctor if your condition is still worse after 2 months of using this medicine. You may need frequent medical tests while using leuprolide.
Does leuprolide reduce estrogen?
Leuprolide reduces the amount of testosterone in men or estrogen in women. Leuprolide is used in men to treat the symptoms of prostate cancer (but does not treat the cancer itself). Leuprolide is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.
Can you take leuprolide if you are allergic to it?
You should not use leuprolide if you are allergic to leuprolide or similar medicines such as buserelin, goserelin, histrelin, nafarelin, or if you have abnormal vaginal bleeding that has not been checked by a doctor.
Can you give a child leuprolide?
risk factors for bone loss (personal or family history of osteoporosis, smoking, alcohol use, taking steroid or seizure medicines long term). Do not give this medicine to any child without medical advice. Le uprolide usually causes women to stop ovulating or having menstrual periods.
