Traditionally, colony stimulating factors are used in patients who are undergoing cancer treatment that causes low white blood cell counts (neutropenia) and puts the patient at risk of infection. Treatment with CSFs reduces the time where patients are neutropenic.
Full Answer
What is the purpose of administering colony stimulating factors to cancer patients?
Colony-stimulating factors are substances that stimulate the production of blood cells and promote their ability to function. They do not directly affect tumors, but though their role in stimulating blood cells, they can be helpful as support of a person's immune system during cancer treatment.
What is the function of colony stimulating factors quizlet?
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells.
What are colony stimulating factors used for?
Colony stimulating factors and interleukins regulate proliferation, differentiation, and functional activation of hematopoietic cells of multiple lineages. These hematopoietic growth factors are proving effective in vivo in stimulation of granulopoiesis in clinical situations associated with myelosuppression.
What does colony stimulating factor do when injected into a patient?
Granulocyte colony-stimulating factor causes cells from the bone marrow to become mature and activated. These cells then circulate into the bloodstream.
Where are colony-stimulating factors produced?
marrowColony-stimulating factors are hematopoietic growth factors that induce clonal growth of hematopoietic progenitors in vitro and in vivo. They are produced by macrophages, stromal cells, endothelial cells, and T lymphocytes in the marrow microenvironment.
What is the role of the granulocyte macrophage colony-stimulating factor?
Granulocyte macrophage colony-stimulating factor is a growth factor that promotes the differentiation of granulocytes and macrophages, which are critically involved in the control of the host's defense to pathogenic microbes.
What are cytokines and colony stimulating factors CSF )?
CSF3, also known as Granulocyte Colony Stimulating Factor (G-CSF) is a glycoprotein which stimulates bone marrow to produce granulocytes and stem cells and then to release them into the blood stream.
When do you give G-CSF?
Patients should receive GCSF from day five until bone marrow recovery. Doses should be rounded to the nearest vial or pre-filled syringe size. G-CSF should not be administered within 24 hours of cytotoxic chemotherapy. The recommended start date is 3 days after the administration of chemotherapy.
How do you stimulate bone marrow growth?
Bone marrow stimulants Certain drugs — including colony-stimulating factors, such as sargramostim (Leukine), filgrastim (Neupogen) and pegfilgrastim (Neulasta), epoetin alfa (Epogen/Procrit), and eltrombopag (Promacta) — help stimulate the bone marrow to produce new blood cells.
What does G-CSF mean?
G-CSF is a type of growth factor. You might have G-CSF after chemotherapy to help your white blood cells recover after treatment. Or you might have it before and after a stem cell transplant.
What are growth factor injections?
Growth factor injections are human blood that is processed to achieve a concentration of platelets above normal values. Platelets are the clotting cells that have an integral role in healing.
Why does G-CSF cause bone pain?
There are four main causes of G-CSF related bone pain: bone marrow quantitative and qualitative expansion, peripheral nociceptor sensitization to nociceptive stimuli, modulation of immune function and direct effect on bone metabolism.