Treatment FAQ

how do chemotherapy treatment work

by Prof. Lionel McDermott Published 3 years ago Updated 2 years ago
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Chemotherapy is the use of drugs to destroy cancer cells. It works by keeping the cancer cells from growing and dividing to make more cells. Because cancer cells usually grow and divide faster than normal cells, chemotherapy has a greater effect on cancer cells.

Chemotherapy damages the genes inside the nucleus of cells. Some drugs damage cells at the point of splitting. Some damage the cells while they're making copies of all their genes before they split. Chemotherapy is much less likely to damage cells that are at rest, such as most normal cells.

How long does chemotherapy take to start working?

How long does chemo usually take to work? Chemotherapy is administered over the course of several weeks. For example, your doctor might recommend chemo daily for up to 1 week, and then 3 weeks off ...

What is the success rate of chemotherapy?

The survival rate for those diagnosed in stages 1-3 is near 100% and about 71% for stage 4. The five-year survival rate is 90% for medullary carcinoma and 7% for anaplastic carcinoma. Chemotherapy side effects can range from mild to severe and can take several forms.

How effective is chemotherapy?

Some put the effectiveness using the chemotherapy at as little as 2 percent to 4 percent. Others say the results of using chemotherapy for cancer are much higher. In most cases, the only thing the two sides agree on is that the effectiveness of chemotherapy is largely dependent on the stage and type of cancer the patient has.

How does chemotherapy kill cancer cells?

Chemotherapy is the use of drugs to destroy cancer cells. It works by keeping the cancer cells from growing and dividing to make more cells. Because cancer cells usually grow and divide faster than normal cells, chemotherapy has a greater effect on cancer cells.

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How does chemotherapy remove cancer?

Chemo is considered a systemic treatment because the drugs travels throughout the body, and can kill cancer cells that have spread (metastasized) to parts of the body far away from the original (primary) tumor. This makes it different from treatments like surgery and radiation.

What happens to your body during chemotherapy?

Chemotherapy can cause fatigue, loss of appetite, nausea, bowel issues such as constipation or diarrhoea, hair loss, mouth sores, skin and nail problems. You may have trouble concentrating or remembering things. There can also be nerve and muscle effects and hearing changes. You will be at increased risk of infections.

How long does it take for chemo treatment to start working?

Some people feel the effects of chemo right away, but for others, it takes a day or two.

How long does a chemo treatment usually take?

In general, chemotherapy can take about 3 to 6 months to complete. It may take more or less time, depending on the type of chemo and the stage of your condition. It's also broken down into cycles, which last 2 to 6 weeks each.

Is the chemotherapy painful?

Does chemotherapy hurt? IV chemotherapy should not cause any pain while being administered. If you experience pain, contact the nurse taking care of you to check your IV line. An exception would be if there is a leak and the drug gets into surrounding tissues.

What are the signs that chemo is working?

Complete response - all of the cancer or tumor disappears; there is no evidence of disease. A tumor marker (if applicable) may fall within the normal range. Partial response - the cancer has shrunk by a percentage but disease remains. A tumor marker (if applicable) may have fallen but evidence of disease remains.

How many rounds of chemo is normal?

During a course of treatment, you usually have around 4 to 8 cycles of treatment. A cycle is the time between one round of treatment until the start of the next. After each round of treatment you have a break, to allow your body to recover.

What should you not do during chemotherapy?

9 things to avoid during chemotherapy treatmentContact with body fluids after treatment. ... Overextending yourself. ... Infections. ... Large meals. ... Raw or undercooked foods. ... Hard, acidic, or spicy foods. ... Frequent or heavy alcohol consumption. ... Smoking.More items...•

What happens on the first day of chemotherapy?

Your nurse will begin with a saline solution through your IV. As soon as the medications are delivered, your nurse will hang the bags of medication on the IV stand and then start the different IVs. You'll be given pre-medications first, then the chemotherapy.

How long can you live on chemo?

For most cancers where palliative chemotherapy is used, this number ranges from 3-12 months. The longer the response, the longer you can expect to live.

Does all chemo cause hair loss?

Most people think that chemotherapy drugs always cause hair loss. But some don't cause any hair loss at all or only slight thinning. Other types of chemotherapy may cause complete hair loss. It might include your eyelashes, eyebrows, underarm, leg and sometimes pubic hair.

Do you need someone to drive you home after chemotherapy?

In most cases, your healthcare provider will ask you to get a ride home after your first session to see how you will tolerate the chemo. If you feel well the first time around, you may be advised that it's okay to drive home for future sessions.

How does chemotherapy work?

Chemotherapy works by stopping or slowing the growth of cancer cells, which grow and divide quickly. Chemotherapy is used to: Chemotherapy can be used to cure cancer, lessen the chance it will return, or stop or slow its growth. Chemotherapy can be used to shrink tumors that are causing pain and other problems.

How does chemo work?

Chemotherapy to Treat Cancer. Chemotherapy works against cancer by killing fast-growing cancer cells. Chemotherapy (also called chemo) is a type of cancer treatment that uses drugs to kill cancer cells.

What is the term for a tumor that is smaller before surgery?

Make a tumor smaller before surgery or radiation therapy. This is called neoadjuvant chemotherapy . Destroy cancer cells that may remain after treatment with surgery or radiation therapy. This is called adjuvant chemotherapy. Help other treatments work better.

How long can a catheter be left in place for chemo?

This needle can be left in place for chemotherapy treatments that are given for longer than one day. Be sure to watch for signs of infection around your port.

What is the treatment for cancer?

Who Receives Chemotherapy . Chemotherapy is used to treat many types of cancer. For some people, chemotherapy may be the only treatment you receive. But most often, you will have chemotherapy and other cancer treatments.

Where do you put a catheter in a chemo patient?

A catheter is a thin, soft tube. A doctor or nurse places one end of the catheter in a large vein, often in your chest area. The other end of the catheter stays outside your body. Most catheters stay in place until you have finished your chemotherapy treatments.

How long is a cycle of chemotherapy?

For instance, you might receive chemotherapy every day for 1 week followed by 3 weeks with no chemotherapy. These 4 weeks make up one cycle. The rest period gives your body a chance to recover and build new healthy cells.

How do chemo drugs work?

Chemotherapy drugs work in a few different ways. They can: 1 Kill both cancerous and healthy cells 2 Fight only cancer cells 3 Keep tumors from growing blood vessels, which help them thrive 4 Attack the cancer cells’ genes so the cells die and can’t grow into new tumors

Why do we need chemotherapy?

Even after surgery to remove a tumor, your body might still have cancer cells. These cells can grow new tumors or spread the cancer to other parts of your body. Chemotherapy drugs help destroy, shrink, or control those cells. It might also treat symptoms the cancer causes, like pain.

What is the most common treatment for cancer?

When Your Chemotherapy Changes. Chemotherapy is one of the most common treatments for cancer. It uses certain drugs to kill cancer cells or to stop them from growing and spreading to other parts of your body. Your doctor might prescribe chemo by itself or with surgery or radiation therapy.

What is chemo drug?

One type of chemo drug interferes with the normal metabolism of cells, which makes them stop growing. These drugs are called antimetabolites. Doctors often use them to treat leukemia and cancer in the breasts, ovaries, and intestines.

What do oncologists look for in cancer patients?

Oncologists look for signs that your tumor is shrinking or growing. They use tests like physical exams, blood tests, or imaging scans like X-rays. If your treatment doesn’t seem to be working, the oncologist might give you a different dose or a mix of other treatments. Next In Chemotherapy for Cancer.

What are the other cancer treatments?

Chemotherapy is a common cancer treatment, but today, doctors often prescribe other kinds of cancer medicines, such as targeted therapies, hormone therapy, and immunotherapy. Unlike chemo, these types of medicine are better at attacking only cancer cells and leaving healthy cells alone.

What is the oldest type of chemo?

They are called alkylating agents, the oldest type of chemotherapy. They treat many different types of cancer, such as leukemia, lymphoma, Hodgkin's disease, multiple myeloma, and sarcoma, as well as breast, lung, and ovarian cancers. Some examples of alkylating agents are cyclophosphamide, melphalan, and temozolomide.

Why do people get chemotherapy after surgery?

For example, many people with breast or bowel cancer have chemotherapy after surgery to help lower the risk of the cancer coming back. With some cancers, if a cure is unlikely, your doctor may still suggest chemotherapy to: shrink the cancer. relieve your symptoms.

How to get chemo?

You can have chemotherapy as: 1 an injection into the bloodstream (through a vein) 2 a drip (intravenous infusion) into the bloodstream through a vein 3 tablets 4 capsules

What is systemic treatment?

capsules. Chemotherapy drugs that you have in these ways circulate all around the body in the bloodstream. They can reach cancer cells almost anywhere in the body. This is known as systemic treatment.

What is the process of killing cells that are in the process of splitting into 2 new cells?

This is known as systemic treatment. Chemotherapy kills cells that are in the process of splitting into 2 new cells. Body tissues are made of billions of individual cells. Once we are fully grown, most of the body's cells don't divide and multiply much. They only divide if they need to repair damage.

What happens when cells divide?

Then these divide to make 4, then 8 and so on. In cancer, the cells keep on dividing until there is a mass of cells. This mass of cells becomes a lump, called a tumour.

How does a symbiotic relationship affect the body?

It affects healthy body tissues where the cells are constantly growing and dividing, such as: your hair, which is always growing. your bone marrow, which is constantly producing blood cells. your skin and the lining of your digestive system, which are constantly renewing themselves.

Does chemo damage cells?

Because these tissues have dividing cells, chemotherapy can damage them. But normal cells can replace or repair the healthy cells that are damaged by chemotherapy. So the damage to healthy cells doesn't usually last. Most side effects disappear once your treatment is over.

Alkylating agents against cancer cells

Some drugs, such as alkylating agents, directly affect each cancer cell’s DNA. For example, the drug may cause DNA strands to break, preventing cell division. Many alkylating agents can be administered at any point during the cell cycle.

Antimetabolites against cancer cells

Antimetabolites replace and mimic the nutrients that cancer cells need to grow, which starves them to death. This type of drug is most effective when given during the S-phase (synthesis of new DNA) of the cell cycle.

Anti-tumor antibiotics against cancer cells

Antitumor antibiotics uncoil cancer cell DNA strands. This stops them from reproducing. This type of drug can be given at any point during the cell cycle.

Alkaloids against cancer cells

Plant alkaloids block cell division. They may be given at any time during the cell cycle but may be most effective during specific stages of cell development.

How does chemotherapy affect healthy cells?

Healthy, normal cells that are fast growing are also affected by chemotherapy drugs. These include:

Chemo for systemic treatment

If the drugs are meant to work through your entire system, you may get chemo:

Chemo by localized delivery

Chemotherapy drugs may also be used to target tumors in a specific area of the body. These localized delivery systems may use slow-dissolving disks containing chemo drugs or other mediums of delivery:

What is the purpose of chemotherapy?

After other treatments, to kill hidden cancer cells. Chemotherapy can be used after other treatments, such as surgery, to kill any cancer cells that might remain in the body. Doctors call this adjuvant therapy. To prepare you for other treatments. Chemotherapy can be used to shrink a tumor so that other treatments, such as radiation and surgery, ...

How is chemotherapy given?

Chemotherapy is most often given as an infusion into a vein (intravenously). The drugs can be given by inserting a tube with a needle into a vein in your arm or into a device in a vein in your chest.

Why is chemo used for bone marrow transplant?

Chemotherapy is often used to prepare for a bone marrow transplant. Immune system disorders. Lower doses of chemotherapy drugs can help control an overactive immune system in certain diseases, such as lupus and rheumatoid arthritis.

What is the best treatment for skin cancer?

Chemotherapy creams. Creams or gels containing chemotherapy drugs can be applied to the skin to treat certain types of skin cancer. Chemotherapy drugs used to treat one area of the body. Chemotherapy drugs can be given directly to one area of the body.

What is the treatment for cancer?

Overview. Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cells in your body. Chemotherapy is most often used to treat cancer, since cancer cells grow and multiply much more quickly than most cells in the body. Many different chemotherapy drugs are available.

Why is chemotherapy used?

To prepare you for other treatments. Chemotherapy can be used to shrink a tumor so that other treatments, such as radiation and surgery, are possible. Doctors call this neoadjuvant therapy. To ease signs and symptoms. Chemotherapy may help relieve signs and symptoms of cancer by killing some of the cancer cells.

What doctor do you see during chemotherapy?

You'll meet with your cancer doctor (oncologist) regularly during chemotherapy treatment. Your oncologist will ask about any side effects you're experiencing, since many can be controlled. Depending on your situation, you may also undergo scans and other tests to monitor your cancer during chemotherapy treatment.

How does chemo work?

Also called “chemo,” it’s a way to treat cancerthat uses drugsto kill cancercells. How does chemotherapy work? It targets cells that grow and divide quickly, as cancercells do. Unlike radiation or surgery, which target specific areas, chemo can work throughout your body.

What is chemo therapy?

Chemotherapy ("Chemo") uses drugs to destroy cancer cells. Learn more about how it works, what to expect during treatment, common side effects, and other FAQs. Skip to main content . Check Your Symptoms . Find A Doctor .

How is chemotherapy delivered?

It may be delivered by a special machine that bombards parts of your body from the outside, or by putting radioactive material on, near, and even inside your body. Biological therapy:Living material in the form of bacteria, vaccines, or antibodiesare carefully introduced to kill cancer cells. Chemotherapy may be used to:

What is the goal of chemo?

The goal of treatment: cure, control growth, or ease pain. The type of chemotherapy. The way your body responds to the treatment. You may have chemotherapy in “cycles,” which means a period of treatment and then a period of rest. For example, a 4-week cycle may be 1 week of treatment and then 3 weeks of rest.

What is the term for shrinking a tumor?

Chemotherapy may be used to: Shrink a tumor before radiation therapy or surgery -- called neoadjuvant chemotherapy. Destroy any remaining cancer cells after surgery or radiation therapy -- called adjuvant chemotherapy. Make other therapies (biological or radiation) more effective.

What is the treatment for cancer?

Sometimes, it treats cancer by itself, but more often it’s used in combination with: Surgery:A doctor removes cancerous tumors or tissue, or organs contaminated with cancerous cells. Radiation therapy: A doctor uses invisible radioactive particles to kill cancer cells.

Where is chemo injected?

Intrathecal(IT) chemotherapy:Medicine is injected into the cerebrospinal fluid (CSF), which is found in the area surrounding the spinal cord and the brain. Intravenous (IV):The chemotherapy goes directly into a vein.

What is chemo used for?

More often, chemo is used with surgery or radiation therapy or both. And it's sometimes used with other drugs, such as targeted therapy, hormone therapy, or immunotherapy. For example, chemo may be used... To shrink a tumor before surgery or radiation therapy. Chemo used in this way is called neoadjuvant therapy.

Who decides what chemotherapy to get?

Planning chemotherapy treatments. You and your cancer doctor ( oncologist) will decide what drug or combination of drugs you will get. Your doctor will choose the doses, how the drugs will be given, and how often and how long you’ll get treatment.

How often is chemo given?

Chemotherapy is commonly given at regular intervals called cycles. A cycle may be a dose of one or more drugs on one or more days, followed by several days or weeks without treatment. This gives normal cells time to recover from drug side effects. Sometimes, doses may be given a certain number of days in a row, or every other day for several days, followed by a period of rest. Some drugs work best when given continuously over a set number of days.

What is the term for the use of drugs to treat cancer?

Chemotherapy refers to the use of any drug to treat any disease. But to most people, the word chemotherapy ( or "chemo") means drugs used for cancer treatment. It's important to know that not all medicines and drugs to treat cancer work the same way. It used to be that the only kind of drug that could treat cancer was traditional or standard chemo, ...

What is the term for the process of shrinking a tumor?

To shrink a tumor before surgery or radiation therapy. Chemo used in this way is called neoadjuvant therapy . After surgery or radiation therapy to help kill any remaining cancer cells in the body. Chemo used in this way is called adjuvant therapy.

Why do people need chemo?

When the cancer is at an advanced stage, probably cannot be controlled, and has spread, the goal of giving chemo may be to improve the quality of life or help the person feel better. For instance, chemo may be used to help shrink a tumor that’s causing pain or pressure so the patient feels better and has less pain.

What is radiation therapy?

Surgery removes a tumor from a part of the body where cancer has been found, and radiation therapy is aimed at a certain area of the body to kill or damage cancer cells. Treatments like these are called local treatments because they affect one part of the body.

How does chemo work?

How does chemotherapy work? Tumor cells, which make up cancer, grow and reproduce (multiply) very quickly. Normal, healthy cells know to stop reproducing and growing when they touch other cells. Cancer cells keep growing, not knowing when to stop. RNA and DNA in the cell tell it how to grow and reproduce.

What is the treatment for cancer?

Your treatment may include more than one type of therapy (surgery, radiation, chemo, etc.). Common terms used to describe chemotherapy treatments: Adjuvant Therapy: chemotherapy given after surgery to reduce the chance of your cancer coming back (recurrence). Neo-adjuvant Therapy: chemotherapy given before surgery to shrink the tumor.

How often can you give chemo?

They may be given in “divided doses” or given multiple times. For example, once a day for 5 days, or every 3 hours for 4 doses. They can also be given as a nonstop infusion. This is an infusion that runs for several hours or more. Some chemotherapy infusions are given over several days.

Why are regimens called combinations?

A combination is given because different chemotherapies can work well together. Regimens can be given “nicknames” based on the chemotherapies used in them. For example, the regimen called “CHOP” contains the medications C ytoxan, H ydroxydaunorubicin (also called Adriamycin), O ncovin, and P rednisone.

What is the difference between neo-adjuvant and concurrent therapy?

Neo-adjuvant Therapy: chemotherapy given before surgery to shrink the tumor. This is to help the surgery be more successful. Concurrent Therapy: when 2 or more therapies (radiation and chemo) are given together.

Why is radiation called local therapy?

Surgery and radiation are called “local” therapies because they treat only a certain part of the body. Chemotherapy can be given to a patient in a number of ways: Orally (by mouth, in pill form).

How to cure cancer?

Curing the cancer. Stopping the cancer from going to other parts of the body. Slowing the growth of the cancer. Killing cancer cells in areas of metastases ( other parts of the body that the cancer has spread to). Ease symptoms that the cancer is causing to make you more comfortable (palliative).

How does chemotherapy work?

Share on Pinterest. Drazen / Getty Images. Chemotherapy (“chemo”) works by destroying cancer cells in your body. Depending on the type and stage of cancer, chemotherapy treatment may target primary tumors or cells that have spread to other parts of your body. Chemo may also help treat cancer-related pain.

Why do people take chemo?

primary reason you’re taking chemo — for example, to prevent tumor spread or to alleviate pain. how your cancer responds to the treatment. how you tolerate the treatment. other possible health conditions you may have, such as diabetes or heart conditions.

What is the first line of treatment for cancer?

To treat cancer cells with chemotherapy, your doctor will determine the best cellular phases in which to administer your treatment. Since cancer cells multiply or divide quickly, chemo may be considered a first line of treatment for more aggressive forms of cancer.

How to tell if chemo is working?

The best way to tell if chemotherapy is working for your cancer is through follow-up testing with your doctor. Throughout your treatment, an oncologist will conduct regular visits, and blood and imaging tests to detect cancer cells and whether they’ve grown or shrunk.

What to do before chemo?

Before each chemotherapy session, your doctor will perform an assessment to make sure that the treatment is safe to administer. If your CBC counts are too low, for example, your doctor may recommend that you reschedule your treatment for another day.

How to know if chemo is effective?

The only way to effectively know for sure is through follow-up tests with your doctor. These are given in regular intervals around each round of chemo. Keep reading to learn how doctors measure and define the effectiveness of chemotherapy.

How far apart can you get chemo?

Depending on these factors, chemotherapy may be administered in multiple rounds that are spaced several weeks (or months) apart. If you or a loved one is in the midst of a chemotherapy treatment plan, you may wonder how you can tell if chemotherapy is working.

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Chemotherapy Works with The Cell Cycle

  • Every time any new cell is formed, it goes through a usual process to become a fully functioning (or mature) cell. The process involves a series of phases and is called the cell cycle. Chemotherapy drugs target cells at different phases of the cell cycle. Understanding how these drugs work helps doctors predict which drugs are likely to work well t...
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Types of Chemo Drugs

  • Chemo drugs can be grouped by how they work, their chemical structure, and their relationships to other drugs. Some drugs work in more than one way, and may belong to more than one group. (Note: not all chemotherapy drugs are listed here.) Knowing how the drug works is important in predicting side effects from it. This helps doctors decide which drugs are likely to work well toge…
See more on cancer.org

Other Types of Drugs Used to Treat Cancer

  • Other drugs and biological treatments are used to treat cancer, but aren’t considered chemotherapy. They often have different side effects than chemotherapy. Many are used along with surgery, chemo, or radiation therapy.
See more on cancer.org

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