What is the sonata treatment?
The Sonata Treatment is an incision-free treatment for uterine fibroids and has been clinically proven to be safe and effective. 1 handpiece to locate and target the individual fibroids. Radiofrequency energy is delivered to shrink the fibroid and reduce symptoms. Why is the Sonata Treatment a breakthrough?
How many clinical trials have been done on sonata?
Clinical Trials. Sonata (typically administered in doses of 5 mg, 10 mg, or 20 mg) has been studied in patients with chronic insomnia (n = 3,435) in 12 placebo- and active-drug-controlled trials. Three of the trials were in elderly patients (n = 1,019). It has also been studied in transient insomnia (n = 264).
What is the sonata treatment for fibroids?
The Sonata Treatment can treat a wide range of fibroid types, sizes, and locations — without even one incision. The fibroids are treated from inside the uterus, so the Sonata Treatment requires no incisions to the abdomen, no tissue is surgically removed, and the uterus is preserved.
Is Sonata safe and effective in pediatric patients?
The safety and effectiveness of Sonata in pediatric patients have not been established. A total of 628 patients in double-blind, placebo-controlled, parallel-group clinical trials who received Sonata were at least 65 years of age; of these, 311 received 5 mg and 317 received 10 mg.
Where is the best place to receive cancer treatment?
US News' 10 top hospitals for cancer careUniversity of Texas MD Anderson Cancer Center (Houston.Memorial Sloan Kettering Cancer Center (New York City)Mayo Clinic (Rochester, Minn.)Dana-Farber Brigham and Women's Cancer Center (Boston)Cleveland Clinic.Johns Hopkins Hospital (Baltimore)
What is the best cancer hospital in the world?
MD Anderson Cancer CenterWorld's Best Specialized Hospitals 2021RankHospitalScore1MD Anderson Cancer Center100.0%2Memorial Sloan Kettering Cancer Center99.2%3Dana-Farber Cancer Institute98.0%4Mayo Clinic - Rochester97.0%73 more rows
What is the name of the cancer Center in Dallas Texas?
Simmons Cancer CenterSimmons Cancer Center: UT Southwestern, Dallas, TX.
What is the most advanced treatment for cancer?
Chemotherapy is one of the most commonly used treatments for advanced cancer. It may also be used for symptom relief. A combination of chemotherapy drugs may be used, or chemotherapy may be combined with other treatments as part of a broader treatment plan.
Who is the best oncologist in the United States?
Recognized OncologistsFoluso Ademuyiwa, MD, MPH, Washington University, St. ... Banu Arun, MD, MD Anderson Cancer Center, Houston.José Baselga, MD, PhD, Memorial Sloan Kettering Cancer Center, New York.Harold Burstein, MD, PhD, Dana-Farber Cancer Institute, Boston.More items...•
Which state has the best cancer doctors?
MinnesotaMinnesota tops our list of states with the best cancer care. The state has low average costs of health insurance and the best access to medical care.
What's the best water to drink for cancer patients?
Tap water should be safe when it comes from a city water supply or a city well that supplies many people with water. It does not need to be filtered. You should boil water that comes from a private well or a small local well, even if you have a filter.
What is the number 1 cancer hospital in the US?
The University of Texas MD Anderson Cancer CenterThe University of Texas MD Anderson Cancer Center again has been named No. 1 in cancer in the U.S. News & World Report's 2021-2022 annual “Best Hospitals” rankings.
Is UT Southwestern A good cancer hospital?
Nationally Ranked by U.S. News & World Report for Cancer Care. UT Southwestern's cancer care has earned top 25 national recognition from U.S. News & World Report, placing us among the country's leading cancer treatment facilities.
What is the newest treatment for cancer?
A groundbreaking drug called pembrolizumab (Keytruda), an immune checkpoint inhibitor, was designed to stop the action of an immune system-blocking protein called PD-L1 so that immune cells can destroy cancer. The concentration of PD-L1 in cancer cells can be higher than 90%, making it a highly targetable protein.
How do doctors know how long you have left to live?
There are numerous measures – such as medical tests, physical exams and the patient's history – that can also be used to produce a statistical likelihood of surviving a specific length of time.
What is Stage 4 cancer life expectancy?
In most cases, how stage 4 cancer is likely to progress (its prognosis) depends on the type of cancer. Some advanced cancers are very aggressive and fast-growing....Survival Rates.Five-Year Survival Rates for Distant (Stage 4) CancerCancer TypeRelative 5-Year Survival RatePancreatic2.9%11 more rows•Mar 5, 2022
What is a sonata?
About the Sonata Treatment. The Sonata Treatment is an incision-free treatment for uterine fibroids and has been clinically proven to be safe and effective. 1. The Sonata Treatment uses an intrauterine ultrasound. handpiece to locate and target the individual fibroids. Radiofrequency.
Why is Sonata a breakthrough?
Why is the Sonata Treatment a breakthrough? The Sonata Treatment can treat a wide range of fibroid types, sizes, and locations — without even one incision. The fibroids are treated from inside the uterus, so the Sonata Treatment requires no incisions to the abdomen, no tissue is surgically removed, and the uterus is preserved.
How does Sonata work?
How the Sonata Treatment Works. at the tip of the handpiece. The doctor passes the Sonata Treatment handpiece through the vagina and into the uterus. Ultrasound waves from the tip are used to locate the fibroid. The Sonata handpiece delivers radiofrequency energy to shrink the fibroid and reduce symptoms. 1.
How does a sonata handpiece work?
Ultrasound waves from the tip are used to locate the fibroid. The Sonata handpiece delivers radiofrequency energy to shrink the fibroid and reduce symptoms. 1. The doctor passes the Sonata Treatment handpiece through the vagina and into the uterus. 2. Ultrasound waves from the tip are used to locate the fibroid. 3.
What is Sonata used for?
It affects chemicals in your brain that may be unbalanced in people with sleep problems (insomnia). Sonata is used to treat insomnia.
What are the side effects of Sonata?
Common Sonata side effects may include: day-time drowsiness, dizziness, "hangover" feeling; feeling light-headed; problems with coordination; or. numbness, tingling, weekness, or prickly feeling on your skin. This is not a complete list of side effects and others may occur.
How long does it take for Sonata to stop working?
Do not stop using Sonata suddenly after taking it over several days in a row, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
What happens if you take Sonata while you are not awake?
This may include walking, driving, or making phone calls. If this happens to you, stop taking Sonata and call your doctor right away. Serious injury or death could occur if you walk or drive while you are not fully awake. Call your doctor at once if you have: anxiety, depression, aggression, agitation;
Can you give away Sonata?
Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law. Sonata will make you fall asleep. Never take this medication during your normal waking hours, unless you have several hours to dedicate to sleeping. Sonata is for short-term use only.
Can Sonata cause drowsiness?
Do not drink alcohol while you are taking this medication. It can increase some of the side effects of zaleplon, including drowsiness. Zaleplon may be habit-forming.
Can you take Sonata if you are allergic to Zaleplon?
You should not use Sonata if you are allergic to zaleplon, or if you have ever taken sleep medicine and engaged in activity you later don't remember. Sonata is not approved for use by anyone younger than 18 years old. To make sure this medicine is safe for you, tell your doctor if you have: liver or kidney disease;
How old is Sonata?
Age: The pharmacokinetics of Sonata (zaleplon) have been investigated in three studies with elderly men and women ranging in age from 65 to 85 years. The pharmacokinetics of Sonata in elderly subjects, including those over 75 years of age, are not significantly different from those in young healthy subjects.
Why do you need to adjust Sonata?
Dosage adjustment may be necessary when Sonata is administered with other CNS-depressant agents because of the potentially additive effects. Because Sonata can cause drowsiness and a decreased level of consciousness, patients, particularly the elderly, are at higher risk of falls.
How long does it take for Sonata to go away?
You may also have more trouble sleeping the first few nights after Sonata is stopped. The problem usually goes away on its own after 1 or 2 nights. These are not all the side effects of Sonata. Ask your doctor or pharmacist for more information. Call your doctor for medical advice about side effects.
Is Sonata a benzodiazepine?
Pharmacodynamics and Mechanism of Action. While Sonata (zaleplon) is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABA-BZ) receptor complex.
Is flumazenil an antagonist to zaleplon?
Intravenous fluids should be administered as needed. Animal studies suggest that flumazenil is an antagonist to zaleplon. However, there is no pre-marketing clinical experience with the use of flumazenil as an antidote to a Sonata overdose. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention.
Is Sonata 10 mg or 20 mg better?
Sonata 10 mg and 20 mg were consistently superior to placebo for TSO, generally for the full duration of all three studies. Although both doses were effective, the effect was greater and more consistent for the 20-mg dose. The 5-mg dose was less consistently effective than were the 10-mg and 20-mg doses.
Now FDA Cleared for Treatment of Symptomatic Uterine Fibroids
The Sonata System combines real-time intrauterine ultrasound guidance with targeted radiofrequency ablation in an incisionless procedure to treat symptomatic uterine fibroids.
Indications and Safety Information
The Sonata System is intended for diagnostic intrauterine imaging and transcervical treatment of symptomatic uterine fibroids, including those associated with heavy menstrual bleeding.
Device Description
Intended Use
- The Sonata System is intended for diagnostic intrauterine imaging and transcervical treatment of symptomatic uterine fibroids, including those associated with heavy menstrual bleeding.
Contraindications
- The Sonata System is contraindicated in the following conditions: 1. Current pregnancy; 2. Active pelvic infection; 3. Known or suspected gynecologic malignancy or premalignant disorders such as atypical endometrial hyperplasia; 4. Presence of one or more intratubal implants for sterilization; and 5. Presence of an intrauterine device (IUD), unless removed prior to the introdu…
Other Considerations
- Safety and effectiveness with regard to fertility and fecundity after the use of the Sonata System have not been established. As a uterus-conserving alternative to hysterectomy, treatment with the...
- Effectiveness in women with clinically significant adenomyosis has not been established.
- Transcervical radiofrequency ablation with the Sonata System should not be performed in pa…
- Safety and effectiveness with regard to fertility and fecundity after the use of the Sonata System have not been established. As a uterus-conserving alternative to hysterectomy, treatment with the...
- Effectiveness in women with clinically significant adenomyosis has not been established.
- Transcervical radiofrequency ablation with the Sonata System should not be performed in patients with known hip implants or other metal implants near the ablation site or along the RF return path t...
- The Sonata System should be used with caution in patients with a known nickel allergy.
Patient Counseling, Potential Postoperative Events, and Risks
- As with any procedure, the clinician should discuss the potential risks and expected outcomes related to the Sonata procedure with patients. The Sonata System is intended for the transcervical ablation of symptomatic uterine fibroids, including those associated with heavy menstrual bleeding. Full benefits may not be realized for several months, as the ablated fibroids shrink ove…