The most common side effects of Injectafer include: In adults: nausea, high blood pressure, flushing, pain or bruising at the injection site, skin redness, low levels of phosphorous in your blood, and dizziness. Potentially long-lasting brown staining of skin near the injection site may occur if Injectafer leaks out of the vein
Full Answer
What are the possible side effects of Injectafer?
Advise patients to report any signs and symptoms of hypersensitivity that may develop during and following Injectafer administration, such as rash, itching, dizziness, lightheadedness, swelling, and breathing problems [ see Warnings and Precautions ( 5.1) ].
How often does Injectafer cause diarrhea?
In clinical studies, diarrhea was reported in less than 1% of people taking Injectafer. It’s not known how often people taking a treatment other than Injectafer had diarrhea.
What do I do if I have an allergic reaction to Injectafer?
Tell your healthcare professional if you have ever had any unusual or allergic reactions to IV iron. Talk to your doctor or healthcare professional if you have any signs and symptoms of an allergic reaction to Injectafer, in particular rashes, shortness of breath, and wheezing, or for medical advice about side effects.
What is Injectafer used to treat?
Iron helps your body produce red blood cells that carry oxygen through your blood to tissues and organs. Injectafer is used in adults to treat iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body).
How long does Injectafer side effects last?
Some people may have a spike in blood pressure accompanied by flushing, dizziness or nausea. This usually resolves in about 30 minutes, according to the drug's prescribing information. Long-lasting skin discoloration may occur if Injectafer spills out of the administration site and onto the skin.
How will I feel after Injectafer?
Most mild side effects of Injectafer typically go away within about 30 minutes of receiving your dose of the drug. Examples of these side effects include dizziness and nausea. After getting each dose of Injectafer, your healthcare professional will monitor you for at least 30 minutes.
How soon after Injectafer Do you feel better?
Injectafer infusions work rapidly and effectively to correct iron levels and some people start to feel an improvement in their symptoms within a week. It takes 2 to 3 weeks for the anaemia to be corrected and then you should have better concentration, more energy and have less breathlessness and fatigue.
What are the side effects of Injectafer infusion?
Injectafer can cause serious side effects, including:Serious allergic reactions that may be life-threatening, including shock, low blood pressure, loss of consciousness, and death. ... High blood pressure, sometimes with facial flushing, dizziness, or nausea, has been seen during treatment with Injectafer.
Is it normal to feel sick after iron infusion?
Generally when side effects occur, they are mild and settle down on their own. The most common risks of iron infusion include: Headache, feeling sick or vomiting, muscle or joint pain. Changes in taste (e.g. metallic)
Do iron transfusions make you sick?
Iron infusion is generally given without any major issues. About one out of ten patients can experience 'flu-like' symptoms, such as muscle or joint ache, headache or mild fever. This usually occurs a couple of days after the infusion and settles with Panadol or Nurofen.
Can iron infusions cause fatigue?
Intravenous iron supplementation compared with placebo resulted in increase of ferritin and hemoglobin levels in repeat blood donors with low iron stores, yet had no effect on fatigue and general well-being.
Why do you gain weight after iron infusion?
Patients who receive iron treatment gain weight, if they do not make diet or have a metabolic disease. So, iron therapy increases serum ferritin levels accompanying with body weight.
Can iron infusion cause chills?
SIDE EFFECTS: Flushing, tingling of the hands/feet, shivering, or dizziness may occur. The area around the injection site may be tender, irritated, or discolored (brown). If any of these effects persist or worsen, contact your doctor or pharmacist promptly.
Is Injectafer safe?
Injectafer's efficacy and safety have been studied in more than 40 clinical trials with more than 8,800 patients worldwide. Most Injectafer side effects are mild or go away after a short time, but the drug has also been linked to hypophosphatemia, or abnormally low phosphate.
Can iron infusions cause dizziness?
The side effects of IV iron are usually minimal, but may include the following: Bloating or swelling of the face, arms, hands, lower legs, or feet. Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position.
Do iron infusions cause diarrhea?
SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Pain, swelling, or redness at the injection site may occur.
What are the side effects of injectafer?
Mild side effects of Injectafer can include: altered sense of taste. constipation. dizziness. flushing ( temporary warmth, redness, or deepening of skin color) headache. high blood pressure †. low blood pressure. hypophosphatemia (low level of phosphorus in the blood)
How long do the side effects of injectafer last?
vomiting. How long side effects of Injectafer last vary from person to person. These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.
What is injectafer used for?
It’s approved by the Food and Drug Administration (FDA) to treat iron deficiency anemia (IDA) in certain adults. Anemia is a condition in which you have low levels of red blood cells. When anemia causes a lack of iron in your body, it’s known as IDA.
What are the side effects of a phosphorus sulfate solution?
Serious side effects† can include: severe high blood pressure. severe hypophosphatemia (low level of phosphorus in the blood) allergic reaction.
Why does my skin darken after injectafer?
This may be due to a type of skin reaction called extravasation. With this reaction, a drug given as an intravenous (IV) infusion * or IV injection leaks into the site around the injection.
How long does injectafer last?
Usually, increases in blood pressure aren’t serious. They generally don’t last more than 30 minutes and go away on their own without treatment.
How long does it take to monitor blood pressure after injectafer?
After each dose of Injectafer, your doctor or another healthcare professional will monitor you for at least 30 minutes for high blood pressure. This includes severe high blood pressure.
What are the side effects of injectafer?
Injectafer side effects. Get emergency medical help if you have signs of an allergic reaction to Injectafer: hives; feeling light-headed; difficult breathing; swelling of your face, lips, tongue, or throat. increased blood pressure - severe headache, pounding in your neck or ears, dizziness, nausea;
Why is injectafer used in adults?
Iron helps your body produce red blood cells that carry oxygen through your blood to tissues and organs. Injectafer is used in adults to treat iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body).
How long should you wait to be watched after injectafer?
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Injectafer is injected. You will be watched closely for at least 30 minutes after receiving Injectafer, to make sure you do not have an allergic reaction to the medication. Tell your doctor if you have any changes in weight.
How many days apart is injectafer?
Injectafer is injected into a vein through an IV. A healthcare provider will give you this injection. Injectafer is usually given in two doses, 7 days apart, or given as a single dose. Your doctor will determine whether you need a repeat course.
Is injectafer safe for anemia?
anemia that is not caused by iron deficiency. To make sure Injectafer is safe for you, tell your doctor if you have:
What are the side effects of phosphorus?
nausea; dizziness; high blood pressure; flushing (warmth, redness, or tingly feeling); or. low phosphorus levels. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Does injectafer cause nausea?
high levels of iron stored in your body - metallic taste in the mouth, bloody or tarry stools, vomiting blood, severe shortness of breath, chest pain, pale skin, blue lips or fingernails, loss of consciousness, or seizure (convulsions). Common Injectafer side effects may include: nausea; dizziness; high blood pressure;
How many days to give injectafer?
For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course.
What is injectafer used for?
What Is Injectafer? Injectafer (ferric carboxymaltose) injection is an iron carbohydrate complex used to treat iron deficiency anemia in adult patients who have intolerance to oral iron or have had unsatisfactory response to oral iron, or who have non- dialysis dependent chronic kidney disease.
Why are adverse reaction rates not directly compared to other clinical trials?
Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in clinical practice.
What are the symptoms of an allergic reaction?
Get emergency medical help if you have signs of an allergic reaction: hives; feeling light-headed; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: increased blood pressure --severe headache, pounding in your neck or ears, dizziness, nausea;
What are the side effects of iron?
Common side effects may include: nausea; dizziness; high blood pressure;
Is injectafer a causal relationship?
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
How long does it take for injectafer to go away?
Most mild side effects of Injectafer typically go away within about 30 minutes of receiving your dose of the drug. Examples of these side effects include dizziness and nausea. After getting each dose of Injectafer, your healthcare provider will monitor you for at least 30 minutes.
How does injectafer work?
With IV infusion, the drug is given as a slow drip into your vein over a period of time. With slow IV injection, the drug is given as a single, slow injection into your vein.
What is the goal of injectafer?
So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value that’s within normal range. If you have questions about the blood tests you’ll need to have done to monitor your anemia, talk with your doctor.
What is the difference between injectafer and feraheme?
Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. Both Injectafer and Feraheme belong to a class of medications known as iron replacement products. (A class of medications describes a group of drugs that work in the same way.)
What is injectafer in medicine?
Injectafer contains the active drug ferric carboxymaltose. It belongs to a class of medications called iron replacement products. (A medication class is a group of medications that work in a similar way.) Injectafer comes as a liquid that’s given by either intravenous (IV) infusion or slow IV injection.
What are the symptoms of an allergic reaction?
flushing (warmth and redness in your skin) A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include: swelling under your skin, typically in your eyelids, lips, hands, or feet. swelling of your tongue, mouth, or throat. trouble breathing.
What to do if you have side effects?
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects, which are explained in more detail below in “Side effect details,” include: allergic reaction, including delayed allergic reaction.
What are the side effects of injectafer?
Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse. Monitor patients for signs and symptoms of hypersensitivity during and after Injectafer administration for at least 30 minutes and until clinically stable following completion of the infusion. Only administer Injectafer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. [see Adverse Reactions ( 6.1, 6.2)]. In clinical trials, serious anaphylactic/anaphylactoid reactions were reported in 0.1% (2/1,775) of subjects receiving Injectafer. Other serious or severe adverse reactions potentially associated with hypersensitivity which included, but not limited to, pruritus, rash, urticaria, wheezing, or hypotension were reported in 1.5% (26/1,775) of these subjects.
What are the symptoms of injectafer?
Advise patients to report any signs and symptoms of hypersensitivity that may develop during and following Injectafer administration, such as rash, itching, dizziness, lightheadedness, swelling, and breathing problems [ see Warnings and Precautions ( 5.1) ].#N#Pregnancy
How much iron is in injectafer?
For patients weighing less than 50 kg, the recommended dosage is Injectafer 15 mg/kg body weight intravenously in two doses separated by at least 7 days per course. Each mL of Injectafer contains 50 mg of elemental iron.
What is injectafer used for?
Injectafer is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron, or. who have non-dialysis dependent chronic kidney disease.
Does injectafer cause hemosiderosis?
Excessive dosages of Injectafer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. A patient who received Injectafer 18,000 mg over 6 months developed hemosiderosis with multiple joint disorder, walking disability, and asthenia. Hypophosphatemic osteomalacia was reported in a patient who received Injectafer 4,000 mg over 4 months. Partial recovery followed discontinuation of Injectafer.
Why are adverse reaction rates not directly compared to other clinical trials?
Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in clinical practice.
Can injectafer be repeated?
Injectafer treatment may be repeated if IDA reoccurs. Monitor serum phosphate levels in patients at risk for low serum phosphate who require a repeat course of treatment [see Warnings and Precautions ( 5.2 )].
What is injectafer used for?
Injectafer is a brand (trade) name for ferric carboxymaltose injection, which may be used for the treatment of iron deficiency anemia (IDA). Injectafer consists of a shell made of carbohydrate polymer called carboxymaltose that is tightly bound around an iron core. Its structure is similar to naturally occurring ferritin, ...
How long does it take to get injectafar?
Injectafar can be given by slow intravenous (IV) push that takes roughly 8 minutes, or as an IV infusion that takes at least 15 minutes. Times may be longer due to preparation and administration. Monitoring for 30 minutes following the infusion is necessary in case an allergic reaction happens.
What is the structure of injectafer?
Its structure is similar to naturally occurring ferritin, which is the body's iron storage protein. Once Injectafer is injected into the body, it is likely taken up by macrophages of the RES which break down the carbohydrate shell and slowly release iron.
How long does it take to get a syringe injection?
Although the injections take about 8 minutes if given by a slow IV push or 15 minutes if given by infusion, expect to be at the clinic for 45minutes to an hour which allows for preparation time beforehand and monitoring time afterward. You may eat and drink normally before and after your appointment.
How long does it take for hypophosphatemia to resolve?
In most cases, hypophosphatemia resolved within three months . High blood pressure was reported in 4% of people in clinical trials; transient elevations with symptoms such as facial flushing, dizziness, and nausea were observed in 6%. Usually occurs immediately after the injection and resolves within 30 minutes.
What are the side effects of phosphorus?
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Nausea, high blood pressure, flushing, dizziness, low levels of phosphorous in the blood , and injection site reactions are the most common side effects reported.
Can injectafer be used in children?
Monitor patients. The safety of Injectafer has not been established in children. An overdosage of Injectafer may lead to hemosiderosis; symptoms include multiple joint disorder, walking disability, and asthenia (weakness or lack of energy). Iron injections have been associated with allergic reactions.
What is an Injectafer Infusion?
Injectafer, also known as ferric carboxymaltose, is a prescription drug prescribed as a treatment for people with anemia or a low red blood cell count due to low iron levels. The drug is given intravenously to patients who have not responded to oral iron supplements.
What to Expect After an Injectafer Infusion
The drug’s website notes that Injectafer is often given at an infusion center. It’s given in two doses at least seven days apart. Once the infusion is administered, patients are monitored for 30 minutes to ensure they don’t experience an allergic reaction.
Injectafer Infusion Side Effects
According to Pittsburgh’s Hillman Medical Center, Injectafer side effects may include flushing, dizziness, nausea, dangerously high blood pressure and low phosphorus levels.
Injectafer Lawsuits
The Daily Hornet reports that drugmaker Daiichi Sankyo failed to warn patients about the risk of low phosphorus when the drug was approved by the U.S. Food and Drug Administration (FDA) in 2013.
Free Injectafer Harmful Side Effects Lawsuit Evaluation
Those who have been diagnosed with or who have experienced the following adverse effects due to Injectafer injections may qualify for this investigation.