How effective is simvastatin for lowering blood pressure?
The BP-lowering effect was found only in patients with hypertension at baseline (n = 57); in these patients, mean SBP decreased by 7.2 (2.44) mm Hg (change, -4.8%; P < 0.005 vs baseline) and DBP decreased by 4.8 (1.29) mm Hg (change, -5.6%; P < 0.001 vs baseline). Also in the simvastatin group, 26 patients (22.6%) achieved their target SBP/DBP.
What medications should I know about simvastatin before taking it?
HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir. Before you start taking simvastatin, tell your doctor if you are already using any of these other medicines:
What medications are added to other medications to treat high blood pressure?
Diuretics are added to other blood pressure medications. For instance, if the person with high blood pressure also retains fluid, a diuretic may be added. ACE inhibitors or angiotensin receptor blockers are often effective when combined with other classes of medications. Sometimes, a beta-blocker is combined with an alpha-blocker.
What is simvastatin used for?
What is simvastatin? Simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).
What are the drugs that can be used in combination with thiazide diuretics for the management of hypertension?
POTASSIUM-SPARING AND THIAZIDE DIURETICS Fixed-dose potassium-sparing–thiazide diuretic combinations have been in use for more than 20 years. Current combinations include spironolactone-hydrochlorothiazide (Aldactazide), triamterene-hydrochlorothiazide (Dyazide, Maxzide) and amiloride-hydrochlorothiazide (Moduretic).
What medication is combined with hydrochlorothiazide?
Lisinopril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries.
What is the best combination of blood pressure meds?
ACE inhibitors or angiotensin receptor blockers are often effective when combined with other classes of medications. Sometimes, a beta-blocker is combined with an alpha-blocker. This may be useful for men who have hypertension and an enlarged prostate. The alpha-blocker may help both problems at the same time.
What is the triple pill for high blood pressure?
This drug, nicknamed the “triple pill” by the investigators, combines low doses of three existing drugs for blood pressure. Namely, these are: telmisartan (20 milligrams), amlodipine (2.5 milligrams), and chlorthalidone (12.5 milligrams).
What supplement is often prescribed with hydrochlorothiazide?
People taking thiazide diuretics should be monitored by their prescribing doctor, who will prescribe potassium supplements if needed. Such supplementation is particularly critical before surgery in patients with a history of heart disease.
Why are atenolol and hydrochlorothiazide prescribed together?
Atenolol is used alone or together with other medicines (such as hydrochlorothiazide) to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.
What is the first drug of choice for hypertension?
The strongest body of evidence indicates that for most patients with hypertension, thiazide diuretics are the best proven first-line treatment in reducing morbidity and mortality.
What is combined therapy for hypertension?
Combination therapy provides greater antihypertensive power than the use of high doses of monotherapy, adding several mechanisms of action that block various pathways of increased blood pressure, in addition to providing greater protection to target organs than monotherapy, and reduced potential for side effects.
Which are the drugs for 2nd line treatment of hypertension?
SubstancesAdrenergic beta-Antagonists.Angiotensin II Type 1 Receptor Blockers.Antihypertensive Agents.Calcium Channel Blockers.Diuretics.Sodium Chloride Symporter Inhibitors.
What is the safest blood pressure medicine for the elderly?
Angiotensin Receptor Blockers ARBs are considered the alternative first-line treatment for hypertension in the elderly population when a diuretic is contraindicated. In elderly hypertensive patients with diabetes or HF, ARBs are considered first-line treatment and an alternative to ACE inhibitors.
Is it normal to take 3 different blood pressure pills?
It's also quite common to take more than one type of blood pressure medication at the same time because they work in different ways. Some people will take three of four, and sometimes five or more. It can take a bit of trial and error to find which medication or combination of medications will work well for you.
Can you take 3 bp meds together?
A combination medication with lower doses could help some patients reach blood pressure goals more easily, according to researchers. People taking one blood pressure medication may reach their blood pressure goals more effectively if they instead take lower doses of three medications.
Before Taking This Medicine
You should not take this medicine if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease.Th...
How Should I Take Simvastatin?
Take simvastatin exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
What Should I Avoid While Taking Simvastatin?
Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products while taking...
Simvastatin Dosing Information
Usual Adult Dose for Prevention of Cardiovascular Disease:Usual dosage range: 5 to 40 mg orally once a day in the eveningPatients with coronary hea...
What Other Drugs Will Affect Simvastatin?
Many drugs can interact with simvastatin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you st...
What is the purpose of simvastatin?
Simvastatin is used to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people ...
What is the name of the drug that is used for hepatitis C?
hepatitis C medications - boceprevir, telaprevir; or. HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir. Before you start taking simvastatin, tell your doctor if you are already using any of these other medicines:
Can simvastatin cause birth defects?
Simvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant or planning to become pregnant. Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not consume grapefruit products while taking this medication.
Can you take simvastatin with meals?
Simvastatin is usually taken at bedtime or with an evening meal. If you take simvastatin more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results. While using simvastatin, you may need frequent blood tests at your doctor's office.
Can simvastatin cause kidney failure?
In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Can simvastatin interact with fluconazole?
fluconazole. This list is not complete and many other drugs can interact with simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Can you take simvastatin with a prescription?
Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects. Simvastatin is usually taken at bedtime or with an evening meal.
How it works
Simvastatin belongs to the drug class known as HMG-CoA reductase inhibitors, also called statins. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Strong CYP3A4 Inhibitors
These drugs block your body from breaking down simvastatin. This can lead to very high levels of the drug in your body. It can also increase side effects, including rhabdomyolysis.
Other cholesterol-lowering drugs
When used with simvastatin, some cholesterol drugs can increase side effects such as myopathy or rhabdomyolysis. If you use these drugs with simvastatin, your doctor may lower your dosage of simvastatin. Examples of these drugs include:
Calcium channel blockers and other drugs that increase risk for myopathy or rhabdomyolysis
Using simvastatin with these drugs can increase the risk of myopathy or rhabdomyolysis. Your doctor may discuss other medication options or lower your dosage of simvastatin. Examples of calcium channel blockers include:
Heart drug
Digoxin is used to treat heart failure and arrhythmias. Taking simvastatin with digoxin can increase levels of digoxin in your body. If you’re taking both drugs, your doctor may want to monitor your digoxin level more closely.
Gout drug
Colchicine is a drug used to treat gout. Using simvastatin with colchicine can increase the risk of both myopathy and rhabdomyolysis.
What is Simvastatin?
Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 219,528 Simvastatin users for its effectiveness, alternative drugs and more.
What is High blood pressure?
High blood pressure is found to be associated with 4,409 drugs and 4,602 conditions by eHealthMe.
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
How the study uses the data?
The study is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study neither.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature.
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
What is combination therapy for high blood pressure?
Combination treatment means another class of blood pressure medication is added to the first drug to increase effectiveness. Many people with mild high blood pressure respond to one medication. It may take a few tries to find the most effective drug. However, sometimes one drug cannot control high blood pressure.
How does angiotensin help lower blood pressure?
They help lower blood pressure by inhibiting the production of angiotensin in the body. Angiotensin is a hormone that causes blood vessels to constrict which can lead to increased blood pressure. Angiotensin II receptor blockers (ARBs): The ARBs block the effects of angiotensin.
What is resistant hypertension?
Resistant hypertension means blood pressure that stays high despite treatment with three different types of blood pressure medications. It's thought that about 30% of people with high blood pressure have resistant hypertension.
What are the risk factors for resistant hypertension?
Other studies suggest that people with resistant hypertension have associated risks factors such as diabetes, obstructive sleep apnea, enlargement of the heart chambers, and or chronic kidney disease.
Can you use thiazide alone?
Sometimes, using lower doses of one or more drugs in combination can minimize side effects. Thiazide diuretics may be used alone to treat hypertension. Low-dose diuretics, though, can also be used with other medications such as beta-blockers. When used in a drug combination, the diuretic has fewer side effects.
Can a diuretic be used in combination with a blood pressure medication?
When used in a drug combination, the diuretic has fewer side effects. It also boosts the blood-pressure-lowering effect of the other medication. Diuretics are added to other blood pressure medications. For instance, if the person with high blood pressure also retains fluid, a diuretic may be added.
Is combination therapy for hypertension individualized?
Combination treatment for hypertension is individualized. It gives the best possible control of blood pressure with the fewest side effects. Also, combination treatment may cost less. There may be less frequent doctor visits as the drug combination effectively manages the hypertension.
What are some examples of blood pressure medications?
Examples are spironolactone (Aldactone, Carospir) and eplerenone (Inspra). How well a drug works for you can depend on your age, sex, race, blood pressure level and overall health.
What are some examples of medications that can cause high blood pressure?
Examples include hydralazine and minoxidil. Aldosterone antagonists. These medications are often used with other drugs, such as a diuretic. Aldosterone antagonists block the hormone aldosterone, which sometimes causes salt and fluid retention, contributing to high blood pressure.
What are some examples of ACE inhibitors?
There are several ACE inhibitors available. Examples include enalapril (Vasotec, Epaned), lisinopril (Prinivil, Zestril, Qbrelis) and ramipril (Altace). Angiotensin II receptor blockers (ARBs). These drugs block the action of angiotensin, a chemical in your body that narrows your arteries and veins.
What are some examples of beta blockers?
Examples of beta blockers include metoprolol (Lopressor, Toprol-XL), nadolol (Corgard) and atenolol (Tenormin). Renin inhibitors. Renin is a substance produced by your kidneys that triggers a series of steps that increases blood pressure.
What are some examples of calcium channel blockers?
Examples of calcium channel blockers include amlodipine (Norvasc), diltiazem (Cardizem, Tiazac, others), nifedipine (Adalat CC, Procardia) and verapamil (Verelan, Calan). Beta blockers. These drugs work by blocking the effects of the hormone epinephrine, also known as adrenaline.
What are the different types of diuretics?
There are three types of diuretics: thiazide, loop and potassium-sparing. Examples of diuretics include chlorothiazide (Diuril), bumetanide (Bumex) and amiloride (Midamor). If diuretics aren't enough to lower your blood pressure, your doctor might recommend adding other blood pressure medications to your treatment.
How well do drugs work?
How well a drug works for you can depend on your age, sex, race, blood pressure level and overall health. Combining two drugs usually works better than a single drug to get your blood pressure under control. Sometimes additional medication is needed to achieve your blood pressure goal.
What is the systolic blood pressure?
According to the World Health Organization and the International Society of Hypertension, high blood pressure is defined when the systolic blood pressure is 140 mmHg (18.7 kPa) or more, and/or level of diastolic blood pressure is 90 mmHg (12.0 kPa) or more, after repeated measurements.
Is hypertension a secondary disease?
Most of the patients with hypertension have essential or primary hypertension with unknown cause, and in which the initially high blood pressure is the only manifestation of the disease. In other patients the hypertension is caused by disease of some other organs and therefore is referred to as secondary hypertension.
Is Lisinopril an ACE inhibitor?
Lisinopril is a potent ACE inhibitor, a potent antihypertensives belonging to the third generation of ACE inhibitors. It is used in treatment of hypertension and heart failure, as well as myocardial infarction and diabetic nephropathy prophylaxis (1-3). Hydrochlorothiazide is a diuretic from the group of thiazides.
How to take HCTZ?
Take HCTZ exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual.
What is HCTZ used for?
HCTZ is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. HCTZ is also used to treat high blood pressure (hypertension).
What are the side effects of HCTZ?
Get emergency medical help if you have signs of an allergic reaction to hydrochlorothiazide ( hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
What happens if you take HCTZ while pregnant?
Tell your doctor if you are pregnant or plan to become pregnant. If you take HCTZ during pregnancy, your newborn baby may develop jaundice or other problems.
How often should I take a 25 mg med?
Usual dose: 25 mg to 100 mg orally once or twice daily. Comments: -Some patients respond to intermittent therapy, (i.e., administration on alternate days or on 3 to 5 days each week). Excessive response and undesirable electrolyte imbalance are less likely to occur with intermittent dosing.
Can you drink alcohol with HCTZ?
Drinking alcohol with HCTZ can cause side effects. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids.
Can you use HCTZ if you are allergic to hydrochlorothiazide?
You should not use HCTZ if you are allergic to hydrochlorothiazide, or if you are unable to urinate. To make sure HCTZ is safe for you, tell your doctor if you have ever had: kidney disease; liver disease; gout; glaucoma; low levels of potassium or sodium in your blood; high levels of calcium in your blood;
