Treatment FAQ

what drug in breast cancer chemo treatment causes you to lose your hair

by Michael Marquardt Published 3 years ago Updated 2 years ago

Some of the chemotherapy medicines used to treat breast cancer that can cause hair loss are: Taxane chemotherapy medicines, including Taxol

Paclitaxel

Paclitaxel is used to treat various types of cancer.

(chemical name: paclitaxel), Taxotere

Docetaxel

This medication is used to treat cancer.

(chemical name: docetaxel), and Abraxane

Protein-bound paclitaxel

Protein-bound paclitaxel, also known as nanoparticle albumin–bound paclitaxel or nab-paclitaxel, is an injectable formulation of paclitaxel used to treat breast cancer, lung cancer and pancreatic cancer, among others. Paclitaxel kills cancer cells by preventing the normal breakdown of microtubules during cell division. In this formulation, paclitaxel is bonded to albumin as a delivery vehicle. It is manufactu…

(chemical name: albumin-bound or nab-paclitaxel)

Hormone (endocrine) therapy
Taking hormone therapy such as tamoxifen, anastrozole (Arimidex), exemestane (Aromasin) or letrozole (Femara) can cause hair thinning. This is usually mild and might only be for a short time. However, in some cases it can continue until treatment ends, which may be many years.

Full Answer

What medications cause hair loss in breast cancer patients?

Some hormonal therapies used to treat breast cancer can cause mild to moderate hair loss, or hair thinning, often at the frontal hairline, the middle part, or the crown of the head. These medicines include: tamoxifen, a selective estrogen receptor modulator (SERM)

Does chemotherapy for cancer cause hair loss?

More in Cancer. Hair loss is one of the more dreaded side effect of chemotherapy for cancer, but not all chemotherapy drugs have the same effect. Some medications almost always result in hair loss, whereas others cause minimal hair loss.

Can breast cancer cause hair loss?

Some women with breast cancer have developed permanent hair loss following a combination of taxanes (such as Taxol or Taxotere) and hormonal therapy, though this is rare. 6  These are not the only treatments implicated.

Does Taxol cause hair loss in breast cancer?

Some women with breast cancer have developed permanent hair loss following a combination of taxanes (such as Taxol or Taxotere) and hormonal therapy, though this is rare. There have also been a few reported cases of permanent and severe hair loss in women with breast cancer who have received a combination of FEC...

Which chemo drugs cause hair loss in breast cancer?

Some women who take the breast cancer hormone treatments tamoxifen, anastrozole, letrozole and exemestane may also experience hair thinning because of the oestrogen-lowering effect of these treatments.

Which chemotherapy drugs cause hair loss?

Chemotherapy drugs that tend to cause hair loss include:adriamycin.cyclophosphamide.dactinomycin.daunorubicin.docetaxel.doxorubicin.etoposide.fluorouracil.More items...•

Will hair grow back after anastrozole?

Anastrozole may cause hair thinning or Grade 1 alopecia because of its estrogen lowering effects; however, it is unlikely to cause complete hair loss. Hair thinning due to anastrozole usually improves after the first year of treatment, although some women may experience it for the total duration of treatment.

Is hair loss from tamoxifen permanent?

No one goes bald from Tamoxifen, but some people do experience thinning hair. Like hair thinning, a lowered libido is common postmenopause and in the setting of reduce estrogen. Some women also attribute weight gain to Tamoxifen.

Which chemo drug does not cause hair loss?

Immunotherapy drugs for cancer, at least checkpoint inhibitors, do not usually cause hair loss, though oftentimes these drugs are used along with chemotherapy.

Which medications cause the most hair loss?

List of medications that cause hair lossamphetamines.angiotensin converting enzyme (ACE) inhibitors.antidepressants, including paroxetine (Paxil), fluoxetine (Prozac), and sertraline (Zoloft)antifungal medications.antiseizure medications.beta-blockers, which doctors use to treat heart problems and glaucoma.More items...

Which is better anastrozole or tamoxifen?

The research team concluded that anastrozole is better than tamoxifen at stopping early stage breast cancer coming back after surgery. And that it caused fewer serious side effects.

What does anastrozole do to your body?

Anastrozole is a type of hormone treatment. It works by lowering the levels of oestrogen hormones in your body. It is mainly prescribed for women who have been through the menopause and have a type of cancer called hormone-dependent breast cancer.

Does anastrozole cause weight gain?

Aromatase inhibitors, which include Arimidex (anastrozole), Femara (letrozole), and Aromasin (exemestane), generally are used to treat estrogen receptor positive (ER+) breast cancer in postmenopausal women. These anti-estrogen drugs have a number of potential side effects, including weight gain.

How much weight do you gain on tamoxifen?

According to an article published in the World Journal of Clinical Oncology , women tend to gain anywhere from 2.2 to 11 pounds after breast cancer treatment.

Does tamoxifen cause GREY hair?

Tamoxifen, a widely used selective oestrogen receptor modulator, SERM, was described occasionally in medical case reports as causing grey hair repigmentation.

What are the most common side effects of tamoxifen?

Tamoxifen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:increased bone or tumor pain.pain or reddening around the tumor site.hot flashes.nausea.excessive tiredness.dizziness.depression.headache.More items...•

When Will Your Hair Grow back?

It may take several weeks after treatment for your hair to recover and begin growing again.When your hair starts to grow back, it will probably be...

Can Hair Loss Be Prevented?

No treatment exists that can guarantee your hair won't fall out during or after chemotherapy. Several treatments have been investigated as possible...

How to Make The Best of It

Your hair loss generally can't be prevented or controlled, but it can be managed. Take the following steps throughout your treatment to minimize th...

Radiation Therapy Also Can Cause Hair Loss

Radiation therapy also attacks quickly growing cells in your body, but unlike chemotherapy, it affects only the specific area where treatment is co...

How does chemotherapy work?

Chemotherapy drugs work systemically (throughout the body) by interfering with the division and growth of rapidly growing cells. While these drugs can be effective in eliminating cancer cells, they also damage normal cells that divide rapidly. This includes hair follicles (leading to hair loss), cells in the digestive tract ...

What are the names of the VEGF inhibitors?

VEGF inhibitors such as Nexavar (sorafenib) BRAF inhibitors such as Zelboraf (vemurafenib) and Tafinlar (dabrafenib) Bcr/Abl inhibitors such as Tasigna (nilotinib) and Gleevec (imatinib) Some of the hormonal therapies commonly used for breast cancer have been associated with thinning of the hair for some people.

How long does it take for hair to grow back after chemo?

Hair re-growth typically begins within three months of concluding chemotherapy. When your hair does grow back, many people find they have what's been coined " chemo curls .". If your hair was straight prior to chemotherapy, it will likely become straight again, but this process can take up to several years.

What causes hair loss?

In addition to medications, illness, surgery, or dietary changes (low-protein diets or very low-calorie diets) may lead to hair loss. Thyroid disease (either hypothyroidism or hyperthyroidism) may cause hair loss and may occur with cancer treatment (such as chemotherapy-induced hyperthyroidism or hypothyroidism, ...

Which cells are responsible for hair loss?

This includes hair follicles (leading to hair loss), cells in the digestive tract (leading to nausea and vomiting), and cells in bone marrow (leading to fewer red blood cells, white blood cells, and platelets). 2 . The keratinocytes in the hair follicle divide faster than many malignant cells, and they have a good blood supply ...

Does immunotherapy cause hair loss?

Immunotherapy drugs for cancer, at least checkpoint inhibitors, do not usually cause hair loss, though oftentimes these drugs are used along with chemotherapy. Researchers are looking at ways of harnessing the gene involved in autoimmune alopecia (hair loss such as with alopecia areata) to improve the effectiveness of chemotherapy.

Does chemo cause hair loss?

Chemo More Likely to Cause Hair Loss. Chemotherapy medications with the highest risk of causing hair loss (or at least significant hair thinning) in many people include: 4 . Alkylating agents: Cytoxan or Neosar (cyclophosphamide), Ifex (ifosfamide), Myleran or Busulfex (busulphan), Thioplex (thiotepa).

How to treat hair after chemo?

The following tips may be helpful for all hair types during treatment: 1 try not to wash your hair for about two days after chemotherapy, especially if having scalp cooling 2 use a mild, unperfumed shampoo and conditioner 3 try not to wash your hair more than twice a week 4 use warm rather than hot water 5 pat your hair dry rather than rubbing it 6 brush or comb your hair gently with a soft hairbrush or wide tooth plastic comb 7 avoid plaiting or braiding it as this may damage your hair 8 avoid using elastic bands to tie back long hair 9 avoid any hair colours and dyes, perms, relaxers and other products containing strong chemicals 10 avoid products containing alcohol, such as hairspray, which can irritate the scalp 11 avoid excessive heat from hair straighteners, hairdryers, hot brushes and heated rollers 12 massaging the scalp may help by improving the blood supply to the hair follicles 13 avoid hair extensions and weaves as these can also weaken the hair

Why is my hair thinning?

Hair thinning, poor condition or a dry and itchy scalp can also be related to poor diet, stress and drinking too much alcohol. Changes to your diet and lifestyle may help improve the condition of your hair. If you lose your hair, read our tips on looking after your scalp after hair loss . Back to top. 6.

What to do if you have long term hair loss?

Treating long-term hair loss. If hair loss after treatment persists, you may wish to ask for advice from a specialist. There are a few dermatologists (doctors who specialise in skin problems) who have a specialist interest in managing hair loss from various causes.

What to avoid when dyeing hair?

avoid any hair colours and dyes, perms, relaxers and other products containing strong chemicals. avoid products containing alcohol, such as hairspray, which can irritate the scalp. avoid excessive heat from hair straighteners, hairdryers, hot brushes and heated rollers.

Does chemotherapy cause hair fall out?

Chemotherapy drugs target rapidly dividing cells, so they damage some healthy cells as well as cancer cells. The healthy cells damaged include the cells in the hair follicles, which is why chemotherapy can make your hair fall out. As well as the hair on your head, this can also affect your body hair including eyebrows, eyelashes and pubic hair, ...

Can breast cancer cause hair loss?

Many people will lose either some or all of their hair as a result of treatment for breast cancer. People who have chemotherapy will often experience hair loss. Some other treatments may cause hair loss or thinning. If there’s a chance that you will lose your hair, your specialist, chemotherapy nurse or breast care nurse will talk to you ...

Can you lose hair from breast cancer?

Men with breast cancer having radiotherapy may lose chest hair from the part of their chest that has been treated. If you are being given radiotherapy to the head to treat secondary breast cancer in the brain, you will lose some or all of the hair from your head.

Emotional Side Effects Of Temporary Hair Loss

Patients can take steps to alleviate emotional side effects from chemotherapy-induced hair loss. Cutting long hair prior to starting chemo can make hair loss seem less dramatic. A wig, scarf or other head covering can also ease the difficult transition and protect the patients scalp.

Chemo Less Likely To Cause Hair Loss

Some chemotherapy drugs result in only minimal hair loss, though these are often combined with drugs that cause more hair loss. These include:

What Happens To Hair Growth Once Chemo Is Over

Hair regrowth after chemotherapy is often a crazy adventure with new color, texture and style for a while. We dont exactly know why, but dark hair may come in snow white, straight hair can come in curly, etc.

About Hair Loss From Treatment

Some cancer treatments may make your hair fall out completely. This may be from your head and other parts of your body. This is usually temporary. Other treatments can cause permanent hair loss in specific areas of your body. Sometimes you may not lose all your hair, but your hair can become thinner or more likely to break .

Limit Brushing And Styling

To avoid additional hair loss during the regrowth period, people should avoid:

Hair Loss During Chemotherapy

Unfortunately, one of the most effective chemo drugs for ovarian cancer does typically cause women to lose their hair

Looking After Your Scalp After Hair Loss

Remember to protect your scalp from the sun. Cover your head when in the sun or use a high protection factor sun cream at all times, as the scalp is particularly sensitive.

How long does hair grow after chemo?

They normally go through a cycle of active growth, then rest. Chemotherapy sends more of them into the rest phase (telogen), which usually lasts for 100 days. 2 .

How does chemotherapy work?

Chemotherapy drugs work by targeting rapidly dividing cells. They damage the genetic material inside cells (RNA and DNA) that guide cell division. Chemotherapy drugs cannot tell the difference between these normal, rapidly dividing cells and cancer cells, so the drug affects these cells as well. The hair follicles have a good blood supply, which ...

How to tell if you have chemo?

Other symptoms you may experience include: 8  1 Your scalp may feel itchy, tender, dry, or have increased sensitivity due to the effects of chemotherapy. A gentle cream or lotion may help. 2 Chemotherapy can make your skin more sensitive to the sun. Wear sunscreen with at least sun protection factor 30, including on your scalp, and wear a hat when outdoors. 3 You may note red or darkened skin or other pigmentation changes. 4 Your remaining hair may be dull or dry.

What are the causes of hair loss?

They are used for breast, lung, and ovarian cancer as well as blood cancers. 3 . Agents more likely to cause hair loss include Cytoxan (cyclophosphamide) and Busulfex (busulphan).

How to get rid of red spots on scalp?

A gentle cream or lotion may help. Chemotherapy can make your skin more sensitive to the sun. Wear sunscreen with at least sun protection factor 30, including on your scalp, and wear a hat when outdoors . You may note red or darkened skin or other pigmentation changes. Your remaining hair may be dull or dry.

How long after breast cancer treatment can you wear a wig?

By about six months after treatment, you may have enough hair to be able to style it. A study of people undergoing breast cancer treatment found that about half stopped wearing a wig by the one-year mark and only 15.2% still wore a wig at the two-year mark. 6 . Still, some people do not see hair regrowth.

What cells stop dividing?

Some normal cells in our bodies also rapidly divide, like hair follicle cells, the mucous membrane cells lining of the digestive tract (mouth, throat, stomach, intestines), and the blood-producing cells in the bone marrow.

by Laurie Wertich and The Look Good Feel Better Foundation

Hair loss is a dreaded side effect of chemotherapy and can be traumatic. Chemotherapy-related hair loss can affect your scalp as well as your eyebrows, eyelashes, and body.

Why does chemotherapy cause hair loss?

Chemotherapy damages rapidly dividing cells, such as cancer cells. Some healthy cells also divide rapidly, such as hair follicles. Chemotherapy damages these cells, leading to hair loss, also called alopecia.

When does hair loss begin and what will happen?

Hair loss will typically begin two or three weeks after your first treatment. In addition to hair on your head, you may lose eyebrows, eyelashes, facial hair, pubic hair, underarm hair and leg hair. The amount of hair that you lose will depend on the type of chemotherapy drug you are taking.

What can be done to cope with hair loss?

Importantly, you should remember that hair loss associated with chemotherapy is temporary and the hair WILL grow back. In the meantime, here are a few tips to help you cope with the loss:

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Dr. Denise Yardley from the Sarah Cannon Research Institute talks about the difficulties of hair loss

Hair loss, I think, is very powerful – and I think the issue with patients who are facing a diagnosis of breast cancer, they realize loss of hair is not life threatening like a diagnosis of breast cancer, but when I talk to patients it is the most visible part of their therapy.

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Mechanism of action

Causes

Overview

  • Hair loss often begins around the time of your second chemotherapy infusion, though this varies widely. It may start slowly, but increases rapidly around 1 month to 2 months after starting treatment. Some people do not lose all of their hair until they have nearly completed chemotherapy. Hair re-growth typically begins within 3 months of concluding chemotherapy. Wh…
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Side effects

  • Some women with breast cancer have developed permanent hair loss following a combination of taxanes (such as Taxol or Taxotere) and hormonal therapy, though this is rare. There have also been a few reported cases of permanent and severe hair loss in women with breast cancer who have received a combination of FEC (fluorouracil/epirubicin/cyclophosphamide) with docetaxel.
See more on verywellhealth.com

Prevention

  • Some techniques have been tried to prevent or reduce hair loss (see below). For those who are interested, it may sometimes be possible to prevent hair loss from chemotherapy. It's important to keep in mind that hair loss may occur all over your body. This includes eyelashes, eyebrows, pubic hair, and more. While women may appreciate a reprieve from shaving their legs (and men, their f…
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Clinical significance

  • There are a number of chemotherapy agents used in breast cancermany of them used in combination. Common regimens for adjuvant treatment such as Cytoxan and Adriamycin followed by Taxol are usually associated with hair loss.
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Treatment

  • Some chemotherapy drugs result in only minimal hair loss, though these are often combined with drugs that cause more hair loss. These include: Some of the targeted therapies that have been linked with hair changes include: There are a number of non-cancer related medications that are associated with hair loss, that might accentuate the effects of chemotherapy drugs if used in co…
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Symptoms

  • The newer targeted therapies for cancer don't usually cause total hair loss like chemotherapy drugs, but can result in changes such as thinning of the hair and dryness, as well as changes in texture similar to the chemo curls noted above. Some targeted therapies may also affect the pigmentation of hair, often causing the hair to become darker.
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Adverse effects

  • In addition to medications, illness, surgery, or dietary changes (low protein diets or very low calorie diets) may lead to hair loss. Thyroid disease (either hypothyroidism or hyperthyroidism) may cause hair loss, and may occur with cancer treatment (such as chemotherapy-induced hyperthyroidism or hypothyroidism which is very common with immunotherapy).
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Cost

  • Scalp cooling units can reduce roughly 50 percent of hair loss, but comes with a price. Many infusion centers do not have these units and therefore you may have to rent a cooling device, and depending on the device, this can be fairly pricey.
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Management

  • Medications such as Rogaine (minoxidil) have also been tried, but are not very effective in reducing hair loss.
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Risks

  • It can be very emotional coping with the hair loss you experience during chemotherapy. Even though this complication is more of a nuisance, it remains one of the most feared side effects. Many oncologists recommend that you purchase a wig, hats, or scarves before beginning chemotherapy. All or a portion of the cost of a wig may be covered by your insurance. To have it …
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