Second-line treatment is treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren't tolerated. It's important to understand "lines of treatment" and how they differ from first line treatment and can play a role in clinical trials.
What is second-line treatment?
second-line drug. Any therapeutic agent that is not the drug of choice, or the 1 st normally used to treat a particular condition; in rheumatoid arthritis, 2 nd-line agents are used when standard 'first-line' therapy–ie, anti-inflammatory agents and corticosteroids fail.
What is the difference between first line and second line therapy?
May 08, 2014 · Definition: Treatment which is given when the initial treatment (also known as first-line therapy or primary therapy) for a disease, disorder or symptom is not effective (does not work, stops working or causes too many negative side effects). This includes treatment for recurring diseases or disorders even many years after initial diagnosis and ...
What does 2nd Line mean in rheumatology?
Second-line therapies are those tried when the first ones do not work adequately. The management of a cancer case requires regular evaluation of treatment and adjustment as needed. A break with the primary treatment and an adoption of a …
What is another name for first-line treatment?
Meaning of SECOND LINE. What does SECOND LINE mean? Information and translations of SECOND LINE in the most comprehensive dictionary definitions resource on the web. ... not a first line of treatment in most cases, it's not a second line of treatment, and maybe not a third line of treatment. Brenard Adams: We have still got a lot of rebuilding ...
What is the difference between first line and second-line drugs?
Your first-line treatment may not work, may start but then stop working, or may cause serious side effects. Your doctor may then suggest a second-line treatment, also called second-line therapy. It is a different treatment that is likely to be effective.
What is second and third line treatment?
Listen to pronunciation. (... THAYR-uh-pee) Treatment that is given when both initial treatment (first-line therapy) and subsequent treatment (second-line therapy) don't work, or stop working.
What does lines of treatment mean?
“Lines of therapy” is the term used to describe the order in which different therapies are given to people as their disease progresses.May 5, 2021
What does 1st line treatment mean?
The first treatment given for a disease. It is often part of a standard set of treatments, such as surgery followed by chemotherapy and radiation. When used by itself, first-line therapy is the one accepted as the best treatment.
How effective is second line chemotherapy?
In three phase III randomised trials of 5-FU-based first-line therapy enrolling a total of 1080 patients, 20% of them went on to receive second-line chemotherapy, with a response rate observed as 13.3% (95% CI, 6.8–22.5%), and a median survival from starting second-line therapy of 5.6 months (Chau et al, 2004a).
What is a second line antibiotic?
Antibiotics were classified as “first-line” (amoxicillin, TMP-SMX, or erythromycin) or “second-line” (clarithromycin, azithromycin, amoxicillin-clavulanate, cephalosporin, or fluoroquinolone).
Is chemo worse the second time around?
Don't plan your chemo response until you've gone through your first infusion. The effects of chemo are cumulative. They get worse with each cycle.
What are the signs that chemo is working?
How Can We Tell if Chemotherapy is Working?A lump or tumor involving some lymph nodes can be felt and measured externally by physical examination.Some internal cancer tumors will show up on an x-ray or CT scan and can be measured with a ruler.Blood tests, including those that measure organ function can be performed.More items...
Can all cancers be treated with the same radiation?
Most types of radiation therapy don't reach all parts of the body, which means they're not helpful in treating cancer that has spread to many places within the body. Still, radiation therapy can be used to treat many types of cancer either alone or in combination with other treatments.Dec 27, 2019
How long does it take for a tumor to shrink after radiation?
For tumors that divide slowly, the mass may shrink over a long, extended period after radiation stops. The median time for a prostate cancer to shrink is about 18 months (some quicker, some slower).
How do you treat lymphoma without chemo?
Other options for DLBCL that is no longer responding to chemo might include some type of immunotherapy (such as CAR T-cell therapy or a monoclonal antibody) or a targeted therapy drug such as selinexor (Xpovio). Clinical trials of new treatments may be another good option for some people.Sep 15, 2021
How long does it take for chemo to shrink tumors?
In general, chemotherapy can take about 3 to 6 months to complete. It may take more or less time, depending on the type of chemo and the stage of your condition.Apr 13, 2021
What is a second line drug?
second-line drug. Any therapeutic agent that is not the drug of choice, or the 1 st normally used to treat a particular condition ; in rheumatoid arthritis, 2 nd-line agents are used when standard 'first-line' therapy–ie, anti-inflammatory agents and corticosteroids fail.
How many people need a second line drug?
More than half of patients nationwide (60 per cent) who need a second-line drug are prescribed one of these two drugs, the study found. Drugs prescribed for type 2 diabetes linked to higher risk of heart disease. Although the patient with recurrent glioblastoma has multiple choices of therapy, the 5-year survival rate is still less than 5%, ...
Is Duo Cotexcin a second line drug?
The head of the National Malaria Control Programme, Dr Waqo Ejersa, said the prescribed drug was only limited to a particular batch that failed to meet quality specifications as laid-down in the ministry and World Health Organization guidelines."Duo-Cotexcin is normally used as a second-line drug in the treatment of malaria in the country.
Identifying and definitional attributes
Treatment which is given when the initial treatment (also known as first-line therapy or primary therapy) for a disease, disorder or symptom is not effective (does not work, stops working or causes too many negative side effects).
Relational attributes
Person with cancer—reason (s) second-line treatment administered Health, Standard 08/05/2014
What is second line therapy?
Second-line therapies are those tried when the first ones do not work adequately. The management of a cancer case requires regular evaluation of treatment and adjustment as needed. A break with the primary treatment and an adoption of a new regimen signals “second-line treatment.”.
What is the first line of treatment?
First line therapy is the treatment regimen or regimens that are generally accepted by the medical establishment for initial treatment of a given type and stage of cancer. It is also called primary treatment or therapy. The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the first assault of chemotherapy drugs on the malignancy.
What is the intent of first line therapy?
The intent of first-line therapy is to cure the cancer if possible. Also called induction therapy, this primary therapy is the first assault of chemotherapy drugs on the malignancy.
Is salvage therapy considered third line therapy?
The terms “third-line therapy ” and even “fourth-line therapy” are occasionally used for subsequent treatment, but salvage therapy is also used. Written guidelines rarely specify anything beyond second-line therapy. The same treatments can be used for subsequent treatment.
Can a first line therapy be approved for second line therapy?
Sometimes first-line therapies show progress for a period of time followed by a stalling or continued growth of the cancer. Often the FDA will specifically approve a new drug for second-line therapy. This labeling is common for new drugs that treat cancers which already have accepted treatments.
Is there a law on first line therapy?
There is no law, or even a community of practice rule, that doctors must use the accepted first-line therapy for a patient, ...
Is there a law that states that doctors must use first line therapy?
There is no law, or even a community of practice rule, that doctors must use the accepted first-line therapy for a patient, although when they do they “cover their backsides” to some extent and reduce their exposure to malpractice suits. Second-line therapies are those tried when the first ones do not work adequately.
What are the best asthma medications?
These medicines are well accepted by the medical community. For asthma, they include systemic corticosteroids like Flovent, Asmanex, and Qvar. They include combination inhalers like Advair, Symbicort, Dulera, and Breo. These medicines are the first choices doctors will prescribe when trying to help you obtain better asthma control.
What makes a drug first line?
What makes a drug first-line? These are the medicines doctors first resort to for a given disease (the doctors first choice try). They are the most commonly prescribed medicines for a particular disease. These medicines are well accepted by the medical community. For asthma, they include systemic corticosteroids like Flovent, Asmanex, and Qvar.
Is albuterol safe for asthma?
They have both been well studied. They are proven safe and effective for asthma. Albuterol ends asthma attacks and Advair prevents them. Side effects are minimal. You can tolerate or easily treat side effects if they occur. Side effects to albuterol and Advair are considered negligible.
Can albuterol cause thrush?
Both medicines may cause tremors, but it’s often considered a good trade-off for being able to breathe. Advair may cause thrush. But, it’s both preventable by rinsing and treatable. It’s cost effective.
Is Atrovent a first line asthma medicine?
Atrovent was once-upon-a-time considered a first-line asthma medicine. It fit all the qualifications of one. But, subsequent studies did not show it benefited most asthmatics. Studies do show, however, that it does help most COPDers. So, it remains a first-line treatment for COPD.
Does Advair keep you awake?
It opened airways and kept them open. But, it also had some unwanted side effects, such as it kept you awake, like coffee does . The advent of combination inhalers like Advair made it so most asthmatics could be weaned off theophylline. This helped to relegate Advair to first-line status.
Do corticosteroids work for asthma?
There’s a greater risk for side effects. Systemic corticosteroids fit nicely into this category. They work great for ending asthma attacks and controlling asthma. But, the risk for side effects is too great. So, they sit as second-line treatments ready to be prescribed if and when needed. It’s not cost effective.
Are we missing a good definition for SECOND LINE? Don't keep it to yourself..
The ASL fingerspelling provided here is most commonly used for proper names of people and places; it is also used in some languages for concepts for which no sign is available at that moment.
Definitions & Translations
Get instant definitions for any word that hits you anywhere on the web!
Why are risk owners important?
These considerations are important because risk owners constitute the second line of defense. Risk owners must do three things: First, they must decide on the risk responses to implement. While they may obtain approval from executive management, the risk response strategy is theirs, and they accept it as their own.
Why is the tone of the organization important in implementing risk management?
When it comes to the second line of defense, the tone of the organization is very important. Implementing a risk management framework requires the identification of risk owners because without them, no one is accountable for managing risk. Resolution of the ownership question for critical risks is a key task in implementing risk management.
What is risk owner?
Risk owners include business unit managers and process owners. As they assume primary accountability for identifying, prioritizing, sourcing, and managing and monitoring risks, they constitute the second line of defense. As the principal owners of risk, they set objectives, establish risk responses, train personnel and reinforce risk response ...
What happens if a company's deficiencies are noted?
If deficiencies are noted, they fix them on a timely basis. With respect to building and executing risk management capabilities, risk owners may elect to outsource these responsibilities. In doing so, their ownership of risk is not compromised as long as they continue to decide, design and monitor.
What is the difference between first line and second line?
In contrast, second-line treatments are used when the first-line treatment failed to improve a cancer, or if it worked for a while and then the cancer progressed, and tend to be less effective.
What are complementary treatments for cancer?
In this setting, therapies such as acupuncture, meditation, massage, and yoga are used in an integrative fashion—that is, they are used along with traditional treatments such as chemotherapy. These complementary treatments may help some people cope with the side effects of cancer and cancer treatments.
What is alternative treatment?
In this setting, therapies such as acupuncture, meditation, massage, and yoga are used in an integrative fashion—that is, they are used along with traditional treatments such as chemotherapy. These complementary treatments may help some people cope with the side effects of cancer and cancer treatments.
What is the first line of treatment for lung cancer?
First-line treatment is usually the standard treatment (the "gold standard") given when someone is diagnosed with a particular disease or condition , such as lung cancer. In other words, it is likely the treatment most oncologists would first choose in treating someone. That said, there are no general "rules" stating which treatment has to absolutely come first, and in addition to that, it's important to work with your oncologist to choose the treatment that is best for you as an individual. Only you can be your own advocate and select the treatments which offer you the best outcome while minimizing the side effects you are willing to tolerate.
What is first line treatment?
First-line treatment or therapy simply refers to the initial, or first treatment recommended for a disease or illness. This may also be referred to as primary treatment, initial treatment, or induction therapy. With many conditions, including cancer, there are many possible treatments that could be effective.
Is second line treatment the same as first line?
In contrast to first-line treatment, second-line treatment is usually a treatment which is chosen after first-line treatment has failed to achieve the goal (either it doesn't work or all, or it works for a period of time and then stops working), or has side effects requiring you to stop using that treatment. Second-line treatments are often inferior to first-line treatments but not always. For example, with metastatic breast cancer, second-line therapy tends not to control the cancer for as long a period of time as first-line therapy. In some cases, there are two treatments (or more) that may offer very similar results (and have similar side effects), and second-line treatment may be equally effective to first-line therapy.
Is neoadjuvant therapy considered a first line treatment?
Neoadjuvant therapy, chemotherapy given before surgery to reduce the size of a tumor, or adjuvant therapy, given after surgery to reduce the risk of recurrence, are considered components of first-line therapy in this setting. First-Line vs. Second-Line Treatment. In contrast to first-line treatment, second-line treatment is usually ...
What is a line of therapy for multiple myeloma?
What is a "Line" of Therapy in Multiple Myeloma? Many myeloma clinic al trials include approval criteria based on the number of "lines" of therapy a patient has already received. For example, daratumumab is now approved for patients who have received one prior line of therapy. Other clinical trials require a patient to have over three lines ...
What does it mean to start a new combination of myeloma?
Starting a new combination or myeloma treatment if you have stopped all drugs in the prior line of treatment. The unplanned addition or substitution of one or more drugs in the existing regimen.
Lines of Treatment
The Option of Clinical Trials
- Understanding line of treatment becomes very important when looking at clinical trialsfor cancer. Some clinical trials require that people have no previous treatments, whereas others are designed for people who have had inadequate results with a previous treatment. For example, one clinical trial may require the treatment to be used as a first line therapy, whereas another may only be en…
Questions to Ask About Second-Line Treatments
- Since the failure of a first treatment can leave you feeling overwhelmed and anxious, having a list of questions to ask your healthcare provider (as well as a friend to attend the visit with you) can be very helpful. 1. How effective is the second-line treatment, and how does it compare to the treatment you had previously? 2. What are the possible side effects of the treatment? 3. What ha…
Example
- An example of the importance of defining lines of treatment is a 2019 study that compared different second-line treatments for lung cancer. Since there are a number of different options, and many studies look at the effectiveness of first line therapies, this can give important information to oncologists. For example, the second line chemotherapy drug Taxotere (docetax…
Coping
- Thinking about and making decisions about second-line treatment can be heartwrenching. It's hard enough the first time around, but at this point many people are exhausted and it's easy to get discouraged. Reach out to people in your support network, and don't be afraid to share your fears. Certainly, not every friend will be comfortable with this, but choose at least a friend or two with …
What Makes A Drug first-line?
What Makes A Drug Second-Line?
- These are your medicines that are less commonly prescribed for a particular disease. But, they are available as options when first-line treatments alone are not working.
What Causes A Drug to Change First-Line Or Second-Line Status?
- Or what causes first-line medicines to become the second-line? What causes second-line drugs to become first-line? Once again, I’m going to make an educated guess here. 1. Studies show it’s not as beneficial as once thought. Muscarinicsare a good example here. Atrovent was once-upon-a-time considered a first-line asthma medicine. It fit all the qualifications of one. But, subsequent …
What to Make of this?
- So, these are just some examples of what makes a drug first-line or second-line? There may be other reasons overlooked here. Still, this should give you a pretty good idea of why that Advair inhaler is first-line and why Singular is second-line.