Treatment FAQ

the treatment of autism with low-dose phenytoin: a case report. what is the intent of the article

by Russ Kunze Published 2 years ago Updated 2 years ago

What is the treatment for phenytoin toxicity?

Sep 22, 2020 · Background: The pharmacological treatment for autism spectrum disorders is often poorly tolerated and has traditionally targeted associated conditions, with limited benefit for the core social deficits. We describe the novel use of a cannabidiol-based extract that incidentally improved core social deficits and overall functioning in a patient with autism spectrum …

Is Phenytoin an anti-seizure drug?

Jan 08, 2021 · Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by markedly impaired social interaction, impaired communication, and restricted/repetitive patterns of behavior, interests, and activities. 1 In addition to challenges caused by core symptoms of the disorder, maladaptive behaviors such as aggression can be associated with …

Can phenytoin be used to treat bipolar disorder in children?

Jan 28, 2016 · Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a lack of social interaction, verbal and nonverbal communication in the first 3 years of life. The distinctive social behaviors include an avoidance of eye contact, problems with emotional control or understanding the emotions of others, and a markedly ...

Which medications are used to treat irritability in children with autism spectrum disorder?

Sep 10, 2010 · Combination treatment was discontinued due to pancreatitis in one child and steatohepatitis in another. Thus it seems that combination treatment of an AED with another AED, or lithium, or an atypical antipsychotic, is more efficacious than treatment with one AED alone. However, the incidence of side effects is also higher.

Does methylphenidate help with autism?

Smaller placebo-controlled studies have shown benefits of methylphenidate for hyperactivity in children with autism spectrum disorder, but effects have been modest and side effects are concerning, especially at higher doses.89-91More studies examining the effects of this medication on core symptoms of autism are needed.

Can antidepressants be used for autism?

Antidepressants have been considered for use in autism spectrum disorder due to the observed symptoms of repetitive, ritualistic behaviors and insistence on restricted patterns of routines. Selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and other antidepressants have been studied in patients with autism spectrum disorders.

What is ABA therapy?

Applied behavior analysis (ABA) is a treatment based on theories of learning and operant conditioning. It includes specific intervention targets, coupled with positive reinforcement (verbal praise, tokens, or edible rewards), with repetition of learning-trials a key component. 10 It was postulated that early, intensive ABA intervention might lead to remarkable outcomes, including almost half of the children receiving this treatment gaining significant IQ points and being mainstreamed into regular classes. 11 Many of the earlier studies lacked methodological rigor, and replication with randomized controlled trials was needed to support such claims. One proposed early intensive ABA therapy model, the Early Start Denver Model, showed significant cognitive and adaptive behavior gains over the course of 2 years in a randomized, controlled trial of 48 preschool-aged children. 12 A meta-analysis examining the efficacy of ABA interventions for young children with autism showed medium to large positive effects on intellectual functioning, language development, daily living skills acquisition, and social functioning, with the larger effect sizes observed on language-related outcomes. 13

What are the symptoms of autism?

Targeted associated symptoms may include, but are not limited to, irritability, aggression, self-injurious behaviors, anxiety, hyperactivity, impulsivity, inattention, and insomnia.

Is aripiprazole approved for autism?

Risperidone and aripiprazole are approved by the Food and Drug Administration (FDA) for the treatment of irritability associated with the diagnosis of autism spectrum disorder. Risperidone is approved in children at least 5 years of age and aripiprazole is approved for children at least 6 years of age.

What are the side effects of quetiapine?

The most commonly observed side effects included vomiting and somnolence. Quetiapine. Several small, open-label studies have examined the efficacy of quetiapine in children and adolescents with autism spectrum disorder.

What is selective serotonin reuptake inhibitor?

Selective Serotonin Reuptake Inhibitors (SSRIs) Studies examining the efficacy of SSRIs in autism spectrum disorder have had mixed results.

What is the treatment for ASD?

A notable treatment approach for people with ASD is called applied behavior analysis (ABA). ABA has become widely accepted among healthcare professionals and used in many schools and treatment clinics. ABA encourages positive behaviors and discourages negative behaviors to improve a variety of skills.

What is the autism treatment network?

(ATN) seeks to create standards of medical treatment that will be made broadly available to physicians, researchers, parents, policymakers, and others who want to improve the care of individuals with autism.

What are the different types of treatment?

The types of treatments generally can be broken down into the following categories: 1 Behavior and Communication Approaches 2 Dietary Approaches 3 Medication 4 Complementary and Alternative Medicine

How to tell if a child has ASD?

In those cases, a thorough physical examination is needed.

What is ABA in healthcare?

ABA has become widely accepted among healthcare professionals and used in many schools and treatment clinics. ABA encourages positive behaviors and discourages negative behaviors to improve a variety of skills. The child’s progress is tracked and measured. There are different types of ABA.

What is DTT in psychology?

DTT is a style of teaching that uses a series of trials to teach each step of a desired behavior or response. Lessons are broken down into their simplest parts, and positive reinforcement is used to reward correct answers and behaviors. Incorrect answers are ignored. Early Intensive Behavioral Intervention (EIBI)

What is EIBI in ABA?

Incorrect answers are ignored. Early Intensive Behavioral Intervention (EIBI) This is a type of ABA for very young children with ASD, usually younger than 5 and often younger than 3.

What is the role of speech pathologists?

Speech-language pathologists play a critical role in screening, assessing, diagnosing, and treating the language and social communication disorders of individuals with autism spectrum disorders (ASD).

What type of communication does Tait use?

He is a multimodal communicator whose verbal communication is not understood by most people. He uses a Palm 3 (Dynavox Technologies), pictures, idiosyncratic signs, gestures, and some words to communicate.

How did Anderson communicate?

Anderson communicated through nonverbal means and used communication solely for behavioral regulation. He communicated requests primarily by reaching for the communication partner’s hand and placing it on the desired object. When cued, he used an approximation of the “more” sign when grabbing the hand along with a verbal production of /m/.

What were Tait's strengths?

Tait’s strengths in the area of social communication included engaging in reciprocal interactions, sharing attention to regulate the behavior of others, and using several modes of communication. His needs in social communication included sharing a range of emotions with symbols and sharing intentions for joint attention by commenting on objects, actions, events, or requesting information across partners and contexts.

What is SAP in education?

It enables providers to select educational objectives that are predictive of gains in language acquisition and social adaptive functioning (Prizant et al., 2005). Sam’s educational team selected objectives shown to predict an individual’s symbolic growth, such as increasing his rate of spontaneous communication and his range of communicative functions. The team worked to move him beyond requesting objects to requesting specific people and actions. The SAP also facilitated the selection of evidence-based supports such as AAC when developing educational accommodations to address these objectives.

How old is Tait?

Tait is a 12-year-old boy who was diagnosed with ASD at age 2. Tait is generally healthy although he has recently been diagnosed with rheumatoid arthritis and is sensitive to pain. He has difficulty with small spaces and “bottlenecks” where many people are congregated. Tait participates in special education at a local elementary school. His strengths include being curious, social, and visually astute. His challenges include communication, impulsivity, and behavior that may include tantrums, aggression, and property destruction. These challenges have made it difficult for Tait to participate in activities with peers.

What was Jaymes Lesovoy's diagnosis?

He hit and bit his parents, and he tore apart his and his sisters’ toys. At 18 months of age, he was diagnosed with autism. Jaymes’ pediatrician suggested behavioral and speech therapy, but neither approach reined in the boy’s aggression. In 2006, when Jaymes was 2, ...

Does aripiprazole cause tardive dyskinesia?

But a decade’s worth of data suggest that is untrue. As with many antipsychotic medications, long-term use of aripiprazole can lead to tardive dyskinesia, as it did for Jaymes.

How much did Bristol Myers Squibb settle?

Bristol-Myers Squibb also settled a 2016 suit for $19.5 million that alleged it had marketed the drug for off-label use — that is, for conditions the drug was not approved to treat. In 2016, the FDA compelled Otsuka and Bristol-Myers Squibb to update the drug’s warning labels.

Types of Treatments

Behavioral Approaches

  • Behavioral approaches focus on changing behaviors by understanding what happens before and after the behavior. Behavioral approaches have the most evidence for treating symptoms of ASD. They have become widely accepted among educators and healthcare professionals and are used in many schools and treatment clinics. A notable behavioral treatment for people with ASD is cal…
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Developmental Approaches

  • Developmental approaches focus on improving specific developmental skills, such as language skills or physical skills, or a broader range of interconnected developmental abilities. Developmental approaches are often combined with behavioral approaches. The most common developmental therapy for people with ASD is Speech and Language Therapy. Speech and Lang…
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Educational Approaches

  • Educational treatments are given in a classroom setting. One type of educational approach is the Treatment and Education of Autistic and Related Communication-Handicapped Children (TEACCH)approach. TEACCH is based on the idea that people with autism thrive on consistency and visual learning. It provides teachers with ways to adjust the classroom st...
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Social-Relational Approaches

  • Social-relational treatments focus on improving social skills and building emotional bonds. Some social-relational approaches involve parents or peer mentors. 1. The Developmental, Individual Differences, Relationship-Based model (also called “Floor time”) encourages parents and therapists to follow the interests of the individual to expand opportunities for communication. 2…
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Pharmacological Approaches

  • There are no medicationsthat treat the core symptoms of ASD. Some medications treat co-occurring symptoms that can help people with ASD function better. For example, medication might help manage high energy levels, inability to focus, or self-harming behavior, such as head banging or hand biting. Medication can also help manage co-occurring psychological conditions…
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Psychological Approaches

  • Psychological approaches can help people with ASD cope with anxiety, depression, and other mental health issues. Cognitive-Behavior Therapy(CBT) is one psychological approach that focuses on learning the connections between thoughts, feelings, and behaviors. During CBT, a therapist and the individual work together to identify goals and then change how the person thin…
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Complementary and Alternative Treatments

  • Some individuals and parents use treatments that do not fit into any of the other categories. These treatments are known as Complementaryand Alternativetreatments. Complementary and alternative treatments are often used to supplement more traditional approaches. They might include special diets, herbal supplements, chiropractic care, animal therapy, arts therapy, mindfu…
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For More Information You Can Visit

  • American Academy of Pediatrics Council on Children with Disabilities: https://pediatrics.aappublications.org/content/145/1/e20193447external icon Autism Society: https://www.autism-society.org/living-with-autism/treatment-options/external icon Autism Speaks: https://www.autismspeaks.org/treatments-autismexternal icon Interagency Autism Coordinatin…
See more on cdc.gov

References

  • Hyman, S.L., Levy, S.E., Myers, S.M., & AAP Council on Children with Disabilities, Section on developmental and behavioral pediatrics. (2020). Identification, evaluation, and  management of childre...
See more on cdc.gov

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