Your doctor may decide to stop Vectibix® treatment. Being in the sun may make skin reactions worse. Wear sunscreen and protective clothing (such as a hat) and avoid direct sunlight while you are on treatment with Vectibix®. Tell your doctor if you have new or worsening skin reactions.
Full Answer
What should I know about Vectibix® before using it?
Take care of your skin while Vectibix ® takes control of your mCRC. In clinical studies, 90% of patients using Vectibix ® experienced some form of skin rash or other skin reactions. Severe or life-threatening skin reactions have been reported. 1
How often can you have Vectibix chemotherapy?
Wear sunscreen and protective clothing (such as a hat) and avoid direct sunlight while you are on treatment with Vectibix®. Tell your doctor if you have new or worsening skin reactions. Inflammation of the eye and injury to the cornea have been reported. Tell your doctor if you have any vision changes or eye problems.
What should I avoid while taking Vectibix®?
In patients who received Vectibix ® + FOLFOX, the most commonly reported side effects (experienced by 20% or more of patients) were diarrhea, sore mouth, inflammation of mucous membranes, weakness, infection of the nail beds, loss of appetite, low magnesium, low potassium, rash, acne-like skin rash, itching, and dry skin. The most common serious side …
Can you take Vectibix if you have a RAS mutation?
Sep 13, 2021 · Use a thick, alcohol-free emollient lotion or cream on your skin at least twice a day, including right after bathing. Avoid sun exposure, as it can worsen the rash or cause a severe burn. Use sunscreen with an SPF of 30 or higher and wear a hat and sunglasses to protect your head and face from the sun.
How do you treat Vectibix rash?
For treatment in patients who have already developed grade 1/2 rash, a similar approach, using topical corticosteroids (hydrocortisone 2.5%, alclometasone) and oral antibiotics (minocycline, doxycycline, or antibiotics covering skin flora) twice daily for at least 4 weeks is suggested.May 15, 2013
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Does vectibix cause rash?
In patients who received Vectibix® alone, the most commonly reported side effects (experienced by 20% or more of patients) were different types of skin rash, infections at the side of the nail beds of the fingers or toes, fatigue (extreme tiredness), nausea, and diarrhea.
What is vectibix for?
Vectibix® (panitumumab) is for treating patients with wild-type RAS metastatic colorectal cancer (cancer that has spread outside of the colon and rectum). RAS status is determined by an FDA-approved test. Wild-type RAS is a cancer without mutations in the KRAS and NRAS genes.
Can Vectibix be used for tumors?
Vectibix® is not to be used to treat patients with tumors that have mutations in the RAS gene (called RAS mutant), or when the RAS mutation status is unknown. Talk to your doctor about your RAS status.
What is vectibix for?
Vectibix® (panitumumab) is for treating patients with wild-type RAS metastatic colorectal cancer (cancer that has spread outside of the colon and rectum). RAS status is determined by an FDA-approved test. Wild-type RAS is a cancer without mutations in the KRAS and NRAS genes.
Can Vectibix be used for tumors?
Vectibix® is not to be used to treat patients with tumors that have mutations in the RAS gene (called RAS mutant), or when the RAS mutation status is unknown. Talk to your doctor about your RAS status.
What is Folfox used for?
About half of the patients were given Vectibix® plus a treatment called FOLFOX, a drug combination that can be used to treat metastatic colorectal cancer , and about half were given FOLFOX alone 1. The study included patients with wild-type and mutant RAS metastatic colorectal cancer.
How to get rid of a scab?
Bathe/shower in cool or lukewarm (not hot) water and pat your skin dry. Use soaps, lotions and laundry detergents without alcohol, perfumes or dyes. Wear gloves to wash dishes or do housework or gardening. Drink plenty of water and try not to scratch or rub your skin.
Does panitumumab affect your eyes?
Eye Concerns: While receiving panitumumab, some patients may develop irritation or damage to the cornea (clear part covers the eyeball) or changes in your eyesight. Notify your healthcare team if you develop any eye pain, swelling, redness or any vision changes, including blurriness and sensitivity to light.
What are the side effects of panitumumab?
Less common, but important side effects can include: 1 Eye Concerns: While receiving panitumumab, some patients may develop irritation or damage to the cornea (clear part covers the eyeball) or changes in their eyesight. Notify your healthcare team if you develop any eye pain, swelling, redness, or any vision changes, including blurriness and sensitivity to light. 2 Infusion-Related Side Effects : The infusion can cause a reaction that may lead to chills, fever, or difficulty breathing. Reactions are most common during the first week of therapy, including the evening after the infusion. Your care team will tell you what to do if this happens. 3 Lung Problems: Patients can develop inflammation or scarring of the lungs (called pneumonitis or fibrosis), or interstitial lung disease while taking this medication. Notify your healthcare provider right away if you develop any new or worsening symptoms, including shortness of breath, trouble breathing, cough, or fever. 4 Electrolyte Abnormalities: This medication can affect the normal levels of electrolytes (potassium, magnesium, calcium, etc.) in your body. Your levels will be monitored using blood tests. If your levels become too low, your care team may prescribe specific electrolytes to be given by IV or taken by mouth. Do not take any supplements without first consulting with your care team.
What is panitumumab used for?
Panitumumab is a type of medication called a monoclonal antibody. Monoclonal antibodies are created in a lab to attach to the targets found on specific types of cancer cells. The antibody “calls” the immune system to attack the cell it is attached to, resulting in the immune system killing the cell. These antibodies can work in different ways, including stimulating the immune system to kill the cell, blocking cell growth or other functions necessary for cell growth. Panitumumab binds specifically to the epidermal growth factor receptor (EGFR).
Does panitumumab work on EGFR?
Panitumumab binds specifically to the epidermal growth factor receptor (EGFR). This medication only works in cancers with a normal RAS gene (called wild type) and your provider will test for this before starting therapy with panitumumab.
Can acne be treated with medication?
While this rash may look like acne, it is not, and should not be treated with acne medications. The rash may appear red, swollen, crusty, dry and feel sore.
How to get rid of a rash on your face?
Avoid sun exposure, as it can worsen the rash or cause a severe burn. Use a sunscreen with an SPF of 30 or higher and wear a hat and sunglasses to protect your head and face from the sun .
Does vectibix cause rash?
The following Vectibix side effects are common (occurring in greater than 30%) for patients taking Vectibix: Skin reactions (including redness, acneform dermatitis, itching, or rash) Low level of magnesium in the blood (hypomagnesemia) These are less common side effects (occurring in about 10-29%) for patients receiving Vectibix:
What is vectibix used for?
What Vectibix Is Used For: Vectibix is used to treat colorectal cancer that has spread. It is used to treat colon cancers that express EGFR and disease that has gotten worse either on or following fluoropyrimidine, oxaliplatin and irinotecan containing chemotherapy regimens.
What are the symptoms of a rash?
Extreme fatigue (unable to carry on self-care activities) Swelling of the hands or feet. Severe rash (causing pain, itching or drainage) Mouth sores ( painful redness, swelling or ulcers) Eye irritation. Always inform your doctor or health care provider if you experience any unusual symptoms.
Can you take aspirin with vectibix?
While taking Vectibix do not take aspirin or products containing aspirin unless your doctor specifically permits this.
What is targeted therapy?
Targeted therapy is about identifying other features of cancer cells. Scientists look for specific differences in the cancer cells and the normal cells. This information is used to create a targeted therapy to attack the cancer cells without damaging the normal cells, thus leading to fewer side effects.
What is monoclonal antibody therapy?
Using Monoclonal Antibodies as Targeted Therapy. Monoclonal antibodies are a relatively new type of "targeted" cancer therapy. Antibodies are part of the immune system. Normally, the body creates antibodies in response to an antigen (such as a protein in a germ) entering the body.
Can monoclonal antibodies be used for cancer?
Monoclonal antibody therapy can be done only for cancers in which antigens (and the respective antibodies) have been identified. Vectibix is a targeted therapy that targets and binds to the epidermal growth factor receptors (EGFR) on the surface of the cell.
