What is combined electrochemical treatment for neuropathy?
Combined electrochemical treatment (CET) represents a safe and effective therapy for all forms of neuropathy. 7 We have now documented the reversal of the neuropathic process both from clinical observations and from objective functional (neurodiagnostic) testing and anatomic (epidural nerve fiber density [ENFD]) data. 8
How can I prevent neuropathy from worsening?
Stick to the dose your doctor recommends to prevent toxicity and worsening symptoms. Vitamin D can also help prevent chronic pain. Your skin will produce vitamin D when it’s exposed to sunlight. But if you have a vitamin D deficiency, it can worsen or cause neuropathy pain.
Is it possible to find a solution for idiopathic neuropathy?
I do not mean idiopathic neuropathy (of unknown cause). It is very difficult to find a solution, other than for symptoms, when the neuropathy is of unknown cause. Help the doctor think and pushing the system to do the testing that is now available. Click here to read about my opinion on Idiopathic Neuropathy.
Will my neuropathy get worse?
One issue neuropathy patient’s face is the fear that their neuropathy will grow progressively worse. Neurologists call this a progressive polyneuropathy. The truth: no one really knows if your neuropathy will worsen, stay the same or disappear.
What can worsen neuropathy?
Nutritional or vitamin imbalances, alcoholism, and exposure to toxins can damage nerves and cause neuropathy. Vitamin B12 deficiency and excess vitamin B6 are the best known vitamin-related causes. Several medications have been shown to occasionally cause neuropathy.
Does electrical stimulation help foot neuropathy?
Electrical stimulation may be an effective alternative and adjunctive therapy to current interventions for diabetic peripheral neuropathy. Electrical stimulation provided improvement in symptoms of painful neuropathy (six studies) and sensory neuropathy (one study) in persons with diabetes.
Can combined electrochemical therapy cure neuropathy?
Treatment (CET) The data strongly suggest that CET is safe and effective in the treatment of peripheral neuropathy in as many as 70-80% of cases. Of the 112 patients recorded for NRS improvement, 82.4% of them reported a decrease in symptoms and 61% reported an improvement of over 50%.
What slows the progression of neuropathy?
For many people, lifestyle changes and management are usually successful in slowing the progression of neuropathy. These changes can include: Losing weight. Exercising.
Can electro stimulation damage nerves?
Generally, greater intensity, higher frequency, and longer pulse width stimulation lead to more severe damage in nerve cells (McCreery et al., 2004). In addition, although short-term electrical stimulation is not damaging to nervous tissue, chronic electrical stimulation can damage nerve structure.
Is electrical stimulation good for nerve damage?
Several studies have shown that direct electrical stimulation of the injured nerves can enhance sensory and motor axon regeneration, hasten functional recovery, and facilitate reinnervation [2, 5–11].
What is the newest treatment for neuropathy?
Gabapentin and Pregabalin have been approved by the Food and Drug Administration (FDA) for the treatment of neuropathic pain.
Are there any breakthroughs for neuropathy?
Scientists from the University of Manitoba and UCSD found that a class of already-approved drugs reversed peripheral neuropathy in mouse models. Treatments for peripheral neuropathy, the numbness and pain most commonly felt in the fingers, arms and legs due to nerve damage, tend to focus on managing pain.
Is there any new help for neuropathy?
An extremely important recent FDA approval was just announced authorizing spinal cord stimulation (SCS) for the treatment of painful diabetic neuropathy.
What is the number one medicine for neuropathy?
The most effective treatment was nortriptyline. Of the study subjects taking this medication, 25% reported their discomfort improved by at least 50%. The least effective treatment was pregabalin: only 15% of study subjects reported that much improvement. Side effects were common with all of the treatments.
Why does neuropathy get worse at night?
At night our body temperature fluctuates and goes down a bit. Most people tend to sleep in a cooler room as well. The thought is that damaged nerves might interpret the temperature change as pain or tingling, which can heighten the sense of neuropathy.
What is the life expectancy of someone with peripheral neuropathy?
There are several key factors that affect a patient's prognosis in familial amyloid polyneuropathy (FAP), but most people with the rare, inherited, progressive disease have a life expectancy of about 10 years after being diagnosed.
What is the A-delta NCS?
The A-delta NCS system has 2 components: an electrical stimulator that generates neuroselective signals specific to A- delta nerves; and a detector that records in real-time the micro-voltage changes of the threshold action potential signal at muscles. The A delta-NCS measures the voltage required to fire peripheral A-delta nerves, and has been shown to be reproducible with localization of nerve root injury sensitivity of about 95% and a specificity of 62%. 15
How does the CET treatment fix my numbness?
Patients occasionally ask, “How does the CET treatment fix my numbness?” The answer to this question is most likely that the healing process is enhanced by factors in the local anesthetic beyond simply its ability to block sodium channels, arresting degenerative pathology and promoting healing.
What causes peripheral neuropathy?
Peripheral neuropathy is most likely caused by disorders of the circulation, neural edema (neurogenic inflammation), and altered microcirculation around nerves. Blood flow is among the least discussed and appreciated factor in pain relief. The influence of blood flow, especially its diminution, is not emphasized enough in the chronic pain literature. 25
How does neuropathy occur?
A neuropathy occurs as a result of basic pathologic processes gone awry—either from injury or disease. The incidence of neuropathy increases with age and its prevalence is growing. In fact, the prevalence of peripheral neuropathy may be as high as 2.4% in the United States. 1
What are the primary nerve fibers in neuropathy?
Four primary nerve fibers are important in small fiber (sensory) neuropathy: A-delta, afferent C, efferent C, and A-beta. Neuropathic pain occurs when normal signaling between adjacent nerve cells attenuates as a result of insufficient oxygen transport. The hypo-oxidative state associated with neuropathic pain appears to be a primary factor, along with demineralization of the synaptic fluid, necessary for axon signal transport. 9
Is CET safe for neuropathic pain?
CET has a remarkable track record of safety. Clinics that have used our protocol for patients with neuropathic pain in the feet and legs have rarely, if ever, observed side effects. In our experience, there has been an occasional allergy to bupivacaine, which is easily solved by switching to xylocaine with no loss of efficacy. Occasional mild, superficial burns have been reported from adhesive-type electrodes when excessive power density is applied. These problems have been resolved by using a venturi-type vacuum cup electrode system. There have been no reports of infection to date.
Abstract and Figures
A safe and effective treatment for diabetic and other neuropathies has shown promise over the past 5 years around the country. Neuropathy is a progressive condition that, up until now, has not been known to reverse its course with or without interventions.
References (39)
ResearchGate has not been able to resolve any citations for this publication.
What is the mechanism of analgesia produced by EST?
Several mechanisms help explain the analgesia produced by EST. Under the influence of rapidly-alternating polarity, ion movement is enhanced , which tends to balance differences in metabolite concentration, leading to pH normalization and reduction in tissue acidosis.
What is the function of conductivity in the synap tic fluid?
Conductivity relies on minerals and specific neurotransmitters in the synap - tic fluid to enable propagation of the nerve signal. These conductive min- erals and neurotransmitters are deliv- ered via the perfusion of adjacent tis- sues with fresh blood.
What are the symptoms of peripheral neuropathy?
Symptoms include pain, dysesthesia, paresthesia, as well as loss or impairment of sensory function, numbness, dry skin, gait instability and fall risk, erectile dysfunction, and incontinence.35Sign s of peripheral neu - ropathy include decreased vibration, reflexes, protective sensation to pain, . Figure 2.
What is the mechanism of action of CET?
The key physiological mechanisms of action of CET necessary for the treatment of neuropathy include: increasing blood flow and available oxygen, increasing second messen- ger(s) responsible for regenerative tis- sue effects, and promoting analgesia and anti-inflammatory effects.
Is blood flow a factor in pain relief?
Blood flow is among the least discussed and appreciated factor in pain relief. The influence of blood flow, especially its diminution, is not emphasized enough in the chronic pain literature.25. CET’s promotion of increased blood flow is likely a primary mechanism for its effectiveness.
Is DPN progressive?
It is compelling to note that the course of DPN, as well as other neuropathies, generally is progressive. To date, most treatments have focused on reduction of symptoms,6 and, in the case of diabetes, control or slowing of the progres- sion of the underlying disease.
What is the benefit of combining electrochemical therapy?
Patients usually say the benefit of Combined Electrochemical Therapy (CET) is taking back their health with a better overall quality of life. With less pain, more energy, more movement, and the ability to exercise- many people can resume the activities they once loved thanks to CET.
Does CET help with mobility?
Studies show that CET improves circulation, reduces inflammation and increases nerve activation. Each of these contributes to enhanced mobility. After receiving Combined Electrochemical Therapy (CET) many patients no longer need to use their walkers to get around. Ability to Exercise.
Does CET help with neuropathy?
CET can eliminate the pain before it leads to serious mobility issues. The benefits can be life-changing for some! Improved Mobility. Peripheral Neuropathy can make it feel like there are needles stabbing the tops and bottoms of your feet with every step.
What is combined electrochemical therapy?
Combined Electrochemical Therapy (CET) is a clinically-proven treatment for both peripheral neuropathies and chronic pain. This treatment prevents the further degradation of the tissue and promotes healing.
How does Combined Electrochemical Therapy Work?
Typically, chronic pain is a result of the nerves relaying improper signals from the brain to the muscles and other parts of the body. Or, the nerves may stop sending signals entirely. Using energy waves produced by the CET system, doctors attempt to harmonize the communication between the axons or nerve cells.
What Results Can I Expect from Combined Electrochemical Therapy?
Regenerative Medicine of South Jersey is all about providing effective and safe treatments for our patients so that they can get back to their normal life again. Our CET treats all causes of peripheral neuropathy and chronic pain. Some potential results can be a reduction of pain and numbness.
What are the benefits of Combined Electrochemical Treatment?
Patients usually say the benefit of CET is taking back their health with a better overall quality of life. With less pain, more energy, more movement, and the ability to exercise - many people can resume the activities they once loved thanks to CET.
Will CET cure my chronic pain?
While CET will not cure pain totally it can make a huge improvement in overall function and symptom relief, and can be used alongside other treatments.
What is the best medication for shooting pain?
For the shooting pains both the anti-seizure and anti-depressant drugs are often used in combination to treat neuropathic pain which is pain caused by the damaged nerves. The one drug that helped give me 80% relief from these pains was called nortriptyline an older anti-depressant that is used for this type of pain.
What is the term for a set of nerves that affect one set of nerves?
The chronic neuropathies (affect one set of nerves) and polyneuropathies (affect many nerves), which increase for years are often referred to as progressive polyneuropathies. The mystery is increased as there seems to be no rhyme or reason for these patterns.
Can neuropathy worsen?
One issue neuropathy patient’s face is the fear that their neuropathy will grow progressively worse. Neurologists call this a progressive polyneuropathy. The truth: no one really knows if your neuropathy will worsen, stay the same or disappear. A neurologist shared that this may have more to do with the underlying cause of the neuropathy, genetics, ...
Is neuropathy a progressive disease?
Neurologists call this a progressive polyneuropathy. The truth: no one really knows if your neuropathy will worsen, stay the same or disappear. A neurologist shared that this may have more to do ... One issue neuropathy patient’s face is the fear that their neuropathy will grow progressively worse. Neurologists call this a progressive ...
Can hematoma cause neuropathy?
While only a doctor can determine if the hematoma on the brain can cause your symptoms, injuries do cause the symptoms of neuropathy according to Dr Norman Latov MD PhD. For the record surgery such as gastric bypass can also cause neuropathy but since this was a long time ago, it is more likely due to the fall.
Do neuropathies come on suddenly?
Neurologists confirm that there are acute neuropathies that come on suddenly and then the symptoms disappear. In other neuropathies symptoms occur, disappear and then return at the same level. Other neuropathies occur, disappear and then return at increased levels and in more places of the body.
Does weight lifting cause neuropathy?
Exercise as in Gym and weight lifting do not cause neuropathy unless you have an injury, but many neuropathies are NOT brought on my an underlying disease. Genetic, nerve entrapment (rotator cuff injury may be an example) for nerves get entrapped by muscle, bones, veins and so forth, would be two good examples.
What nerves control what you feel?
Sensory nerves control what you feel, such as pain, temperature or a light touch. Sensory neuropathy affects these groups of nerves. Autonomic nerve neuropathy. Autonomic nerves control functions that you are not conscious of, such as breathing and heartbeat. Damage to these nerves can be serious. Combination neuropathies.
What is the most common type of neuropathy?
The most common type of peripheral neuropathy is diabetic neuropathy, caused by a high sugar level and resulting in nerve fiber damage in your legs and feet. Symptoms can range from tingling or numbness in a certain body part to more serious effects, such as burning pain or paralysis.
What are the symptoms of a numb body?
Symptoms can range from tingling or numbness in a certain body part to more serious effects such as burning pain or paralysis. Loss of balance or other functions as a side effect of the loss of feeling in the legs, arms, or other body parts.
Why do people get peripheral neuropathy?
Others develop it because of an injury or another disorder. In many cases, a different type of problem, such as a kidney condition or a hormone imbalance, leads to peripheral neuropathy.
How many types of neuropathy are there?
There are more than 100 types of peripheral neuropathy, each with its own set of symptoms and prognosis. To help doctors classify them, they are often broken down into the following categories:
What is the best medicine for irregular heartbeat?
Some of these medicines include mexiletine, a medicine developed to correct irregular heart rhythms; antiseizure drugs, such as gabapentin, phenytoin, and carbamazepine; and some classes of antidepressants, including tricyclics such as amitriptyline. Lidocaine injections and patches may help with pain in other instances.
What tests can be done to detect vibrations?
Muscle strength tests. Tests of the ability to detect vibrations. Depending on what basic tests reveal, your healthcare provider may want to do more in-depth scanning and other tests to get a better look at your nerve damage.
Why is neuropathy worse in 2021?
March 10, 2021. March 16, 2021. by Jonathan Walker. Even though it’s treatable, nerve damage or neuropathy can cause extreme pain and add complications to your life. If you suffer from neuropathy, you will likely have to monitor your diet and exercise.
What are the causes of peripheral neuropathy?
Vitamins. Some cases of peripheral neuropathy are actually caused by vitamin deficiencies. For example, vitamin B is essential for nerve health. A vitamin B deficiency can lead to significant nerve damage. You should try to get most of your vitamin D from your food, but your doctor may also recommend supplements.
Why does my nerve hurt at night?
Strenuous exercise and the accompanying soreness can contribute to nerve pain during the night. Living in a chronic state of stress will wreak havoc on your physical and mental health. High stress levels could be a reason why neuropathy is worse on some days, as well as when you take medications. -back to top.
How to reduce pain in the arm?
Exercising regularly can combat pain and improve your overall health. Staying active reduces your blood sugar, which will reduce or slow down damage to your nerves. Exercise will also increase the blood flow to your arms and legs and reduces stress. These are all factors that help to reduce discomfort and chronic pain.
How to relax when you are stressed?
This is not only good for your body but it’s good for your mental well-being. Spend some quiet time in nature, listen to relaxing music, or enjoy a warm bath if you feel extra stressed. -back to top.
Does vitamin D help with pain?
Vitamin D can also help prevent chronic pain . Your skin will produce vitamin D when it’s exposed to sunlight. But if you have a vitamin D deficiency, it can worsen or cause neuropathy pain. Taking a vitamin D supplement can help reduce neuropathic symptoms.
Can neuropathic pain medication wear off?
Even though your medication is working the way it should during the day, it will eventually wear off.
Peripheral Neuropathy
Basis of CET
- CET involves the use of local anesthetics to block pain and other nerve function in the distal lower extremities, followed by electrical cell signaling treatments (EST) to both lower extremities. First, a low-dose, low-volume injection of local nutrient-infused anesthetic (Na+ channel blocker) is injected into the target region, followed by treatment with the EST device.¹⁹ The device combine…
Key Mechanisms of Action
- Patients occasionally ask, “How does the CET treatment fix my numbness?” The answer to this question is most likely that the healing process is enhanced by factors in the local anesthetic beyond simply its ability to block sodium channels, arresting degenerative pathology and promoting healing. The key physiological mechanisms of action of CET necessary for the treatm…
Restoring Metabolic Equilibrium
- Equilibration of differences in metabolic concentration by alternating-polarity EST will result in an increase in the redistribution of ions and water within tissues.¹⁰˒¹³˒¹⁹˒²⁰˒²⁸ This rebalancing results in the dilution of toxic, pain and/or inflammatory mediators; an increase in tissue clearance by an improvement in the efficacy of the local blood flow; and an overall improvement of diffusion an…
Distal Phenomena
- Axon Circulation
Neuropathies also may result from interference in axon transport by products of glucose metabolism, such as sorbitol.³¹ Axon transport problems also are accompanied by inflammation. Some unique factors must be used to explain nerve hypofunction, which depends on how distal …
Synergistic Interaction of Est and Anesthetics
- Local anesthetics are known to depress mitochondrial function by hyperpolarization, a “locking down” of the cell’s voltage channels.¹⁴˒³² However, EST has been shown to increase the number, size, and overall activity of mitochondria.³³˒³⁴ Increased mitochondrial activity allows for substantially more energy for bio-utilization and regeneration of cells. This physiologic benefit o…
Objective Testing
- The effectiveness of interventions can only be self-reported by patients. However, numerous difficulties exist in describing, standardizing, and quantifying pain and the other aspects of neuropathic symptoms in clinical evaluations. Objective measures of improved neurological function and regeneration should satisfy even the most skeptical of government regulators, stak…
Safety of CET
- CET has a remarkable track record of safety. Clinics that have used our protocol for patients with neuropathic pain in the feet and legs have rarely, if ever, observed side effects. In our experience, there has been an occasional allergy to bupivacaine, which is easily solved by switching to xylocaine with no loss of efficacy. Occasional mild, superficial burns have been reported from a…
Summary
- The time has come for a paradigm shift in the approach to chronic disease. Although complex, the basic mechanisms of cell signaling could easily be the normalization of cAMP, which leads to the opening of voltage-gated channels in pain neurons and the sympathetic nervous system. Vessels then vasodilate, increasing local circulation, allowing incoming nutrients and a “washin…
Peripheral Neuropathy
Basis of CET
Key Mechanisms of Action
Restoring Metabolic Equilibrium
Distal Phenomena
Synergistic Interaction of Est and Anesthetics
Clinical Markers and Results
- Formal studies and clinical experience with CET have shown improvement in 80% to 85% of patients with peripheral neuropathy, and a major functional improvement in 75% of patients.7,21 The difficulty in defining improvement arises because neuropathy is more multidimensional than chronic pain in its presentation. Symptoms include pain, dysesthesia, p...
Objective Testing
Safety of CET
Summary