Progesterone suppresses both MMP's and oestrogen. It also prevents hyperplasia and cancer, please see our page on Cancer and progesterone. It is essential to use a high amount of progesterone, between 400-600mg/day. If the bleeding is continual, use it both daily and hourly. Using it hourly keeps the level high throughout the day.
What is the role of progesterone in the treatment of endometrial hyperplasia?
The significance of progesterone in controlling estrogen-driven proliferation is underlined by its efficacy in preventing endometrial cancer. Progestins are used in the clinic effectively to eradicate some but not all endometrial hyperplasia and well-differentiated endometrioid endometrial cancer.
How long does it take for progesterone to correct hyperplasia?
I haven't found it takes as long as 6 months to correct the hyperplasia, but 400mg/day is safe for that long. Some women are using far higher for over a year, see here, here, here and here. There's no need to stop using the progesterone for a biopsy, in fact I wouldn't advise it, as symptoms can come back.
What are the benefits of progesterone injections?
Early research suggests that single injections of progesterone reduce blood pressure, swelling, and other symptoms in women with pre-eclampsia. Injury to the brain, spine, or nerves (neurological trauma). Some research suggests that injecting progesterone soon after brain injury prevents death and disability.
What is the progesterone response to cancer treatment?
The response to progesterone will ultimately manifest as death or regression of the tumor, cessation of growth, or no change in behavior. One can appreciate the potential that lies in progestin therapy given its vast modes of action. However, the process of elucidating such mechanisms can be at times fraught with significant limitations.
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Can progesterone reverse endometrial hyperplasia?
Progestins used alone are clearly efficacious in reversing pre-malignant endometrial hyperplasia, preventing the development of frank carcinomas, and even treating early-grade endometrial neoplasia in women seeking to preserve fertility.
Does progesterone help endometrial hyperplasia?
Endometrial hyperplasia is more common after menopause when the hormone progesterone is no longer made. A common treatment for endometrial hyperplasia is progestin, which is man-made progesterone.
How long do you take progesterone for endometrial hyperplasia?
Approximately 1% of patients who are on combined HRT develop benign EH. In such cases, the dose should be increased or they should be switched to 3 months of progestin-only therapy to encourage the regression of the hyperplastic endometrium.
How much progesterone is needed for endometrial hyperplasia?
Studies have shown regression of hyperplasia without atypia to normal endometrium in 80 to 90% of patients when treated with either medroxyprogesterone acetate (MPA), 10 mg daily for 12 to 14 days each month, or micronized progesterone in vaginal cream, when treated for 3 to 6 months.
Why is progesterone given in endometrial hyperplasia?
The progesterone drop triggers the uterus to shed its lining as a menstrual period. Women who have endometrial hyperplasia make little, if any, progesterone. As a result, the uterus doesn't shed the endometrial lining.
What is the best treatment for endometrial hyperplasia?
In many cases, endometrial hyperplasia can be treated with progestin. Progestin is given orally, in a shot, in an intrauterine device (IUD), or as a vaginal cream. How much and how long you take it depends on your age and the type of hyperplasia. Treatment with progestin may cause vaginal bleeding like a period.
How do you reverse endometrial hyperplasia?
CONCLUSIONS. We conclude that endometrial hyperplasia developing under the influence of exogenous estrogens can often be reversed with progestin therapy.
How does progesterone thin the endometrium?
Endometrial effects However, when the progestin-only pill is administered, the constant low level of a progestogen leads to the development of endometrial thinning with scanty and atrophied glands and very much reduced synthesis of progesterone receptors, which is hostile towards the implantation of a fertilized ovum.
Can endometrial thickness be reduced?
Medical Treatments Hormones may be used to moderate the thickness of the endometrial lining. Progesterone may be used in hyperplasia to decrease endometrial thickness. Estrogen may be used to thicken the endometrial lining of if it is too thin.
Does progesterone thin uterine lining?
Two hormones produced from the ovaries thicken and prepare the uterine lining for implantation. Estrogen causes the thin uterine lining to thicken. Progesterone causes the thickened uterine lining to develop the characteristics needed for implantation.
Can thickened endometrium be cured?
In most cases, endometrial hyperplasia is very treatable. Work with your doctor to create a treatment plan. If you have a severe type or if the condition is ongoing, you might need to see your doctor more often to monitor any changes.
What does progesterone do to the endometrium?
Progesterone prepares the endometrium for the potential of pregnancy after ovulation. It triggers the lining to thicken to accept a fertilized egg. It also prohibits the muscle contractions in the uterus that would cause the body to reject an egg.
How much progesterone should I take a day?
But you don't really need more than 400mg/day, possibly 500mg, what you do need is to get all the progesterone, not the small amount you are now. Oral progesterone can make one sleepy, in fact doctors often give it for insomnia. In which case it's best taken at night only. I hope the compounder can help with a cream.
What happens when oestrogen is overactive?
If they are over active, as would be the case with excess oestrogen in the body, as oestrogen stimulates their production, the result is a pathological reaction.
What happens if you have a high level of MMP?
A high level of MMP's can lead to inflammation and excessive bleeding in the uterus. If a low level of progesterone is present, and a high level of oestrogen, the lining will continue to grow. With a high level of MMP's the lining will also continue to break down. Progesterone suppresses both MMP's and oestrogen.
Can you stop progesterone for a biopsy?
Some women are using far higher for over a year, see here, here, here and here. There's no need to stop using the progesterone for a biopsy, in fact I wouldn't advise it, as symptoms can come back. The nausea could be caused by excess oestrogen, which is what happens when we fall pregnant.
Is oestrogen a mitogen?
Hyperplasia. by: Wray. Hi Cathy Your integrative MD knows what he's doing, stick with him and not the Obgyn! Oestrogen is a mitogen, it stimulates cells to grow. Vital in stimulating the endometrium each month to grow and thicken ready for a possible fertilised egg.
Does progesterone make you tired?
But oral progesterone does make one tired, in fact doctors often give it to help with sleep. I always recommend 400mg/day to stop bleeding, which is usually does in a few days. But that's in a cream or suppository form, not oral. Then to begin reducing very slowly, by 16-33mg per day.
Complex Hyperplasia Treatment With Progesterone IUD
Hi everyone. I am 35 and was recently diagnosed with Complex Hyperplasia without atypia and am scheduled to have an IUD inserted in hopes of thinning the lining and preserving my fertility.
Complex Hyperplasia Treatment With Progesterone IUD
I'm sorry to hear that you have been diagnosed with complex hyperplasia without atypia and I can appreciate why you are worried about what your condition could mean as far as your fertility is concerned.
Complex Hyperplasia Treatment With Progesterone IUD
I am in the exact same boat as you. I'm sorry to hear that you got that diagnosis! I got the results of my biopsy yesterday and was also diagnosed with Compex Hyperplasia, but I do have Atypia.
Complex Hyperplasia Treatment With Progesterone IUD
I know these posts were a few years ago but I wondered how you were all getting on? I am now in a similar position except they are unable to tell me if it's cancer or not but have said I can either have a hysterectomy or try the mirena coil. I am edging towards the mirena coil but I wondered how this worked for you? Thanks x
Complex Hyperplasia Treatment With Progesterone IUD
I was diagnosed with Atypia Complex Hyperplasia & i had the awful discussion & decision of either having a hysterectomy and Chemotherapy or a Mirena Coil ? Luckily i have the best ( in my eyes ) Gynaecology consultant the NHS has to offer and he is an amazing human being.
Complex Hyperplasia Treatment With Progesterone IUD
Helen that is so reassuring to hear and I'm glad it worked out for you. I'm in a similar position and have also been diagnosed with Atypia Complex Hyperplasia and have had the Mirena coil fitted. Waiting to hear back about my biopsy so feeling worried at the moment. I'm also trying to conceive so hoping that it works out for me the same as you :)
Complex Hyperplasia Treatment With Progesterone IUD
So I was due to have an appointment to talk to me about it but it was cancelled because of Covid-19. Instead I had a telephone consultation and he said the cells are still the same. I had only had the mirena coil done that same day too though so it's not had much chance to do anything yet. My next biopsy is due at the beginning of June.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Why is progesterone important for menopause?
Changing progesterone levels can contribute to abnormal menstrual periods and menopausal symptoms. Progesterone is also necessary for implantation of the fertilized egg in the uterus and for maintaining pregnancy. Lab-made progesterone is used to imitate the functions of the progesterone released by the ovaries.
What is natural progesterone made of?
"Natural progesterones," including the prescription products Crinone and Prometrium, are made from a chemical called diosgenin that is isolated from wild yam or soy. In the laboratory, diosgenin is converted to progesterone.
Is progesterone better than clobetasol?
In fact, progesterone seems to be less effective than clobetasol ( Temovate) for treating this condition. Miscarriage. Most research shows that applying progesterone into the vagina does not reduce the risk of having a miscarriage in women who are bleeding during pregnancy or with a history of miscarriages in the past.
Does progesterone help with endometrial hyperplasia?
Abnormal thickening of the lining of the uterus (endometrial hyperplasia). Some research suggests that applying progesterone (Cri none) into the vagina prevents endometrial hyperplasia in women with an intact uterus that are taking estrogen replacement therapy.
Can progesterone and estrogen be taken together?
Progesterone can decrease some of the side effects of estrogen. But progesterone might also decrease the beneficial effects of estrogen. Taking progesterone along with estrogen might cause breast tenderness.
Does progesterone help with infertility?
Research shows that adding progesterone to HRT protects against side effects of estrogen . Inability to become pregnant within a year of trying to conceive ( infertility ). Intravaginal progesterone gel (Crinone 8%) is FDA-approved for use as a part of infertility treatment in women.
Does progesterone help with premature birth?
Most research suggests that applying progesterone gel or inserts into the vagina, alone or along with therapy to delay labor (tocolytic therapy), reduces the risk of premature birth in some women at high risk of premature birth.
How old do you have to be to take progesterone?
Talk to your healthcare provider about alternatives to progesterone if you: are over 60 years old. have been menopausal for longer than 10 years. have a personal or family history of breast cancer. are at a higher risk for dementia, heart attack, stroke, blood clots, osteoporosis, or liver disease.
What hormone is used to prepare the uterus for pregnancy?
Progesterone is often called the pregnancy hormone. During the reproductive years, progesterone influences the preparation of the uterus for possible pregnancy. It also plays a role in the formation of a mucus barrier around the cervix and the availability of breast milk.
How to stop menopause symptoms?
What else may help ease menopause symptoms? 1 Consider natural products. Natural alternatives like black cohosh or evening primrose oil may help reduce hot flashes and night sweats. 2 Exercise regularly. Exercise helps you maintain a healthy body weight, improves sleep, and eases the anxiety and mood shifts that can accompany menopause. 3 Be mindful of what you eat. Avoid spicy food, caffeine, and alcohol, all of which can trigger hot flashes and night sweats. 4 Find healthy ways to manage stress. When you’re stressed, it can impact your sleep and mood. It can also increase the frequency of hot flashes. Consider yoga, meditation, breathing exercises, tai chi, or spending time on a favorite hobby to keep your stress manageable.
How to get rid of hot flashes during menopause?
Exercise regularly. Exercise helps you maintain a healthy body weight, improves sleep, and eases the anxiety and mood shifts that can accompany menopause. Be mindful of what you eat. Avoid spicy food, caffeine, and alcohol, all of which can trigger hot flashes and night sweats. Find healthy ways to manage stress.
How to get rid of hot flashes?
When you’re stressed, it can impact your sleep and mood. It can also increase the frequency of hot flashes. Consider yoga, meditation, breathing exercises, tai chi, or spending time on a favorite hobby to keep your stress manageable.
Can you take estrogen if you don't have a uterus?
If you don’t have a uterus, the most common therapy is estrogen alone. If you do have a uterus, a combination of estrogen and progesterone is often recommended because there’s evidence that estrogen on its own increases the risk of uterine cancer and other serious health problems.
Does estrogen help with menopause?
Progesterone is often combined with estrogen to treat the symptoms of menopause. In combination, these two hormones can reduce the hot flashes, night sweats, and other side effects of menopause.