Treatment FAQ

how does methadone maintenance work for the treatment of opioid dependence

by Mya Dibbert Published 2 years ago Updated 2 years ago
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Methadone maintenance treatment (MMT) involves the daily administration of the oral opioid agonist methadone as a treatment for opioid dependence-a persistent disorder with a substantial risk of premature death. MMT improves health and reduces illicit heroin use, infectious-disease transmission, and overdose death.

Methadone works by changing how the brain and nervous system respond to pain. It lessens the painful symptoms of opiate withdrawal and blocks the euphoric effects of opiate drugs such as heroin, morphine, and codeine, as well as semi-synthetic opioids like oxycodone and hydrocodone.

Full Answer

What is a methadone maintenance program, and do they work?

Methadone is an opioid, like heroin or opium. Methadone maintenance treatment has been used to treat opioid dependence since the 1950s.14The opioid dependent patient takes a daily dose of methadone as a liquid or pill. This reduces their withdrawal symptoms and cravings for opioids. Methadone is addictive, like other opioids.

How can I be successful in methadone maintenance treatment?

  • Reduction in infectious disease due to stopping opiate abuse, particularly injection drug abuse
  • Reduction in criminal activity due to stopping illicit drug use
  • Overall improvement in quality of life
  • Better chance at long-term recovery success
  • Improved social functioning

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What if I want to stop methadone maintenance treatment?

What if I want to Stop Methadone Maintenance Treatment?

  • Tapering Off Methadone. First off, you should know that in order to stop taking methadone you will need to gradually taper the drug off in order to prevent any withdrawal ...
  • Allowing the Body to Adjust. ...
  • Reaching Your Goal of Freedom from Methadone Dependence. ...

How long does methadone maintenance treatment take?

This can take up to 3 months. When you have stabilised on methadone, it may be possible to take some of your doses at home. You’ll discuss this with your key worker and prescriber to work out what is right for you. How long will I take it for? If you’re taking methadone for maintenance therapy, you will usually take it long term.

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What does methadone maintenance do?

Methadone maintenance treatment has been used to treat opioid dependence since the 1950s. The opioid dependent patient takes a daily dose of methadone as a liquid or pill. This reduces their withdrawal symptoms and cravings for opioids.

How long can you stay on methadone?

According to the National Institute on Drug Abuse publication Principles of Drug Addiction Treatment: A Research-Based Guide (Third Edition), the length of methadone treatment should be a minimum of 12 months. Some patients may require long-term maintenance.

What is the most effective treatment for a person dependent on an opioid?

Medications, including buprenorphine (Suboxone®, Subutex®), methadone, and extended release naltrexone (Vivitrol®), are effective for the treatment of opioid use disorders.

What is the relationship between opioids and methadone?

Methadone is a synthetic opioid that is an agonist of μ-opioid receptor. First synthesized in 1930s, it was approved by the FDA as an analgesic in 1947. Subsequent studies showed that it is effective in treating opioid addiction, and in 1972, FDA approved methadone for treating opioid addiction.

What should you not take with methadone?

Drugs that you should not use with methadone Pentazocine, nalbuphine, butorphanol, and buprenorphine. These drugs may reduce methadone's pain-relieving effects. This can cause withdrawal symptoms.

What are the doses of methadone?

Adults—At first, 20 to 30 milligrams (mg) taken as a single dose per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg per day. Do not take more than your prescribed dose in 24 hours.

Which medication is frequently used to treat opioid addiction is?

The most common medications used in treatment of opioid addiction are methadone and buprenorphine. Sometimes another medication, called naltrexone, is used.

What medication is prescribed to avoid withdrawal symptoms?

The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, is pleased to announce that lofexidine, the first medication for use in reducing symptoms associated with opioid withdrawal in adults, has been approved by the U.S. Food and Drug Administration.

Why is it so easy to become addicted to opioids?

Opioids are highly addictive, in large part because they activate powerful reward centers in your brain. Opioids trigger the release of endorphins, your brain's feel-good neurotransmitters. Endorphins muffle your perception of pain and boost feelings of pleasure, creating a temporary but powerful sense of well-being.

What are strategies for treating an opioid addiction?

Evidence-based approaches to treating opioid addiction include medications and combining medications with behavioral therapy. A recovery plan that includes medication for opioid addiction increases the chance of success.

Does methadone change your brain chemistry?

Methadone is a medication prescribed for severe pain. It is also given to individuals recovering from heroin and prescription drug addiction. People who abuse these substances often change their brain chemistry.

Is there a ceiling effect with methadone?

The half-life of methadone can vary from 8 to 59 hours83 depending on the patient. The average is 24 hours. Methadone has no ceiling effect. As a full agonist, increasing doses of methadone produce maximal physiological effects at the opioid receptors.

How does methadone help with opioid abuse?

These programs combine methadone with appropriate counseling services, drug monitoring, and supportive resources, and have been proven to decrease opioid abuse and related crimes, reduce the spread of diseases such as HIV, AIDS, and Hepatitis, improve physical and mental health, and reduce mortality, including opioid overdose.

Is methadone a synthetic opioid?

Because methadone is a synthetic opioid, it is highly addictive and causes physical dependency when used frequently or in high amounts. Withdrawal symptoms are much like other opioid withdrawals and many opioid addicts use methadone as a replacement to continue their opioid dependency, but, in a methadone maintenance program, the physical and psychological aspects of methadone use can be maintained.

What is methadone hydrochloride?

Methadone hydrochloride is a white powder or colorless crystals commonly available in tablet or liquid form. Common brands for Methadone include Diskets, Dolophine, and Methadose. An injectable version of the drug is less common, although some physicians may recommend this method to avoid the uncommon gastrointestinal distress experienced with oral administration. Some additional side effects of Methadone include:

When was methadone first used?

Methadone (formerly Dolantin) was discovered in the late 1930s by German chemists Gustav Ehrhart and Max Bockmuhl. The drug was introduced in the US in 1947 , then later used to aid in the detox process of rehabilitation from opioid substances. In 2005, Methadone was added to the World Health Organization’s List of Essential Medicines (WHO). WHO is a list of the most essential medications in the healthcare field. When used as directed by a physician, Methadone can be a powerful tool in recovery from opioid dependence.

What is the best medicine for opiate addiction?

The most common buprenorphine brands are Suboxone and Subutex. Another medication for opioid or opiate addiction treatment is the opioid antagonist Naltrexone, which works to block opioids from activating receptors.

Is methadone a medication?

Methadone is a medication which must be carefully monitored by an administering physician. While in recovery from opiate or opioid addiction, it is important to follow up with your physician to avoid adverse reactions and accidental overdose. Identifying and understanding overdose symptoms can be lifesaving. Some symptoms of a Methadone overdose include:

Does methadone help with withdrawal?

In the early stages of recovery, the body undergoes a multitude of adverse reactions. The withdrawal process can lead to many physiological and psychological changes that can be controlled through medical monitoring. Methadone helps to curb these reactions through its analgesic and synthetic opioid qualities.

Is methadone good for recovery?

The initial effects of withdrawal can be disheartening for many people in recovery. Methadone offers many patients relief from the discomfort, allowing for an easier transition into sobriety. For maintenance care, Methadone offers a solution to the unfortunate recurrence of relapse in many individuals. While there is a certain stigma attached to methadone treatments, the results are often worth trying to regain control of your recovery.

Opioid Agonists and Partial Agonists (Maintenance Medications)

Studies show that people with opioid use disorder who follow detoxification with complete abstinence are very likely to relapse, or return to using the drug. 10 While relapse is a normal step on the path to recovery, it can also be life threatening, raising the risk for a fatal overdose.

Opioid Antagonists

Naltrexone is an opioid antagonist, which means that it works by blocking the activation of opioid receptors. Instead of controlling withdrawal and cravings, it treats opioid use disorder by preventing any opioid drug from producing rewarding effects such as euphoria.

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The Discovery of Methadone

  • Methadone (formerly Dolantin) was discovered in the late 1930s by German chemists Gustav Ehrhart and Max Bockmuhl. The drug was introduced in the US in 1947, then later used to aid in the detox process of rehabilitation from opioid substances. In 2005, Methadone was added to the World Health Organization’s List of Essential Medicines (WHO). WHO is ...
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Who Does Methadone Help?

  • Methadone treatments have been used to treat heroin addiction for decades. With the significant increase in opiate dependency across the US, the need for a feasible treatment is more necessary than ever. Methadone is most effective when combined with psychological treatments such as cognitive behavioral therapy, which works to increase skills for overcoming relapse triggers. This process also works to modify brain patterns in preventin…
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The Initial Opioid Recovery Process

  • In the early stages of recovery, the body undergoes a multitude of adverse reactions. The withdrawal process can lead to many physiological and psychological changes that can be controlled through medical monitoring. Methadone helps to curb these reactions through its analgesic and synthetic opioid qualities. Some of the initial symptoms of opiate withdrawalinclude: 1. Muscle aches, restlessness, and anxiety 2. Teary eyes, runny nose, an…
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Methadone Administration and Side Effects

  • Methadone hydrochloride is a white powder or colorless crystals commonly available in tablet or liquid form. Common brands for Methadone include Diskets, Dolophine, and Methadose. An injectable version of the drug is less common, although some physicians may recommend this method to avoid the uncommon gastrointestinal distress experienced with oral administration. Some additional side effects of Methadone include: 1. Drowsiness…
See more on rehabcenter.net

Methadone Overdose

  • Methadone is a medication which must be carefully monitored by an administering physician. While in recovery from opiate or opioid addiction, it is important to follow up with your physician to avoid adverse reactions and accidental overdose. Identifying and understanding overdose symptoms can be lifesaving. Some symptoms of a Methadone overdose include: 1. Pale and clammy skin 2. Constricted pupils, disorientation, nausea, and letharg…
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Alternative Treatment Options

  • There are many medicinal options for treating opiate addiction in patients. The most commonly used medication is buprenorphine, a partial opioid agonist which works to block symptoms of withdrawal and stifle opiate cravings. The most common buprenorphine brands are Suboxone and Subutex. Another medication for opioid or opiate addiction treatment is the opioid antagonist Naltrexone, which works to block opioids from activating receptors.
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Methadone For Recovery

  • The initial effects of withdrawal can be disheartening for many people in recovery. Methadone offers many patients relief from the discomfort, allowing for an easier transition into sobriety. For maintenance care, Methadone offers a solution to the unfortunate recurrence of relapse in many individuals. While there is a certain stigma attached to methadone treatments, the results are often worth trying to regain control of your recovery.
See more on rehabcenter.net

We Can Help

  • Methadone is a proven method of treatment for opiate addiction. If you or someone you know is considering methadone treatment, you may wonder where to begin. The friendly staff at RehabCenter.netis here to help guide you in the right direction and assist in finding rehabilitation options in your area. Contact us today with any questions you may have. We’re here to help you.
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