Cyanocobalamine (Nascobal, Vitamin B12, VitaMelts Energy Bitamin B-12) is a supplement used to treat vitamin deficiencies due to malabsorption associated with conditions like pernicious anemia, folic acid deficiency, pancreatic and bowel cancer, and tape worm infestation.
What are the uses of vitamin B12 and cyanocobalamin?
Jul 25, 2021 · Cyanocobalamin is a synthetic compound of vitamin B12 used mainly to treat deficiencies of the vitamin.[1] Chemically it belongs to a class called "corrinoids," and it is a crystallizable cobalt complex. The name cyanocobalamin derives from the cyanide group attached to the molecule.[2]
What is oral cyanocobalamin?
Jan 11, 2021 · Cyanocobalamin is used to treat vitamin B12 deficiency in people with pernicious anemia or other conditions such as folic acid deficiency, pregnancy, thyroid problems, stomach and intestinal disorders, bleeding, liver or kidney disease, parasite infection, or cancer. Cyanocobalamin may also be used for purposes not listed in this medication guide.
Can cyanocobalamin treat pernicious anemia?
Aug 26, 2021 · Cyanocobalamin is a prescription and over-the-counter man-made form of vitamin B12 used to prevent and treat low blood levels of vitamin B12. Most people get enough vitamin B12 from their diet. Vitamin B12 is important to maintain the health of your metabolism, blood cells and nerves. Serious vitamin B12 deficiency may result in a low number of red blood cells , …
Why is vitamin B12 important for your body?
Vitamin B12 (cyancobalamin, Cbl) has two active co-enzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdCbl). There has been a paradigm shift in the treatment of vitamin B12 deficiency such that MeCbl is being extensively used and promoted. This is despite the fact that both MeCbl and AdCb …
What is cyanocobalamin vitamin B12 used for?
Cyanocobalamin is a manufactured version of vitamin B12. It's used to treat and prevent vitamin B12 deficiency anaemia (when you have low levels of this vitamin in your body). Your body requires vitamin B12 to make red blood cells.Mar 10, 2021
What condition is vitamin B12 used for?
What is vitamin B12 and what does it do? Vitamin B12 is a nutrient that helps keep your body's blood and nerve cells healthy and helps make DNA, the genetic material in all of your cells. Vitamin B12 also helps prevent megaloblastic anemia, a blood condition that makes people tired and weak.Jul 7, 2021
What is the indication of cyanocobalamin?
Cyanocobalamin is indicated for vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia. Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy.
Which disease is caused by lack of cyanocobalamin B12 )?
Vitamin B-12 deficiency anemia is a condition in which your body doesn't have enough healthy red blood cells because of a lack of vitamin B-12. This vitamin is needed to make red blood cells. These cells carry oxygen to all parts of your body.
What is the treatment for high vitamin B12?
In many older adults, the secretion of hydrochloric acid in the stomach is reduced, causing a reduction in the absorption of vitamin B12. If your body has difficulty absorbing vitamin B12, your doctor may recommend intramuscular injections of B12 to increase your levels.Jun 14, 2018
What is the difference between cyanocobalamin and methylcobalamin?
Cyanocobalamin is a synthetic form of vitamin B12 found only in supplements, while methylcobalamin is a naturally occurring form that you can get through either food sources or supplements.May 11, 2020
What does vitamin B12 as cyanocobalamin mean?
Cyanocobalamin is a man-made form of vitamin B12 used to prevent and treat low blood levels of this vitamin. Most people get enough vitamin B12 from their diet. Vitamin B12 is important to maintain the health of your metabolism, blood cells, and nerves.
What is the therapeutic effect of cyanocobalamin?
Cyanocobalamin is used to treat vitamin B12 deficiency in people with pernicious anemia or other conditions such as folic acid deficiency, pregnancy, thyroid problems, stomach and intestinal disorders, bleeding, liver or kidney disease, parasite infection, or cancer.Jan 11, 2021
Why is methylcobalamin used?
Methylcobalamin is used to treat vitamin B12 deficiency. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells. Methylcobalamin is sometimes used in people with pernicious anemia, diabetes, and other conditions.Oct 8, 2020
What is thiamine for prescribed?
Thiamine is used to treat beriberi (tingling and numbness in feet and hands, muscle loss, and poor reflexes caused by a lack of thiamine in the diet) and to treat and prevent Wernicke-Korsakoff syndrome (tingling and numbness in hands and feet, memory loss, confusion caused by a lack of thiamine in the diet).Oct 15, 2020
What is the most common cause of B12 deficiency?
Low levels of vitamin B-12 can be caused by: Diet. Vitamin B-12 is mainly found in meat, eggs and milk, so people who don't eat these types of foods may need to take B-12 supplements. Some foods have been fortified with B-12, including some breakfast cereals and some nutritional yeast products.Jan 18, 2022
What causes B12 deficiency anemia?
You can get vitamin B12 deficiency anemia if you don't get enough vitamin B12 in your diet from foods like milk, eggs, and meat. You're more likely to be low in this vitamin if you're older, or you eat a vegetarian diet. It can also happen if your body can't absorb enough of it from the foods you eat.Dec 16, 2020
What Is Oral Cyanocobalamin?
Cyanocobalamin is a man-made form of vitamin B12. Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue s...
Before Taking This Medicine
You should not use this medicine if you are allergic to cobalt, or if you have Leber's disease. Cyanocobalamin can lead to optic nerve damage (and...
How Should I Take Oral Cyanocobalamin?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.Your dose n...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Oral Cyanocobalamin Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.C...
Cyanocobalamin Dosing Information
Usual Adult Dose for Pernicious Anemia:Initial dose: 100 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 daysIf clinical improvement...
What Other Drugs Will Affect Oral Cyanocobalamin?
Other drugs may interact with cyanocobalamin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your docto...
What does it mean when you have trouble swallowing?
trouble swallowing; little or no urination; heart problems--swelling, rapid weight gain, feeling short of breath; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or.
Can you take cyanocobalamin if you have Leber's disease?
You should not use this medicine if you are allergic to cobalt or if you have Leber's disease. Cyanocobalamin can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.
Why is B12 important?
Most people get enough vitamin B12 from their diet. Vitamin B12 is important to maintain the health of your metabolism, blood cells and nerves. Serious vitamin B12 deficiency may result in a low number of red blood cells ( anemia ), stomach / intestine problems, and permanent nerve damage. Vitamin B12 deficiency may occur in certain health ...
How long does it take to take 100 mg of a sulfate supplement?
Manufacturer recommendation: 100 mcg intramuscularly or subcutaneously once daily for 6-7 days, then every other day for 7 doses, then 3-4 days for 2-3 weeks, then monthly. Alternative parenteral dosing: 1,000 mcg intramuscularly or subcutaneously once daily for 7 days, then weekly for 1 month, then monthly.
What are the side effects of a syringe?
inflammation of the tongue. numbness. itching. swelling ( edema) muscle cramps. low blood levels of potassium. irregular heartbeat. This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Does cyanocobalamin interact with other drugs?
Cyanocobalamin has no known severe interactions with other drugs. Cyanocobalamin has no known serious interactions with other drugs. Moderate interactions of cyanocobalamin include: Dichlorphenamide. Cyanocobalamin has minor interactions with at least 71 different drugs.
Can you stop taking a medicine before checking with your doctor?
Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
What is the role of B12 in the synthesis of methionine?
Vitamin B12 can be converted to coenzyme B12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate. In the absence of coenzyme B12, tetrahydrofolate cannot be regenerated from its inactive storage form, 5-methyltetrahydrofolate, and a functional folate deficiency occurs. Vitamin B12 also may be involved in maintaining sulfhydryl (SH) groups in the reduced form required by many SH-activated enzyme systems. Through these reactions, vitamin B12 is associated with fat and carbohydrate metabolism and protein synthesis.
How is B12 absorbed?
It is then transported by the transcobalamin binding proteins. A small amount (approximately 1% of the total amount ingested) is absorbed by simple diffusion, but this mechanism is adequate only with very large doses.
Where is B12 stored?
In the blood, B12 is bound to transcobalamin II, a specific B-globulin carrier protein, and is distributed and stored primarily in the liver and bone marrow.
How long after a hot meal should you take Nascobal?
Advise patients to administer NASCOBAL at least one hour before or one hour after ingestion of hot foods or liquids since hot foods may cause nasal secretions and a resulting loss of medication.
Does chloramphenicol decrease the efficacy of Nascobal?
Chloramphenicol may decrease the efficacy of NASCOBAL when used for treatment of anemia. If NASCOBAL is used for the treatment of anemia concomitantly with chloramphenicol, monitor for reduced efficacy and if needed, consider an alternative therapy
Is B12 in milk?
Vitamin B12 is present in the milk of lactating women in concentrations which approximate the mother’s vitamin B12 blood level. Vitamin B12 does not appear to pose more than a minimal risk to breastfeeding children.
Does B12 help with anemia?
Parenteral (intramuscular) administration of vitamin B12 completely reverses the megaloblastic anemia and GI symptoms of vitamin B12 deficiency; the degree of improvement in neurologic symptoms depends on the duration and severity of the lesions, although progression of the lesions is immediately arrested. In pernicious anemia patients, once weekly intranasal dosing with 500 mcg B12 gel resulted in a consistent increase in pre-dose serum B12 levels during one month of treatment (p < 0.003) above that seen one month after 100 mcg intramuscular dose (Figure 2).
Pregnancy & Lactation
Administration of approved recommended dose is not expected to cause major birth defects, miscarriage or adverse maternal or fetal outcomes
Pharmacology
Coenzyme; metabolic functions include protein synthesis and carbohydrate metabolism
Formulary
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