Cyanocobalamin is used to treat vitamin B12 deficiency
Vitamin B12 Deficiency
A condition characterized by low levels of vitamin B12.
What are the uses of vitamin B12 and cyanocobalamin?
Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue synthesis. Cyanocobalamin is used to treat vitamin B12 deficiency in people with pernicious anemia and other conditions. Cyanocobalamin may also be used for purposes not listed in this medication guide.
What should I know about cyanocobalamin before taking it?
Cyanocobalamin can lead to optic nerve damage (and possibly blindness) in people with Leber's disease. Tell your doctor if you have ever had: heart disease; diabetes; a bleeding or blood clotting disorder; gout; an iron or folic acid deficiency; low levels of potassium in your blood; or.
Can cyanocobalamin treat pernicious anemia?
To treat pernicious anemia, you will have to use cyanocobalamin on a regular basis for the rest of your life. Not using the medication can lead to irreversible nerve damage in your spinal cord. Pernicious anemia is also treated with folic acid to help maintain red blood cells.
How much cobalamin should I take for vitamin B12 deficiency?
High-dose oral cobalamin is also sufficient to replenish the B12 level absorbed through passive absorption or if the patient refuses to take injections. Oral daily 1-2mg of cobalamin seems to be suitable in these scenarios.
What is the indication of cyanocobalamin?
Cyanocobalamin is indicated for vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia. Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy.
Why do patients take cyanocobalamin?
Cyanocobalamin injection is used to treat or prevent vitamin B12 deficiency caused by the following conditions: Addisonian (pernicious) anemia. Stomach or bowel problems.
Why would vitamin B12 be prescribed?
Vitamin B12 shots are injections that a doctor may prescribe to treat a vitamin B12 deficiency, especially if a person's body has difficulty absorbing the vitamin. A deficiency in vitamin B12 can lead to various health problems, ranging from fatigue to permanent neurological changes.
Which condition can be treated using B12 injections?
Treating vitamin B12 deficiency anaemia. Vitamin B12 deficiency anaemia is usually treated with injections of vitamin B12. There are 2 types of vitamin B12 injections: hydroxocobalamin.
What is cyanocobalamin used to treat?
Cyanocobalamin is a manufactured version of vitamin B12. It's used to treat and prevent vitamin B12 deficiency anaemia (when you have low levels of this vitamin in your body). Your body requires vitamin B12 to make red blood cells.
What is pernicious anaemia?
Pernicious anaemia is the most common cause of vitamin B12 deficiency in the UK. Pernicious anaemia is an autoimmune condition that affects your stomach. An autoimmune condition means your immune system, the body's natural defence system that protects against illness and infection, attacks your body's healthy cells.
What autoimmune disease causes pernicious anemia?
Pernicious anemia is sometimes seen in association with certain autoimmune endocrine diseases, such as type 1 diabetes, hypoparathyroidism, Addison's disease, and Graves' disease.
What is a deficiency in B12?
What is vitamin B12 deficiency anemia? Vitamin B12 deficiency anemia is a condition in which your body does not have enough healthy red blood cells, due to a lack (deficiency) of vitamin B12. This vitamin is needed to make red blood cells, which carry oxygen to all parts of your body.
Who is at risk for vitamin B12 deficiency?
Any person can develop vitamin B12 deficiency at any age. People who are 60 years old or older are more likely to have vitamin B12 deficiency compared to other age groups.
When should B12 be taken?
Vitamin B12 As a general rule of thumb, take your B vitamins in the morning or with a meal. Vitamin B12, for example, should definitely be taken in the morning. This is because it is important for energy metabolism, which may interrupt your sleep if taken at night.
What Is Oral Cyanocobalamin?
Cyanocobalamin is a man-made form of vitamin B12. Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue s...
Before Taking This Medicine
You should not use this medicine if you are allergic to cobalt, or if you have Leber's disease. Cyanocobalamin can lead to optic nerve damage (and...
How Should I Take Oral Cyanocobalamin?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.Your dose n...
What Happens If I Miss A Dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
Oral Cyanocobalamin Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.C...
Cyanocobalamin Dosing Information
Usual Adult Dose for Pernicious Anemia:Initial dose: 100 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 daysIf clinical improvement...
What Other Drugs Will Affect Oral Cyanocobalamin?
Other drugs may interact with cyanocobalamin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your docto...
What is the B12 that is broken down?
What we’ve found is that no matter what source of B12 you’re consuming with food, it’s still hard for people to break down! But, in the normal biochemical process, if the body breaks down B12, it's going to break it down into two molecules, which is methylcobalamin and adenosylcobalamin.
What is the best B12 supplement?
It’s an essential vitamin so make sure that any supplement you choose has the most bioavailable forms of B12 — methylcobalamin and adenosylcobalamin . Cheaply made, lesser products typically use cyanocobalamin, which is synthetic and far less effective.
What are the different types of B12?
There are four types of vitamin B12: methylcobalamin, adenosylcobalamin, hydroxocobalamin, and cyanocobalamin. While methylcobalamin and adenosylcobalamin are active natural forms, hydroxoco balamin and cyanocobalamin are synthetic forms of vitamin B12. Because it can be cheaply made, cyanocobalamin is perhaps the most commonly used type ...
Is B12 a good vitamin?
Vitamin B12 is an essential vitamin that’s necessary for good health. Your body cannot naturally produce it. However, vitamin B12 is commonly available in various foods and supplements. If you’ve been searching for a B12 supplement, you might have seen many scientific-sounding ingredients that aren’t fully explained.
What is B12 used for?
Vitamin B12 (cobalamin) is an essential vitamin and medication used in the management and treatment of pernicious anemia, ileal resection, treatment of spinal cord myelopathy, and other conditions. This activity reviews the indications, action, and possible contraindications for cobalamin as a valuable agent.
What is the role of cobalamin in the body?
In the systemic circulation, cobalamin binds with transporter protein termed transcobalamin II (TCII) and enters into the tissue with the receptor of transcobalamin II. Cobalamin has many cellular effects with the greatest impact on new blood cell generation and neurological function.
What is the FDA approved indication for pernicious anemia?
FDA approved indications: Pernicious anemia: Intrinsic factor of Castle deficiency due to autoantibody formation against parietal cells of the stomach, which results in decreased absorption of vitamin B12 through ileum. Malabsorption: Impairment of vitamin B12 absorption.
What happens if cobalamin is not present?
If cobalamin is not present in sufficient amount, megaloblastic anemia occur s by inhibition of DNA synthesis due to the folate trap. Cobalamin (vitamin B12) in the form of adenosylcobalamin acts as a cofactor for enzyme methyl- malonyl-co A mutase, which converts methyl malonyl CoA to succinyl CoA.
Which cobalamins are synthetic?
Cyanocobalamin and hydroxocobalamin are synthetic forms of cobalamin, whereas adenosylcobalamin (AdoCbl) and methylcobalamin have a biological activity to act as cofactors in enzymatic reactions that play a role in the synthesis of DNA, myelin and fatty acids which are vital for cell division and growth.
Is it necessary to take folate with B12 deficiency?
So, regular monitoring should be done frequently in these conditions. Folate supplementation is necessary if the patient has concomitant folate deficiency, but folate treatment in a patient with vitamin B12 deficiency may cause irreversible neurological symptoms because folic acid can aggravate vitamin B12 deficiency.
Can cobalamin be taken intravenously?
Because of the tendency to develop anaphylaxis, cobalamin administration is never via the intravenous route. [15] Adverse Effects. Significant pain is the common adverse effects of intramuscular vitamin B12, especially in thin people. Injectable cobalamin may also cause bleeding if the patient is taking anticoagulants.
What is the active form of B12?
Vitamin B12 (cyancobalamin, Cbl) has two active co-enzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdCbl). There has been a paradigm shift in the treatment of vitamin B12 deficiency such that MeCbl is being extensively used and promoted.
What is the role of MeCbl in the development of the brain?
MeCbl is primarily involved along with folate in hematopiesis and development of the brain during childhood. Whereas deficiency of AdCbl disturbs the carbohydrate, fat and amino-acid metabolism, and hence interferes with the formation of myelin.
