What are the side effects of arsenic?
Arsenic was used in some medicinal applications until the 1970s. Inorganic arsenic was used in the treatment of leukaemia, psoriasis, and chronic bronchial asthma, and organic arsenic was used in antibiotics for the treatment of spirochetal and protozoal disease (ATSDR, 2007).
What are the advantages of arsenicum?
After a decline in the use of arsenic during the mid-20th century, arsenic trioxide was reintroduced as an anticancer agent after reports emerged from China of the success of an arsenic trioxide-containing herbal mixture for the treatment of acute promyelocytic leukaemia.
Is arsenic used in medicines?
Jul 12, 2010 · Specifically, a form called arsenic trioxide has been used as a therapy for a particular type of leukemia for more than 10 years. Now researchers at the Stanford University School of Medicine have shown that it may be useful in treating a variety of other cancers.
Is arsenic used for cancer treatment?
Arsenic trioxide is a chemotherapy drug and is also called Trisenox or ATO. It is a treatment for a type of acute myeloid leukaemia called acute promyelocytic leukaemia (APL). How it works. Arsenic works by speeding up the death of leukaemic cells and encouraging normal blood cells to develop properly.
Why are drugs studied?
Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
What is APL in cancer?
Acute promyelocytic leukemia (APL) in patients whose cancer has a certain type of chromosome mutation that affects the PML gene and RARA gene. It is used: In adults with newly diagnosed APL that is low risk. In patients whose disease has not gotten better or has relapsed after retinoid and anthracycline chemotherapy.
Is a syringe a substitute for medical advice?
It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.
How does arsenic trioxide work?
It works by stopping Gli2 from moving into the cell’s primary cilium, a communication hub, where many of the events of Hedgehog signaling take place.
What is the hedgehog inhibitor?
Cyclopamine, a plant-derived molecule identified as a Hedgehog pathway inhibitor by Beachy in 1998, binds to a protein on the surface of the cell called Smoothened and blocks its ability to transmit the Hedgehog signal to the cell’s innards.
Who funded the Stanford study?
The research was funded by the Stanford Center for Children’s Brain Tumors, the Howard Hughes Medical Institute and the National Institutes of Health.
Is itraconazole an antifungal?
In addition, Beachy recently identified an antifungal drug commonly used in humans, itraconazole, as a Hedgehog pathway inhibitor. “However, these compounds target a component of the pathway that can be mutated with patients then becoming resistant to the therapy. Arsenic blocks a different step of the cascade.”.
Is arsenic trioxide good for leukemia?
Specifically , a form called arsenic trioxide has been used as a therapy for a particular type of leukemia for more than 10 years. Now researchers at the Stanford University School of Medicine have shown that it may be useful in treating a variety of other cancers.
How long does arsenic trioxide last?
Or if your treatment has come back (relapsed) or not gone away (refractory). You have it for 5 days a week with a 2 day break, for 4 to 5 weeks.
How to control sickness?
Feeling or being sick is usually well controlled with anti sickness medicines. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniques can all help.
What are the effects of a syringe?
Each of these effects happens in between 1 and 10 out of 100 people (1 and 10%). You might have one or more of them. They include: 1 increased risk of getting an infection 2 breathlessness and looking pale due to a low number of red blood cells carry oxygen around your blood 3 bruising, bleeding gums or nosebleeds due to a low number of platelets in your blood 4 fluid around the heart or lungs 5 weight gain 6 kidney changes - you will have regular blood tests to check this 7 eye changes such as blurred vision 8 low blood pressure 9 seizures 10 herpes virus 11 chills 12 tummy (abdominal) pain 13 bone and joint pain 14 high number of white blood cells in your blood (leucocytosis) 15 a build up of a substance called ketones in the blood and urine (ketoacidosis) 16 inflammation of the blood vessels 17 chest pain 18 bleeding in the lung 19 reddening of the skin 20 swollen face (oedema) 21 sudden sharp, stabbing or burning pain in the chest when you take a breath in or breathe out
Why do you have to have a blood test?
You have regular blood tests to check for any changes in the way your liver is working. Less commonly your blood might show high levels of bilirubin in the blood. You have regular blood tests to check for any changes in the levels of chemicals produced by the liver.
What do they check before and during a chemo treatment?
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
How long does a central line last?
It stays in while you’re having treatment, which may be for a few months. Find out about central lines.
Can you get numbness in your fingers after a syringe?
Numbness or tingling in fingers or toes is often temporary and can improve after you finish treatment. Tell your doctor if you're finding it difficult to walk or complete fiddly tasks such as doing up buttons.
What is the best way to prevent arsenic poisoning?
One of the most effective preventive measures against arsenic poisoning is to make sure you drink clean, filtered water. You can also make sure that all foods are prepared in clean water.
What causes arsenic poisoning?
Other possible causes of arsenic poisoning can include: 1 breathing air that contains arsenic 2 smoking tobacco products 3 breathing contaminated air from plants or mines that use arsenic 4 living near industrialized areas 5 being exposed to landfill or waste sites 6 breathing in smoke or dust from wood or waste that was previously treated with arsenic 7 eating arsenic-contaminated food — this isn’t common in the United States, but some seafood and animal products may contain small levels of arsenic
What happens if you get exposed to arsenic?
You should seek emergency help if you experience any of the following after a suspected arsenic exposure: darkening skin.
How long does it take for arsenic to be detected in urine?
There are tests to measure high levels of arsenic in the body via the: Urine tests are most commonly used in cases of acute exposure that has happened within a few days. According to the U.S. Centers for Disease Control and Prevention, all other tests measure long-term exposure of at least six months.
Where does arsenic poisoning occur?
Countries that have high levels of arsenic-containing groundwater include the United States, India, China, and Mexico.
How long does it take to recover from arsenic poisoning?
The best way to treat the condition is to eliminate arsenic exposure. Full recovery may not happen for weeks or months. It all depends on how long you’ve been exposed. The severity of your symptoms can also play a role.
Can you get arsenic poisoning from a job?
Short-term arsenic poisoning can cause unpleasant symptoms, but the outlook remains good overall. The most serious problems tend to occur from exposure to arsenic over long periods of time. This can happen at a daily job, or by eating or breathing contaminants on a regular basis. The earlier you catch arsenic exposure, the better the outlook. You can also reduce your cancer risk when you catch it early.
Does the Source of My Water Make a Difference?
The source of your water makes a difference to the amount of arsenic III versus arsenic V in your water. This matters for choosing appropriate treatment options.
Does Reverse Osmosis Remove Arsenic?
Reverse Osmosis water treatment technology can reliably remove arsenic V but does not reliably remove arsenic III.
Do I Need Whole Home Water Treatment to Remove Arsenic?
Pure Water Solutions has 5 different methods to remove Arsenic from one sink or Whole treatment for arsenic removal in every tap in the house.
What to Do If You Have Arsenic in Your Well Water?
Assuming you do not currently have a detailed water lab report of your top 35 – 50 contaminants in your well, the next step might be to test your water using a certified laboratory.
