How much weight can a patient gain on doxorubicin?
A patient who is on doxorubicin gains 6 pounds in a week of treatment. What is the possible cause? Nice work! You just studied 51 terms! Now up your study game with Learn mode.
What should I know about doxorubicin before taking it?
Do not receive any kind of vaccination without your doctor’s approval while taking Doxorubicin. Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D, Doxorubicin may be hazardous to the fetus.
What are the risks of doxorubicin therapy?
Another rare, yet serious risk that is associated with doxorubicin therapy is the risk of developing a blood cancer, such as leukemia, up to years after taking the drug. Talk to your doctor about this risk.
What happens if doxorubicin seeps out of the vein?
If doxorubicin accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the doctor or nurse right away if you notice redness, pain, or swelling at the place of injection.
Which adverse effects may occur in a patient who is taking cisplatin select all that apply?
Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.
Which adverse effects are expected in a patient using bleomycin?
Bleomycin can commonly cause skin reactions (such as redness, itching, blisters, rash, swelling), usually in the second or third week of treatment. These reactions are not always serious.
Which drug causes cell death through intercalation?
Doxorubicin, as other anthracyclines, is considered to damage DNA through intercalation or direct alkylation and may result in the formation of DNA double-strand breaks47.
Which adverse effect may occur in a patient receiving busulfan?
Nausea, vomiting, diarrhea, constipation, loss of appetite, mouth sores, stomach/abdominal pain, dizziness, swelling ankles/feet/hand, flushing, headache, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Nausea and vomiting can be severe.
What are the side effects of doxorubicin?
Side EffectsCough or hoarseness accompanied by fever or chills.darkening or redness of the skin (if you recently had radiation treatment)fast or irregular heartbeat.fever or chills.joint pain.lower back or side pain accompanied by fever or chills.pain at the injection site.More items...•
What are the major adverse effects specific to the cytotoxic antibiotics?
While some adverse effects can be treated symptomatically, others may be lifethreatening. Less common, but nonetheless significant, adverse effects include hypersensitivity reactions, ocular, cardiac, pulmonary, hepatic, renal, neurological and vascular toxicities.
How can doxorubicin be fatal to a cell?
By binding to DNA and blocking mRNA synthesis, adriamycin effectively inhibits protein synthesis. Cessation of this process prevents the cell from replacing enzymes and other proteins required for cellular survival.
How does doxorubicin work in the body?
Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow. You might have doxorubicin in combination with other chemotherapy drugs.
Where does doxorubicin bind to?
Doxorubicin (DOX) is a cancer drug that binds to dsDNA through intercalation.
What is the side effect of daunorubicin?
Common side effects of Cerubidine include: nausea, vomiting, constipation, diarrhea, and loss of appetite. Cerubidine may cause urine to turn a reddish color. This is a normal, harmless effect of Cerubidine and should not be mistaken for blood in the urine.
Which of the following side effects has been associated with cumulative doses of busulfan?
Busulfan can cause interstitial fibrosing lung disease (“busulfan lung”) with an estimated incidence of 6% [5]. It begins gradually, causes dyspnea and cough, and is often accompanied by skin pigmentation. It usually occurs after prolonged treatment (on average 41 months, cumulative dose 2900 mg).
What is busulfan conditioning?
IV busulfan is gradually replacing total body radiation as pre-transplant "conditioning" treatment for both pediatric and adult patients. This is especially important in children because total body radiation affects physical and mental development.
What is the name of the state of deep adrenocortical insufficiency?
An adrenal crisis is a life-threatening state of profound adrenocortical insufficiency and requires immediate medical management. The symptoms of adrenal crisis include hyperkalemia, a drop in extracellular fluid volume, and hyponatremia. A buffalo hump is a clinical manifestation of Cushing's syndrome.
How long should a nurse take capecitabine?
The primary health care provider should advise the nurse to administer capecitabine to the patient twice a day for 2 weeks. The nurse should then stop administering capecitabine for 1 week to prevent the adverse effects related to prolonged use of the.
Why should a nurse stop taking warfarin?
The nurse discontinues administration of warfarin under the discretion of the provider, because warfarin interacts with capecitabine and increases the risk of bleeding. The nurse should avoid administration of warfarin in a double dose, because it can cause bleeding.
How long do you have to keep medication for transplant?
A week's medication supply must be kept available. 4. For a transplantation patient, a medication supply for 1 week must be stored in advance, so that the patient never runs out of the supply. Immunosuppressive therapy is lifelong, and it is very important for patients to receive emotional and spiritual support.
Why do tumors have a reduced blood supply?
Changes in alanine transaminase (ALT) levels are seen in patients with impaired liver function. Because the tumors are highly vascular, there is a reduced blood supply to the surrounding tissue.
Is diarrhea a side effect of overdose?
Diarrhea is also observed as a side effect in the event of an overdose. However, bloody stools are not observed. Patients who are administered an overdose of the drug develop insomnia as a side effect. Irregularities in urine output are a symptom of declined renal function.
Can you restrict your activities during chemotherapy?
Weakness may require planning rest and activity but does not require the patient to restrict activities.
How much doxorubicin pills depend on?
The amount of Doxorubicin you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your exact dosage and schedule.
How long does it take for doxorubicin to cause heart problems?
Dose-related heart problems can occur as late as 7 or 8 years after treatments have ended. Another rare, yet serious risk that is associated with doxorubicin therapy is the risk of developing a blood cancer, such as leukemia, up to years after taking the drug. Talk to your doctor about this risk.
What are the cells that are most affected by chemo?
The “normal” cells most commonly affected by chemotherapy are blood cells; cells in the mouth, stomach and bowel, and hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss. Different drugs may affect different parts of the body. Doxorubicin is classified as an antitumor antibiotic.
How is doxorubicin given?
How Doxorubicin Is Given: Doxorubicin is administered via an intravenous (IV) injection through a central line or a peripheral venous line , and the drug is given over several minutes. Doxorubicin can also be given by continuous infusion through a central catheter line. There is no pill form of Doxorubicin. Doxorubicin is a vesicant.
What happens if you take vesicant?
A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein. The nurse or doctor who gives Doxorubicin must be carefully trained. If you notice redness or swelling at the IV site while you are receiving Doxorubicin, alert your health care provider immediately.
What is the trade name for Rubex?
Trade Names: Adriamycin ®, Rubex®. Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®. In some cases health care professionals may use the trade names Adriamycin® or Rubex® when referring to the generic drug name Doxorubicin.
Why is chemotherapy given in cycles?
The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles. Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells.
What happens if you take doxorubicin?
If doxorubicin accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Tell the doctor or nurse right away if you notice redness, pain, or swelling at the place of injection.
How long does doxorubicin last?
This is not blood. It is to be expected and only lasts for 1 or 2 days after each dose is given.
Why is it important to check your progress with a doctor?
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Can you get immunizations with doxorubicin?
While you are being treated with doxorubicin, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Doxorubicin may lower your body's resistance, and there is a chance you might get the infection the immunization is meant to prevent.