Is Doxil as bad as taxol?
I will say Doxil is not quite as bad as taxol. Did not lose all my hair but lost a lot of it. I had many side effects; sores in my mouth, rash, hand and foot syndrome. I was so sick from frontline and sick again for recurrence with Doxil.
What happens if Doxil is given intravenously?
Doxil is given by injection through a vein (intravenously, by IV). Doxil is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If Doxil escapes from the vein it can cause tissue damage. The nurse or doctor who gives Doxil must be carefully trained.
What type of antibiotic is Doxil?
Doxil is classified as an antitumor antibiotic. Antitumor antibiotics are made from natural products produced by species of the soil fungus Streptomyces. These drugs act during multiple phases of the cell cycle and are considered cell-cycle specific. There are several types of antitumor antibiotics:
Does Doxil cause a rash?
The rash is a known side effect of Doxil. Especially for fair skinned people. I don’t think your doctor was lying to you, but may not have realized how bad it can affect some. As your doctor said, it was the easiest treatment my mom had and she felt completely fine on it.
What cancers does Doxil treat?
What Doxil Is Used For: Doxil is used to treat AIDS-related Kaposi's sarcoma, breast cancer, ovarian cancer, and other solid tumors. Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful.
How effective is Doxil for metastatic breast cancer?
Forty women received a median initial dose of 42.5 mg/m2 usually every 4 weeks and a median cumulative dose of 135 mg/m2 (range: 40-595 mg/m2). There were 10 partial responses and seven patients with stable disease for more than 6 months resulting in a clinical benefit rate of 43% in the intent-to-treat analysis.
Is paclitaxel stronger than doxorubicin?
The doxorubicin arm had greater toxicity, but this was counterbalanced by better symptom control. CONCLUSION: At the dosages and schedules used in the present study, doxorubicin achieves better disease and symptom control than paclitaxel in first-line treatment.
How effective is Doxil for ovarian cancer?
Doxil® plus Eloxatin® Highly Active in Recurrent Ovarian Cancer. Researchers from Italy recently conducted a clinical trial to evaluate the effectiveness of Doxil plus Eloxatin in 40 patients with recurrent ovarian cancer. Regression of cancer was achieved in 68% of patients.
How quickly does Doxil work?
Liposomal doxorubicin is a light red liquid that you have through a drip (infusion) into your bloodstream. It usually takes between 30 to 90 minutes each time you have it.
What are the side effects of Doxil?
Side EffectsBody aches/pains, headache, nausea, vomiting, constipation, diarrhea, stomach upset, and loss of appetite may occur. ... This medication may give a reddish-orange color to your urine, tears, and sweat. ... Temporary hair loss may occur.More items...
Is doxorubicin worse than Taxol?
HAMBURG-In previously un-treated women with advanced breast cancer, doxorubicin (Adriamycin) yields a higher response rate and longer progression-free survival than does paclitaxel (Taxol), according to the results of a randomized crossover trial conducted by the EORTC and presented at the Ninth European Cancer ...
Does chemo get harder with each cycle?
The effects of chemo are cumulative. They get worse with each cycle. My doctors warned me: Each infusion will get harder. Each cycle, expect to feel weaker.
Which chemo is worse AC or Taxol?
AC was worse for me I had 4 rounds every 2 weeks of AC and 12 weekly of taxol. The AC made me nauseas and taxol did not. I was actually able to go back to work when I started the taxol. I could not work through the AC, the nausea was hard on me but I never vomited.
Is Doxil well tolerated?
Pegylated liposomal doxorubicin, an effective, well-tolerated treatment for refractory aggressive fibromatosis.
How well does Doxil work?
Overall median survival was 14.4 months in the Doxil arm and 13.7 months in the topotecan group (P = . 05), yielding an 18% reduction in risk of death (hazard ratio [HR] = 1.216). Overall tumor response rates were 19.7% (47 patients) in the Doxil arm, and 17% (40 patients) in the topotecan arm.
Does Doxil always cause hair loss?
v Hair loss is unusual with liposomal doxorubicin, but some patients do experience more hair loss than others. If hair loss occurs, hair growth should return upon completion of treatment. v Nausea and vomiting are not unusual but are less common today than in the past because of much improved anti-nausea medications.
How is doxil given?
Doxil is given by injection through a vein (intravenously, by IV). Doxil is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If Doxil escapes from the vein it can cause tissue damage. The nurse or doctor who gives Doxil must be carefully trained.
What is doxil used for?
What Doxil Is Used For: Doxil is used to treat AIDS-related Kaposi's sarcoma, breast cancer, ovarian cancer, and other solid tumors. Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful.
What does nadir mean in chemo?
Nadir: Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts. Hand -foot syndrome (Palmar-plantar erythrodysesthesia or PPE) -skin rash, swelling, redness, pain and/or peeling of the skin on the palms of hands and soles of feet.
Why is chemotherapy given in cycles?
The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles. Chemotherapy is most effective at killing cells that are rapidly dividing.
What is the term for a drug that affects cells only when they are dividing?
They also induce cell suicide (self-death or apoptosis). Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific.
Does Doxil go away?
Doxil side effects are almost always reversible and will go away after treatment is complete. There are many options to help minimize or prevent Doxil side effects.
Is there a pill form of Doxil?
There is no pill form of Doxil. The amount of Doxil you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dose and schedule.
How to help nausea and vomiting from oncology?
Talk to your oncology care team so they can prescribe medications to help you manage nausea and vomiting. In addition, dietary changes may help. Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Try saltines, or ginger ale to lessen symptoms.
Can you take a syringe alone?
It can be given alone or with other drugs. The dosage and schedule is determined by the person's size, type of cancer, and mode of administration. Even when carefully and correctly administered by trained personnel, this drug may cause a feeling of burning and pain.
Does doxorubicin help with cancer?
As a result, Doxil has more time to reach the tumor tissue, where the medication is then slowly released.
Does Doxil slow down the spread of cancer?
As a result, Doxil has more time to reach the tumor tissue, where the medication is then slowly released. Doxorubicin liposomal interferes with the growth of cancer cells and slows their spread in the body by inhibiting DNA synthesis and causing the production of harmful free radicals.
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