Sildenafil, also known as Viagra, is an FDA-approved therapy for male erectile dysfunction. One of its effects is to relax (or open) the lung vessels, thereby lowering the blood pressure in the lungs. We hypothesize that sildenafil will result in an improvement in exercise capacity, quality-of-life, and shortness of breath.
What is the role of sildenafil citrate in the treatment of pulmonary arterial hypertension?
Abstract. Background and objective: Limited data suggest a benefit following sildenafil treatment in patients with pulmonary hypertension (PH) and interstitial lung disease (ILD). The role of sildenafil in the management of PH in ILD is not clear. We report our experience of ILD patients with PH after 6-month sildenafil therapy.
What is sildenafil used to treat?
Feb 04, 2006 · It may be useful in adults, children, and neonates after cardiac surgery, with left heart failure, in fibrotic pulmonary disease, high altitude exposure, and thromboembolic disease, and in combination with other therapies for pulmonary hypertension, such as inhaled iloprost.
What are sildenafil and Revatio used for?
Background: Lung fibrosis can be complicated by pulmonary hypertension, limiting exercise tolerance and life expectancy. Furthermore, vasodilators might cause deterioration in gas exchange. Our aim was to compare acute effects of sildenafil, nitric oxide, and epoprostenol in individuals with pulmonary hypertension secondary to lung fibrosis.
How does sildenafil work to treat PAH?
Mar 26, 2021 · Sildenafil citrate has been used in the treatment of erectile dysfunction throughout the world, and it has recently been used in the treatment of other diseases, primarily pulmonary hypertension . Sildenafil citrate is a phosphodiesterase type 5 (PDE 5) enzyme inhibitor, and it causes relaxation in the smooth muscles by increasing cGMP.
Is sildenafil good for lungs?
Exercise capacity is limited in part by high blood pressure in the blood vessels in the lungs. Sildenafil, also known as Viagra, is an FDA-approved therapy for male erectile dysfunction. One of its effects is to relax (or open) the lung vessels, thereby lowering the blood pressure in the lungs.
How effective is sildenafil for pulmonary hypertension?
Compared with placebo, there was a significant decrease in mPAP of 6.7 and 11.6 mmHg after the first dose of sildenafil and at 12 weeks, respectively. Six minute walk and physical symptoms score improved significantly by 43.5 m and 10.4 points at 12 weeks compared with placebo.
Can sildenafil help with COPD?
Since in COPD the synthesis of nitric oxide in pulmonary arteries is impaired [10], sildenafil could be beneficial for treating COPD-associated pulmonary hypertension.
What else can sildenafil be used for?
Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take Viagra while also taking Revatio, unless your doctor tells you to.
Can sildenafil worsen pulmonary hypertension?
Increased blood pressure in the pulmonary artery might persist after valve treatment, according to the study, which points out that sildenafil—which usually is used to treat erectile dysfunction—is frequently prescribed off-label in patients with retrograde pulmonary hypertension.Sep 13, 2017
When should I take sildenafil for pulmonary hypertension?
To treat high blood pressure in the lungs, take this medication by mouth with or without food as directed by your doctor, usually 3 times a day (about 4-6 hours apart). The dosage is based on your medical condition, response to treatment, and other medications you may be taking.
Does sildenafil help with shortness of breath?
Two patients with severe COPD and erectile dysfunction reported that their dyspnea improved when they took oral sildenafil for erectile dysfunction. Spirometry performed in these patients revealed an improvement in FEV(1) by 24% and 12%.
Does sildenafil help asthma?
The scientific basis for using sildenafil in airway flow limitation comes from the fact that cGMP mediates relaxation of airway smooth muscle via “classic” protein kinase/protein phosphorylation cascade mechanisms and since sildenafil increases the tissue levels of cGMP, so it has the potential to relieve the ...
Can sildenafil cause shortness of breath?
chest pain. worsening shortness of breath. erection that is painful or lasts longer than 4 hours. itching or burning during urination.
What is the difference between Sildenafil citrate and sildenafil?
For the most part, there are no differences between Viagra (sildenafil citrate) and sildenafil. The active ingredients are identical and the only differences are due to marketing.May 3, 2021
What age does a man stop getting a hard on?
The research, published in the August 2003 issue of Annals of Internal Medicine, shows that ED is common among older men and sexual function sharply decreases after age 50. Erectile dysfunction is the inability to attain or maintain an erection adequate for the sexual satisfaction of both partners.Aug 4, 2003
Does sildenafil keep you hard after coming?
Viagra is also prescribed for many men with early ejaculation. Viagra helps to maintain the erection after ejaculation and reduces the refractory time before a second erection can be obtained.
How do you know if you have a symtom?
The disease develops slowly and may take years to show symptoms, which include: 1 Cough 2 Sputum (mucus) production 3 Shortness of breath (especially with exercise) 4 WheezingWheezing 5 Chest tightness
Can smoking cigarettes cause COPD?
COPD is a lung disease in which breathing is difficult. It's usually caused by smoking cigarettes, but it can also be caused by other lung irritants. The disease develops slowly and may take years to show symptoms, which include: Those symptoms may or may not indicate COPD, states the NHLBI's web site.
Does Viagra lower blood pressure?
Oct. 25, 2006 -- Viagra may ease blood pressure in the lungs of people with chronic obstructive pulmonary disease ( COPD ). That's according to a small Dutch study presented in Salt Lake City at Chest 2006, held by the American College of Chest Physicians.
What is the condition that causes shortness of breath?
Patients with chronic obstructive pulmonary disease (COPD) suffer from impaired exercise capacity and quality-of-life, largely related to shortness of breath. Many of the therapies currently available for COPD are aimed at improving these factors. Exercise capacity is limited in part by high blood pressure in the blood vessels in the lungs.
Does Sildenafil lower blood pressure?
One of its effects is to relax (or open) the lung vessels, thereby lowering the blood pressure in the lungs. We hypothesize that sildenafil will result in an improvement in exercise capacity, quality-of-life, and shortness of breath.
Does Sildenafil help with lung function?
The purpose of this study is to determine if sildenafil improves the exercise capacity and lung function of patients with chronic obstructive pulmonary disease. Patients with chronic obstructive pulmonary disease (COPD) suffer from impaired exercise capacity and quality-of-life, largely related to shortness of breath.
What is the difference between Viagra and Sildenafil?
Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in adults with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, ...
What to do if you are allergic to Sildenafil?
tell your doctor and pharmacist if you are allergic to sildenafil, any other medications, or any of the ingredients in sildenafil products. Ask your pharmacist for a list of the ingredients.
What are the side effects of a syringe?
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: 1 sudden severe loss of vision (see below for more information) 2 blurred vision 3 sudden decrease or loss of hearing 4 ringing in ears 5 dizziness or lightheadedness 6 fainting 7 chest pain 8 worsening shortness of breath 9 erection that is painful or lasts longer than 4 hours 10 itching or burning during urination 11 rash
How long before sex can you take Sildenafil?
The best time to take sildenafil is about 1 hour before sexual activity, but you can take the medication any time from 4 hours to 30 minutes before sexual activity. Sildenafil usually should not be taken more than once every 24 hours.
Does Sildenafil help with erectile dysfunction?
Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily. If you are taking sildenafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire.
What is the phone number to call for poison control?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Can you take Sildenafil with food?
You can take sildenafil with or without food. However, if you take sildenafil with a high-fat meal, it will take longer for the medication to start to work. If you are taking sildenafil to treat PAH, follow your doctor's directions and the guidelines in this paragraph.
What is the baseline for the safety data in the Super-2 study?
Baseline for the safety data in the SUPER-2 study was considered to be week 12 of the SUPER-1 study . All observed or volunteered AEs in patients entering the extension study were recorded using Medical Dictionary for Regulatory Activities, with severity and the investigator's opinion of the relationship to the study treatment noted. Laboratory results were considered AEs if they were associated with accompanying symptoms; required additional testing or intervention; precipitated a change in study drug dose, discontinuation, or significant additional therapy; or were designated an AE by the investigator.
Is sildenafil safe for pulmonary arterial hypertension?
Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide.
When was Sildenafil approved?
Sildenafil was just approved this month (June 6, 2005) for the treatment of pulmonary arterial hypertension. According to Pfizer Inc., clinical trials have demonstrated that sildenafil (Revatio™) 20 mg taken three times daily was effective for the treatment of PAH in comparison to placebo. The most common side effects reported with therapy were ...
What is pulmonary arterial hypertension?
Introduction: Pulmonary arterial hypertension (PAH) is a progressive, and often fatal, debilitating disorder.1,2 The clinical hallmarks of this disease include: 1) progressive breathlessness 2) exertion limitation and 3) frequent decline and failure of the right ventricle.2 It is estimated that pulmonary arterial hypertension (PAH) ...
What is the PAH?
The increased pulmonary artery (PA) pressure found in PAH is due to disturbances in key vascular mediator pathways including relative deficiencies of vasodilators such as nitric oxide (NO) and prostacyclin, as well as exaggerated production of vasoconstrictors such as endothelin and thromboxanes. 2 Given the generally accepted role of pulmonary vasoconstriction in PAH, vasodilators such as bosentan, epoprostenol, iloprost, and sildenafil are a natural initial therapeutic choice. 2,3,4,5
Is Sildenafil good for pulmonary hypertension?
According to previous studies, sildenafil appears to be an important therapeutic addition for patients with pulmonary arterial hypertension. This agent has the advantage of having a low incidence of side effects, is easy to administer (oral dosage form), and is much cheaper compared to many of the alternatives.
Is Sildenafil safe for heart failure?
Study conclusion: The authors concluded that sildenafil was well tolerated with no adverse effects. They also stated that therapy with sildenafil reduces symptoms, improves effort tolerance and controls refractory heart failure significantly by 2 weeks in 70% of patients at 50 mg twice daily. 8.
Is Sildenafil a vasodilator?
Sildenafil is a select ive Phosphodiesterase-5 inhibi tor that has been reported to be a potent pulmonary vasodilator. 6 Sildenafil selectively inhibits phosphodiesterase 5 (PDE5 is abundant in pulmonary and penile tissue) which leads to stabilization of cyclic guanosine monophosphate (cGMP). 7 cGMP is a second messenger of nitric oxide (NO).
What to do if you forget to take Sildenafil?
If you are giving sildenafil liquid medicine to your child, shake the bottle well before you measure out the dose.
How many times a day should I take Sildenafil?
Take sildenafil exactly as your doctor tells you to. The usual dose for adults is one 20 mg tablet three times daily (6-8 hours apart), but your doctor will tell you what dose is right for you. Try to take your doses at the same times of day each day, as this will help you to remember to take the tablets regularly.
What is PAH in medicine?
Pulmonary arterial hypertension (PAH) is a condition where there is too high a blood pressure in the arteries which supply blood to your lungs from your heart. The arteries become narrowed so your heart has to work harder to pump blood to your lungs.
What is the name of the pill that is used for erectile dysfunction?
Another brand of sildenafil tablets called Viagra® is used by men for a completely different condition called erectile dysfunction. There is another medicine leaflet called Sildenafil for erectile dysfunction which gives more information about this.
How to take a syringe out of a bottle?
Turn the bottle (with the syringe connected to it) upside down. Gently pull out the plunger of the syringe so that the solution fills the syringe to the mark which corresponds to your dose. Turn the bottle the correct way up again and remove the syringe from the bottle.
Can you take Sildenafil while pregnant?
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sildenafil it is important that your doctor knows: If you are pregnant or breastfeeding. If you have any other heart or blood vessel disease.
Does grapefruit juice affect sildenafil?
This is because a chemical in grapefruit juice is thought to increase the amount of sildenafil in your bloodstream. This makes side-effects more likely. Each time you collect a new supply of tablets from your pharmacy, check to make sure that the tablets look to be the same as you have had before.