why is pindolol contraindicated in angina treatment?

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Is pindolol contraindicated in bradycardia?

Because beta blockers, like pindolol, depress conduction through the AV node, these drugs are contraindicated in patients with severe bradycardia or advanced AV block unless a functioning pacemaker is present. Beta-blockers should also be avoided in patients with sick sinus syndrome unless a functioning pacemaker is present.

Can pindolol be used to treat congestive heart failure?

Although beta-blockers should be avoided in overt congestive heart failure, if necessary, Pindolol tablets can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate.

What should I know about pindolol before taking it?

You should not use pindolol if you have asthma, or if you have a serious heart condition such as "AV block" (2nd or 3rd degree), uncontrolled heart failure, slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly. You should not use pindolol if you are allergic to it, or if you have:

Can disopyramide and pindolol be taken together for heart arrhythmias?

Disopyramide: (Major) Disopyramide and beta-blockers, like pindolol, have been used together for the treatment of ventricular arrhythmias; however, this combination should be used with caution due to the potential for additive AV blocking effects.

Precautions

Why are beta blockers contraindicated?

The blockade of these receptors with beta-blocker medications can lead to many adverse effects. Bradycardia and hypotension are two adverse effects that may commonly occur. Fatigue, dizziness, nausea, and constipation are also widely reported. Some patients report sexual dysfunction and erectile dysfunction.

Can beta blockers make angina worse?

Worsening of angina – Beta blockers can promote arterial spasm, meaning they cause the walls of the arteries to spasm and narrow, so they may actually worsen angina in people with variant angina (angina caused by spasm).

Why non selective β blockers are contraindicated in these patients?

Therefore, non-selective beta-blockers are contraindicated in patients with asthma or chronic obstructive pulmonary disease. Bronchoconstriction occurs because sympathetic nerves innervating the bronchioles normally activate β2-adrenoceptors that promote bronchodilation.

In which conditions beta blockers are contraindicated?

Traditional contraindications to beta-blockers are peripheral vascular diseases, diabetes mellitus, chronic obstructive pulmonary disease (COPD) and asthma.

Why are beta-blockers contraindicated in variant angina?

Beta-blockers can increase coronary artery spasm and cause chest pain so they are contraindicated in these patients.

Which drug should be avoided in angina?

The nitrate-induced acceleration of heart rate should be compensated by the addition of beta-blockers or heart rate-decreasing calcium channel blockers. Therefore, the combination of nitrates with heart-rate-increasing calcium channel blockers, such as nifedipine, should be avoided.

Why do beta-blockers cause vasoconstriction?

Propranolol, a non-selective β-blocker, exerts an indirect effect on the vasculature by leaving α-adrenergic receptors unopposed, resulting in peripheral vasoconstriction. We have previously shown that propranolol diminishes peripheral blood following burn injury by increasing vascular resistance.

Why do beta-blockers cause bronchoconstriction?

Early β-blockers are non-selective, in that they block both β-1 (cardiac) and β-2 (bronchial) adrenoceptors and can lead to unwanted β-2-blockade effects such as airflow obstruction.

How do beta-blockers cause vasodilation?

beta 1-blockers with beta 2 agonist activity are vasodilatory because they activate postsynaptic beta 2 receptors on vascular smooth muscle cell membranes, via the formation of cyclic AMP.

Is beta blockers contraindicated in first degree heart block?

Although first-degree AV block is not an absolute contraindication for administration of drugs such as calcium channel blockers, beta-blockers, digoxin, and amiodarone, extreme caution should be exercised in the use of these medications in patients with first-degree AV block.

How does a beta-blocker affect cardiovascular function?

Beta blockers work by blocking the effects of the hormone epinephrine, also known as adrenaline. Beta blockers cause the heart to beat more slowly and with less force, which lowers blood pressure. Beta blockers also help widen veins and arteries to improve blood flow.

Do beta blockers decrease myocardial contractility?

Beta-adrenergic blocking drugs decrease myocardial oxygen requirements by reducing systemic arterial pressure, heart rate and myocardial contractility at rest and during exercise, making them useful for treating ischemia.

Before Taking This Medicine

You should not use pindolol if you are allergic to it, or if you have: 1. asthma; 2. "AV block" (2nd or 3rd degree); 3. uncontrolled heart failure;...

How Should I Take Pindolol?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amou...

What Happens If I Miss A Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...

What Happens If I Overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include slow heartbeats, shortness of breath,...

What Should I Avoid While Taking Pindolol?

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.Avoid getting up too fast...

Pindolol Dosing Information

Usual Adult Dose for Hypertension:Initial dose: 5 mg orally 2 times a dayTitration: The dose may be adjusted in increments of 10 mg per day every 3...

What Other Drugs Will Affect Pindolol?

Tell your doctor about all your current medicines and any you start or stop using, especially: 1. digoxin, digitalis; 2. insulin or oral diabetes m...

What is the drug pindolol used for?

Pindolol is used to treat high blood pressure, but it's usually only given if other medications aren't working well enough.

What are the side effects of pindolol?

Some side effects of pindolol include fatigue, muscle pain and temporary dizziness when first starting the medication or increasing your dose.

How quickly does pindolol work?

Most people will notice lower blood pressure about 1 week after starting pindolol, but for some people, this can take 2 weeks to start lowering blo...

Why is pindolol contraindicated in angina?

While not listed as a contraindication in the package insert, most doctors will avoid prescribing pindolol if you have Prinzmetal's angina (vasospa...

Is pindolol a beta blocker?

Yes, pindolol is a nonselective beta blocker.

Where is pindolol administered?

Pindolol is administered orally. The drug is distributed throughout the body and is found in breast milk. Pindolol is moderately bound to plasma proteins (40—60%). The apparent volume of distribution is decreased by about 50% in uremic patients. Pindolol is substantially (about 60%) metabolized in the liver to hydroxylated metabolites that are then excreted in the urine as glucuronides and ethereal sulfate conjugates; in addition, 35—50% of a dose is excreted unchanged in the urine. Plasma half-life ranges from 3—4 hours in healthy adults.

How long does it take for pindolol to work?

Unlike other lipophilic beta-blockers, first-pass metabolism is minimal and affects only about 20% of the dose. Pindolol's onset and peak pharmacodynamic effects are generally seen within 1—3 hours, with a dose-dependent duration of action of 8—24 hours. Back to top.

Can pindolol cause double vision?

Beta-blockers, like pindolol, may exacerbate conditions such as psoriasis. Beta-blockers may potentiate muscle weakness and double vision in patients with myasthenia gravis.

Does pindolol cause Raynaud's disease?

Administration of pindolol can exacerbate Raynaud's phenomenon or peripheral vascular disease because beta-blockade can indirectly cause peripheral arterial insufficiency through unopposed alpha stimulation. In the case of pindolol, however, the ISA characteristics, which cause vasodilation, can lessen the severity of this reaction.

Is pindolol contraindicated for asthma?

Pindolol is contraindicated in patients with bronchial asthma. Pindolol should generally not be used in patients with nonallergic bronchospastic disease [e.g., chronic obstructive pulmonary disease (COPD), emphysema, bronchitis], or during acute bronchospasm because bronchodilation can be inhibited by beta-blockers.

Is pindolol metabolized by the kidney?

Since pindolol is substantially metabolized by the liver (60%) and kidney (40%), dosage reduction is recommended for patients with severe hepatic impairment, or for patients with hepatic disease and renal failure.

Can you breastfeed with pindolol?

According to the manufacturer, pindolol is distributed into breast milk and should not be used in women breast-feeding their infants. The American Academy of Pediatrics regards labetalol, metoprolol, and propranolol as usually compatible with breast feeding; these agents may represent alternatives for some patients. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA.

What is pindolol used for?

Pindolol is used to treat hypertension ( high blood pressure ). Pindolol may also be used for purposes not listed in this medication guide.

What are the side effects of taking pindolol?

Pindolol side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. shortness of breath (even with mild exertion), swelling, rapid weight gain; unusual changes in mood or behavior. feeling tired.

How to stop pindolol from making you dizzy?

pindolol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Can you take pindolol if you have asthma?

You should not use pindolol if you have asthma, or if you have a serious heart condition such as "AV block" (2nd or 3rd degree), uncontrolled heart failure, slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly.

Can you stop using pindolol for a short time?

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. If you need surgery, tell the surgeon ahead of time that you are using pindolol. You may need to stop using the medicine for a short time.

Can you breastfeed while taking pindolol?

It is not known whether pindolol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Pindolol can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Is pindolol safe for bronchitis?

if your heart cannot pump blood properly. To make sure pindolol is safe for you, tell your doctor if you have ever had: bronchitis, emphysema;

How effective is pindolol?

As monotherapy, Pindolol tablets are as effective as propranolol, α-methyldopa, hydrochlorothiazide, and chlorthalidone in reducing systolic and diastolic blood pressure.

How long does it take to stop taking pindolol?

When discontinuing chronically administered Pindolol tablets, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1 to 2 weeks and the patient should be carefully monitored.

How long does it take for pindolol to work?

alone or in combination with other antihypertensive agents. An antihypertensive response usually occurs within the first week of treatment. Maximal response, however, may take as long as or occasionally longer than 2 weeks. If a satisfactory reduction in blood pressure does not occur within 3 to 4 weeks, the dose may be adjusted in increments of 10 mg/day at these intervals up to a maximum of 60 mg/day.

How much is pindolol metabolized?

Pindolol tablets are only 40% bound to plasma proteins and are evenly distributed between plasma and red cells. The volume of distribution in healthy subjects is about 2 L/kg. Pindolol tablets undergo extensive metabolism in animals and man. In man, 35% to 40% is excreted unchanged in the urine and 60% to 65% is metabolized primarily ...

Can pindolol be reinstituted?

If angina markedly worsens or acute coronary insufficiency develops, Pindolol tablets administration should be reinstituted promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken.

Is pindolol a beta blocker?

These mechanisms appear less likely for Pindolol than other beta-blockers in view of the modest effect on resting cardiac output and renin. Beta-blockade therapy is useful when it is necessary to suppress the effects of beta-adrenergic agonists in order to achieve therapeutic goals.

Does pindolol lower blood pressure?

The effect on blood pressure is not orthostatic, i.e., Pindolol tablets were equally effective in reducing the supine and standing blood pressure. In open, long-term studies up to 4 years, no evidence of diminution of the blood pressure lowering response was observed.

Can medicine cause side effects?

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Can you get heart failure from taking pindolol?

There have been reports of people getting heart failure while taking pindolol. Talk to your doctor if you notice swelling in your feet or ankles, if your pulse feels fast or irregular, or if you have shortness of breath when you lie down or exercise.

Can you take pindolol with liver problems?

People with liver problems can sometimes have higher levels of pindolol in their body than people without liver problems. This can lower your blood pressure too much or cause more side effects. Tell your doctor if you have any issues with your liver or a history of liver disease so they can monitor you more closely while taking pindolol.

Can you stop taking pindolol before surgery?

If you're planning to undergo a major surgery requiring anesthesia, tell your surgeon that you are on pindolol, so they can monitor your heart closely. The surgeon may choose to have you temporarily stop taking pindolol a few days before surgery.

Can beta blockers cause breathing problems?

People who have asthma or COPD and are taking beta blockers like pindolol have had problems breathing. This medication can worsen your condition. Talk to your doctor if you have questions.

Can pindolol cause low blood sugar?

pindolol may cause the blood sugar to get too low and hide symptoms of dangerous low blood sugar in people with diabetes. Talk to your doctor about how to monitor your blood sugar if you are started on pindolol.

Can you stop taking pindolol if you have hyperthyroidism?

People taking pindolol who also have overactive thyroid may not recognize the signs of hyperthyroidism, such as fast heart rate. Don't stop taking pindolol suddenly without talking to your doctor, since this can worsen thyroid problems.

What is pindolol used for?

About pindolol. Type of medicine. A beta-adrenoceptor blocking medicine (often referred to as a beta-blocker) Used for. Hypertension; angina. Available as. Tablets. Pindolol belongs to the group of medicines referred to as beta-blockers. It is a medicine which works on the heart and blood vessels.

What are the side effects of taking pindolol?

The most common side-effects are feeling tired or dizzy, sleeping problems, and cold hands and feet. Pindolol - a beta-blocker. In this article. About pindolol. Before taking pindolol. How to take pindolol. Getting the most from your treatment.

How to get the most out of pindolol?

Getting the most from your treatment. Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Treatment with pindolol is usually long-term. Continue to take the tablets unless your doctor tells you to stop.

How many times a day should I take pindolol?

You may be asked to take one, two, or three doses each day. Your doctor may prescribe you a small dose initially, such as 2.5-5 mg, up to three times a day.

Can you drink alcohol with pindolol?

If you drink alcohol, ask your doctor for advice about taking pindolol and alcohol. Alcohol will add to the blood pressure-lowering effect of pindolol which will make you feel dizzy and so may not be recommended for you.

Can you take any other medicine without a prescription?

If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. If you have ever had an allergic reaction to a medicine, or if you have ever had any other serious allergic reaction.

Can you take pindolol while pregnant?

For these reasons, before you start taking pindolol it is important that your doctor knows : If you are pregnant or breastfeeding. If you have asthma or any other breathing disorder.

Pindolol Description

Pindolol - Clinical Pharmacology

Pharmacodynamics

Pharmacokinetics and Metabolism

Indications and Usage For Pindolol

Contraindications

Warnings

Precautions

Clinical Laboratory

Adverse Reactions