WHO Guidelines for Treatment of Cervical Intraepithelial Neoplasia 2–3 and Adenocarcinoma in situ: Cryotherapy, Large Loop Excision of the Transformation Zone, and Cold Knife Conization Cervical intraepithelial neoplasia (CIN) is a premalignant lesion that is diagnosed by histology as CIN1, CIN2, or CIN3.
Full Answer
What is the treatment for cervical intraepithelial neoplasia II–III (ii–iii)?
Li H, Zhang B, Lv J. [Clinical analysis of 168 cases of cervical intraepithelial neoplasia II–III treated by loop electrosurgical excision]. Chinese Journal of Clinical Oncology, 2008,
What screen-and-treat strategies should be used to prevent cervical cancer?
Results: There are nine recommendations for screen-and-treat strategies to prevent cervical cancer, including the HPV test, cytology, and visual inspection with acetic acid. There are seven for treatment of CIN with cryotherapy, loop electrosurgical excision procedure, and cold knife conization.
Does LEEP reduce the risk of cervical cancer?
x Residual/recurrence rates of CIN2+ are probably lower with LEEP resulting in lower risk of cervical cancer and related mortality compared to no treatment. These benefits outweigh the low risk of major bleeding and infection with LEEP, and the unclear risk of premature delivery or spontaneous abortion.
Do women in low-income countries prefer LEEP or CKC?
income countries may not have as much aversion to CKC (e.g. anaesthesia), while women in lower income countries – where there may be other risks from invasive surgery – may prefer LEEP. Resource implications
Is adenocarcinoma in-situ the same as CIN3?
CIN3 is not cancer of the cervix, but it is important to treat CIN3 as soon as possible. CIN3 may be referred to as severe dyskaryosis or severe dysplasia. Less commonly, it is called carcinoma-in-situ, though this term is rarely used these days.
What is the difference between CIN3 and carcinoma-in-situ?
CIN 3 means the full thickness of the cervical surface layer is affected by abnormal cells. CIN 3 is also called carcinoma-in-situ. This sounds like cancer, but CIN 3 is not cervical cancer. Cancer develops when the deeper layers of the cervix are affected by abnormal cells.
Is CIN 2 and CIN 3 a cancer?
Abnormal cells are found on the surface of the cervix. CIN 2/3 is usually caused by certain types of human papillomavirus (HPV) and is found when a cervical biopsy is done. CIN 2/3 has features of CIN 2 and CIN 3. It is not cancer, but may become cancer and spread to nearby normal tissue if not treated.
What is the most common method used to treat CIN 2 and CIN 3?
laser or loop electrosurgical excision procedure (leeP) are the preferred treatment methods for recurrent CIN 2 and CIN 3 (sor: B, based on clinical trials without randomization).
How is adenocarcinoma in situ of cervix treated?
The standard treatment for cervical adenocarcinoma in situ (AIS) is hysterectomy, which is a more aggressive treatment than that used for squamous intraepithelial lesions.
What is adenocarcinoma in situ cervix?
Adenocarcinoma in situ (AIS)* represents a pre-cancerous condition that can progress to cervical adenocarcinoma. Cervical adenocarcinoma in situ occurs in the glandular tissue of the cervix and is the condition which leads to invasive adenocarcinoma1.
What percentage of CIN 3 turns into cancer?
Natural history of CIN 2,3 – Data on the natural history of untreated high-grade disease (CIN 2,3) are limited since most patients are treated. For CIN 3, the estimated spontaneous regression rate is 32 to 47 percent, with 12 to 40 percent progressing to invasive cancer if untreated [8-13].
What is the difference between CIN 2 and CIN 3?
CIN 2: Refers to abnormal cells affecting about one-third to two-thirds of the epithelium. CIN 3: Refers to abnormal cells affecting more than two-thirds of the epithelium.
What happens if I have CIN 3?
CIN 3 is not cancer, but may become cancer and spread to nearby normal tissue if not treated. Treatment for CIN 3 may include cryotherapy, laser therapy, loop electrosurgical procedure (LEEP), or cone biopsy to remove or destroy the abnormal tissue. CIN 3 is sometimes called high-grade or severe dysplasia.
Will a hysterectomy cure CIN3?
A hysterectomy will not cure the HPV which has caused the CIN, as there is no cure for HPV, but the CIN cannot have spread anywhere else in your body and will only be in your cervix area-it doesn't travel through the bloodstream, and remains where the HPV infection is.
How long does it take for CIN 2 to become CIN3?
In a meta-analysis of 36 studies involving 3,160 women with CIN2 who were actively monitored for at least 3 months, 50% of the lesions regressed spontaneously, 32% persisted, and just under one in five (18%) progressed to CIN3 or worse within 2 years.
Is CGIN worse than CIN?
CGIN is usually classified as low grade (mild) or high grade (severe). High grade CGIN is the equivalent of CIN3. CGIN can be multi-focal – this means that more than one area is affected at one time, with normal tissue lying between them.
How long does it take for CIN 2 to develop into cancer?
However, it is estimated that 5% of CIN 2 and 12% of CIN 3 cases will progress to invasive cancer if untreated. In general, it takes 10 to 20 years for CIN to progress to cancer, allowing a significant time period for detection and treatment. Progression from CIN to cancer requires persistent HPV infection.
Is cervical intraepithelial neoplasia cancer?
Cervical intraepithelial neoplasia is not cancer, but may become cancer and spread to nearby normal tissue. It is graded on a scale of 1 to 3, based on how abnormal the cells look under a microscope and how much of the cervical tissue is affected.
Is CGIN a cancer?
About 6 in every 10 people have abnormal cells in their cervix – known as cervical intra-epithelial neoplasia (CIN) or cervical glandular intra-epithelial neoplasia (CGIN). This is not cancer, but there's a risk it could turn into cancer if untreated.
How long does it take for precancerous cells to turn into cancer?
These aren't cancer cells, but cells that may turn cancerous if left untreated for many years. It takes 10-15 years for pre-cancer to progress to cancer. If you already have cancer cells, this would show up as malignancy.