Medication
Update of Antibiotic Therapy of Brucellosis
- Introduction. Brucellosis is a zoonotic disease that can affect humans around the world, and it can affect any organ system.
- Antibiotic treatment. The principal objective of the treatment in brucellosis is to control the disease, prevent complications, relapse, and unfavorable outcomes.
- Other considerations about treatment. ...
- Conclusion. ...
Nutrition
Publication types
- Meta-Analysis
- Research Support, Non-U.S. Gov't
- Review
- Systematic Review
What is the optimal antibiotic therapy for brucellosis?
unpasteurized dairy products, including: milk cheese ice cream
- milk
- cheese
- ice cream
Which antibiotics are used in the treatment of brucellosis?
You are more likely to get brucellosis if you:
- Eat or drink unpasteurized dairy products from cows, goats, or other animals that are infected with the bacteria
- Eat other unpasteurized cheeses called "village cheeses." These come from high-risk regions, including the Mediterranean
- Travel to areas where Brucella is common
- Work in a meat-processing plant or slaughterhouse
- Work on a farm
How to cure and treat brucellosis?
What can you do to prevent brucellosis?
What is best treatment for brucellosis?
Depending on the timing of treatment and severity of illness, recovery may take a few weeks to several months. Death from brucellosis is rare, occurring in no more than 2% of all cases. Generally, the antibiotics doxycycline and rifampin are recommended in combination for a minimum of 6-8 weeks.
Can azithromycin treat brucellosis?
Azithromycin may be an effective therapy for treatment of brucellosis, but, to our knowledge, its use has not been assessed in humans.
How is brucellosis managed?
General principles of brucellosis treatment include use of antibiotics with activity in acidic intracellular environments (such as doxycycline and rifampin), use of combination therapy (given high relapse rates with monotherapy), and prolonged duration of treatment [8-10].
Can ciprofloxacin treat Brucella?
Ciprofloxacin can be considered as an alternative drug for the treatment of brucellosis, more effective (clinically and immunologically) than a combination of two antibiotics: doxycycline and rifampicin.
Is levofloxacin good for brucellosis?
The results of this study indicate that levofloxacin and dirithromycin are ineffective in the treatment of experimental murine brucellosis as monotherapy or in combination with rifampicin.
Does levofloxacin treat Brucella?
Conclusions. Adding levofloxacin to the dual therapy for acute/subacute brucellosis (doxycycline–rifampin) may increase its efficacy in terms of lowering the relapse rate of the disease.
Can amoxicillin treat brucellosis?
Twenty-eight cases of acute brucellosis were diagnosed and confirmed by positive blood culture. They were treated with amoxycillin in a daily dosage of two capsules of 375 mg every eight hours. Treatment lasted for one month of which the first 15 days were spent in hospital.
Does ceftriaxone treat brucellosis?
It is concluded that ceftriaxone may be considered a second-line therapy for brucellosis in patients who cannot be given conventional therapy. Further evaluation of ceftriaxone, either alone or preferably in combination with streptomycin or rifampicin on a larger scale, is indicated.
Can streptomycin injection treat brucellosis?
Two-drug regimen consisting of streptomycin and doxycycline (streptomycin for 2 to 3 weeks and doxycycline for 8 weeks) or gentamicin plus doxycycline (gentamicin for 5-7 days and doxycycline for 8 weeks) should be recommended as the treatment of choice for uncomplicated brucellosis.
Does doxycycline treat brucellosis?
Chronic brucellosis is treated with triple-antibiotic therapy. The combination of rifampin, doxycycline, and streptomycin often is used.
Can doxycycline alone treat brucellosis?
Doxycycline has also been used as adjunctive monotherapy in cases of residual focal brucellosis for a protracted period, although there are no official data supporting its effectiveness when used as a single agent after an initial combination with another compound.
Is gentamicin used to treat brucellosis?
Gentamicin is an aminoglycoside antibiotic that exerts a bacteriostatic effect by inhibiting protein synthesis through binding to 30S ribosomal subunits. It is commonly used to treat brucellosis in combination with either TMP-SMZ or doxycycline. Dosing regimens are numerous.