who definition on mdr tb treatment outcome

by Barrett Yundt Published 3 years ago Updated 2 years ago

In 2017, the overall proportion of successfully treated MDR-/RR-TB patients (i.e., cure plus treatment completed) globally was 55%, 8% were treatment failures, 15% of patients died and 22% were lost to follow-up (LTFU). 1 In 2014, the WHO revised outcome definitions for patients treated for MDR-TB. 2 The main weakness of these definitions was that the definition of a successful treatment outcome was based mainly on treatment completion rather than cure, and failed to consider early post-treatment follow-up of patients. 3 TBnet (Tuberculosis Network European Trials Group), a network to promote clinically oriented research in the field of TB in Europe, recently proposed simplified treatment outcome definitions for MDR-TB that aim to overcome these limitations. 4 The new simplified definitions describe the following outcome groups: 1) cure: culture-negative 6 months after treatment initiation, no positive culture thereafter and no relapses within 1 year of treatment completion; 2) treatment failure: culture-positive 6 months after treatment initiation or thereafter, or relapse within 1 year of treatment completion; 3) death: death in the observation period; 4) loss to follow-up: non-receipt of care 6 months after treatment initiation; 5) undeclared outcome: outcome not assessed due to transfer out of the patient, no culture status at 6 months while the patient was receiving care or no post-treatment assessment....

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What does MDR stand for in tuberculosis?

Apr 01, 2018 · Failure of MDR-TB treatment is defined by WHO as termination of the treatment or need for permanent regimen change of at least two antituberculosis drugs because of (i) lack of conversion by the end of the intensive phase, (ii) bacteriological reversion in the continuation phase after conversion to negative, (iii) evidence of additional acquired resistance to …

What is the prognosis of multidrug-resistant tuberculosis (MDR)?

Numerator: Total number of patients entered on the second-line treatment register in the given year who had a final outcome of 'cured' or 'completed'. Denominator: Total number of patients entered on the second-line treatment register in the given year All confirmed MDR-TB patients entered on the second-line treatment register should be assigned one of six mutually exclusive …

What are the final outcomes for drug-susceptible TB and Dr-TB?

Affiliations. 1 Research Center Borstel, Clinical Infectious Diseases, German Center for Infection Research (DZIF), Borstel 23845, Germany; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany; Department of Medicine, Karolinska Institute, Stockholm, Sweden. Electronic address: [email protected]. 2 Department of ...

Why do MDR-TB patients respond poorly to treatment?

The new treatment outcome definitions make a clear distinction between two types of patients: – patients treated for drug-susceptible TB; – patients treated for drug-resistant TB using second-line treatment (defined as combination chemotherapy for drug-resistant TB, which includes drugs other than those in Group 1 ). The two groups are mutually exclusive.

WHO tuberculosis treatment outcomes?

Prevalence of poor TB treatment outcome

Successful treatment outcomes constituted 85.5% where 27.5% were cured and 58.0% completed treatment. Treatment outcomes by complete year of assessment were 11.2% (16/143) in 2017, 16.9% (30/177) in 2018 and 16.4% (12/73) in 2019.Mar 10, 2022

Which treatment outcomes are considered as treatment success for TB patient?

Of the total TB patients with known treatment outcome, the overall treatment success rate was 82.5%. Of these 65 (28%) were cured and 126 (54.3%) had completed their treatment. The treatment success rate of HIV-co-infected TB patients (n=40) included in TB treatment outcome analysis was 77.5%.

WHO guidelines MDR-TB treatment?

Current policy recommendations on treatment and care for DR-TB. In patients with confirmed rifampicin-susceptible and isoniazid-resistant tuberculosis, treatment with rifampicin, ethambutol, pyrazinamide and levofloxacin is recommended for a duration of 6 months.

What is treatment outcome?

5.1 Definition. Treatment outcome research was defined by Mowrer (1953) as a situation whereby the “emphasis is upon measuring significant aspects of personality before and after treatment and noting the nature and extent of the resulting changes” (p. 4).

What is the outcome of tuberculosis?

Before the advent of antituberculous chemotherapy, the majority of patients with TB died within months or years after the development of disease. Approximately 70% of patients with untreated smear-positive TB were dead after 10 years [8]. Death was the only certain marker of the epidemiology and outcome of TB.

At what intervals TB patients are evaluated during the course of TB treatment?

After completion of treatment the patients should be followed up with clinical and/or sputum examination at the end of 6, 12, 18 and 24 months.

WHO consolidated guidelines on tuberculosis module?

The WHO consolidated guidelines on tuberculosis: tuberculosis preventive treatment provides a comprehensive set of recommendations for programmatic management of tuberculosis preventive treatment (PMTPT) geared towards the implementers of the WHO End TB Strategy and also for countries intent upon TB elimination (9).

WHO TB drug classification?

2. Classifications

(1) WHO 2011 TB drugs classification
Group 1 First-line oral anti-TB drugs	• Isoniazid • Rifampicin • Ethambutol • Pyrazinamide
Group 2 Injectable anti-TB drugs (injectable or parenteral agents)	• Streptomycin • Kanamycin • Amikacin • Capreomycin

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WHO developed Pretomanid?

Pretomanid was developed by TB Alliance. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.

What are Treatment Outcome Studies?

Treatment outcome studies are designed to answer commonsense questions. To determine whether a treatment accomplishes anything, we have to know how patients who have not received the treatment fare. Perhaps untreated patients do just as well, implying that the treatment does not influence outcome at all.

What is treatment outcome research?

research designed to evaluate the efficacy of interventions and to investigate the mechanism by which effective interventions produce change.

What is therapy outcome study?

research that investigates the end results of therapy or other interventions to which patients are exposed. The focus is primarily on the “cure” (or not) of patients, but the research also evaluates their experiences, preferences, and values, as well as the wider influence on society.

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